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1. Botaya Turón, Luis. Caracterización eléctrica de muestras biológicas con resonadores de cuarzo como nanosensores.

Degree: Departament d'Enginyeries: Secció d'Electrònica, 2016, Universitat de Barcelona

Electrical characterization of biological samples can give important information about the properties of the biological agents, their relationship with the medium, their chemical behavior and the basis of diverse biological phenomena. However, these types of characterization technologies have to overcome many limitations and difficulties, especially in microscopic and nanoscopic scenarios. The main objective accomplished by this Thesis is the development of high precision technological platforms applied to electrical characterization of biological samples at nanoscale. The present work shows different technologies based on a novel Conductive-AFM nanosensor using a QTF-metallic tip nanotool capable of simultaneously imaging the topography and conductance of a sample with nanoscale spatial resolution. The system is based on a header design which allows the metallic tip to be placed in tight and stable mechanical contact with the QTF without the need to use any glue. This technology allows force measurements while the electrical current is acquired by the metallic tip. The equipment has been validated with calibration sets and biological samples (CC and AC conditions). Results obtained show the possibilities of this technology for being adapted to a nanorobotic multitool platform. This platform consists of a two nanosensor systems composed by two 3 DoF motor units (micro and macro range) for each tool, and an optical microscope for the tip positioning. The combination of this C-AFM technology with the multitool station gives a new vision of the possibilities of the developed microscopy. During this work it has been demonstrated the great behavior of this novel platform validated by several calibration tests with known substrates, resistors and capacitors. Last experiments presented in this work explore the equipment capabilities studying the impedance of selected aluminum microparticles, the electrical behavior evolution of Escherichia Coli biofilms with the culture time and the nanoelectrical mapping of bacteria. Concept essays exploring the capabilities of the equipment with SECM/AFM measurements are also presented in the document. Results provided during this Thesis gives an overview of the behavior and the possibilities of this C-AFM nanorobotic multiplatform for the study of the electrical behavior of biological samples. Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Puig i Vidal, Manuel (director), Otero Díaz, Jorge (director), true (authorsendemail).

Subjects/Keywords: Nanoelectrònica; Nanoelectrónica; Nanoelectronics; Mostres biològiques; Especímenes biológicos; Biological specimens; Ciències Experimentals i Matemàtiques; 53

…51 8 Universitat de Barcelona Caracterización eléctrica de muestras biológicas con… …120 10 Universitat de Barcelona Caracterización eléctrica de muestras biológicas con… …12 Universitat de Barcelona Caracterización eléctrica de muestras biológicas con… …topográfica de la muestra. 16 Universitat de Barcelona Caracterización eléctrica de muestras… …̅ Ec.1 18 Universitat de Barcelona Caracterización eléctrica de muestras biológicas con… 

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APA (6th Edition):

Botaya Turón, L. (2016). Caracterización eléctrica de muestras biológicas con resonadores de cuarzo como nanosensores. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/400400

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Botaya Turón, Luis. “Caracterización eléctrica de muestras biológicas con resonadores de cuarzo como nanosensores.” 2016. Thesis, Universitat de Barcelona. Accessed August 06, 2020. http://hdl.handle.net/10803/400400.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Botaya Turón, Luis. “Caracterización eléctrica de muestras biológicas con resonadores de cuarzo como nanosensores.” 2016. Web. 06 Aug 2020.

Vancouver:

Botaya Turón L. Caracterización eléctrica de muestras biológicas con resonadores de cuarzo como nanosensores. [Internet] [Thesis]. Universitat de Barcelona; 2016. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/10803/400400.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Botaya Turón L. Caracterización eléctrica de muestras biológicas con resonadores de cuarzo como nanosensores. [Thesis]. Universitat de Barcelona; 2016. Available from: http://hdl.handle.net/10803/400400

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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