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You searched for +publisher:"Université Catholique de Louvain" +contributor:("Lonneux, Max"). Showing records 1 – 2 of 2 total matches.

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Université Catholique de Louvain

1. Krug, Bruno. Economic evaluation of positron emission tomography : activity-based costing and modelling techniques in malignant melanoma.

Degree: 2009, Université Catholique de Louvain

Diagnostic accuracy studies alone are not sufficient; the test's impact on patient outcome ought to be performed. Before introducing a test in clinical practice, its societal impact should be assessed as well.The cost-effectiveness of diagnostic tests is often assessed by means of economic models. Modelling is particularly well suited for diagnostic tests because of the complexity and the uncertainty of many clinical decisions. Its major strength lies on an explicit and systematic approach to decision making. But the results of such an analysis are also largely dependent on the assumptions underlying the model and on the inclusion of all relevant costs and outcomes. This search for valid input parameters has been pursued in the current thesis. Implicit in economic analysis is the concept of assigning some monetary cost to the considered intervention. Accurate data on resource cost of 18F-FDG-PET are often scarce and contradictory. One possible way to calculate reliable cost data is Activity-Based Costing (ABC), a cost calculation method that allocates resource costs to products based on activity consumption. ABC goes beyond being just a more accurate accounting system. This approach can be used for operational decision making to improve the departmental workflow as well as to understand the financial impact of changes in consumption patterns or of the acquisition of new equipment (cost management), like acquiring a new hybrid scanner or establishing a PET-CT facility. In the first chapter of the thesis, we will conduct two comprehensive descriptive cost analyses based on the ABC methodology of an 18F-FDG-PET study and of the commercial production of 18F-FDG patient dose. The determination of accurate costs estimates will better identify the critical cost components and evaluate the impact in changes in cost patterns. The quality of a pharmaco-economic evaluation crucially depends on the value of the data based on the best available up-to-date evidence on the intervention and its comparator. As in other branches of science and medical care, the majority of PET review articles are narrative rather than systematic. The key difference between them is, for the latter, the explicit and systematic searching methodology and the critical appraisal of the studies. One of the goals of the thesis is to illustrate the advantage of a systematic review. We therefore designed, in the second chapter, a systematic review of 18F-FDG-PET in the staging Cutaneous Malignant Melanoma work-up. Patients with metastatic melanoma have traditionally been managed with various systemic treatments; however, overall survival with this approach has been disappointing. Conventional teaching has been that resection was not indicated when the cancer is disseminated. Several series have however reported long-term survival after resection of distant metastases. In the absence of more active agents, surgery should be therefore reconsidered in the treatment paradigm at least for some highly selected patients. Recently, Petersen et al published a large… Advisors/Committee Members: UCL - (MGD) Service de médecine nucléaire, Vander Borght, Thierry, Crott, Ralph, Gregoire, Vincent, Lonneux, Max, Dierckx, Rudi, Severens, Hans, Dervaux, Benoit.

Subjects/Keywords: Economic evaluation; Cost-effectiveness; Positron emission tomography; Malignant melanoma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Krug, B. (2009). Economic evaluation of positron emission tomography : activity-based costing and modelling techniques in malignant melanoma. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/28717

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Krug, Bruno. “Economic evaluation of positron emission tomography : activity-based costing and modelling techniques in malignant melanoma.” 2009. Thesis, Université Catholique de Louvain. Accessed April 03, 2020. http://hdl.handle.net/2078.1/28717.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Krug, Bruno. “Economic evaluation of positron emission tomography : activity-based costing and modelling techniques in malignant melanoma.” 2009. Web. 03 Apr 2020.

Vancouver:

Krug B. Economic evaluation of positron emission tomography : activity-based costing and modelling techniques in malignant melanoma. [Internet] [Thesis]. Université Catholique de Louvain; 2009. [cited 2020 Apr 03]. Available from: http://hdl.handle.net/2078.1/28717.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Krug B. Economic evaluation of positron emission tomography : activity-based costing and modelling techniques in malignant melanoma. [Thesis]. Université Catholique de Louvain; 2009. Available from: http://hdl.handle.net/2078.1/28717

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Université Catholique de Louvain

2. Geets, Xavier. Adaptive biological image-guided radiation therapy in pharyngo-laryngeal squamous cell carcinoma.

Degree: 2008, Université Catholique de Louvain

In recent years, the impressive progress performed in imaging, computational and technological fields have made possible the emergence of image-guided radiation therapy (IGRT) and adaptive radiation therapy (ART). The accuracy in radiation dose delivery reached by IMRT offers the possibility to increase locoregional dose-intensity, potentially overcoming the poor tumor control achieved by standard approaches. However, before implementing such a technique in clinical routine, a particular attention has to be paid at the target volumes definition and delineation procedures to avoid inadequate dosage to TVs/OARs. In head and neck squamous cell carcinoma (HNSCC), the GTV is typically defined on CT acquired prior to treatment. However, providing functional information about the tumor, FDG-PET might advantageously complete the classical CT-Scan to better define the TVs. Similarly, re-imaging the tumor with optimal imaging modality might account for the constantly changing anatomy and tumor shape occurring during the course of fractionated radiotherapy. Integrating this information into the treatment planning might ultimately lead to a much tighter dose distribution. From a methodological point of view, the delineation of TVs on anatomical or functional images is not a trivial task. Firstly, the poor soft tissue contrast provided by CT comes out of large interobserver variability in GTV delineation. In this regard, we showed that the use of consistent delineation guidelines significantly improved consistency between observers, either with CT and with MRI. Secondly, the intrinsic characteristics of PET images, including the blur effect and the high level of noise, make the detection of the tumor edges arduous. In this context, we developed specific image restoration tools, i.e. edge-preserving filters for denoising, and deconvolution algorithms for deblurring. This procedure restores the image quality, allowing the use of gradient-based segmentation techniques. This method was validated on phantom and patient images, and proved to be more accurate and reliable than threshold-based methods. Using these segmentation methods, we proved that GTVs significantly shrunk during radiotherapy in patients with HNSCC, whatever the imaging modality used (MRI, CT, FDG-PET). No clinically significant difference was found between CT and MRI, while FDG-PET provided significantly smaller volumes than those based on anatomical imaging. Refining the target volume delineation by means of functional and sequential imaging ultimately led to more optimal dose distribution to TVs with subsequent soft tissue sparing. In conclusion, we demonstrated that a multi-modality-based adaptive planning is feasible in HN tumors and potentially opens new avenues for dose escalation strategies. As a high level of accuracy is required by such approach, the delineation of TVs however requires a special care.

(MED 3)  – UCL, 2008

Advisors/Committee Members: UCL - MD/MINT - Département de médecine interne, Grégoire, Vincent, Gianello, Pierre, Scalliet, Pierre, Lonneux, Max, Lartigau, Eric, De Neve, Wilfried, Coche, Emmanuel, Bol, Anne.

Subjects/Keywords: FDG-PET; Adaptive radiotherapy; Image segmentation; Target volume delineation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Geets, X. (2008). Adaptive biological image-guided radiation therapy in pharyngo-laryngeal squamous cell carcinoma. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/12558

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Geets, Xavier. “Adaptive biological image-guided radiation therapy in pharyngo-laryngeal squamous cell carcinoma.” 2008. Thesis, Université Catholique de Louvain. Accessed April 03, 2020. http://hdl.handle.net/2078.1/12558.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Geets, Xavier. “Adaptive biological image-guided radiation therapy in pharyngo-laryngeal squamous cell carcinoma.” 2008. Web. 03 Apr 2020.

Vancouver:

Geets X. Adaptive biological image-guided radiation therapy in pharyngo-laryngeal squamous cell carcinoma. [Internet] [Thesis]. Université Catholique de Louvain; 2008. [cited 2020 Apr 03]. Available from: http://hdl.handle.net/2078.1/12558.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Geets X. Adaptive biological image-guided radiation therapy in pharyngo-laryngeal squamous cell carcinoma. [Thesis]. Université Catholique de Louvain; 2008. Available from: http://hdl.handle.net/2078.1/12558

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.