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You searched for +publisher:"University of Alabama – Birmingham" +contributor:("Joel L. Berry"). Showing records 1 – 2 of 2 total matches.

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1. Fee, Timothy John. Novel device to quantify the mechanical properties of electrospun nanofibers.

Degree: MS, 2012, University of Alabama – Birmingham

Electrospun biomaterials are gaining popularity as scaffolding for engineered tissues. These fibrous scaffolds of natural or synthetic polymers can mimic the nano-scale properties of the natural extra-cellular matrix. It is becoming clear that the mechanical deformation of any electrospun matrix plays an important role in cell signaling. However, electrospun biomaterials have inherently complex geometries due to the random deposition of fibers during the electrospinning process. This complex fiber geometry complicates any attempt at quantifying forces exerted on adherent cells during electrospun matrix deformation. In order to quantify the mechanical properties of arrays of individual electrospun fibers in physiological conditions, a novel mechanical test platform has been designed and constructed. To facilitate wet testing, optical strain recording, and cellular substrate testing, the novel device is capable of testing in a cell culture environment and can keep the electrospun fibers within the focal plane of an inverted microscope. To limit the complications arising from the inherent random orientation of electrospun fibers, a method of manually depositing parallel electrospun poly(?-caprolactone) (PCL) fibers was developed in this research. The designed micro-tensile testing platform was used to quantify the mechanical and viscoelastic properties of these parallel electrospun PCL fibers. It has been shown that the novel device can perform direct observations of strain along an electrospun fiber using a non-contact optical strain recording method. The development of a device capable of recording true strain from arrays of individual electrospun fibers is significant in that an understanding of the materials used in designing tissue engineered implants can lead to improved engineered tissue substitutes.

M.S.

1 online resource (xi, 74 p.) :col. ill.

Biomedical Engineering

Engineering

Electrospinning, Micro-Tensile Testing, Viscoelasticity, Biomechanics, Optical Strain Recording, Nanofibers

UNRESTRICTED

Advisors/Committee Members: Joel L. Berry, Additional advisors: Derrick Dean, Alan Eberhardt, Ho-Wook Jun..

Subjects/Keywords: Tissue scaffolds – Materials – Mechanical properties – Measurement – Equipment and supplies – Design and construction<; br>; Polymers in medicine – Mechanical properties – Measurement – Equipment and supplies – Design and construction<; br>; Nanofibers – Mechanical properties – Measurement – Equipment and supplies – Design and construction<; br>; Polycaprolactone – Mechanical properties – Measurement – Equipment and supplies – Design and construction<; br>; Electrospinning

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Fee, T. J. (2012). Novel device to quantify the mechanical properties of electrospun nanofibers. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1324

Chicago Manual of Style (16th Edition):

Fee, Timothy John. “Novel device to quantify the mechanical properties of electrospun nanofibers.” 2012. Masters Thesis, University of Alabama – Birmingham. Accessed July 20, 2019. http://contentdm.mhsl.uab.edu/u?/etd,1324.

MLA Handbook (7th Edition):

Fee, Timothy John. “Novel device to quantify the mechanical properties of electrospun nanofibers.” 2012. Web. 20 Jul 2019.

Vancouver:

Fee TJ. Novel device to quantify the mechanical properties of electrospun nanofibers. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2012. [cited 2019 Jul 20]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1324.

Council of Science Editors:

Fee TJ. Novel device to quantify the mechanical properties of electrospun nanofibers. [Masters Thesis]. University of Alabama – Birmingham; 2012. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1324

2. Marshall, Lauren. In Vitro Prevascularization Of 3d Tissue Constructs.

Degree: 2013, University of Alabama – Birmingham

There is a need for more effective therapies to combat breast cancer. One reason for the inefficiency of therapeutics is that testing technologies currently employed in drug discovery and development are not reliable when transitioning drugs into human clinical trials. To supplement the currently used <italic>in vitro</italic> cell culture studies and <italic>in vivo</italic> animal studies, an <italic>in vitro</italic> three-dimensional breast tumor system has been suggested with integration of human cells, hydrogel biomaterials, 3D architecture, and endothelialized microchannels. Therefore, the objective of the thesis project, as an initial step in fabrication of the supplemental system for drug testing, is to fabricate and characterize a tissue volume with pre-fabricated EC-lined microchannels representing the vasculature of a breast tumor. It is hypothesized that an <italic>in vitro</italic> three-dimensional microphysiologic system can be constructed with extracellular matrix and flow-through microchannels that will support a confluent endothelial layer. Results have shown that fabricated three-dimensional microenvironments, composed of extracellular matrix components, had a matrix elasticity similar to that of normal mammary tissue. An iterative design process of bioreactor fabrication led to a bioreactor that could contain a three-dimensional scaffold with a mean wall shear stress in the range of 0-5 dyne/cm<super>2</super> inside the microchannels. In addition, the bioreactor system and endothelialization protocol facilitated the localization and attachment of endothelial cells inside the prefabricated microchannels. Future work will include further characterization of endothelial cell morphology and function and assessment of barrier function and permeability of the engineered endothelium. Continuation of this proof-of-concept project will lead to the formation of a confluent endothelial cell monolayer, which may be used to perfuse the three-dimensional tissue-engineered scaffold, to act as a dissemination route for tumor cells, or to act as a route for therapeutics to the tumor site.

MS

1 online resource (xiii, 88 pages) :illustrations (some color)

M.S.University of Alabama at Birmingham2013.

Biomedical Engineering

Engineering

3D tumor architecture</br>breast cancer</br>microvessels</br>perfusion flow bioreactor

UNRESTRICTED

Advisors/Committee Members: Joel L. Berry, Berry, Joel L. Frost, Andra R. Penman,Andrew Murphy-Ullrich,Joanne Wick, Timothy M..

Subjects/Keywords: Breast – Tumors – Simulation methods – Equipment and supplies – Design and construction. Breast – Blood-vessels – Simulation methods – Equipment and supplies – Design and construction. Blood flow – Simulation methods – Equipment and supplies – Design and construction. Bioreactors – Design and construction. Tissue scaffolds – Design and construction. Tissue engineering. Three-dimensional imaging in medicine. Perfusion (Physiology) Vascular endothelium.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Marshall, L. (2013). In Vitro Prevascularization Of 3d Tissue Constructs. (Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1691

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Marshall, Lauren. “In Vitro Prevascularization Of 3d Tissue Constructs.” 2013. Thesis, University of Alabama – Birmingham. Accessed July 20, 2019. http://contentdm.mhsl.uab.edu/u?/etd,1691.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Marshall, Lauren. “In Vitro Prevascularization Of 3d Tissue Constructs.” 2013. Web. 20 Jul 2019.

Vancouver:

Marshall L. In Vitro Prevascularization Of 3d Tissue Constructs. [Internet] [Thesis]. University of Alabama – Birmingham; 2013. [cited 2019 Jul 20]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1691.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Marshall L. In Vitro Prevascularization Of 3d Tissue Constructs. [Thesis]. University of Alabama – Birmingham; 2013. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1691

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.