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You searched for +publisher:"University of Alabama – Birmingham" +contributor:("Gower, Barbara<br>"). Showing records 1 – 2 of 2 total matches.

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1. Stuart, Wilma Powell. A grounded theory study: Hispanic adolescents' experience of being overweight.

Degree: PhD, 2007, University of Alabama – Birmingham

The number of overweight adolescents worldwide has continued to increase over the past several decades. Intervention studies for weight management with overweight adolescents are challenged by high rates of attrition and have failed to achieve sustained outcomes. Hispanic adolescents have a higher risk of being overweight than their African American and White peers do. However, Hispanic overweight adolescents have been poorly represented in intervention studies with overweight adolescents. The factors that influence the Hispanic overweight adolescents’ perceptions of weight and weight loss management are not known. This qualitative study used ground theory methodology to identify the factors that influence perceptions of weight and weight loss management of the Hispanic overweight adolescent and to develop a theory for weight loss interventions from the perceptions of the Hispanic overweight adolescent. Nineteen overweight Hispanic adolescents, 9 males and 10 females, between the ages of 16 and 17 years of age participated in the study. Audio taped structured interviews were used for data collection. Data were analyzed through a comparison process to identify core categories. The core categories representing the cycle of being overweight were identification of difference, family influences, teasing and bullying, anger, depression, avoiding stigma, and failed change efforts. The core variable was the resolution of self, I’m not different, I’m just me. The important influence of teasing and bullying behaviors and family influences are the drivers of the cycle of being overweight. Future research with overweight Hispanic adolescents should address both the prevention of early teasing and bullying behaviors in the school setting and the inclusion of family in planned interventions.

xi, 212 p. : ill., digital, PDF file.

Nursing

Nursing

Overweight Adolescent Grounded Theory Obesity Teasing Bullying Hispanic Family

UNRESTRICTED

Advisors/Committee Members: Rice, Marti, Broome, Marion <br>, Davies, Susan <br>, Gower, Barbara <br>, Habermann, Barbara.

Subjects/Keywords: Adaptation, Psychological <; br>; Adolescent <; br>; Body Image <; br>; Food Habits  – ethnology <; br>; Health Behavior  – ethnology <; br>; Hispanic Americans <; br>; Overweight  – ethnology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Stuart, W. P. (2007). A grounded theory study: Hispanic adolescents' experience of being overweight. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,384

Chicago Manual of Style (16th Edition):

Stuart, Wilma Powell. “A grounded theory study: Hispanic adolescents' experience of being overweight.” 2007. Doctoral Dissertation, University of Alabama – Birmingham. Accessed October 19, 2019. http://contentdm.mhsl.uab.edu/u?/etd,384.

MLA Handbook (7th Edition):

Stuart, Wilma Powell. “A grounded theory study: Hispanic adolescents' experience of being overweight.” 2007. Web. 19 Oct 2019.

Vancouver:

Stuart WP. A grounded theory study: Hispanic adolescents' experience of being overweight. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2007. [cited 2019 Oct 19]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,384.

Council of Science Editors:

Stuart WP. A grounded theory study: Hispanic adolescents' experience of being overweight. [Doctoral Dissertation]. University of Alabama – Birmingham; 2007. Available from: http://contentdm.mhsl.uab.edu/u?/etd,384

2. Fulzele, Keertik. Insulin signaling and function in osteoblasts.

Degree: PhD, 2009, University of Alabama – Birmingham

Insulin and insulin-like growth factor-1 (IGF-1) are evolutionarily conserved hormonal signaling pathways with structurally similar ligands and receptors. Recent studies suggest that that insulin and IGF-1 exert distinct as well as overlapping functions to regulate different aspects of skeletal development. A major problem in distinguishing the actions of insulin and IGF-1 is the fact that the receptors are co-expressed in many cell types and each ligand is able to cross-activate the other ligands’ receptor. To distinguish direct skeletal actions of insulin from that of IGF-1, we have conditionally disrupted each receptor in vitro and in vivo specifically in osteoblasts. Studies using osteoblasts lacking the IGF-1R in vitro have allowed us to demonstrate that insulin exerts direct anabolic actions in osteoblasts by activation of its cognate receptor, and that the strength of insulin generated signals is tempered through interactions with IGF-1R. Moreover, insulin treatment of ΔIGF-1R osteoblasts rescues the differentiation defect in these cells whereas the differentiation defect in ΔIR osteoblasts cannot be rescued by IGF-1 treatment. To unequivocally establish insulin actions in bone, we have compared the phenotypes of mice which lack either the insulin receptor (Ob-ΔIR) or the IGF-1 receptor (Ob- ΔIGF-1R) in osteoblasts using a Cre/loxP recombination technique. Mice lacking the IR in osteoblasts failed to accumulate bone primarily due to a reduction in number and/or activity of osteoblasts. By contrast, mice lacking IGF-1R in osteoblasts also had reduced trabecular bone but exhibited normal or even elevated numbers of osteoblasts. The primary defect in these mice was due to a failure to mineralize osteoid matrix. As Ob-ΔIR mice aged, they developed features resembling those seen in metabolic syndrome including increased peripheral fat, glucose intolerance, and insulin insensitivity. These changes were accompanied by decreased serum adiponectin. Most importantly, circulating undercarboxylated osteocalcin, a recently identified secretagogue for insulin, was decreased in serum from Ob-ΔIR mice. Our findings indicate that insulin signaling regulates postnatal bone acquisition through mechanisms distinct from IGF-1. Moreover, insulin action in osteoblasts also influences fat accumulation, likely by regulating secretion and bioavailability of osteocalcin.

1 online resource (vii, 109 p. : ill., digital, PDF file)

Joint Health Sciences;

Osteoblasts Insulin Body composition Bone accumulation

UNRESTRICTED

Advisors/Committee Members: Clemens, Thomas L., Gower, Barbara<br>, Sanderson, Ralph D.<br>, Wood, Philip A.<br>, Zhang, Jianhua.

Subjects/Keywords: Insulin  – metabolism<; br>; Osteoblasts  – metabolism<; br>; Osteogenesis  – physiology<; br>; Receptor, IGF Type 1  – metabolism<; br>; Receptor, Insulin  – metabolism<; br>; Signal Transduction  – physiology<; br>; Skull  – metabolism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Fulzele, K. (2009). Insulin signaling and function in osteoblasts. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,999

Chicago Manual of Style (16th Edition):

Fulzele, Keertik. “Insulin signaling and function in osteoblasts.” 2009. Doctoral Dissertation, University of Alabama – Birmingham. Accessed October 19, 2019. http://contentdm.mhsl.uab.edu/u?/etd,999.

MLA Handbook (7th Edition):

Fulzele, Keertik. “Insulin signaling and function in osteoblasts.” 2009. Web. 19 Oct 2019.

Vancouver:

Fulzele K. Insulin signaling and function in osteoblasts. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2009. [cited 2019 Oct 19]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,999.

Council of Science Editors:

Fulzele K. Insulin signaling and function in osteoblasts. [Doctoral Dissertation]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,999

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