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You searched for +publisher:"Université Catholique de Louvain" +contributor:("Vander Borght, Thierry"). Showing records 1 – 2 of 2 total matches.

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Université Catholique de Louvain

1. Krug, Bruno. Economic evaluation of positron emission tomography : activity-based costing and modelling techniques in malignant melanoma.

Degree: 2009, Université Catholique de Louvain

Diagnostic accuracy studies alone are not sufficient; the test's impact on patient outcome ought to be performed. Before introducing a test in clinical practice, its societal impact should be assessed as well.The cost-effectiveness of diagnostic tests is often assessed by means of economic models. Modelling is particularly well suited for diagnostic tests because of the complexity and the uncertainty of many clinical decisions. Its major strength lies on an explicit and systematic approach to decision making. But the results of such an analysis are also largely dependent on the assumptions underlying the model and on the inclusion of all relevant costs and outcomes. This search for valid input parameters has been pursued in the current thesis. Implicit in economic analysis is the concept of assigning some monetary cost to the considered intervention. Accurate data on resource cost of 18F-FDG-PET are often scarce and contradictory. One possible way to calculate reliable cost data is Activity-Based Costing (ABC), a cost calculation method that allocates resource costs to products based on activity consumption. ABC goes beyond being just a more accurate accounting system. This approach can be used for operational decision making to improve the departmental workflow as well as to understand the financial impact of changes in consumption patterns or of the acquisition of new equipment (cost management), like acquiring a new hybrid scanner or establishing a PET-CT facility. In the first chapter of the thesis, we will conduct two comprehensive descriptive cost analyses based on the ABC methodology of an 18F-FDG-PET study and of the commercial production of 18F-FDG patient dose. The determination of accurate costs estimates will better identify the critical cost components and evaluate the impact in changes in cost patterns. The quality of a pharmaco-economic evaluation crucially depends on the value of the data based on the best available up-to-date evidence on the intervention and its comparator. As in other branches of science and medical care, the majority of PET review articles are narrative rather than systematic. The key difference between them is, for the latter, the explicit and systematic searching methodology and the critical appraisal of the studies. One of the goals of the thesis is to illustrate the advantage of a systematic review. We therefore designed, in the second chapter, a systematic review of 18F-FDG-PET in the staging Cutaneous Malignant Melanoma work-up. Patients with metastatic melanoma have traditionally been managed with various systemic treatments; however, overall survival with this approach has been disappointing. Conventional teaching has been that resection was not indicated when the cancer is disseminated. Several series have however reported long-term survival after resection of distant metastases. In the absence of more active agents, surgery should be therefore reconsidered in the treatment paradigm at least for some highly selected patients. Recently, Petersen et al published a large… Advisors/Committee Members: UCL - (MGD) Service de médecine nucléaire, Vander Borght, Thierry, Crott, Ralph, Gregoire, Vincent, Lonneux, Max, Dierckx, Rudi, Severens, Hans, Dervaux, Benoit.

Subjects/Keywords: Economic evaluation; Cost-effectiveness; Positron emission tomography; Malignant melanoma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Krug, B. (2009). Economic evaluation of positron emission tomography : activity-based costing and modelling techniques in malignant melanoma. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/28717

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Krug, Bruno. “Economic evaluation of positron emission tomography : activity-based costing and modelling techniques in malignant melanoma.” 2009. Thesis, Université Catholique de Louvain. Accessed April 03, 2020. http://hdl.handle.net/2078.1/28717.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Krug, Bruno. “Economic evaluation of positron emission tomography : activity-based costing and modelling techniques in malignant melanoma.” 2009. Web. 03 Apr 2020.

Vancouver:

Krug B. Economic evaluation of positron emission tomography : activity-based costing and modelling techniques in malignant melanoma. [Internet] [Thesis]. Université Catholique de Louvain; 2009. [cited 2020 Apr 03]. Available from: http://hdl.handle.net/2078.1/28717.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Krug B. Economic evaluation of positron emission tomography : activity-based costing and modelling techniques in malignant melanoma. [Thesis]. Université Catholique de Louvain; 2009. Available from: http://hdl.handle.net/2078.1/28717

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Université Catholique de Louvain

2. Karmani, Linda. Radiolabelled antibody-targeted gold nanoparticles for cancer imaging : effects of nanoparticle conjugation on the biological properties of the antibody and tumor targeting.

Degree: 2014, Université Catholique de Louvain

The last fifty years have seen remarkable progress in the prevention, detection and treatment of cancer. However, the current methods for cancer management including radiation, surgery and chemotherapy suffer from many disappointments, such as non-specific suppression of proliferating cancer cells, non-specific systemic distribution, inadequate drug concentration at the target site, developpment of resistance, and a limited ability to monitor the response to therapy. The concept of the “magic bullet”, proposed by Paul Ehrlich more than 100 years ago, postulated that the ideal drug should selectively target and destroy the cause of disease. Therefore, due to their high specificity, the monoclonal antibodies have shown a great promise in the treatment of cancer. However, the effectiveness of antibodies against cancer, and specifically against solid tumours, which are harder to treat, might be improved. In this context, antibodies are being administered in combination with other therapeutic strategies, such as chemotherapy or radiation, or developed as targeted vehicles by attaching toxins or radionuclides. An extension of these approaches is the study of antibody-modified nanomaterials, and particularly antibody-functionalized gold nanoparticles, which use gold nanoparticles as therapeutic agents and antibodies as targeting ligands, offering a promise of selectively conducting the nanoparticles to tumour cells, and thus a focused targeting thanks to the antibody selectivity. These gold nanoparticles may be used for photothermal therapy, as sensitizers in radiation therapy, and offer more flexibility of design in providing platforms for binding of several therapeutic agents in a single structure for effective improvement of cancer therapy. The general goal of this thesis was to explore the efficiency of targeting cancer cells by using antibodies directed against EGFR, or anti-CD105 antibodies directed against endoglin after their conjugation to gold nanoparticles. It is a proof of concept, where these immunonanoconjugates were evaluated as an imaging tool with the hope of operating them in future therapies and even in theranostic purposes. The approach of conjugating bioactive anticancer molecules, such as antibodies, to nanoparticles has some limitations, notably the risk of losing the antibody specificity for the target after the conjugation reaction. Thus, the assessment of target recognition properties and comparative biodistribution studies of antibodies before and after conjugation to gold nanopaticles were performed. In order to trace these immunonanoconjugates in vivo, the antibodies were firstly radiolabelled before nanoparticle conjugation. For conjugation reaction to gold nanoparticles, we chose two types of monoclonal antibodies directed against EGFR or endoglin (CD105). In this work, our efforts focused on the development of a tool that could be used as an imaging probe in a first step. The first specific aim consisted in the assessment of the effect of nanoparticle conjugation on the antibody… Advisors/Committee Members: UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - Faculté de pharmacie et des sciences biomédicales, Gallez, Bernard, Vander Borght, Thierry, Feron, Olivier, Grégoire, Vincent, Lucas, Stéphane, Lahoutte, Tony, Kraeber-Bodere, Françoise.

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Karmani, L. (2014). Radiolabelled antibody-targeted gold nanoparticles for cancer imaging : effects of nanoparticle conjugation on the biological properties of the antibody and tumor targeting. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/141637

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Karmani, Linda. “Radiolabelled antibody-targeted gold nanoparticles for cancer imaging : effects of nanoparticle conjugation on the biological properties of the antibody and tumor targeting.” 2014. Thesis, Université Catholique de Louvain. Accessed April 03, 2020. http://hdl.handle.net/2078.1/141637.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Karmani, Linda. “Radiolabelled antibody-targeted gold nanoparticles for cancer imaging : effects of nanoparticle conjugation on the biological properties of the antibody and tumor targeting.” 2014. Web. 03 Apr 2020.

Vancouver:

Karmani L. Radiolabelled antibody-targeted gold nanoparticles for cancer imaging : effects of nanoparticle conjugation on the biological properties of the antibody and tumor targeting. [Internet] [Thesis]. Université Catholique de Louvain; 2014. [cited 2020 Apr 03]. Available from: http://hdl.handle.net/2078.1/141637.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Karmani L. Radiolabelled antibody-targeted gold nanoparticles for cancer imaging : effects of nanoparticle conjugation on the biological properties of the antibody and tumor targeting. [Thesis]. Université Catholique de Louvain; 2014. Available from: http://hdl.handle.net/2078.1/141637

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.