+publisher:"University of Adelaide" +contributor:("School of Physical Sciences")

University of Adelaide

1. Lam, Hiu Chun. Biomimetic total synthesis of natural products.

Degree: 2018, University of Adelaide

► This thesis describes several syntheses of natural products. The overall synthetic approach is to mimic how these secondary metabolites could be derived in Nature, where… (more)

Subjects/Keywords: total synthesis; natural products; organic chemistry; biomimetic

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APA (6^th Edition):

Lam, H. C. (2018). Biomimetic total synthesis of natural products. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/113263

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lam, Hiu Chun. “Biomimetic total synthesis of natural products.” 2018. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/113263.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lam, Hiu Chun. “Biomimetic total synthesis of natural products.” 2018. Web. 25 Jun 2019.

Vancouver:

Lam HC. Biomimetic total synthesis of natural products. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/113263.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lam HC. Biomimetic total synthesis of natural products. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/113263

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

2. Arboit, Francesco. The tectonic evolution of Khao Khwang Fold-Thrust Belt, 4 Central Thailand: new insights in the Permian and Triassic 5 evolution of the Indosinian orogeny in SE Asia.

Degree: 2016, University of Adelaide

URL: http://hdl.handle.net/2440/113358

► The south-western margin of the Indochina Block and more specifically the Khao Khwang Fold-Thrust Belt (KKFTB) within the Saraburi region in the southern portion of… (more)

▼ The south-western margin of the Indochina Block and more specifically the Khao Khwang Fold-Thrust Belt (KKFTB) within the Saraburi region in the southern portion of the Loei volcanic belt, holds a pivotal role in the reconstruction of the Permo-Triassic evolution of the Indosinian orogeny in SE Asia. Bound to the east by the Khorat Plateau and to the west by the Nan-Uttardit-Sa Kaeo Suture Zone; the KKFTB offers a breath of information regarding inter-terrane correlations and the Late Palaeozoic –Early Mesozoic tectonic setting on the northern margin of the Palaeo and Meso Tethys. The KKFTB offers a natural and ideal laboratory to work out critical components of the tectonic evolution of SE Asia. However it has not often been deeply considered in the models describing the Palaeozoic and Mesozoic phases of the Indosinian tectonic events. The trend of the regional suture zones between the terranes involved in the Indosinian orogeny, such as the sutures between the Sukhothai and Indochina terranes (Chiang Rai Tect. Line, Nan Suture Zone), and between the Sukhothai and Sibumasu terranes (Sa Kaeo Chanthaburi Accretionary complex), are roughly N-S oriented. Hence, in the last decades it has been widely accepted the interpretation where the Indosinian orogeny developed between strongly linear terranes. However, the effects of the Permian and Triassic tectonic events in Thailand have often been interpreted without considering the detailed tectonic evolution of the portion of the Indochina terrane’s margin formed by Khao Khwang Carbonate Platform area of the Saraburi Group, in central Thailand. This area is unusual because: 1) an extensive area representing a thin-skinned fold and thrust belt is well-exposed due to quarrying; and, 2) the fold and thrust belt displays a series of E-W and WNW-ESE striking thrusts and associated folds that are not easily explained in the context of the traditional interpretation where the terranes have been accreted broadly along N-S striking collisional zones. Detailed structural observations in numerous quarries around Highway 21, in a 13 km long dip-direction traverse, revealed that overall the thrust belt is composed of several large thrusts with an approximately northwards transport direction. In the southern part of the area, south-verging structures are present. Although the dominant structural trend is northwards-verging, interference structures, and late strike-slip faults indicate there is more than one phase of structural development present. Considering the polyphase tectonic history of this zone, we considered that integrating a study of fault and fracture with calcite twin analysis might be useful in order to determine the evolving paleo- stress magnitudes and principle stress directions that developed during the tectonic evolution of this highly deformed, polyphase orogen. The tectonic data from the Permian and Triassic carbonates of the Khao Khad Formation of the Saraburi Group, revealed that five tectonic stages might have developed before, during, and after, the Triassic… Advisors/Committee Members: Collins, Alan Stephen (advisor), School of Physical Sciences (school).

Subjects/Keywords: Indosinian orogeny; central Thailand; SE Asia; Khao Khwang Fold-Thrust Belt; tectonic framework; sedimentology; geochronology; structural geology; geochemistry; Research by Publication

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APA (6^th Edition):

Arboit, F. (2016). The tectonic evolution of Khao Khwang Fold-Thrust Belt, 4 Central Thailand: new insights in the Permian and Triassic 5 evolution of the Indosinian orogeny in SE Asia. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/113358

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arboit, Francesco. “The tectonic evolution of Khao Khwang Fold-Thrust Belt, 4 Central Thailand: new insights in the Permian and Triassic 5 evolution of the Indosinian orogeny in SE Asia.” 2016. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/113358.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arboit, Francesco. “The tectonic evolution of Khao Khwang Fold-Thrust Belt, 4 Central Thailand: new insights in the Permian and Triassic 5 evolution of the Indosinian orogeny in SE Asia.” 2016. Web. 25 Jun 2019.

Vancouver:

Arboit F. The tectonic evolution of Khao Khwang Fold-Thrust Belt, 4 Central Thailand: new insights in the Permian and Triassic 5 evolution of the Indosinian orogeny in SE Asia. [Internet] [Thesis]. University of Adelaide; 2016. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/113358.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arboit F. The tectonic evolution of Khao Khwang Fold-Thrust Belt, 4 Central Thailand: new insights in the Permian and Triassic 5 evolution of the Indosinian orogeny in SE Asia. [Thesis]. University of Adelaide; 2016. Available from: http://hdl.handle.net/2440/113358

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

3. Carrillo Serrano, Manuel Eduardo. Properties of hadrons from a non-perturbative approach.

Degree: 2016, University of Adelaide

URL: http://hdl.handle.net/2440/99169

► The composition and structure of matter remains a fundamental problem in physics. The closest theory that tries to deal with this problem is the Standard… (more)

▼ The composition and structure of matter remains a fundamental problem in physics. The closest theory that tries to deal with this problem is the Standard Model of particle physics, which encodes the electromagnetic, weak and strong interactions. The strong interaction is the main ingredient in the description of hadronic properties such as their masses, distribution of charge and magnetisation, decay parameters, and interactions between them. These properties have the common feature that they are modelled at low four momentum transfer. At those conditions the theory of the strong interactions becomes impossible to use and the best approach is to calculate the hadronic properties using expensive numerical simulations called lattice QCD. Because lattice QCD requires a lot of computational resources, models close to the theory of strong interactions are still of great importance. The work presented in this thesis uses different quark models (in particular the NJL model), in the calculation of the masses, electromagnetic form factors and weak decay properties of some light mass hadrons. In addition, it explores (in the context of the NJL model and others) the consequences that possible changes in fundamental constants could have for the binding energies of certain nuclei. Throughout the whole thesis the results are compared with other models, existing experimental data, and extrapolations of the lattice QCD simulations. In general terms, the agreement in those comparisons is outstanding. In some cases the quark models give predictions for and insights into what is expected for future experiments and lattice calculations. The main thrust of this thesis is to investigate the validity of the NJL model and the other models used here, because they can be crucial in the computation of physical properties of more complex structures such as many hadron systems or systems at very extreme conditions. Lattice QCD in those cases will still require a lot of work, time and computational resources. So far, it is fair to say that the models used here are to a very good extent, a good approximation to first principle calculations in the properties that were calculated in this thesis. Advisors/Committee Members: Thomas, Anthony William (advisor), School of Physical Sciences (school).

Subjects/Keywords: hadrons; NJL model; variations of fundamental constants; kaon decay; electromagnetic form factors; baryon octet; beta decays

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carrillo Serrano, M. E. (2016). Properties of hadrons from a non-perturbative approach. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/99169

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carrillo Serrano, Manuel Eduardo. “Properties of hadrons from a non-perturbative approach.” 2016. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/99169.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carrillo Serrano, Manuel Eduardo. “Properties of hadrons from a non-perturbative approach.” 2016. Web. 25 Jun 2019.

Vancouver:

Carrillo Serrano ME. Properties of hadrons from a non-perturbative approach. [Internet] [Thesis]. University of Adelaide; 2016. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/99169.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carrillo Serrano ME. Properties of hadrons from a non-perturbative approach. [Thesis]. University of Adelaide; 2016. Available from: http://hdl.handle.net/2440/99169

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

4. Sorokin, Jennifer. Large-scale-structure in the Pierre Auger Observatory data directions.

Degree: 2016, University of Adelaide

URL: http://hdl.handle.net/2440/99908

► This thesis presents a method of analysis of Pierre Auger Observatory Cosmic Ray (CR) directions. I look for evidence of large-scale-structure within these CR directions.… (more)

Subjects/Keywords: Yggdrasil; minimum spanning tree

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sorokin, J. (2016). Large-scale-structure in the Pierre Auger Observatory data directions. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/99908

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sorokin, Jennifer. “Large-scale-structure in the Pierre Auger Observatory data directions.” 2016. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/99908.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sorokin, Jennifer. “Large-scale-structure in the Pierre Auger Observatory data directions.” 2016. Web. 25 Jun 2019.

Vancouver:

Sorokin J. Large-scale-structure in the Pierre Auger Observatory data directions. [Internet] [Thesis]. University of Adelaide; 2016. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/99908.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sorokin J. Large-scale-structure in the Pierre Auger Observatory data directions. [Thesis]. University of Adelaide; 2016. Available from: http://hdl.handle.net/2440/99908

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

5. Spence, Justin Thomas James. Biomimetic synthesis of natural products via reactions of ortho-quinone methides.

Degree: 2016, University of Adelaide

URL: http://hdl.handle.net/2440/102583

► In recent times, natural product synthesis has become central to many scientific fields; from chemistry, through to biology and pharmacology. As synthetic chemists, natural products… (more)

▼ In recent times, natural product synthesis has become central to many scientific fields; from chemistry, through to biology and pharmacology. As synthetic chemists, natural products are attractive targets due to their interesting and complex structures, combined with some intriguing biological properties. One field that is of particular interest is the use of a biomimetic approach towards the synthesis of complex natural products. This thesis will describe the use ortho-quinone methides and cascade reactions towards the biomimetic synthesis of the penilactones A and B, the peniphenones A-D, virgatolide B and epicolactone. The total synthesis of ent-penilactone A and penilactone B has been achieved via biomimetic Michael reactions between tetronic acids and o-quinone methides. A fivecomponent cascade reaction between a tetronic acid, formaldehyde, and a resorcinol derivative that generates four carbon-carbon bonds, one carbon-oxygen bond and two stereocenters in a one-pot synthesis of penilactone A is also reported. The total synthesis of peniphenones A-D has been achieved via Michael reactions between appropriate nucleophiles and a common ortho-quinone methide intermediate. This strategy, which was based on a biosynthetic hypothesis, minimised the use of protecting groups and thus facilitated concise syntheses of the natural products. The most complex target, the benzannulated spiroketal peniphenone A, was synthesised enantioselectively in nine linear steps from commercially available starting materials. A synthesis for the ortho-quinone methide precursor of virgatolide B has been developed. A simplified enol ether was employed for the biomimetic [4+2] cycloaddition reaction to afford a simplified virgatolide B analogue. An isomerised compound containing a cis fused ring junction, thought to arise via a [4+2] cycloaddition of an ortho-quinone methide and an endocyclic enol ether formed by acid catalysed tautomerisation in situ will also be reported. Finally, preliminary studies towards the synthesis of epicolactone have been conducted. A synthesis of the proposed key proposed biosynthetic intermediate epicoccone B has been achieved in four steps. Efforts towards the synthesis of epicoccine via our proposed cycloetherification route proved to be challenging. Furthermore, the synthesis of epicolactone through our proposed biosynthesis was not viable, which was also observed by Trauner and co-workers in their 2014 synthesis of dibefurin. Advisors/Committee Members: George, Jonathan (advisor), School of Physical Sciences (school).

Subjects/Keywords: natural product synthesis; biomimetic synthesis; ortho-quinone methides

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Spence, J. T. J. (2016). Biomimetic synthesis of natural products via reactions of ortho-quinone methides. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/102583

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Spence, Justin Thomas James. “Biomimetic synthesis of natural products via reactions of ortho-quinone methides.” 2016. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/102583.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Spence, Justin Thomas James. “Biomimetic synthesis of natural products via reactions of ortho-quinone methides.” 2016. Web. 25 Jun 2019.

Vancouver:

Spence JTJ. Biomimetic synthesis of natural products via reactions of ortho-quinone methides. [Internet] [Thesis]. University of Adelaide; 2016. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/102583.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Spence JTJ. Biomimetic synthesis of natural products via reactions of ortho-quinone methides. [Thesis]. University of Adelaide; 2016. Available from: http://hdl.handle.net/2440/102583

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

6. Atkins, Natasha Jade. IceCube's neutrinos: galactic or extra-galactic?.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/115171

► The exact origin and production method of the astrophysical neutrino, a subatomic particle that is very difficult to detect, is yet to be confirmed. Here,… (more)

▼ The exact origin and production method of the astrophysical neutrino, a subatomic particle that is very difficult to detect, is yet to be confirmed. Here, two source scenarios for the origin of the neutrino are considered: Galactic and extra-galactic. In the Galactic scenario, neutrinos are searched for from the disk and the halo of the Milky Way, whereas in the extra-galactic case neutrinos might be coming from Active Galactic Nuclei, Starburst Galaxies and other highly energetic regions of the Universe. The IceCube Neutrino Observatory has detected an astrophysical neutrino intensity which may reveal the origin of these neutrinos. The Milky Way is not a unique galaxy. If it were to produce some fraction of the neutrinos that IceCube detects then there must be other similar spiral galaxies in the Universe also contributing to the intensity. This could create a contradiction of how many other Milky Way-like galaxies there would be allowed in the rest of the Universe if the assumption is made that the Milky Way produces nearly all of IceCube’s neutrinos. The overall number density of Milky Way-like objects in the Universe can be calculated for different Galactic source distributions. The neutrino sources could be distributed throughout the halo of the Galaxy or confined to the Galactic disk. By considering various models and calculating the number density of equivalent Milky Way-like galaxies in the rest of the Universe, constraints are placed on the fraction of the IceCube intensity that could be coming purely from the Milky Way. According to the results of this research it is ultimately found that, under the simplifying assumption that the halo is spherical, the halo of the Milky Way cannot account for all of IceCube’s neutrinos and under certain assumptions the disks of Milky Way-like galaxies cannot be the sole origin of neutrinos in light of experimental observations. Advisors/Committee Members: Hill, Gary C. (advisor), School of Physical Sciences (school).

Subjects/Keywords: neutrinos; Milky Way; halo

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APA (6^th Edition):

Atkins, N. J. (2018). IceCube's neutrinos: galactic or extra-galactic?. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/115171

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Atkins, Natasha Jade. “IceCube's neutrinos: galactic or extra-galactic?.” 2018. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/115171.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Atkins, Natasha Jade. “IceCube's neutrinos: galactic or extra-galactic?.” 2018. Web. 25 Jun 2019.

Vancouver:

Atkins NJ. IceCube's neutrinos: galactic or extra-galactic?. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/115171.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Atkins NJ. IceCube's neutrinos: galactic or extra-galactic?. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/115171

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

7. Teo, Jesse. Studies of Metal-Organic Polyhedra: Synthesis and Applications in Gas Storage and Separation.

Degree: 2017, University of Adelaide

URL: http://hdl.handle.net/2440/119197

► Metal-organic polyhedra (MOPs) are a class of porous materials, comprised of metal ions and organic ligands, which form discrete cage-like structures. Possessing large internal void… (more)

▼ Metal-organic polyhedra (MOPs) are a class of porous materials, comprised of metal ions and organic ligands, which form discrete cage-like structures. Possessing large internal void volumes, the physical and chemical properties of MOPs can be tuned by appropriate selection of the metal and organic building units. The work presented in this thesis investigates the application of MOPs to environmentally significant gas storage and separation. The first chapter introduces MOPs as an emerging class of promising materials and discusses their historical development since the first examples of synthetic supramolecular structures. As microporous materials, MOPs demonstrate strong interactions with small molecules giving them promise as a medium for selective gas adsorption. These attributes are of interest in the areas of H2 storage and the capture of CO2. As such, Chapter 1 discusses the benefits and challenges of utilising porous materials in these areas. Chapter 2 presents synthetic routes to MOPs containing both internal and external functionalisation by modifying both the metal nodes and the organic components which constitute the supramolecular structure. Presented herein are the first permanently porous examples of this class of materials to incorporate two different metal elements into a single paddlewheel unit in a controlled manner. These bimetallic MOPs demonstrate a strong binding affinity as well as an impressive volumetric capacity for H2 gas furthering development of a suitable H2 storage solution. Chapter 3 explores the decoration of MOPs with various external functionality and the effect these motifs have on MOP packing in the crystalline matrix. The synthesis of several new organic pro-ligands and subsequent MOPs is also detailed within. A method of modelling single crystal X-ray diffraction data is described that provides insight into the interactions between MOP structures which are dominated by the chemistry of the MOP exteriors. The tendency of these large structural entities to reduce porosity is further studied using X-ray diffraction data and computational methods. The work in Chapter 4 focuses on the use of MOPs in a composite system rather than as a singular material. By combining MOPs with a highly permeable polymer, poly[1- (trimethylsilyl)-1-propyne] (PTMSP), a series of mixed matrix membranes are synthesised for application in separating N2 and CO2 gases, a challenge of global significance from both an environmental and economic perspective. The compatibility of these constituents is shown to have a significant impact on the physical properties as well as the gas separation performance of the resulting composites. Advisors/Committee Members: Sumby, Christopher (advisor), School of Physical Sciences (school).

Subjects/Keywords: Metal organic polyhedra; Gas storage; Supramolecular chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Teo, J. (2017). Studies of Metal-Organic Polyhedra: Synthesis and Applications in Gas Storage and Separation. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/119197

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Teo, Jesse. “Studies of Metal-Organic Polyhedra: Synthesis and Applications in Gas Storage and Separation.” 2017. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/119197.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Teo, Jesse. “Studies of Metal-Organic Polyhedra: Synthesis and Applications in Gas Storage and Separation.” 2017. Web. 25 Jun 2019.

Vancouver:

Teo J. Studies of Metal-Organic Polyhedra: Synthesis and Applications in Gas Storage and Separation. [Internet] [Thesis]. University of Adelaide; 2017. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/119197.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Teo J. Studies of Metal-Organic Polyhedra: Synthesis and Applications in Gas Storage and Separation. [Thesis]. University of Adelaide; 2017. Available from: http://hdl.handle.net/2440/119197

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

8. Leong, Noby Charn Keng. Azobenzene-Modified Betacyclodextrin: Molecules, Materials and Molecular Devices.

Degree: 2017, University of Adelaide

URL: http://hdl.handle.net/2440/119198

► Cyclodextrins (CD) are naturally occurring macrocycles composed of alpha-1,4-linked D-glucopyranose units. CDs are common components in supramolecular chemistry owing to their ability to act as… (more)

▼ Cyclodextrins (CD) are naturally occurring macrocycles composed of alpha-1,4-linked D-glucopyranose units. CDs are common components in supramolecular chemistry owing to their ability to act as hosts to complex a wide variety of guests. Similarly, azobenzene has frequently been used in supramolecular chemistry as a photoswitchable moiety. We have explored the combined utility of CDs and azobenzene to explore supramolecular systems on the molecular, material and molecular device scale. Chapter 1 summarises CD and azobenzene chemistry. The applications of CDs are explored, including its use as components of polymeric hydrogels, mechanically interlocked molecules and molecular devices. Chapter 2 describes the attempted synthesis of three structural isomers of azobenzene-linked beta-CD dimers, in which the beta-CD substituent is attached to the para, meta or ortho position of both phenyl rings of azobenzene to give bis(6A-deoxy-beta-cyclodextrin-6A-yl)-4,4’-aminocarbonylazobenzene (p-beta-CD2az), bis(6A-deoxy-beta-cyclodextrin-6A-yl)-3,3’-aminocarbonylazobenzene (m-beta-CD2az) and bis(6A-deoxy-beta-cyclodextrin-6A-yl)-2,2’-aminocarbonylazobenzene (o-beta-CD2az), respectively. The aim of this research was to determine the effect of structural isomerisation on the photochemical properties of beta-CD dimers. The synthesis of p-beta-CD2az and m-beta-CD2az was successful, while the synthesis of o-beta-CD2az did not yield the desired compound. Instead, (6A-deoxy-beta-cyclodextrin-6A-yl)-2-aminocarbonyl-aminobenzene (beta-CDab) was produced. The photoisomerisation properties of p-beta-CD2az and m-beta-CD2az were examined by NMR and UV-vis spectroscopy. Chapter 3 investigated the host-guest complexation properties of beta-CD, beta-CDab and E-p-beta-CD2az. Three dyes were chosen as guests: cationic crystal violet (CV+), zwitterionic rhodamine B (RB) and anionic ethyl orange (EO-). The host-guest complexes were qualitatively studied by NMR spectroscopy. The complexation constants and thermodynamic parameters were determined by UV-vis spectroscopy. Chapter 4 explored the effect of guest modification on the host-guest complexation properties of beta-CD and beta-CDab. Four porphyrins were chosen as guests: meso-tetra(4-sulfonatophenyl)porphine (TSPP), meso-tetra(4-carboxyphenyl)porphine (TCPP), meso-tetra(4-N,N,N-trimethylanilinium)porphine (TMAP) and meso-tetra(N-methyl-4-pyridyl)porphine (TMPyP). The host-guest complexation properties were studied by NMR spectroscopy. The complexation constants and thermodynamic parameters were determined by UV-vis spectroscopy. Chapter 5 investigated the complexation between beta-CD, beta-CDab, E-p-beta-CD2az and E/Z-m-beta-CD2az and hydrophobe-substituted poly(acrylates) (PAA) in the formation of polymer hydrogels. The molecular-scale complexation properties were investigated to understand the factors that influence the bulk-material properties of the solutions. Three adamantane (AD) substituted PAAs were chosen for study, in which the length of the alkyl tether connecting the AD group to the PAA… Advisors/Committee Members: Kee, Tak W. (advisor), School of Physical Sciences (school).

Subjects/Keywords: Cyclodextrin; Azobenzene; Supramolecular chemistry; Host-guest chemistry; Hydrogels; Molecular devices

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APA (6^th Edition):

Leong, N. C. K. (2017). Azobenzene-Modified Betacyclodextrin: Molecules, Materials and Molecular Devices. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/119198

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Leong, Noby Charn Keng. “Azobenzene-Modified Betacyclodextrin: Molecules, Materials and Molecular Devices.” 2017. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/119198.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Leong, Noby Charn Keng. “Azobenzene-Modified Betacyclodextrin: Molecules, Materials and Molecular Devices.” 2017. Web. 25 Jun 2019.

Vancouver:

Leong NCK. Azobenzene-Modified Betacyclodextrin: Molecules, Materials and Molecular Devices. [Internet] [Thesis]. University of Adelaide; 2017. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/119198.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Leong NCK. Azobenzene-Modified Betacyclodextrin: Molecules, Materials and Molecular Devices. [Thesis]. University of Adelaide; 2017. Available from: http://hdl.handle.net/2440/119198

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

9. Voisin, Fabien. Environment Studies of Pulsar Wind Nebulae and Their Interactions with the Interstellar Medium.

Degree: 2017, University of Adelaide

URL: http://hdl.handle.net/2440/119266

► Pulsars, rapidly rotating neutron star born from the core-collapse of massive stars, convert a fraction of their rotational energy to accelerate electrons up to high… (more)

▼ Pulsars, rapidly rotating neutron star born from the core-collapse of massive stars, convert a fraction of their rotational energy to accelerate electrons up to high energies. The generated pulsar wind eventually reaches the termination shock and creates a pulsar wind nebula (PWN). There, the particles’ trajectories become randomized, and they produce radio to X-ray emission via synchrotron radiation; and TeV γ-ray emission from the interaction of high energy electrons with the Cosmic Microwave Background; and the infra-red emission from Galactic dust. Although progress has been made towards the understanding of the structure of the pulsar environment, several issues, such as the composition of the pulsar winds, still need to be addressed. Indeed, no direct evidence of hadronic components have yet been discovered inside the PWN. However, nearby dense molecular clouds could provide sufficient target particles for the potential hadrons from the PWN and its progenitor supernova remnant (SNR) to produce significant TeV emission via proton-proton (p-p) interaction. My work thus first consists of conducting interstellar matter (ISM) studies towards several PWNe using the 22-metre Mopra and the 4-metre Nanten radio telescopes. Among the studied PWNe, I particularly focus on HESS J1825−137 and its plausible association with the nearby unidentified TeV source HESS J1826−130. I have mapped the HESS J1826−130 region with Mopra in the 7 and 12 mm bands which, combined with the Nanten CO(1–0) survey and the GRS ¹³CO(1–0), enable an accurate analysis of the morphological and physical properties of several dense molecular clouds found in the line of sight. Interestingly, I have found a massive molecular cloud adjacent to the PWN HESS J1825−137 and overlapping the HESS J1826−130 TeV emission. From our mass estimates, I suggest that the cosmic-rays originating from the progenitor SNR of the pulsar PSRJ1826−1334 can significantly contribute to the TeV emission. We then attempt to model and predict spectral and morphological properties of the TeV emission from the propagation of high energy CRs and electrons, originating from the progenitor SNR and potentially from the PWN.We find that the resulting spectral shape of the TeV γ-ray emission is very sensitive to the diffusion coefficient of high energy particles inside molecular clouds. I also find that only a ‘slow’ diffusion’ of CRs (diffusion coefficient D(E) ∼ 10²⁶ √E/10GeV cm² s⁻¹) results in a significant contribution of the gamma-ray emission towards HESS J1826−130 at all energies. We finally notice that the contribution from hypothetical CRs escaping the PWN HESS J1825−137 is expected to be overshadowed by the contribution of CRs escaping the progenitor SNR. As one expects the latter’s contribution to decrease as time evolves while the former’s contribution to remain somewhat constant, I thus argue that older PWNe may be more suitable candidates to obtain direct evidence of CRs inside PWNe. Among the studied PWNe, I find that, based on simplistic diffusion studies, the ISM… Advisors/Committee Members: Rowell, Gavin (advisor), School of Physical Sciences (school).

Subjects/Keywords: Pulsar wind nebulae; gamma-ray astronomy; line emission study; cosmic-ray diffusion

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Voisin, F. (2017). Environment Studies of Pulsar Wind Nebulae and Their Interactions with the Interstellar Medium. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/119266

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Voisin, Fabien. “Environment Studies of Pulsar Wind Nebulae and Their Interactions with the Interstellar Medium.” 2017. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/119266.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Voisin, Fabien. “Environment Studies of Pulsar Wind Nebulae and Their Interactions with the Interstellar Medium.” 2017. Web. 25 Jun 2019.

Vancouver:

Voisin F. Environment Studies of Pulsar Wind Nebulae and Their Interactions with the Interstellar Medium. [Internet] [Thesis]. University of Adelaide; 2017. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/119266.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Voisin F. Environment Studies of Pulsar Wind Nebulae and Their Interactions with the Interstellar Medium. [Thesis]. University of Adelaide; 2017. Available from: http://hdl.handle.net/2440/119266

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

10. Kostecki, Roman. Corrosion Detection: A Fibre Optic Approach.

Degree: 2017, University of Adelaide

URL: http://hdl.handle.net/2440/119273

► Corrosion is a multi-billion dollar problem faced by industry. High acquisition costs associated with modern military and civilian aircraft coupled with tighter budgets has resulted… (more)

▼ Corrosion is a multi-billion dollar problem faced by industry. High acquisition costs associated with modern military and civilian aircraft coupled with tighter budgets has resulted in the need for greater utilisation of existing aircraft eets. With advancing aircraft age there is increased possibility that protective coatings will break down or be damaged, resulting in exposure of the base material to the environment and an increased possibility of corrosion. Corrosion is most difficult to detect in inaccessible metallic structures within aircraft. Monitoring these areas requires a sensor capable of spatially resolved detection of corrosion (distributed measurements), so that the location of the detected corrosion can be determined. Optical fibre based sensors are inherently suited to distributed sensing and are typically in the order of only a few hundred microns in diameter making them very lightweight and suitable for embedding in otherwise inaccessible corrosion-prone areas. This thesis describes the development of an optical fibre based corrosion sensing element. Transition of exposed-core microstructured optical fibres from soft glass to silica is shown to provide a platform for optical fibre sensors requiring long term and/or harsh environmental applications while providing real time analysis anywhere along the fibres length. The portion of light guided outside of the glass core, often described as the `evanescent field,' is affected by the refractive index and absorption characteristics of the surrounding medium. Functionalising this core with chemosensors sensitive to corrosion by-products, turns the light guiding fibre into a corrosion sensing element, with which insitu kinetic measurements of accelerated corrosion in simulated aluminium aircraft joints is demonstrated. This provides a fibre optic approach for detection of corrosion inside the hidden part of structures and opens up new opportunities for distributed optical fibre chemical sensing with a capacity for long-term application in harsh environments. Advisors/Committee Members: Monro, Tanya (advisor), School of Physical Sciences (school).

Subjects/Keywords: Corrosion; Sensor; Smart structures; Nondestructive evaluation; Structural health monitoring; Fiber optic sensors; Microstructural fibers; Nanostructure fabrication; Optical sensing and sensors; Thin film devices and applications

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kostecki, R. (2017). Corrosion Detection: A Fibre Optic Approach. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/119273

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kostecki, Roman. “Corrosion Detection: A Fibre Optic Approach.” 2017. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/119273.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kostecki, Roman. “Corrosion Detection: A Fibre Optic Approach.” 2017. Web. 25 Jun 2019.

Vancouver:

Kostecki R. Corrosion Detection: A Fibre Optic Approach. [Internet] [Thesis]. University of Adelaide; 2017. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/119273.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kostecki R. Corrosion Detection: A Fibre Optic Approach. [Thesis]. University of Adelaide; 2017. Available from: http://hdl.handle.net/2440/119273

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

11. McFadden, Aoife. Uncovering the role of biomineralisation in otolith trace element uptake by microstructural and microchemical analysis.

Degree: 2016, University of Adelaide

URL: http://hdl.handle.net/2440/118860

► Otolith biomineralisation was examined in order to uncover its role in trace element uptake within otolith structures by microstructural and chemical analysis. The mechanism of… (more)

▼ Otolith biomineralisation was examined in order to uncover its role in trace element uptake within otolith structures by microstructural and chemical analysis. The mechanism of otolith elemental incorporation, the orientation of aragonite and the organic matrix in otoliths of four marine species were investigated in conjunction with the otolith growth patterns and the distribution of trace and minor elemental composition. Results for otoliths of Platycephalus bassensis, Chrysophrys auratus, Trachurus novaezelandiae and Lates calcarifer suggest a common biomineralisation mechanism for marine species, with consistent results across all species. The aragonite orientation, as mapped by electron backscatter diffraction (EBSD), revealed the aragonite c-axis was preferentially aligned parallel with the otolith growth axis and perpendicular to the insoluble organic matrices orientation, as determined by Raman microspectroscopy, in the otoliths of Platycephalus bassensis, Chrysophrys auratus, Trachurus novaezelandiae and Lates calcarifer. The orientation results indicate that otolith mineral growth is directed and controlled by the organic matrix, which acts as a template for the mineral growth, constraining the aragonite orientation and alignment. The organic rich zones (D-zone bands) within the otolith were composed of both insoluble and soluble organic matrices in all four species, with the insoluble matrices bridging the gap between mineral rich zones (L- zone bands) so as to retain crystal orientation across the otolith. Optimisation of electron probe microanalysis (EPMA) quantitative mapping achieved both high spatial resolution (<3 μm) and two dimensional visualisation of the fine scale Sr and S distributions in the otoliths with minimal otolith damage. The otolith growth patterns showed a clear association with the distribution of Sr and S, with D-zone bands exhibiting elevated concentrations of both elements as compared to the L-zone bands. Further examination by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) showed that incorporation of Mg and Ba appears independent of both the S distribution and the growth patterns in all four species. The results suggest that element incorporation into the otolith is linked to the organic composition in the endolymph during mineralisation, and the organic matrices may in part assist the uptake of Sr. The study revealed that whilst the otolith biomineralisation is directed and templated, with aragonite orientation constrained by the insoluble organic matrices, this process has no direct influence over trace element uptake. The association between the distribution of Sr, S and the organic matrices within the otoliths suggests however that the soluble organic matrices may play a role in trace element incorporation, particularly Sr incorporation. These findings may therefore have significant implications for the interpretation of otolith Sr chemistry. Advisors/Committee Members: Harris, Hugh (advisor), School of Physical Sciences: Chemistry (school).

Subjects/Keywords: Otoliths; biomineralisation; biochemistry; trace element analysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McFadden, A. (2016). Uncovering the role of biomineralisation in otolith trace element uptake by microstructural and microchemical analysis. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/118860

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McFadden, Aoife. “Uncovering the role of biomineralisation in otolith trace element uptake by microstructural and microchemical analysis.” 2016. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/118860.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McFadden, Aoife. “Uncovering the role of biomineralisation in otolith trace element uptake by microstructural and microchemical analysis.” 2016. Web. 25 Jun 2019.

Vancouver:

McFadden A. Uncovering the role of biomineralisation in otolith trace element uptake by microstructural and microchemical analysis. [Internet] [Thesis]. University of Adelaide; 2016. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/118860.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McFadden A. Uncovering the role of biomineralisation in otolith trace element uptake by microstructural and microchemical analysis. [Thesis]. University of Adelaide; 2016. Available from: http://hdl.handle.net/2440/118860

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

12. Stoate, Katherine A. The landscape evolution, geochemistry and biogeochemistry of Kangaroo Island.

Degree: 2017, University of Adelaide

URL: http://hdl.handle.net/2440/119519

► This work provides a landscape context and framework for the use of regolith and vegetation in mineral exploration on Kangaroo Island, South Australia. Regolith field… (more)

▼ This work provides a landscape context and framework for the use of regolith and vegetation in mineral exploration on Kangaroo Island, South Australia. Regolith field observations and the production of a regolith–landform map have improved constraints on the ferricrete plateau formation and also on the landscape history of the Island. The ferricrete and ferruginous materials on Kangaroo Island have been found to be the result of continous formation but have been largely in place since the Eocene. Through field observations, microanalysis and a large scale geochemical survey, the nature of the ferruginous materials and the processes that form them have been examined. Ferrolysis and the movement of groundwater have been interpreted to play major roles in the formation of the ferruginous materials. These processes have a significant impact on the use of the weathered materials for mineral exploration as economic and indicator elements are leached early in the weathering process. Ferruginous materials do contain the signature of mineralisation over areas that contain known deposits, however, the apparent lack of dispersion halos makes these materials difficult to use for a large scale geochemical survey for mineral exploration as target zones may be missed by low sampling densities. Despite this, the ferricrete materials can be useful for mineral exploration, as although potentially only providing small target areas, they do highlight areas of mineralisation. Conversely, the underlying weathered bedrock potentially has less use for mineral exploration as the economic metals have been readily mobilised out of the bedrock during the weathering processes on Kangaroo Island. The biogeochemical surveys were successful in highlighting areas of mineralisation, and displayed a greater dispersion halo than observed in the ferruginous materials. The biogeochemical surveys also helped to provide further information into the processes occurring in the landscape. The eucalypts are interpreted to source groundwater from the weathering zone in the bedrock and effectively pick up elements as they are leached. While displaying a high degree of variability, even over areas of known mineralisation, this dataset was better suited to identifying signals of mineralisation at a larger scale than the ferricrete. A limiting factor on the use of eucalypt for biogeochemical surveys is the occurrence of systematic inter-species variations. This makes large, regional scale surveys difficult, as there is a high possibility that there will not be a consistent vegetation species, resulting in a dataset in which different species need to be compared and potentially excluded in order to correctly identify meaningful anomalies. The xanthorrhoea, overall, was less successful in taking up elements of interest, most likely due to its shallower root system, which is likely to tap into the already leached saprolite or groundwater that has only been recently recharged by meteoric water (diluting any chemical signature of the underlying bedrock). This thesis has… Advisors/Committee Members: Giles, David (advisor), School of Physical Sciences (school).

Subjects/Keywords: geology; regolith; geochemistry; biogeochemistry; landscape evolution; Kangaroo Island; South Australia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stoate, K. A. (2017). The landscape evolution, geochemistry and biogeochemistry of Kangaroo Island. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/119519

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stoate, Katherine A. “The landscape evolution, geochemistry and biogeochemistry of Kangaroo Island.” 2017. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/119519.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stoate, Katherine A. “The landscape evolution, geochemistry and biogeochemistry of Kangaroo Island.” 2017. Web. 25 Jun 2019.

Vancouver:

Stoate KA. The landscape evolution, geochemistry and biogeochemistry of Kangaroo Island. [Internet] [Thesis]. University of Adelaide; 2017. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/119519.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stoate KA. The landscape evolution, geochemistry and biogeochemistry of Kangaroo Island. [Thesis]. University of Adelaide; 2017. Available from: http://hdl.handle.net/2440/119519

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

13. Kontonikas-Charos, Alkiviadis. Feldspar Petrography and Geochemistry: Insights into the Magmatic-Hydrothermal Evolution of IOCG Systems from South Australia.

Degree: 2017, University of Adelaide

URL: http://hdl.handle.net/2440/119372

► The iron-oxide copper-gold (IOCG) class of mineral deposits is characterized by, among other properties, widespread alkali alteration and an enrichment of multiple trace elements, including… (more)

▼ The iron-oxide copper-gold (IOCG) class of mineral deposits is characterized by, among other properties, widespread alkali alteration and an enrichment of multiple trace elements, including REE and U. The ability of feldspar replacement reactions to alter physical and chemical properties of host rocks invokes the idea that the early widespread alkali alteration stage within IOCG genesis may prove critical in the subsequent enrichment of trace elements within such magmatic-hydrothermal systems. Based on detailed petrographic investigations and geochemistry, the link between these two fundamental IOCG properties is tested in one of the largest IOCG metallogenic belts in the world, the Olympic Cu-Au Province. Firstly, the temporal evolution of a deeper-style IOCG system (Moonta-Wallaroo) is tracked from protolith through to early and late mineralization stages using mineral reactions associated with regional alkali alteration (namely, albitization), their relative textures and chondrite-normalised REE+Y (hereafter REY) fractionation patterns. Different stages can be distinguished based on variation in REY-anomalies (e.g., Eu, Y), slope (LREE/HREE) and ΣREY concentration. The results also highlight how feldspar alteration is expressed across various lithologies within a single IOCG terrane, which is largely dependent on the style of fluid/rock interaction. In contrast to Moonta-Wallaroo, mineralization at Olympic Dam is hosted largely within a single lithology; the Roxby Downs Granite. Thus, changes in feldspar textures and geochemistry from magmatic to hydrothermal stages within a single lithology can be tracked based on proximity to mineralization within the Olympic Dam Breccia Complex. From observations and analyses of cryptoperthitic alkali feldspars, patch perthite, plagioclase and albite, it is evident that feldspars preserve the major element exchange (loss of Na -> gain of K and Fe -> Cu-U-Au-Ag mineralization) occurring within the Olympic Dam deposit. Moreover, results also highlight the ability of widespread feldspar replacement reactions (with a coupled dissolution-reprecipitation mechanism) to produce significant microporosity within the host rocks that facilitate subsequent fluid/rock interaction and mineralization. The contribution and distribution of REE elements within the Roxby Downs Granite is also investigated and compared to other IOCG terranes within the Olympic Cu-Au province, as well as pre-Hiltaba Suite lithologies, such as the Donington Suite granite. Chondrite-normalized REY fractionation patterns obtained from magmatic and hydrothermal feldspars, show that feldspars in the Roxby Downs Granite are significantly enriched in lattice-bound REY relative to Donington Suite granite. Moreover, although it appears that hydrothermal albite and K-feldspar inherit REY concentrations from the respective parent phases, variation in ΣREE (~1-100 ppm) at Olympic Dam indicate an increase in mobility of REE from feldspars with proximity to the Olympic Dam Breccia Complex. Nanoscale characterization is also… Advisors/Committee Members: Cook, Nigel (advisor), School of Physical Sciences (school).

Subjects/Keywords: Feldspar; Alteration; IOCG; REE remobilisation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kontonikas-Charos, A. (2017). Feldspar Petrography and Geochemistry: Insights into the Magmatic-Hydrothermal Evolution of IOCG Systems from South Australia. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/119372

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kontonikas-Charos, Alkiviadis. “Feldspar Petrography and Geochemistry: Insights into the Magmatic-Hydrothermal Evolution of IOCG Systems from South Australia.” 2017. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/119372.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kontonikas-Charos, Alkiviadis. “Feldspar Petrography and Geochemistry: Insights into the Magmatic-Hydrothermal Evolution of IOCG Systems from South Australia.” 2017. Web. 25 Jun 2019.

Vancouver:

Kontonikas-Charos A. Feldspar Petrography and Geochemistry: Insights into the Magmatic-Hydrothermal Evolution of IOCG Systems from South Australia. [Internet] [Thesis]. University of Adelaide; 2017. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/119372.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kontonikas-Charos A. Feldspar Petrography and Geochemistry: Insights into the Magmatic-Hydrothermal Evolution of IOCG Systems from South Australia. [Thesis]. University of Adelaide; 2017. Available from: http://hdl.handle.net/2440/119372

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

14. Evans, Jack D. Simulations of Molecular and Extended Porous Materials.

Degree: 2015, University of Adelaide

URL: http://hdl.handle.net/2440/119471

► Porous materials play vital roles in many industries and currently there is intense interest in developing new examples due to their direct application to clean… (more)

Subjects/Keywords: Molecular simulations; Porous materials; MOFs; DFT

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APA (6^th Edition):

Evans, J. D. (2015). Simulations of Molecular and Extended Porous Materials. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/119471

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Evans, Jack D. “Simulations of Molecular and Extended Porous Materials.” 2015. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/119471.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Evans, Jack D. “Simulations of Molecular and Extended Porous Materials.” 2015. Web. 25 Jun 2019.

Vancouver:

Evans JD. Simulations of Molecular and Extended Porous Materials. [Internet] [Thesis]. University of Adelaide; 2015. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/119471.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Evans JD. Simulations of Molecular and Extended Porous Materials. [Thesis]. University of Adelaide; 2015. Available from: http://hdl.handle.net/2440/119471

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

15. Poulter, Harry David. Investigating the effect of primordial black hole Hawking radiation on the cosmic microwave background.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/118023

► Due in part to the recent gravitational wave events discovered by the LIGO collaboration, primordial black holes (PBHs) have made their way back in vogue… (more)

▼ Due in part to the recent gravitational wave events discovered by the LIGO collaboration, primordial black holes (PBHs) have made their way back in vogue as a possible dark matter candidate. Dynamically, PBHs are interesting objects as they have a mass-dependent energy injection mechanism. As such, their presence in the early universe would have interfered with the formation of the cosmic microwave background (CMB). This work examines the effect such injections would have on CMB formation through comparison with the latest Planck measurements. We consider light-mass PBHs in the range 10¹⁵ g to 10¹⁷g which inject energy through Hawking radiation. In this work we present a review of the current state-of-the-art models of recombination and their extensions which incorporate energy injections from nonstandard sources. We also give a basic introduction to Bayesian inference in the context of parameter inference, and explain in detail how nested sampling and the Planck likelihood code operate. With this knowledge, we create a new cosmological parameter estimation program, pc_multinest, which utilises the nested sampler MultiNest, the Boltzmann code class and the Planck likelihood code to place constraints on PBH parameter space. During the completion of the program, we also improve the existing HyRec recombination code to correctly account for large energy injections. We then reproduce the current limits on PBH fraction ƒPBH presented by Clark et al. [1], before extending the analysis to examine the effects a set of free ΛCDM parameters has on the resulting bounds. By allowing the base ΛCDM parameters to vary, we show the exclusion bounds are alleviated by a full order of magnitude across the mass range. We also present results extending the typical monochromatic mass distribution to a log normal one. Fixing the PBH fraction and allowing both the mean and standard deviation of the distribution to vary indicates that delta mass distributions are more sensitive to freeing ΛCDM parameters than a mass distribution with finite spread. Results for different PBH mass distributions show that increasing the spread of the mass distribution results in tighter constraints at heavier masses and a slight relaxation for masses MPBH ∼ 10¹⁵ g. For a uniform mass distribution, the 95% exclusion limits are independent of PBH mass, giving ƒPBH < 6.1 × 10⁻⁷ when base ΛCDM parameters are fixed and ƒPBH < 1.3 × 10⁻⁵ when they are allowed to vary. Advisors/Committee Members: White, Martin (advisor), Williams, Anthony (advisor), School of Physical Sciences (school).

Subjects/Keywords: Cosmology; physics; ΛCDM model; recombination; primordial black holes; black holes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Poulter, H. D. (2018). Investigating the effect of primordial black hole Hawking radiation on the cosmic microwave background. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/118023

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Poulter, Harry David. “Investigating the effect of primordial black hole Hawking radiation on the cosmic microwave background.” 2018. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/118023.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Poulter, Harry David. “Investigating the effect of primordial black hole Hawking radiation on the cosmic microwave background.” 2018. Web. 25 Jun 2019.

Vancouver:

Poulter HD. Investigating the effect of primordial black hole Hawking radiation on the cosmic microwave background. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/118023.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Poulter HD. Investigating the effect of primordial black hole Hawking radiation on the cosmic microwave background. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/118023

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

16. Jepson, Gilby Mats Morrison. The low-temperature tectonic evolution of the Western Tian Shan (Kazakhstan, Kyrgyzstan, Uzbekistan, Tajikistan).

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/118072

► The evolution of intracontinental mountain ranges represent a unique challenge in our understanding of the Earth’s history. One of the largest of these intracontintal mountain… (more)

▼ The evolution of intracontinental mountain ranges represent a unique challenge in our understanding of the Earth’s history. One of the largest of these intracontintal mountain ranges on Earth is the Tian Shan in Central Asia. The crustal architecture of the Tian Shan formed during the closure of the Palaeo-Asian Ocean in the Palaeozoic and underwent multiple reactivations in response to distant tectonic events at the Eurasian plate margin, to give rise to the modern expression of the Tian Shan we see today. Most of the previous thermochronological studies in the Tian Shan focused on the core of the mountain range, deciphering a punctuated tectonic history throughout the Mesozoic, with a dominant Cenozoic overprint as a result of the India-Eurasia collision. However, little work has been done on the eastern and western extents of the Tian Shan. These regions are characterised by low relief and record less Cenozoic overprint, providing opportunity to better constrain the Mesozoic thermo-tectonic history of the Tian Shan. In this project, we used multiple thermochronometers (apatite uranium-lead, zircon (UTh- Sm)/He), zircon fission track, apatite fission track, and apatite (U-Th-Sm)/He) on >100 basement samples taken along the western-most extent of the Tian Shan. More specifically, samples from the Karatau–Talas range in the north (Kazakhstan and Uzebkistan), the Chaktal–Kurama range (Uzbekistan and Tajikistan) and the Kyzylkum–Nurata Segment (Uzbekistan and Tajikistan) in the middle, and the Garm region in the south, were analysed to decipher key periods of deformation and mountain building in the Tian Shan. Initially, the western Tian Shan underwent a period of Triassic–early Jurassic fast-cooling and exhumation interpreted as a response to the collision of the Qiangtang block with the Eurasian margin. Subsequently a period of slow-cooling and denudation during the late Jurassic–Cretaceous was recorded, as the western margin of the Tian Shan experienced a hiatus in reactivation. However, the major suture zones in the western Tian Shan still preserve a signal of late Jurassic–Cretaceous fast-cooling and reactivation, as a possible response to extensional tectonics on the Eurasian margin. Finally, much of the Mesozoic Tian Shan is overprinted by the distal effects of the India-Eurasia collision in the Cenzoic. The India- Eurasia collision, the latest and possibly the largest of the Gondwanan fragments to collide with the Eurasian continent, generated a thermal overprint along faults and generated most of the topography that we see today. Using multiple middle to low temperature thermochronometers, this study attempted to unpack the complex and convoluted evolution of the world’s largest intracontinental mountain range. Showing that it is possible to track the evolution, both spatially and temporally, of such a vast orogen from its ancestral foundation through to the more modern controls of continental growth. Furthermore, it has been possible to apply constraints and unpack the tectonic regimes that influence the… Advisors/Committee Members: Glorie, Stijn (advisor), Collins, Alan (advisor), School of Physical Sciences (school).

Subjects/Keywords: Thermochronology; tectonics; Tian Shan; apatite fission track

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APA (6^th Edition):

Jepson, G. M. M. (2018). The low-temperature tectonic evolution of the Western Tian Shan (Kazakhstan, Kyrgyzstan, Uzbekistan, Tajikistan). (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/118072

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jepson, Gilby Mats Morrison. “The low-temperature tectonic evolution of the Western Tian Shan (Kazakhstan, Kyrgyzstan, Uzbekistan, Tajikistan).” 2018. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/118072.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jepson, Gilby Mats Morrison. “The low-temperature tectonic evolution of the Western Tian Shan (Kazakhstan, Kyrgyzstan, Uzbekistan, Tajikistan).” 2018. Web. 25 Jun 2019.

Vancouver:

Jepson GMM. The low-temperature tectonic evolution of the Western Tian Shan (Kazakhstan, Kyrgyzstan, Uzbekistan, Tajikistan). [Internet] [Thesis]. University of Adelaide; 2018. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/118072.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jepson GMM. The low-temperature tectonic evolution of the Western Tian Shan (Kazakhstan, Kyrgyzstan, Uzbekistan, Tajikistan). [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/118072

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

17. Ritchie, Louis. Synchronisation on non-compact manifolds.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/118084

► The Kuramoto model is a widely studied model of phase synchronisation which continues to display novel and interesting emergent behaviours with its many extensions and… (more)

Subjects/Keywords: Sychronisation

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APA (6^th Edition):

Ritchie, L. (2018). Synchronisation on non-compact manifolds. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/118084

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ritchie, Louis. “Synchronisation on non-compact manifolds.” 2018. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/118084.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ritchie, Louis. “Synchronisation on non-compact manifolds.” 2018. Web. 25 Jun 2019.

Vancouver:

Ritchie L. Synchronisation on non-compact manifolds. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/118084.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ritchie L. Synchronisation on non-compact manifolds. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/118084

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

18. Child, Stella Agnes. Deciphering electron transfer and cytochrome P450 activity in Mycobacterium marinum.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/118202

► Cytochrome P450s are haem-monooxygenase enzymes, responsible for the catalytic hydroxylation of a large variety of organic molecules. The bacterium Mycobacterium marinum, has a larger genome… (more)

▼ Cytochrome P450s are haem-monooxygenase enzymes, responsible for the catalytic hydroxylation of a large variety of organic molecules. The bacterium Mycobacterium marinum, has a larger genome than its close relatives, the causative agents of human tuberculosis (Mycobacterium tuberculosis) and Buruli ulcer (Mycobacterium ulcerans), which have undergone substantial reductive evolution. The genome of M. marinum contains an unusually large number of P450 genes (47). Twelve ferredoxin genes are associated with the CYPome and eleven of these are uncharacterised ferredoxins of the 3/4Fe-4S type. In their iron-sulfur cluster binding motif (CXX?XXC(X)nCP), these ferredoxins (Fdx1 – Fdx11) have non-standard residues at the ? position of the sequence. Instead of the cysteine residue expected of a [4Fe-4S] ferredoxin, or the alanine/glycine residue expected in a [3Fe-4S] ferredoxin, they contain histidine, asparagine, tyrosine, serine, threonine and phenylalanine residues. In the course of this work, they have been purified aerobically and anaerobically. When isolated anaerobically, three of these ferredoxins were determined, by non-denaturing ESI-MS and EPR to contain 3Fe-4S clusters. The reduction potentials for the three varied from +150 mV to -360 mV, which are highly anomalous for [3Fe-4S] ferredoxins. Similar ferredoxins were found to accompany P450s in the biosynthetic gene clusters of other bacteria, especially in Actinomycete species. These ferredoxins were demonstrated to support the activity of a number of the M. marinum P450s, some of which were from previously uncharacterised families. CYP147G1, in combination with the electron transfer partners Fdx3 and FdR1 was demonstrated to act as a ω-1 fatty acid hydroxylase. CYP147G1 selectivity favoured the ω carbon when branched methyl substrates were used. The same ferredoxin reductase, FdR1, was also shown to support the activity of CYP278A1 (with Fdx2), and CYP150A5 (with Fdx8), both of which were shown to regioselectively hydroxylate β-ionone. CYP150A5 binds terpenes and polycyclic substrates. An additional CYP150 enzyme, CYP150A6, was crystallised and structurally resolved to 1.6 Å in the substrate-free form. CYP268A2, when reconstituted with a non-native electron transfer chain, hydroxylated the branched fatty acetate derivatives, pseudoionone and geranyl acetate, at the terminal position. The structure of CYP268A2 with trans-pseudoionone bound in the active site was solved by X-ray crystallography to a resolution of 2.0 Å and from this the selectivity of the enzyme was rationalised. Several M. marinum P450s that have close counterparts in M. tuberculosis were selected for comparison, in order to investigate whether the substrate and inhibitor binding affinities were preserved between species. The P450s investigated were analogues of the steroid metabolising P450s in M. tuberculosis. CYP125A6 and CYP125A7 have a single counterpart in M. tuberculosis (CYP125A1). The sequence identity and cholesterol binding affinity of CYP125A7 indicates it more closely resembles… Advisors/Committee Members: Bell, Stephen (advisor), Pyke, Simon (advisor), School of Physical Sciences (school).

Subjects/Keywords: Electron transfer; cytochrome P450; mycobacteria; biocatalysis

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APA (6^th Edition):

Child, S. A. (2018). Deciphering electron transfer and cytochrome P450 activity in Mycobacterium marinum. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/118202

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Child, Stella Agnes. “Deciphering electron transfer and cytochrome P450 activity in Mycobacterium marinum.” 2018. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/118202.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Child, Stella Agnes. “Deciphering electron transfer and cytochrome P450 activity in Mycobacterium marinum.” 2018. Web. 25 Jun 2019.

Vancouver:

Child SA. Deciphering electron transfer and cytochrome P450 activity in Mycobacterium marinum. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/118202.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Child SA. Deciphering electron transfer and cytochrome P450 activity in Mycobacterium marinum. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/118202

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

19. Rollison, Laura Anne. Stratigraphy, sedimentology, and geochemistry of the Pandurra Formation.

Degree: 2016, University of Adelaide

URL: http://hdl.handle.net/2440/101785

► Life on Earth during the Mesoproterozoic was challenging with an aggressive low oxygen atmosphere, acidic hydrosphere, intense weathering of the lithosphere, and simple bacteria-plankton biosphere.… (more)

▼ Life on Earth during the Mesoproterozoic was challenging with an aggressive low oxygen atmosphere, acidic hydrosphere, intense weathering of the lithosphere, and simple bacteria-plankton biosphere. The research within the following thesis investigates the interaction between the atmosphere, hydrosphere, lithosphere, and biosphere through an assessment of provenance, sedimentology, and characterisation of mineral systems of the Pandurra Formation in southern Australia during the Mesoproterozoic. The Pandurra Formation preserves evidence of the gradual erosion of the Gawler Range Volcanics and subsequent climate variation of the region. This study characterises the mechanisms for sedimentation of the Pandurra Formation from the rapid lateral and vertical variation that resembles a multi-thread anabranching braided distributive fluvial system. This research identifies seven lithological associations that are not consistent with the existing four-member model. This investigation reveals that the Pandurra Formation commenced sedimentation soon after 1562 ± 32 Ma. The zircon geochronology of the Pandurra Formation is similar that of the underlying pre-Mesoproterozoic basement geology, and matches with the observed regional geology of the Archean (2560 to 2500 Ma) and late Palaeoproterozoic to early Mesoproterozoic (1900 to 1450 Ma) Gawler Craton. Sm-Nd isotopic geochemistry reveals that the source age of the Pandurra Formation sediments varied with time from Archean dominated to Palaeoproterozoic back to an Archean signature. This research indicates a connection with the Pandurra Formation to the coeval Belt-Purcell Supergroup in North America, but not to the Rocky Cape Group in Tasmania or the East Antarctic Shield during the Mesoproterozoic. The Pandurra Formation represents a series of elevated terrestrial distributive fluvial systems that supplied sediment to the deep water Pritchard Formation from 1470 to 1454 Ma. Evidence of two fluid flow events at 1211 ± 24 Ma (Vanguard-1) within the Pandurra Formation and at 469 ± 28 Ma (WHD-1) within the overlying Beda Volcanics is described. The spatial and detrital relationship between the Pandurra Formation and Palaeoproterozoic to early Mesoproterozoic IOCG-U enriched basement, indicates the potential to for the sedimentary sequence to host placer (Au and heavy mineral) and remobilised U and/or Cu systems. The Pandurra Formation within Vanguard-1 and numerous other diamond drill cores exhibit kaolinite-dickite and sericite alteration, typical of unconformity U and low temperature epithermal systems. The Beda Volcanics are determined to be prospective for Mississippi Valley-type systems (Pb-Zn-Ba), similar to that in the Adelaide Fold Belt during the waning stages of the ca. 510 to 490 Ma Delamerian Orogeny. The closure age of 1211 ± 24 Ma (Vanguard-1) precludes further hydrothermal activity during the Delamerian Orogeny within the Pandurra Formation. Advisors/Committee Members: Giles, David (advisor), Forbes, Caroline (advisor), School of Physical Sciences (school).

Subjects/Keywords: Pandurra formation; Mesoproterozoic; South Australia; sedimentary geology; detrital zircon analysis; isotope geochemistry; mineral systems

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rollison, L. A. (2016). Stratigraphy, sedimentology, and geochemistry of the Pandurra Formation. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/101785

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rollison, Laura Anne. “Stratigraphy, sedimentology, and geochemistry of the Pandurra Formation.” 2016. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/101785.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rollison, Laura Anne. “Stratigraphy, sedimentology, and geochemistry of the Pandurra Formation.” 2016. Web. 25 Jun 2019.

Vancouver:

Rollison LA. Stratigraphy, sedimentology, and geochemistry of the Pandurra Formation. [Internet] [Thesis]. University of Adelaide; 2016. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/101785.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rollison LA. Stratigraphy, sedimentology, and geochemistry of the Pandurra Formation. [Thesis]. University of Adelaide; 2016. Available from: http://hdl.handle.net/2440/101785

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

20. Klaebe, Robert Matthew. The palaeoenvironmental context of Neoproterozoic carbon-isotope excursions.

Degree: 2015, University of Adelaide

URL: http://hdl.handle.net/2440/102804

► The Neoproterozoic record of sedimentary carbonates preserves > 20‰ of variability in carbon-isotope (δ¹³C) values that dwarfs the ~4‰ variability recorded in Phanerozoic marine carbonates… (more)

▼ The Neoproterozoic record of sedimentary carbonates preserves > 20‰ of variability in carbon-isotope (δ¹³C) values that dwarfs the ~4‰ variability recorded in Phanerozoic marine carbonates known to record changes in the Earth’s carbon cycle through time. When interpreted as primary seawater values, large magnitude δ¹³C swings in Neoproterozoic strata are commonly interpreted to reflect significant changes to the biosphere that are causally related to the oxygenation of the Earth’s atmosphere, global-scale glaciations and the evolution of complex metazoan life. This thesis considers each of the key isotopic features used to define the δ¹³C record of Neoproterozoic seawater to identify the potential for local sedimentary controls on δ¹³C variation versus global secular change by focussing on the origin of the host carbonate phases from which the δ¹³C values are recorded. The expected bias toward shallow-water intracratonic basins preserved in the Precambrian record predicts that intervals of the record are particularly susceptible to hydrologic restriction and physical isolation from marine connections. The Bitter Springs Formation of the Amadeus Basin in central Australia records a positive-negative-positive stratigraphic δ¹³C trend in its upper Gillen Member. This δ¹³C excursion has been termed the Bitter Springs Anomaly and is routinely used as a global stratigraphic tie point at ~800 Ma. A detailed sedimentological study of the Wallara-1 and BRO5 drill cores and two field sections in the Amadeus Basin reveal that two distinctly different facies associations occur, a lower unit of cyclic-bedded microbial and grainstone marine limestones and an upper unit of red beds and dolostones interbedded with evaporites and characterised by evidence of subaerial exposure and desiccation. The abrupt decline in recorded δ¹³C values from +6‰ to -4‰ and the following recovery back to +6‰ occurs across the stratigraphic transitions between the evaporative lacustrine and shallow-marine carbonate intervals. Positive δ¹³C values occur exclusively in the evaporative lacustrine facies and were likely modified locally by evaporative processes in a highly restricted sabkha-type basin, indicated by interbedded and nodular anhydrites, halite pseudomorphs and karstic dissolution. Where local facies changes to subaqueous cyclic stromatolitic facies are preserved, δ¹³C values abruptly fall to -4‰ producing the binary isotopic shift that defines the Bitter Springs Anomaly here. The recurrence of this stratigraphic and isotopic association across the basin suggests that changes to local depositional conditions resulting from periodic hydrological restriction and evaporation explain the Bitter Springs Anomaly here rather than global isotopic change in a seawater value that should be decoupled from changes in local sediment composition. The Trezona Formation in the South Australian Flinders Ranges records a -18‰ decline in δ¹³C values stratigraphically below Marinoan-aged (~635 Ma) glacial deposits that is used to argue for a link between carbon… Advisors/Committee Members: Kennedy, Martin (advisor), Fairchild, Ian (advisor), School of Physical Sciences (school).

Subjects/Keywords: Neoproterozoic; carbon isotopes; carbonates

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Klaebe, R. M. (2015). The palaeoenvironmental context of Neoproterozoic carbon-isotope excursions. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/102804

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Klaebe, Robert Matthew. “The palaeoenvironmental context of Neoproterozoic carbon-isotope excursions.” 2015. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/102804.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Klaebe, Robert Matthew. “The palaeoenvironmental context of Neoproterozoic carbon-isotope excursions.” 2015. Web. 25 Jun 2019.

Vancouver:

Klaebe RM. The palaeoenvironmental context of Neoproterozoic carbon-isotope excursions. [Internet] [Thesis]. University of Adelaide; 2015. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/102804.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Klaebe RM. The palaeoenvironmental context of Neoproterozoic carbon-isotope excursions. [Thesis]. University of Adelaide; 2015. Available from: http://hdl.handle.net/2440/102804

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

21. Rees, Nigel. Magnetotelluric monitoring of unconventional resources.

Degree: 2016, University of Adelaide

URL: http://hdl.handle.net/2440/117260

► Extraction of unconventional gas involves the movement of fluids at depth. In the case of shale gas, hydraulic fracturing is performed, where fluids are injected… (more)

▼ Extraction of unconventional gas involves the movement of fluids at depth. In the case of shale gas, hydraulic fracturing is performed, where fluids are injected into sequences at high pressures resulting in permeable pathways for the trapped gas to escape. Coal seam gas (CSG) extraction involves a process termed depressurisation, where large volumes of groundwater are extracted from coal measures causing a pressure reduction that allows trapped gas to desorb from the coal seams. One of the key questions the industry sector is facing is whether it can effectively monitor movement of fluids and changes in Earth as these unconventional energy resources are being developed. We present two MT monitoring surveys of unconventional energy resource development. The first survey involves an industrial field study conducted in Queensland, Australia, where MT responses indicated the orientation of fluid flow resulting from depressurisation, which can be mapped and directly attributed to spatial and temporal variations in permeability. The second survey involves monitoring deep hydraulic fracturing of a shale gas reservoir in the Cooper Basin, Australia. MT observations indicated increases in bulk conductivity of 20 – 40% in both the temporal and spatial domain, with these changes caused by a combination of both injected fluid permeability and an increase in wider-scale in-situ permeability. Finally the telluric sounding method is introduced as a potential tool for monitoring hydraulic fracturing at depth. The advantage of this method is that it is relatively easy to measure electric fields with many dipoles and multi-channel systems and therefore electric field arrays could be deployed and left out for continuous monitoring. Additionally, electric field transfer functions are essentially the identity matrix for a 1D Earth no matter what the vertical structure is and therefore monitoring involves plotting deviations relative to the identity matrix. Advisors/Committee Members: Heinson, Graham (advisor), Thiel, Stephan (advisor), School of Physical Sciences (school).

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rees, N. (2016). Magnetotelluric monitoring of unconventional resources. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/117260

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rees, Nigel. “Magnetotelluric monitoring of unconventional resources.” 2016. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/117260.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rees, Nigel. “Magnetotelluric monitoring of unconventional resources.” 2016. Web. 25 Jun 2019.

Vancouver:

Rees N. Magnetotelluric monitoring of unconventional resources. [Internet] [Thesis]. University of Adelaide; 2016. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/117260.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rees N. Magnetotelluric monitoring of unconventional resources. [Thesis]. University of Adelaide; 2016. Available from: http://hdl.handle.net/2440/117260

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

22. Mitchell, Charlotte. Lateral and Vertical Geochemical Dispersion into Deep Cover: 4D Landscape Geochemistry and Biogeochemistry of the Barrier Ranges.

Degree: 2017, University of Adelaide

URL: http://hdl.handle.net/2440/119328

► The aim of this thesis is to determine the relative contribution of lateral, as opposed to vertical, dispersion of the geochemical signals of basement-hosted mineralisation… (more)

▼ The aim of this thesis is to determine the relative contribution of lateral, as opposed to vertical, dispersion of the geochemical signals of basement-hosted mineralisation in prospective geological provinces that are mantled by transported cover. The study focuses on three areas within and on the margins of, the highly-mineralised Broken Hill Block and the Barrier Ranges in western New South Wales. Fowlers Creek overlies low-grade metasedimentary bedrock with no known mineralisation on the eastern margins of the Barrier Ranges. Stream sediments show a downstream decreasing trend in concentrations in both Pb and Zn with values decreasing by 50% over 7 km of creek. Lead and Ag values were less important along Fowlers Creek in terms of biogeochemical results, with concentrations at background levels Pb 0.27 ppm and Ag 3.04 ppb. Rather, elements of interest along Fowlers Creek included; Cs, Y, U, Co and Ni. These elements peaked at 2 distinct points along the creek, by an order of magnitude above background, at points where the local geology interrupts the flow of the stream base aquifer (SBA). Pine Creek cross-cuts the partially exposed Pinnacles Pb-Zn-Ag mine. Stream sediment samples contain elevated concentrations of Pb, Zn and Ag (Pb 4.5x and Ag 3.5x background values observed along Fowlers and Umberumberka Creeks) for at least 4.5 km downstream of mineralisation. River red gum (RRG) leaves from trees within the creek provided the clearest delineation of the underlying mineralisation. Lead and Ag concentrations steadily increase toward mineralisation and reach concentrations 2.5 orders of magnitude above background immediately above mineralisation. Leaf samples collected after a severe El Niño event where the previous year’s rainfall was 188 mm, had Pb and Ag concentrations 5 -10 times greater than samples from the same trees collected after a La Niña event where the previous year’s rainfall was 605 mm. These results demonstrate that changes in available water plays on the SBA and the significant role it plays in diluting the resulting metal concentration within the trees and the importance of temporal variation. Umberumberka Creek is underlain by high-grade metamorphic rocks with numerous small mineral occurrences. Umberumberka Creek discharges at the western margin of the Broken Hill Block as an alluvial fan system which extends at least 10 km onto the Mundi Mundi Plain. This area is underlain by prospective bedrock but is buried by up to 150 m of transported sediments. On the plains, stream sediment results reflected a catchment average that was carried 10 km onto the plains before values decreased. Silver results on the plains had a mean value of 30 ppb and are comparable to soil survey results obtained by an exploration company over an area of Pb-Ag-Zn mineralisation identified beneath 150+ m of cover, situated on the fan floodout boundaries of Umberumberka Creek. The biogeochemical results for Umberumberka Creek fall within the same range of values as Fowlers creek, suggesting that these values are the natural… Advisors/Committee Members: Giles, David (advisor), School of Physical Sciences : Earth Sciences (school).

Subjects/Keywords: Geochemical dispersion; biogeochemistry; geochemistry; Broken Hill; Eucalyptus camaldulensis; mineral exploration; landscape geochemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mitchell, C. (2017). Lateral and Vertical Geochemical Dispersion into Deep Cover: 4D Landscape Geochemistry and Biogeochemistry of the Barrier Ranges. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/119328

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mitchell, Charlotte. “Lateral and Vertical Geochemical Dispersion into Deep Cover: 4D Landscape Geochemistry and Biogeochemistry of the Barrier Ranges.” 2017. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/119328.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mitchell, Charlotte. “Lateral and Vertical Geochemical Dispersion into Deep Cover: 4D Landscape Geochemistry and Biogeochemistry of the Barrier Ranges.” 2017. Web. 25 Jun 2019.

Vancouver:

Mitchell C. Lateral and Vertical Geochemical Dispersion into Deep Cover: 4D Landscape Geochemistry and Biogeochemistry of the Barrier Ranges. [Internet] [Thesis]. University of Adelaide; 2017. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/119328.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mitchell C. Lateral and Vertical Geochemical Dispersion into Deep Cover: 4D Landscape Geochemistry and Biogeochemistry of the Barrier Ranges. [Thesis]. University of Adelaide; 2017. Available from: http://hdl.handle.net/2440/119328

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

23. Coleman, Tom. Utilising CYP199A4 from Rhodopseudomonas palustris HaA2 for investigation of the mechanism of cytochrome P450-catalysed oxidations.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/115180

► The work herein details efforts towards developing a system to better understand the mechanistic details of various oxidative reactions catalysed by cytochrome P450 enzymes (P450s).… (more)

▼ The work herein details efforts towards developing a system to better understand the mechanistic details of various oxidative reactions catalysed by cytochrome P450 enzymes (P450s). The bacterial P450 enzyme CYP199A4, from Rhodopseudomonas palustris HaA2, is highly selective for substrates with a para-substituted benzoic acid framework, such as 4-methoxybenzoic acid. The substrates are oxidised regioselectively at the para-substituent. For example, 4-methoxybenzoic acid is demethylated to 4-hydroxybenzoic acid. CYP199A4 has previously been shown to support other P450 mono-oxygenase reactions such as desaturation, heteroatom oxidation and dealkylation. The ready access to simple substrates compatible with CYP199A4, and the ease of purifying this enzyme in high yield, make it suitable for mechanistic study of P450-catalysed oxidations. The effect of substituents at the benzene ring ortho and meta positions on the substrate’s binding and enzyme activity have been investigated. These revealed that CYP199A4-catalysed demethylation outside of the para moiety was feasible with certain meta-substituted substrates but occurred with low activity. For example, it was found that CYP199A4 could catalyse the ring-opening of a 3,4-methylenedioxy bridge, but not the ring-opening of an ethylenedioxy substituent, which was hydroxylated to a cyclic hemiacetal. Substrates containing nitrogen and sulfur moieties at the para-position were in- vestigated to determine the catalytic parameters of N- and S-dealkylation versus heteroatom oxidation. CYP199A4 catalysed the sulfoxidation but not the S-dealkylation of sulfur substrates. Nitrogen substrates were N-dealkylated, and no N-oxidation was observed. CYP199A4 was able to generate an unexpected amide metabolite with ethy-lamino substituted benzoic acids. Halogen oxidation, which has also been previously observed in certain P450 systems, was studied. CYP199A4 did not show activity with 4-halobenzoic acids (F, Cl, Br, I) though these substrates did bind to the enzyme. Furthermore, alkyl substituents which contained halogens were investigated, and oxidative dehalogenation products were observed. CYP199A4 has been shown to catalyse hydroxylation of the benzylic α-carbon and desaturation of the α,β-carbons of 4-ethyl- and 4-isopropyl-benzoic acids. The partition between hydroxylation and desaturation was investigated by employing substrates with longer and/or more substituted alkyl groups. The substrates tested were all hy- droxylated at the benzylic α-carbon when a C−H bond was available. Otherwise, the β-carbon was hydroxylated. Additionally, α,β-desaturation was observed with the linear alkylbenzoic acid substrates. CYP199A4 was able to catalyse the oxidation of cy- cloalkane functional groups. Hydroxylation products were observed with 4-cyclopropyl- and 4-cyclohexyl-benzoic acids although there was very little desaturation. It is hypothesised that desaturation by CYP enzymes proceeds from either a radical or cation species.… Advisors/Committee Members: Bell, Stephen G. (advisor), Harris, Hugh Hamlyn (advisor), School of Physical Sciences (school).

Subjects/Keywords: cytochrome P450; enzymes; monooxygenases; X-ray crystallography; biochemistry; chemistry; mechanism; oxidation

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APA (6^th Edition):

Coleman, T. (2018). Utilising CYP199A4 from Rhodopseudomonas palustris HaA2 for investigation of the mechanism of cytochrome P450-catalysed oxidations. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/115180

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Coleman, Tom. “Utilising CYP199A4 from Rhodopseudomonas palustris HaA2 for investigation of the mechanism of cytochrome P450-catalysed oxidations.” 2018. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/115180.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Coleman, Tom. “Utilising CYP199A4 from Rhodopseudomonas palustris HaA2 for investigation of the mechanism of cytochrome P450-catalysed oxidations.” 2018. Web. 25 Jun 2019.

Vancouver:

Coleman T. Utilising CYP199A4 from Rhodopseudomonas palustris HaA2 for investigation of the mechanism of cytochrome P450-catalysed oxidations. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/115180.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Coleman T. Utilising CYP199A4 from Rhodopseudomonas palustris HaA2 for investigation of the mechanism of cytochrome P450-catalysed oxidations. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/115180

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

24. Forster, Jake Cameron. Spatio-temporal, multicellular and Monte Carlo track-based model of radiotherapy in silico.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/118076

► A notable short-coming in the way radiotherapy is currently practised is that patient-specific radiobiology is minimally and rarely accounted for in the treatment planning process.… (more)

▼ A notable short-coming in the way radiotherapy is currently practised is that patient-specific radiobiology is minimally and rarely accounted for in the treatment planning process. If this is to be remedied, in silico radiobiological models of radiotherapy will play an essential role. By increasing the complexity of such models, greater accuracy and utility are gained, along with opportunities for new radiobiological insights. A new computational model was developed called “Stochastic Squared Radiotherapy” (S2RT). It is a spatio-temporal/four-dimensional radiotherapy model for head and neck squamous cell carcinoma (HNSCC), that uses stochastic modelling of tumour cells and Monte Carlo track structure simulations. The four main components of the model are tumour growth, tumour irradiation, DNA damage induction and cell death/survival. The tumour growth module generates the initial multicellular tumour and evolves it spatio-temporally in-between dose fractions. Ellipsoidal tumour cells occupy randomised, non-overlapping locations. Cells are pushed outward and fall inward following cell division and cell death, respectively. An epithelial cell hierarchy of stem, transit and differentiated cells is modelled. A connected and chaotic network of blood vessels grows interwoven between the cells. Chronic hypoxia and necrotic cells are simulated at distances far from blood vessels. Hypoxic cells divide slower and necrotic cells are gradually resorbed. Accelerated repopulation may be simulated by increasing the symmetric division of cancer stem cells. Dose fractions are delivered to the tumour in Monte Carlo simulations of radiation tracks. The multicellular tumour is voxelised into nucleus, cytoplasm and intercellular voxels of size 2 μm and imported into Geant4 to perform irradiation. A Geant4 application was developed that uses Geant4-DNA to simulate low-energy physical interactions and radiolytic chemical tracks to account for the indirect effect. The tracks through cell nuclei are converted to DNA damage, including doublestrand breaks (DSBs). This was done by spatially clustering physical interactions such as ionisations and excitations and hydroxyl radical interactions into simulated DNA volumes, each of size 10 base pairs. The DNA damage was made dependent upon the cellular pO2 by increasing the efficiency of DNA radical-to-strand break conversion with increasing pO2. In the model, complex DSBs (cDSBs) produced DNA free-ends that can misrejoin with one another and produce exchange-type chromosome aberrations. Complete exchanges are assumed. The misrejoining probability is modelled as an exponential function of the initial distance between the two cDSBs involved. Cells die if they contain an asymmetric chromosome aberration. Notable findings from the S2RT model include: 1. Symmetric division of cancer stem cells may be as high as 50% during accelerated repopulation. 2. The decrease in the oxygen enhancement ratio for DSB induction with increasing LET can be attributed to spatial clustering alone; i.e., at higher LET, the… Advisors/Committee Members: Bezak, Eva (advisor), Phillips, Wendy (advisor), Douglass, Michael (advisor), School of Physical Sciences (school).

Subjects/Keywords: Radiobiology; computational modelling; radiotherapy; Monte Carlo track structure; head and neck cancer; stochastic

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Forster, J. C. (2018). Spatio-temporal, multicellular and Monte Carlo track-based model of radiotherapy in silico. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/118076

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Forster, Jake Cameron. “Spatio-temporal, multicellular and Monte Carlo track-based model of radiotherapy in silico.” 2018. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/118076.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Forster, Jake Cameron. “Spatio-temporal, multicellular and Monte Carlo track-based model of radiotherapy in silico.” 2018. Web. 25 Jun 2019.

Vancouver:

Forster JC. Spatio-temporal, multicellular and Monte Carlo track-based model of radiotherapy in silico. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/118076.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Forster JC. Spatio-temporal, multicellular and Monte Carlo track-based model of radiotherapy in silico. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/118076

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

25. Crouch, Benjamin. Application of magnetic resonance imaging to the study of age related changes and gender differences in the human brain.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/118127

► Magnetic Resonance Imaging (MRI) is an invaluable tool used in medical research and clinical practice. T1 weighted (T1w) and T2 weighted (T2w) magnetic resonance images… (more)

▼ Magnetic Resonance Imaging (MRI) is an invaluable tool used in medical research and clinical practice. T1 weighted (T1w) and T2 weighted (T2w) magnetic resonance images are used to detect pathological changes in brain tissue such as demyelination and iron accumulation. Voxel based statistical analysis (VBSA) is a technique used to identify brain regions that show evidence of abnormality in disease populations or individual patients. While VBSA is used extensively in the analysis of functional magnetic resonance imaging and voxel based morphometry images, its use in T1w and T2w image datasets has been much more limited. In this work, age related changes and gender differences in T1w and T2w images are examined in a dataset of 152 subjects taken from a publicly available dataset of healthy volunteers, demonstrating the utility of VBSA when applied to these mage types. To investigate the most suitable intensity normalisation method, VBSA results were obtained with three different global intensity normalisation algorithms, the first algorithm was based on the whole brain mean, the second method was the voxel based iterative sensitivity (VBIS) method of (Abbott et al. 2009) and the third was based on the location of the intensity histogram peak. The latter two algorithms showed good agreement. The most striking and statistically strongest result obtained is a strong negative correlation between T2w signal and age in the putamen, caudate head, para-hippocampal gyrus and amygdala, consistent with iron accumulation in these regions and most likely due to a higher rate of micro-bleeds occurring in these brain regions. Other results include decreased T1w signal and increased T2w signal in the thalamus with advancing age. Results for Gender differences include a significantly higher T2w signal in the superior longitudinal fasciculus and internal capsule for females and a significantly higher T2w intensity in the medulla for males. T1w intensity was significantly higher in males in parts of the midbrain. These results demonstrate that VBSA of T1w and T2w images is an effective tool for establishing physiologically meaningful localised patterns of change in cross-sectional neuro-image data-sets. Advisors/Committee Members: Barnden, Leighton (advisor), Pollard, Judith (advisor), Mohammadi, Mohammad (advisor), School of Physical Sciences : Physics (school).

Subjects/Keywords: Magnetic resonance imaging; statistical parametric mapping

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Crouch, B. (2018). Application of magnetic resonance imaging to the study of age related changes and gender differences in the human brain. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/118127

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Crouch, Benjamin. “Application of magnetic resonance imaging to the study of age related changes and gender differences in the human brain.” 2018. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/118127.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Crouch, Benjamin. “Application of magnetic resonance imaging to the study of age related changes and gender differences in the human brain.” 2018. Web. 25 Jun 2019.

Vancouver:

Crouch B. Application of magnetic resonance imaging to the study of age related changes and gender differences in the human brain. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/118127.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Crouch B. Application of magnetic resonance imaging to the study of age related changes and gender differences in the human brain. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/118127

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

26. Lee, Joel Hoong Zhang. Harnessing P450 enzymes as biocatalysts for selective C-H bond hydroxylation.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/118161

► The cytochrome P450 enzyme, CYP101B1 from Novosphingobhium aromaticivorans can catalyse the highly efficient and regioselective oxidation of norisoprenoids. However, it has lower affinity towards hydrophobic… (more)

▼ The cytochrome P450 enzyme, CYP101B1 from Novosphingobhium aromaticivorans can catalyse the highly efficient and regioselective oxidation of norisoprenoids. However, it has lower affinity towards hydrophobic substrates. Site-saturation mutagenesis of its Histidine85 (H85) residue was carried out as the equivalent tyrosine residue in the sequence of the closely related P450cam enzyme (CYP101A1 from a Pseudomonas species) provides hydrophilic interactions with camphor. Mutagenesis of the H85 residue to a phenylalanine residue (H85F) has been reported to increase the enzyme's affnity towards small hydrophobic molecules. Eleven mutants that differ at position 85 were successfully produced and these were incorporated into two separate plasmid vectors for enzyme purification and whole-cell studies. Whole-cell oxidation of the CYP101B1 mutants with various substrates that include norisoprenoids, terpenoids, and hydrophobic molecules of varying sizes were carried out to screen if the mutants have activity towards these substrates. A number of the mutants such as H85V, H85S, H85G and H85I displayed increased product formation and altered product selectivity but most were not as effective as the WT or the H85F mutant in oxidising hydrophobic molecules. Purification of both the H85A and H85G mutants was also carried out and ferrous- CO assays showed they were functional P450 enzymes. In vitro studies with these two mutants demonstrated they have poorer binding affnity and oxidation activity towards phenylcyclohexane when compared to the WT enzyme and the H85F variant. A mutant library of rationally designed P450cam variants which have been created to increase the affinity and oxidation activity towards the monoterpene, α-pinene, was tested with other monoterpenoids and related compounds. The mutations in this library were incorporated at residues in the active site. The library was screened using a whole-cell system with five substrates of similar size and chemical functionality to camphor and pinene. These were fenchone, fenchyl acetate, isophorone, 1,8-cineole and 1,4-cineole. The screening of these mutants displayed higher selectivity for the oxidations of these substrates compared to the WT. The metabolites were produced in larger quantities for isolation and identification. Fenchone and fenchyl acetate oxidation by different mutants generated a mixture of the C5, C6 and C7 hydroxylation products with the exo face being preferred. Isophorone oxidation by the mutants F87W-Y96FL244A- V247L (WFAL) and F87W-Y96F-L244A (WFA) gave selective formation of (4R)-hydroxyisophorone. This product is valuable as a avouring agent. Several of the mutants also selectively oxidised 1,8- and 1,4-cineole at different C-H bonds. A desaturation product was observed at the isopropyl group during 1,4-cineole oxidation. Concurrent studies of isophorone and cineole oxidation by mutants of another enzyme (P450BM3) also gave selective transformation of both substrates with high yields in whole-cell turnover systems. The whole-cell oxidation of… Advisors/Committee Members: Bell, Stephen (advisor), Abell, Andrew (advisor), School of Physical Sciences : Chemistry (school).

Subjects/Keywords: P450; biocatalysis; food; fragrance; hydroxylation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, J. H. Z. (2018). Harnessing P450 enzymes as biocatalysts for selective C-H bond hydroxylation. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/118161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lee, Joel Hoong Zhang. “Harnessing P450 enzymes as biocatalysts for selective C-H bond hydroxylation.” 2018. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/118161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lee, Joel Hoong Zhang. “Harnessing P450 enzymes as biocatalysts for selective C-H bond hydroxylation.” 2018. Web. 25 Jun 2019.

Vancouver:

Lee JHZ. Harnessing P450 enzymes as biocatalysts for selective C-H bond hydroxylation. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/118161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lee JHZ. Harnessing P450 enzymes as biocatalysts for selective C-H bond hydroxylation. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/118161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

27. Tucker, Naomi Marie. Metamorphic and crustal evolution of Australian-Antarctic Proterozoic margins.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/118203

► Regional, long-lived (>>50 Myr), high temperature–ultrahigh temperature (HT–UHT) metamorphism challenges conventional notions on the thermal state of the crust as it requires the sustaining of… (more)

▼ Regional, long-lived (>>50 Myr), high temperature–ultrahigh temperature (HT–UHT) metamorphism challenges conventional notions on the thermal state of the crust as it requires the sustaining of high energy thermal gradients (>>75 °C/kbar). Regional, long-lived, high thermal gradient metamorphism occurring at continental margins further questions the relationship between continental amalgamation, the mechanisms that promote and maintain elevated heat flow, and thus the tectonic setting(s) of which this metamorphic expression is the hallmark. The Musgrave–Albany–Fraser–Wilkes Orogen (MAFWO) is outstanding in its record of regionally expansive, prolonged, and thermally extreme conditions during the Mesoproterozoic (D1/M1: 1345–1260 Ma; D2/M2: 1220–1130 Ma). Occurring along the margins of the Australian and East Antarctic Archean–Paleoproterozoic cratons, this system is geographically and geodynamically central to models for the Proterozoic amalgamation of the Australian–Antarctic continent in the Rodinia system. Despite its significance, precise details of the Mesoproterozoic metamorphic evolution of some constituent terranes of the MAFWO are unclear. A metamorphic framework for the orogen in its entirety is also non-existent. To address this deficiency, this thesis firstly presents an integrated metamorphic, geochronological and geochemical (together “petrochronology”), and isotopic study that characterises the metamorphic and crustal evolution of two key and understudied tectonic regions at opposing ends of the MAFWO. High thermal gradients at mid-crustal levels (6.0–6.5 kbar, 900 °C) prevailed in the east Musgrave Inlier, central Australia (east MAFWO), between ca. 1220–1140 Ma. Despite the protracted record of age data, the excursion to peak UHT metamorphic conditions was transient, and was followed by a slight increase in pressure. It is argued that high thermal gradient conditions occurred in response to magmatic loading and heat advection of coevally-emplaced granite. These new constraints provide insight into local-scale heat sources operating within a regional, mantle-driven thermal system. The Bunger Hills and Highjump Archipelago, East Antarctica (west MAFWO), are characterised by similarly high thermal gradient conditions to the east MAFWO (5.5–7.1 kbar, 800–960 °C and 6–9 kbar, 850–950 °C, respectively). Metamorphic age data also suggest an extremely long duration of high temperatures (>150 Myr) but peak metamorphism itself is constrained to a comparatively shorter time period (ca. 1220–1180 Ma). In contrast to the east Musgrave Inlier, peak metamorphism was followed by a pressure decrease that is interpreted to reflect the extension of thickened crust. New isotopic datasets from the Bunger Hills have allowed for re-examination of the pre-existing tectonic setting and thus potential tectonic control(s) on metamorphism. The Bunger Hills is now understood to represent a detached fragment of the Archean Yilgarn Craton that underwent (para)autochthonous crustal reworking during the Paleo–Mesoproterozoic. The… Advisors/Committee Members: Hand, Martin (advisor), Kelsey, David (advisor), Payne, Justin (advisor), School of Physical Sciences : Earth Sciences (school).

Subjects/Keywords: East Antarctica; crustal evolution; high-temperature metamorphism; Musgrave-Albany-Fraser; Proterozoic; Australia; petrochronology; rodinia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tucker, N. M. (2018). Metamorphic and crustal evolution of Australian-Antarctic Proterozoic margins. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/118203

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tucker, Naomi Marie. “Metamorphic and crustal evolution of Australian-Antarctic Proterozoic margins.” 2018. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/118203.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tucker, Naomi Marie. “Metamorphic and crustal evolution of Australian-Antarctic Proterozoic margins.” 2018. Web. 25 Jun 2019.

Vancouver:

Tucker NM. Metamorphic and crustal evolution of Australian-Antarctic Proterozoic margins. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/118203.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tucker NM. Metamorphic and crustal evolution of Australian-Antarctic Proterozoic margins. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/118203

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

28. Berthiaume, Jonathan David Donauer. Neotectonic faults of the Paralana Escarpment and their influence on uranium-bearing fluid flow.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/118205

► The Paralana Fault Zone is situated on the eastern flank of the northern Flinders Ranges and separates the Mesoproterozoic Mount Painter Domain to the west… (more)

▼ The Paralana Fault Zone is situated on the eastern flank of the northern Flinders Ranges and separates the Mesoproterozoic Mount Painter Domain to the west and the Mesozoic-Cenozoic Lake Frome Embayment to the east. West-over-east neotectonic faults within the fault zone have been identified previously; the main ones having been described in literature but to date there have been no regional structural studies focusing on the geometry and kinematics of the Paralana Fault Zone. The fault zone juxtaposes uraniferous granites of the Mount Painter Inlier and the sandstone-hosted uranium deposits of the Lake Frome Embayment. Due to their proximity to such prospective zones of economic mineralization, understanding the interplay between these faults and the groundwater of the area is of crucial importance for future mineral exploration strategies. We have identified three individual thrust fault sets from a total of 56 catalogued faults, within an area of 150km2. Fault Set 1 strikes approximately NW-SE with moderate dip in both directions and a NE-SW principal stress direction (σ1). Fault Set 2 strikes N-S and has a shallow dip and E-W σ1. Fault Set 3 has an overall NE-SW strike, moderate dip, and is representative of the current stress regime with a σ1of NW-SE. Fault Set 3 features spectacular examples of neotectonic faulting, with Mesoproterozoic marbles and granites of the Mount Painter Inlier overlying Quaternary sandstones and conglomerates of the Frome Embayment. Observed fault displacements since the end of the Miocene range from 10 cm up to an estimated maximum of 800 m. We have sampled fault rocks from 34 measured faults and characterized micro textures ranging from unconsolidated fault gouge and breccia to heavily silicified fault gouge, indicating a range of fluid-flow conditions. To understand the possible fluids to have flowed through the faults, a hydrogeochemical study was conducted with water samples taken from range-proximal natural springs. After careful consideration of the fault orientation and attitudes, fault rock textures and chemical composition of spring waters, I conclude that there is no evidence for direct interaction between surficial neotectonic faults and uranium-bearing fluids. Advisors/Committee Members: King, Rosalind (advisor), Holford, Simon (advisor), Bunch, Mark (advisor), School of Physical Sciences : Earth Sciences (school).

Subjects/Keywords: Geology; South Australia; neotectonic; fault; uranium; geomorphology; Arkaroola; Paralana; structure; hydrogeology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Berthiaume, J. D. D. (2018). Neotectonic faults of the Paralana Escarpment and their influence on uranium-bearing fluid flow. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/118205

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Berthiaume, Jonathan David Donauer. “Neotectonic faults of the Paralana Escarpment and their influence on uranium-bearing fluid flow.” 2018. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/118205.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Berthiaume, Jonathan David Donauer. “Neotectonic faults of the Paralana Escarpment and their influence on uranium-bearing fluid flow.” 2018. Web. 25 Jun 2019.

Vancouver:

Berthiaume JDD. Neotectonic faults of the Paralana Escarpment and their influence on uranium-bearing fluid flow. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/118205.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Berthiaume JDD. Neotectonic faults of the Paralana Escarpment and their influence on uranium-bearing fluid flow. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/118205

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

29. Amarasinghe, Udeni Bandara. A geochronological U-Pb zircon La-ICPMS age and provenance study of Wanni, Highland and Vijayan Complexes of Sri Lanka and Proterozoic Pranhita Godavari Purana Basin of India unveils origin of Sri Lanka.

Degree: 2017, University of Adelaide

URL: http://hdl.handle.net/2440/113324

► The island of Sri Lanka is the focus of Neoproterozoic super continent Gondwana. But the geological origin and paleotectonic position of Sri Lanka are least… (more)

▼ The island of Sri Lanka is the focus of Neoproterozoic super continent Gondwana. But the geological origin and paleotectonic position of Sri Lanka are least understood without knowing age and provenance of the four main crustal units, the Wanni Complex (WC), Highland Complex (HC), Vijayan Complex (VC) and the Kadugannawa Complex (KC). The study of age and provenance of metaquartzites of the WC and HC, leucosomes and paleosomes of migmatites of the WC, and charnockites of the HC and VC of Sri Lanka and sedimentary rocks of neighboring Proterozoic rift basins like Pranhita-Godavari basin of central India is significant in research on origin of Sri Lanka and also continental evolution to unravel the paleotectonic position of Sri Lanka before Gondwana being amalgamated in the Neoproterozoic. This study examined age of detrital zircon cores and metamorphic rims of metaquartzite, migmatite and charnockite samples along two west to east transects across the island of Sri Lanka as well as sedimentary rock samples from the Pranhita-Godavari rift basin of India using the LA-ICPMS method. The U-Pb zircon isotopic data from metaquartzites of WC ( near WC-HC boundary) and HC demonstrate dominant Mesoarchaean to Paleoproterozoic (2.0-2.8 Ga) detrital input into the metasedimentary make up and near boundary WC and HC metaquartzites were deposited between 2000 Ma and ~550 Ma with a maximum age of deposition ~ 2000 Ma, however a sample from the western WC was deposited in early Neoproterozpoic and mixed with Paleoproterozoic to Neoarchaean detritus indicating WC and HC terranes existed adjacent to each other since early Neoproterozoic and current WC-HC boundary is inaccurate and to be shifted westwards. This study reveals that parent materials of leucosomes of WC migmatitic gneisses are metasedimentary and showing late Mesoproterozoic to Neoproterozoic provenance (0.70-1.15 Ga) with maximum age of deposition at ~700 Ma. But paleosomes of WC migmatites show metaigneous origin with older Mesoarchaean ages (2.85-3.0 Ga) and have been identified in this study as the Mesoarchaean reworked continental basement material of WC. The HC charnockites clearly show metaigneous origin and primary intrusion ages of ~1.82 to 1.85 Ga. whilst a sample from the VC shows metasedimentary origin. A weighted mean of all rim data of WC and HC yields an age of 545.1 ± 9.7 Ma, supporting the age of Ediacaran-Cambrian metamorphism. Metaquartzite rocks of the HC of Sri Lanka are correlated with the Trivandrum Block and Northern Madurai Block of South India and the Itremo Group of Madagascar whilst metaquartzites of the western WC of Sri Lanka are correlated with the Southern Madurai Block of South India and the Molo Group of Madagascar and Sri Lankan metaquartzites were most probably sourced from east African igneous protolith sources. These differences in sedimentary provenance and maximum age of deposition prove and confirm that WC was a different crustal domain from the HC terrane. All this strongly supports a double subduction and collisional geological… Advisors/Committee Members: Collins, Alan Stephen (advisor), Hand, Martin Phillip (advisor), School of Physical Sciences (school).

Subjects/Keywords: LA-ICPMS; U-Pb ages; detrital peaks; maximum age of deposition; Highland complex; Wanni complex; Vijayan Complex; Research by Publication

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APA (6^th Edition):

Amarasinghe, U. B. (2017). A geochronological U-Pb zircon La-ICPMS age and provenance study of Wanni, Highland and Vijayan Complexes of Sri Lanka and Proterozoic Pranhita Godavari Purana Basin of India unveils origin of Sri Lanka. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/113324

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Amarasinghe, Udeni Bandara. “A geochronological U-Pb zircon La-ICPMS age and provenance study of Wanni, Highland and Vijayan Complexes of Sri Lanka and Proterozoic Pranhita Godavari Purana Basin of India unveils origin of Sri Lanka.” 2017. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/113324.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Amarasinghe, Udeni Bandara. “A geochronological U-Pb zircon La-ICPMS age and provenance study of Wanni, Highland and Vijayan Complexes of Sri Lanka and Proterozoic Pranhita Godavari Purana Basin of India unveils origin of Sri Lanka.” 2017. Web. 25 Jun 2019.

Vancouver:

Amarasinghe UB. A geochronological U-Pb zircon La-ICPMS age and provenance study of Wanni, Highland and Vijayan Complexes of Sri Lanka and Proterozoic Pranhita Godavari Purana Basin of India unveils origin of Sri Lanka. [Internet] [Thesis]. University of Adelaide; 2017. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/113324.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Amarasinghe UB. A geochronological U-Pb zircon La-ICPMS age and provenance study of Wanni, Highland and Vijayan Complexes of Sri Lanka and Proterozoic Pranhita Godavari Purana Basin of India unveils origin of Sri Lanka. [Thesis]. University of Adelaide; 2017. Available from: http://hdl.handle.net/2440/113324

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

30. Downey, Kayla Monique. Design and synthesis of protein chemical crosslinkers: a modular approach.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/114024

► The study of protein structure and interactions is pivotal in understanding the function and malfunction of complex biological systems. The structures of some proteins are… (more)

▼ The study of protein structure and interactions is pivotal in understanding the function and malfunction of complex biological systems. The structures of some proteins are unable to be determined using traditional high resolution biophysical techniques, requiring the development of amenable low resolution alternatives. Chemical Crosslinking Mass Spectrometry (CXMS) is one technique which can be used to probe protein structure through the formation of covalent linkages between protein residues. The formation of these links is facilitated by chemical crosslinking reagents. Widespread use of the CXMS technique has been hampered primarily by analytical challenges pertaining to the detection and identification of crosslinked species using Mass Spectrometry (MS). Attempts to mitigate the challenges have been made by modifying the structure of chemical crosslinkers through the addition of functional groups such as affinity tags, isotope labels and cleavable bonds. Crosslinkers combining more than one type of functional group (combination crosslinkers) present the most promising targets for CXMS applications, combining the benefits of each functional group. However, combination crosslinkers are not commercially available, thus necessitating in-house synthesis. Incorporating more than one functionality also results in more complex molecular structures and synthetic processes, making the crosslinkers difficult to adapt to suit a particular experiment. Consequently, the use of combination crosslinkers has been limited to date to a small number of studies. The research presented in this thesis describes the development of a modular chemical crosslinker design and corresponding synthetic protocol for the synthesis of combination crosslinkers. The modular crosslinker structure can be readily modified to include a range of functional groups using a small number of different reactions, including amide coupling and O-alkylation, and commercially available starting materials such as Boc-serine, from a minimum of five synthetic steps. The utility of the synthetic process was validated through the synthesis of a crosslinker containing an alkyne functional group, which can be used to attach a biotin affinity tag through alkyne-azide Huisgen Cyclisation. Synthesis of two custom designed combination crosslinkers utilising alkyne tags and cleavable bonds is also described. The function of the cleavable bonds was established using collision induced dissociation processes within the mass spectrometer. Ensuring that a crosslinker is effective in probing quaternary structure and protein- protein interactions is essential as the investigation of these structures is a major goal of CXMS. Therefore, a crosslinking assay using Staphylococcus aureus biotin protein ligase, which forms homodimers when substrate bound, was also developed using the commercially available crosslinkers Disuccinimidyl Suberate (DSS) and Dithiobis(succinimidyl) Propionate (DSP), to enable the efficacy of crosslinkers synthesised using the modular synthetic protocol to be… Advisors/Committee Members: Pukala, Tara Louise (advisor), Abell, Andrew David (advisor), School of Physical Sciences (school).

Subjects/Keywords: chemistry; chemical crosslinking; modular; CXMS; protein structure; structure determination

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Downey, K. M. (2018). Design and synthesis of protein chemical crosslinkers: a modular approach. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/114024

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Downey, Kayla Monique. “Design and synthesis of protein chemical crosslinkers: a modular approach.” 2018. Thesis, University of Adelaide. Accessed June 25, 2019. http://hdl.handle.net/2440/114024.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Downey, Kayla Monique. “Design and synthesis of protein chemical crosslinkers: a modular approach.” 2018. Web. 25 Jun 2019.

Vancouver:

Downey KM. Design and synthesis of protein chemical crosslinkers: a modular approach. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2019 Jun 25]. Available from: http://hdl.handle.net/2440/114024.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Downey KM. Design and synthesis of protein chemical crosslinkers: a modular approach. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/114024

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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