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You searched for +publisher:"University of Alabama" +contributor:("Williams, Thomas M."). One record found.

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University of Alabama

1. Wang, Wei. The development and regulation of adult abdominal segment reduction in drosophila.

Degree: 2014, University of Alabama

A central aim of evolutionary research is to understand the genetic and molecular mechanisms underlying the morphological divergence of species. A growing body of evidence has been accumulated showing mutations in cis-regulatory elements that affect the regulation of gene expression are a common source of morphological evolution. A number of fundamental studies have been done on several rapidly evolving traits, including Drosophila pigmentation patterns and larval trichome patterns, and skeletal structures of stickleback fish. However, the evolution of conserved traits is not well understood. For my dissertation, I focused on understanding the genetic mechanisms that lead to the robustness and maintenance of conserved traits. Specifically, I use abdominal segment reduction as a genetic model to address my question. Adult female Drosophila develops seven abdominal segments, while adult males only have six segments. In the following studies, we investigated 1) When and how male A7 segment is reduced during development. We found male A7 segment is reduced between 24 h APF and 40 h APF. 2) The mechanisms responsible for the loss of male A7. We found male A7 is eliminated by the combination of suppression of cell proliferation and differentiation, segment compartmental transformation and apoptosis. 3) The genetic regulation of male A7 reduction. I found male A7 reduction is controlled by the Hox protein Abd-B and sex-determination factor Dsx through negative regulation of Wg and DER activity. 4) Gene interactions within the regulatory network that controls male A7 reduction. I found the regulation of wg is the key node in this highly interactive regulatory network. 5) The regulatory control of wg during pupal development. I identified two CREs (wg8 and wg9) regulating wg expression in pupal abdomen. These findings show that the regulation wg is at the center of a highly interactive regulatory network, which may contribute to the robustness and long-term maintenance of segment reduction in Cyclorrhapha. (Published By University of Alabama Libraries) Advisors/Committee Members: Yoder, John H., O'Donnell, Janis M., Caldwell, Guy A., Harris, Phillip M., Jenny, Matthew, Williams, Thomas M., University of Alabama. Dept. of Biological Sciences.

Subjects/Keywords: Electronic Thesis or Dissertation;  – thesis; Developmental biology; Genetics; Evolution & development; Doublesex; Drosophila; Hox proteins; Segment reduction; Sexual dimorphism; Wingless

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APA (6th Edition):

Wang, W. (2014). The development and regulation of adult abdominal segment reduction in drosophila. (Thesis). University of Alabama. Retrieved from http://purl.lib.ua.edu/105108

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Wang, Wei. “The development and regulation of adult abdominal segment reduction in drosophila.” 2014. Thesis, University of Alabama. Accessed December 14, 2019. http://purl.lib.ua.edu/105108.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Wang, Wei. “The development and regulation of adult abdominal segment reduction in drosophila.” 2014. Web. 14 Dec 2019.

Vancouver:

Wang W. The development and regulation of adult abdominal segment reduction in drosophila. [Internet] [Thesis]. University of Alabama; 2014. [cited 2019 Dec 14]. Available from: http://purl.lib.ua.edu/105108.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang W. The development and regulation of adult abdominal segment reduction in drosophila. [Thesis]. University of Alabama; 2014. Available from: http://purl.lib.ua.edu/105108

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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