+publisher:"Università degli Studi di Milano" +contributor:("LICANDRO, EMANUELA")

1. P. Thakare. ¿DESIGN AND SYNTHESIS OF MODIFIED PEPTIDE NUCLEIC ACID (PNAS) WITH IMPROVED PHYSICO-CHEMICAL PROPERTIES FOR DNA, RNA AND MICRO RNA TARGETING¿.

Degree: 2017, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/474378

► The present dissertation is divided into four chapters. Chapter one deals with the introduction to Peptide Nucleic Acid (PNA) its properties and its applications. The… (more)

Subjects/Keywords: Settore CHIM/06 - Chimica Organica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thakare, P. (2017). ¿DESIGN AND SYNTHESIS OF MODIFIED PEPTIDE NUCLEIC ACID (PNAS) WITH IMPROVED PHYSICO-CHEMICAL PROPERTIES FOR DNA, RNA AND MICRO RNA TARGETING¿. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/474378

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Thakare, P.. “¿DESIGN AND SYNTHESIS OF MODIFIED PEPTIDE NUCLEIC ACID (PNAS) WITH IMPROVED PHYSICO-CHEMICAL PROPERTIES FOR DNA, RNA AND MICRO RNA TARGETING¿.” 2017. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/474378.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Thakare, P.. “¿DESIGN AND SYNTHESIS OF MODIFIED PEPTIDE NUCLEIC ACID (PNAS) WITH IMPROVED PHYSICO-CHEMICAL PROPERTIES FOR DNA, RNA AND MICRO RNA TARGETING¿.” 2017. Web. 15 Jan 2021.

Vancouver:

Thakare P. ¿DESIGN AND SYNTHESIS OF MODIFIED PEPTIDE NUCLEIC ACID (PNAS) WITH IMPROVED PHYSICO-CHEMICAL PROPERTIES FOR DNA, RNA AND MICRO RNA TARGETING¿. [Internet] [Thesis]. Università degli Studi di Milano; 2017. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/474378.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Thakare P. ¿DESIGN AND SYNTHESIS OF MODIFIED PEPTIDE NUCLEIC ACID (PNAS) WITH IMPROVED PHYSICO-CHEMICAL PROPERTIES FOR DNA, RNA AND MICRO RNA TARGETING¿. [Thesis]. Università degli Studi di Milano; 2017. Available from: http://hdl.handle.net/2434/474378

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. D. Dova. METHODOLOGIES FOR THE SYNTHESIS OF THIAHELICENE-BASED PHOSPHORUS DERIVATIVES AND THEIR APPLICATIONS IN ASYMMETRIC CATALYSIS.

Degree: 2014, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/243581

► Helicenes are ortho-annulated polycyclic aromatic or heteroaromatic compounds endowed with inherent chirality due to the helical shape of their π-conjugated system, whose unique structural features… (more)

Subjects/Keywords: thiahelicenes, asymmetric catalysis, phosphorus derivatives, inherent chirality; Settore CHIM/06 - Chimica Organica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dova, D. (2014). METHODOLOGIES FOR THE SYNTHESIS OF THIAHELICENE-BASED PHOSPHORUS DERIVATIVES AND THEIR APPLICATIONS IN ASYMMETRIC CATALYSIS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/243581

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dova, D.. “METHODOLOGIES FOR THE SYNTHESIS OF THIAHELICENE-BASED PHOSPHORUS DERIVATIVES AND THEIR APPLICATIONS IN ASYMMETRIC CATALYSIS.” 2014. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/243581.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dova, D.. “METHODOLOGIES FOR THE SYNTHESIS OF THIAHELICENE-BASED PHOSPHORUS DERIVATIVES AND THEIR APPLICATIONS IN ASYMMETRIC CATALYSIS.” 2014. Web. 15 Jan 2021.

Vancouver:

Dova D. METHODOLOGIES FOR THE SYNTHESIS OF THIAHELICENE-BASED PHOSPHORUS DERIVATIVES AND THEIR APPLICATIONS IN ASYMMETRIC CATALYSIS. [Internet] [Thesis]. Università degli Studi di Milano; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/243581.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dova D. METHODOLOGIES FOR THE SYNTHESIS OF THIAHELICENE-BASED PHOSPHORUS DERIVATIVES AND THEIR APPLICATIONS IN ASYMMETRIC CATALYSIS. [Thesis]. Università degli Studi di Milano; 2014. Available from: http://hdl.handle.net/2434/243581

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. M.A.K. Elatawy. SYNTHESIS OF NITROGEN HETEROCYCLES BY INTRAMOLECULAR CYCLIZATION OF ALPHA, BETA-UNSATURATED NITRO COMPOUNDS, CATALYZED BY PALLADIUM COMPLEXES AND WITH CARBON MONOXIDE AS THE REDUCTANT.

Degree: 2015, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/331319

► This work consists of four main parts. Part I describes the synthesis of medicinally relevant indoles by palladium-catalyzed reductive cyclization of readily obtainable β-nitrostyrenes using… (more)

Subjects/Keywords: homogeneous catalysis; phenanthroline; Pd catalyst; nitro olefins; nitro dienes; thienopyrroles; pyrroles; indoles; Settore CHIM/03 - Chimica Generale e Inorganica; Settore CHIM/06 - Chimica Organica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Elatawy, M. (2015). SYNTHESIS OF NITROGEN HETEROCYCLES BY INTRAMOLECULAR CYCLIZATION OF ALPHA, BETA-UNSATURATED NITRO COMPOUNDS, CATALYZED BY PALLADIUM COMPLEXES AND WITH CARBON MONOXIDE AS THE REDUCTANT. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/331319

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Elatawy, M.A.K.. “SYNTHESIS OF NITROGEN HETEROCYCLES BY INTRAMOLECULAR CYCLIZATION OF ALPHA, BETA-UNSATURATED NITRO COMPOUNDS, CATALYZED BY PALLADIUM COMPLEXES AND WITH CARBON MONOXIDE AS THE REDUCTANT.” 2015. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/331319.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Elatawy, M.A.K.. “SYNTHESIS OF NITROGEN HETEROCYCLES BY INTRAMOLECULAR CYCLIZATION OF ALPHA, BETA-UNSATURATED NITRO COMPOUNDS, CATALYZED BY PALLADIUM COMPLEXES AND WITH CARBON MONOXIDE AS THE REDUCTANT.” 2015. Web. 15 Jan 2021.

Vancouver:

Elatawy M. SYNTHESIS OF NITROGEN HETEROCYCLES BY INTRAMOLECULAR CYCLIZATION OF ALPHA, BETA-UNSATURATED NITRO COMPOUNDS, CATALYZED BY PALLADIUM COMPLEXES AND WITH CARBON MONOXIDE AS THE REDUCTANT. [Internet] [Thesis]. Università degli Studi di Milano; 2015. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/331319.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Elatawy M. SYNTHESIS OF NITROGEN HETEROCYCLES BY INTRAMOLECULAR CYCLIZATION OF ALPHA, BETA-UNSATURATED NITRO COMPOUNDS, CATALYZED BY PALLADIUM COMPLEXES AND WITH CARBON MONOXIDE AS THE REDUCTANT. [Thesis]. Università degli Studi di Milano; 2015. Available from: http://hdl.handle.net/2434/331319

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. G. Rainoldi. A JOURNEY IN THE ORGANOCATALYSED AND MULTICOMPONENT SYNTHESIS OF 3,3-DISUBSTITUTED AND SPIRO-OXINDOLES.

Degree: 2018, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/544286

► 2-Oxindoles, especially those 3,3-disubstituted or spiro-fused to other cyclic frameworks, continue to be recognized as valuable compounds for drug discovery. They are present in a… (more)

▼ 2-Oxindoles, especially those 3,3-disubstituted or spiro-fused to other cyclic frameworks, continue to be recognized as valuable compounds for drug discovery. They are present in a large number of natural and unnatural compounds with important biological activities and serve as key intermediates for the synthesis of many kinds of drug candidates.1 In particular, spirooxindoles, having cyclic structures fused at the C3 carbon, move away from the flat heterocycles encountered in many drug discovery programs. For this reason, they are of special interest, being able to potentially provide improved physicochemical properties in their interaction with biological systems.2 As more examples of the enantiospecific biological activity are identified, efficient and reliable asymmetric synthesis of such compounds becomes more and more valuable. In this context, the identification of asymmetric methods that achieve high stereoselectivity in the synthesis of heterocyclic compounds, in particular bearing tetrasubstituted or spiro-stereocenters, remains challenging. In this context, my research was aimed to the synthesis of oxindole-based libraries, exploiting protocols at the cutting edge of synthetic chemistry, such as MCRs and organocatalysis. Considering the great attention around optically active δ-amino-α,β-unsaturated carbonyl compounds as important building blocks in the synthesis of biologically active compounds,3 for my first project I focused my attention on the synthesis of 3-amino-3-(5-oxo-2,5-dihydrofuran-2-yl)indolin-2-ones derivatives via a BINOL-based phosphoric acids organocatalyzed vinylogous Mannich-type reaction.4 The desired products were obtained in general good yields and high enantiomeric excesses considering the challenge in the formation of a quaternary stereocenter consecutive with a bulky tertiary one. The stereochemistry of the final products was assigned by chemical correlation with respect to a reported compound5 and the stereochemical outcome was also rationalized by computational study. Moreover, I studied the Biginelli reaction, a three component cyclocondensation between alkyl acetoacetates, urea and a carbonyl compound, as a practical method for the synthesis of biologically important 3,4-dihydropyrimidine-2(1H)-ones.6 In particular, BINOL-phosphoric acids have been used in the development of the first enantioselective organocatalyzed multicomponent Biginelli-like reaction applied to a ketone, allowing to obtain a small library of spiro[indoline-pyrimidine]-dione derivatives in good yields and enantioselectivity.7 During the second year, I focused my attention on the synthesis of 2-oxindoles spiro-fused with four- and five-membered rings. Considering the recent medicinal chemists' interest in oxindole-based thiazolidine compounds as antitumor agents for the inhibition of the p53-MDM2 PPI,8 a novel synthetic approach towards spirooxindole-fused thiazolidines has been developed, based on two sequential multicomponent reactions (MCRs), namely the Asinger and two different Ugi-type reactions,… Advisors/Committee Members: tutor: G. Lesma, co-tutor. A. Silvani, LICANDRO, EMANUELA.

Subjects/Keywords: Spirooxindole; Organocatalysis; Multicomponent reaction; Settore CHIM/06 - Chimica Organica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rainoldi, G. (2018). A JOURNEY IN THE ORGANOCATALYSED AND MULTICOMPONENT SYNTHESIS OF 3,3-DISUBSTITUTED AND SPIRO-OXINDOLES. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/544286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rainoldi, G.. “A JOURNEY IN THE ORGANOCATALYSED AND MULTICOMPONENT SYNTHESIS OF 3,3-DISUBSTITUTED AND SPIRO-OXINDOLES.” 2018. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/544286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rainoldi, G.. “A JOURNEY IN THE ORGANOCATALYSED AND MULTICOMPONENT SYNTHESIS OF 3,3-DISUBSTITUTED AND SPIRO-OXINDOLES.” 2018. Web. 15 Jan 2021.

Vancouver:

Rainoldi G. A JOURNEY IN THE ORGANOCATALYSED AND MULTICOMPONENT SYNTHESIS OF 3,3-DISUBSTITUTED AND SPIRO-OXINDOLES. [Internet] [Thesis]. Università degli Studi di Milano; 2018. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/544286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rainoldi G. A JOURNEY IN THE ORGANOCATALYSED AND MULTICOMPONENT SYNTHESIS OF 3,3-DISUBSTITUTED AND SPIRO-OXINDOLES. [Thesis]. Università degli Studi di Milano; 2018. Available from: http://hdl.handle.net/2434/544286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. D.M. Carminati. METAL PORPHYRIN COMPLEXES: SMART CATALYSTS TO PROMOTE ECO-FRIENDLY C-C AND C-N BOND FORMATIONS.

Degree: 2018, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/541869

► Cyclopropanes and nitrogen-containing compounds, such as aziridines, indoles and amines, are interesting molecules from a synthetic point of view because they are often used as… (more)

▼ Cyclopropanes and nitrogen-containing compounds, such as aziridines, indoles and amines, are interesting molecules from a synthetic point of view because they are often used as building blocks in organic synthesis. They also constitute the active part of many natural and synthetic products owing to their biological and pharmaceutical properties. Over the years, the scientific community focused its attention in the development of new eco-friendly catalytic process to obtain these compounds in good yields and selectivity respecting the basic principles of ‘green chemistry’. Based on these concepts, carbene and nitrene transfer reactions are useful synthetic strategies to produce compounds stated above and they can be efficiently promoted by metal porphyrin complexes due to their high catalytic activity and chemical versatility. The first part of this thesis describes the synthesis of cyclopropanes using chiral iron porphyrin complexes which show a ‘Totem’ tridimensional structure. In the second half part of the thesis we describe the ruthenium porphyrin-catalysed nitrene-transfer reactions to synthesis nitrogen-containg compounds. In Chapter II we describe the synthesis of new ‘Totem porphyrin ligands’ and their iron(III) porphyrin complexes to promote cyclopropanation reactions. Since, high diastereo- and enantioselectivities are attributed to a synergic action of the active metal center with the ligand periphery, several structural modifications of the ligand skeleton were performed to give catalysts whose efficiency could be maximised by a metal/periphery synergy to promote stereoselective cyclopropanation reactions. In Chapter III we describe the Ru(TPP)CO-catalysed aziridination of styrenes by aryl azides in mesoreactors under continuos flow conditions. We also report the reactivity of aziridines towards carbon dioxide. The coupling reaction between aziridines and carbon dioxide, the most abundant greenhouse gas, is one of the most important routes to obtain oxazolidinones. The mechanism of this reaction was also computationally investigated by using DFT methods. In Chapter IV we report the synthesis of indoles by an intermolecular reaction between aryl azides and aryl alkynes using a ruthenium bis-imido complex as the catalyst. The generality of the reaction was proved by synthesising several indoles from differently substituted aryl azides and alkynes. We also performed kinetic and DFT studies to clarify the reaction mechanism. In Chapter V we describe the influence of the axial ligand electronic features on the catalytic activity of ruthenium porphyrin complexes in promoting amination reactions. The influence was studied both from an experimental and theoretical (DFT study) points of view, by comparing the catalytic performance of Ru(TPP)CO to that of Ru(TPP)(py)2 (py=pyridine) complex. Advisors/Committee Members: tutor: E. Gallo, coordinator: E. Licandro, LICANDRO, EMANUELA.

Subjects/Keywords: porphyrin; metal porphyrin complexes; catalysis; cyclopropanes; aziridines; oxazolidinones; indoles; amines; Settore CHIM/03 - Chimica Generale e Inorganica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carminati, D. (2018). METAL PORPHYRIN COMPLEXES: SMART CATALYSTS TO PROMOTE ECO-FRIENDLY C-C AND C-N BOND FORMATIONS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/541869

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carminati, D.M.. “METAL PORPHYRIN COMPLEXES: SMART CATALYSTS TO PROMOTE ECO-FRIENDLY C-C AND C-N BOND FORMATIONS.” 2018. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/541869.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carminati, D.M.. “METAL PORPHYRIN COMPLEXES: SMART CATALYSTS TO PROMOTE ECO-FRIENDLY C-C AND C-N BOND FORMATIONS.” 2018. Web. 15 Jan 2021.

Vancouver:

Carminati D. METAL PORPHYRIN COMPLEXES: SMART CATALYSTS TO PROMOTE ECO-FRIENDLY C-C AND C-N BOND FORMATIONS. [Internet] [Thesis]. Università degli Studi di Milano; 2018. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/541869.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carminati D. METAL PORPHYRIN COMPLEXES: SMART CATALYSTS TO PROMOTE ECO-FRIENDLY C-C AND C-N BOND FORMATIONS. [Thesis]. Università degli Studi di Milano; 2018. Available from: http://hdl.handle.net/2434/541869

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. J. LASSO FERNANDEZ. HYDROGEN PRODUCTION FROM RENEWABLE PRIMARY SOURCES.

Degree: 2016, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/366899

► ABSTRACT One of the most attracting renewable sources for energy production is bioethanol, which can be obtained from biomass. Special attention is here focused on… (more)

Subjects/Keywords: Ethanol steam reforming, catalytic activity, metal support interaction, coking inhibition.; Settore ING-IND/22 - Scienza e Tecnologia dei Materiali

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

FERNANDEZ, J. L. (2016). HYDROGEN PRODUCTION FROM RENEWABLE PRIMARY SOURCES. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/366899

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

FERNANDEZ, J. LASSO. “HYDROGEN PRODUCTION FROM RENEWABLE PRIMARY SOURCES.” 2016. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/366899.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

FERNANDEZ, J. LASSO. “HYDROGEN PRODUCTION FROM RENEWABLE PRIMARY SOURCES.” 2016. Web. 15 Jan 2021.

Vancouver:

FERNANDEZ JL. HYDROGEN PRODUCTION FROM RENEWABLE PRIMARY SOURCES. [Internet] [Thesis]. Università degli Studi di Milano; 2016. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/366899.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

FERNANDEZ JL. HYDROGEN PRODUCTION FROM RENEWABLE PRIMARY SOURCES. [Thesis]. Università degli Studi di Milano; 2016. Available from: http://hdl.handle.net/2434/366899

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. A. Tamburrini. ONE-POT SYNTHESIS OF THIO-GLYCOMIMETICS THROUGH RING OPENING REACTIONS.

Degree: 2019, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/607912

► Glycomimetics are compounds able to mimic structural and functional aspects of the corresponding natural carbohydrates. The main goal of using these mimetics, e.g. as therapeutic… (more)

▼ Glycomimetics are compounds able to mimic structural and functional aspects of the corresponding natural carbohydrates. The main goal of using these mimetics, e.g. as therapeutic agents, is the manipulation of the chemical information encoded by sugars, controlling and altering the flow of these information. Sugars, and their mimetics, are selectively recognised by certain proteins, called lectins. An example of these lectins is DC-SIGN. DC-SIGN (Dendritic Cell-Specific ICAM-3 Grabbing Non-integrin) is a tetrameric calcium dependent (C-type) lectin expressed by dermal dendritic cells (DCs) and it is known to play a crucial role in the immunological system. In particular, DC-SIGN is the primary target of Human Immunodeficiency Virus type I (HIV-1) that hijacks DCs to disseminate the infection in the human body. With the aim to develop DC-SIGN antagonists able to mimic the main natural ligand, the Bernardi’s group has developed a series of mono- and multivalent ligands that all contain a mannose unit (whose hydroxyl groups in position 3 and 4 are involved in the interaction with the calcium ion of the Carbohydrate Recognition Domain (CRD) of DC-SIGN) connected with a conformationally locked cyclohexandiol moiety (the aglycon part, that is known to exploit additional interaction with residues present in the binding site). In the course of my PhD, I have developed a straightforward synthesis for a new class of glycomimetic DC-SIGN ligands more metabolically stable, thanks to the presence of a sulfur atom in the interglycosidic position rather than the oxygen atom of the previous library of compounds. The key step of the preparation of these thio-glycomimetics is a one-pot ring opening reaction of an enantiomerically pure epoxide by an S-acetyl-α-mannose that affords the desired pseudo-thiodisaccharide as a single isomer in 77% yield after 1 hour at 60°C under micro-wave irradiation. To further improve the process, the same reaction was also performed into a flow micro-reactor at different flow rates, temperatures and residence times. Although at certain conditions a promising conversion of 69% was observed, the results were not competitive with the ones already achieved by using a MW system, which allowed also the scale up of the process. Computational studies supported by NMR analysis showed that the new thio-glycomimetic shares a very similar conformational behaviour as the corresponding O-linked pseudo-disaccharide. Furthermore, SPR inhibition assay revealed that they share also the same affinity towards DC-SIGN (IC50 value of 0.8 mM). However, a stability test, performed against an α-mannosidase enzyme, proved that the presence of the sulfur in the interglycosidic position makes the structure significantly more stable than that of the same molecule bearing instead an oxygen in that position. The low sub-millimolar activity of monovalent ligands is characteristic of oligosaccharide-protein interactions and is overcome both in Nature and in the development of biological active glycomimetics by exploiting… Advisors/Committee Members: tutor: A. Bernardi, coordinatore: E. Licandro, BERNARDI, ANNA, LICANDRO, EMANUELA.

Subjects/Keywords: Glycomimetics; DC-SIGN; one-pot reaction; carbohydrates; aziridines; Settore CHIM/06 - Chimica Organica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tamburrini, A. (2019). ONE-POT SYNTHESIS OF THIO-GLYCOMIMETICS THROUGH RING OPENING REACTIONS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/607912

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tamburrini, A.. “ONE-POT SYNTHESIS OF THIO-GLYCOMIMETICS THROUGH RING OPENING REACTIONS.” 2019. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/607912.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tamburrini, A.. “ONE-POT SYNTHESIS OF THIO-GLYCOMIMETICS THROUGH RING OPENING REACTIONS.” 2019. Web. 15 Jan 2021.

Vancouver:

Tamburrini A. ONE-POT SYNTHESIS OF THIO-GLYCOMIMETICS THROUGH RING OPENING REACTIONS. [Internet] [Thesis]. Università degli Studi di Milano; 2019. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/607912.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tamburrini A. ONE-POT SYNTHESIS OF THIO-GLYCOMIMETICS THROUGH RING OPENING REACTIONS. [Thesis]. Università degli Studi di Milano; 2019. Available from: http://hdl.handle.net/2434/607912

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. E. Massolo. NOVEL SYNTHETIC ORGANOCATALYTIC METHODOLOGIES.

Degree: 2015, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/330262

► The objective of this PhD study was to apply organocatalytic synthetic methods for the regio- and stereoselective synthesis of highly functionalized compounds. We exploited different… (more)

Subjects/Keywords: stereoselective organocatalysis; aminocatalysis; nitroacrylates; bifunctional organocatlysts; cascade reactions; fluorinated compounds; deep eutectic solvents; photocatalysis; acyl anion mimic; Settore CHIM/06 - Chimica Organica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Massolo, E. (2015). NOVEL SYNTHETIC ORGANOCATALYTIC METHODOLOGIES. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/330262

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Massolo, E.. “NOVEL SYNTHETIC ORGANOCATALYTIC METHODOLOGIES.” 2015. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/330262.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Massolo, E.. “NOVEL SYNTHETIC ORGANOCATALYTIC METHODOLOGIES.” 2015. Web. 15 Jan 2021.

Vancouver:

Massolo E. NOVEL SYNTHETIC ORGANOCATALYTIC METHODOLOGIES. [Internet] [Thesis]. Università degli Studi di Milano; 2015. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/330262.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Massolo E. NOVEL SYNTHETIC ORGANOCATALYTIC METHODOLOGIES. [Thesis]. Università degli Studi di Milano; 2015. Available from: http://hdl.handle.net/2434/330262

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. V.M. Pappalardo. STUDIES ON UMAMI TASTE.PREPARATION OF HYDROLYZED VEGETABLE PROTEINS(HVPS) AND GLUTAMATE-RIBONUCLEOTIDE HYBRIDS.

Degree: 2014, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/229388

► Studies on Umami Taste. Preparation of Hydrolyzed Vegetable Proteins (HVPs) and Glutamate-Ribonucleotide Hybrids - ABSTRACT. Until the 1980’s, it was assumed that there were only… (more)

▼ Studies on Umami Taste. Preparation of Hydrolyzed Vegetable Proteins (HVPs) and Glutamate-Ribonucleotide Hybrids - ABSTRACT. Until the 1980’s, it was assumed that there were only four basic tastes: salty, sweat, sour, and bitter. It is now well recognized that a taste quality exists which is distinct from any combination of the four basic ones. This palatable fifth taste was first discovered in 1908 by K. Ikeda. He identified it as “umami”, a Japanese word that means delicious. Related terms can be savory, meaty, broth-like, mouthfilling, etc. Umami is an essential element in our appreciation of food and is imparted by monosodium L-glutamate (MSG) and 5’-ribonucleotides such as disodium inosine 5’-monophosphate (IMP) and disodium guanosine 5’-monophosphate (GMP). These compounds are now used extensively as seasonings or condiments to supplement, enhance or round-off the flavor of many savory-based processed foods. They are the best flavor enhancers that are in commercial use worldwide. The term flavor enhancer (or potentiator) is reserved for substances which have very little taste of their own but have the ability to significantly influence the taste perception of others, e.g. the components of certain types of food so that these foods become organoleptically attractive to the human palate. What is perhaps the most interesting property about MSG and 5’-ribonucleotides is their capacity to interact synergistically, i.e. the detection threshold of MSG was markedly lowered in the presence of IMP (or GMP) and vice versa. It is noteworthy that the synergistic interactions of MSG with IMP and/or GMP also occur in certain savory foods bringing about a flavor effect which is greater than the sum of the individual flavor-enhancing effects. This phenomenon of synergism is of the utmost importance, because it provides an opportunity for the food processor to use less MSG in the formulation without affecting flavor quality. For instance, it has been found that food processors who use 100 g of MSG can reduce usage levels to 17 g in the presence of 0.9 g of 50:50 blends of IMP and GMP with a substantial (25-30%) cost reduction and without an adverse effect on the organoleptic properties of the processed food. Furthermore, considering that excessive sodium intake (resulting from the traditional usage of table salt as a seasoning and a preservative agent) is believed to contribute to hypertension and the development of cardiovascular disease, it has been suggested that the low pleasantness of reduced-salt foods could be increased by addition of appropriate blends of umami flavor enhancers. Recently, the negative aura around MSG, which is accused of causing the so called Chinese restaurant syndrome, has strongly stimulated research for new umami compounds. Among them some peptides isolated from Hydrolyzed Vegetable Proteins (HVPs) have a preeminent role. HVPs are produced by chemical and/or enzymatic hydrolysis of vegetable materials rich in proteins. During this thesis we found that the mixture of peptides obtained from… Advisors/Committee Members: tutor: G. Speranza, coordinator: E. Licandro, SPERANZA, GIOVANNA, LICANDRO, EMANUELA.

Subjects/Keywords: Umami; flavor enhancers; hydrolyzed vegetable proteins; ribonucleotides; Settore CHIM/06 - Chimica Organica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pappalardo, V. (2014). STUDIES ON UMAMI TASTE.PREPARATION OF HYDROLYZED VEGETABLE PROTEINS(HVPS) AND GLUTAMATE-RIBONUCLEOTIDE HYBRIDS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/229388

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pappalardo, V.M.. “STUDIES ON UMAMI TASTE.PREPARATION OF HYDROLYZED VEGETABLE PROTEINS(HVPS) AND GLUTAMATE-RIBONUCLEOTIDE HYBRIDS.” 2014. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/229388.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pappalardo, V.M.. “STUDIES ON UMAMI TASTE.PREPARATION OF HYDROLYZED VEGETABLE PROTEINS(HVPS) AND GLUTAMATE-RIBONUCLEOTIDE HYBRIDS.” 2014. Web. 15 Jan 2021.

Vancouver:

Pappalardo V. STUDIES ON UMAMI TASTE.PREPARATION OF HYDROLYZED VEGETABLE PROTEINS(HVPS) AND GLUTAMATE-RIBONUCLEOTIDE HYBRIDS. [Internet] [Thesis]. Università degli Studi di Milano; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/229388.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pappalardo V. STUDIES ON UMAMI TASTE.PREPARATION OF HYDROLYZED VEGETABLE PROTEINS(HVPS) AND GLUTAMATE-RIBONUCLEOTIDE HYBRIDS. [Thesis]. Università degli Studi di Milano; 2014. Available from: http://hdl.handle.net/2434/229388

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. G. Borghese. STUDIES ON NATURAL AND EDIBLE BIOPOLYMERS. ISOLATION, CHARACTERIZATION AND CHEMICAL MODIFICATIONS OF POLY(Γ-GLUTAMIC ACID) (Γ-PGA) FROM BACILLUS SUBTILIS.

Degree: 2013, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/219916

► Poly(γ-glutamic acid) (γ-PGA) is a unusual anionic, water-soluble homopolyamide composed of D- and/or L-glutamic acid monomers, connected by amide bonds between α-amino and γ-carboxyl groups,… (more)

▼ Poly(γ-glutamic acid) (γ-PGA) is a unusual anionic, water-soluble homopolyamide composed of D- and/or L-glutamic acid monomers, connected by amide bonds between α-amino and γ-carboxyl groups, mainly produced by Gram-positive bacteria of the genus Bacillus. γ-PGA is hygroscopic and water-soluble; in the salt form is able to form gels containing water in more than 3,000 times its weight. It is fairly resistant to hydrolysis, although it is degraded in basic medium at high temperature; it appears to be insensitive to common proteases such as pepsin or tripsin. γ-PGA is completely innocuous and edible. The popular food known as natto in Japan or dan-douchi in China, a soybean fermented compound that contains about 1% of γ-PGA, has formed part of the diet of Asian people for hundreds of years. Due to its biodegradability and to the intrinsic absence of toxicity as well as to the classification as GRAS (Generally Regarded As Safe) of the main producers, i.e. Bacilli, γ-PGA represents one of the naturally occurring polymers of interest for the production of environmentally friendly derivatives. Although having been known and even used for industrial applications for a long time, and considerable efforts having been spent in investigating its chemical and biological properties, much lies ahead to be elucidated about this polymer biosynthesis and conformational aspects. In addition, its potential applications appear to be still almost unexploited in the Western world. This Ph.D. thesis deals with the bioproduction, characterization and derivatization of γ-PGA from Bacillus subtilis in order to obtain novel biomaterials useful for biopackaging, biomolecule immobilization, and as drug carriers. In particular, the problems we have addressed were: the optimization of productivity, by means of genetic engineering technologies; the characterization of the polymer, with regard to its stereochemical composition and molecular weight, which deeply affect its chemical-physical properties and reactivity; the development of effective methodologies for chemical modification of the polymer, in view of preparing derivatives of pharmaceutical and technological interest. Finally, we also established a synthetic approach for the preparation of standard samples with controlled stereochemistry necessary for conformational studies. Advisors/Committee Members: tutor: G. Speranza, coordinatore: E. Licandro, SPERANZA, GIOVANNA, LICANDRO, EMANUELA.

Subjects/Keywords: Settore CHIM/06 - Chimica Organica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Borghese, G. (2013). STUDIES ON NATURAL AND EDIBLE BIOPOLYMERS. ISOLATION, CHARACTERIZATION AND CHEMICAL MODIFICATIONS OF POLY(Γ-GLUTAMIC ACID) (Γ-PGA) FROM BACILLUS SUBTILIS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/219916

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Borghese, G.. “STUDIES ON NATURAL AND EDIBLE BIOPOLYMERS. ISOLATION, CHARACTERIZATION AND CHEMICAL MODIFICATIONS OF POLY(Γ-GLUTAMIC ACID) (Γ-PGA) FROM BACILLUS SUBTILIS.” 2013. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/219916.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Borghese, G.. “STUDIES ON NATURAL AND EDIBLE BIOPOLYMERS. ISOLATION, CHARACTERIZATION AND CHEMICAL MODIFICATIONS OF POLY(Γ-GLUTAMIC ACID) (Γ-PGA) FROM BACILLUS SUBTILIS.” 2013. Web. 15 Jan 2021.

Vancouver:

Borghese G. STUDIES ON NATURAL AND EDIBLE BIOPOLYMERS. ISOLATION, CHARACTERIZATION AND CHEMICAL MODIFICATIONS OF POLY(Γ-GLUTAMIC ACID) (Γ-PGA) FROM BACILLUS SUBTILIS. [Internet] [Thesis]. Università degli Studi di Milano; 2013. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/219916.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Borghese G. STUDIES ON NATURAL AND EDIBLE BIOPOLYMERS. ISOLATION, CHARACTERIZATION AND CHEMICAL MODIFICATIONS OF POLY(Γ-GLUTAMIC ACID) (Γ-PGA) FROM BACILLUS SUBTILIS. [Thesis]. Università degli Studi di Milano; 2013. Available from: http://hdl.handle.net/2434/219916

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. M.M. Fusari. SYNTHESIS OF FRAGMENTS OF SALMONELLA TYPHI CAPSULAR POLYSACCHARIDE AND THEIR ZWITTERIONIC ANALOGUES.

Degree: 2014, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/243479

► Polysaccharide antigens are T cell-independent antigens, and do not induce immune B cell memory. Consequently, vaccines based on polysaccharides have limited clinical usefulness and induce… (more)

▼ Polysaccharide antigens are T cell-independent antigens, and do not induce immune B cell memory. Consequently, vaccines based on polysaccharides have limited clinical usefulness and induce short-lasting antibody responses in adults. Their immunogenicity can be enhanced by conjugation to an immunogenic carrier protein, generating T cell-dependent glycoconjugate antigens able to induce immunological memory. However, these glycoconjugates suffer from some problems. Recent investigations have found a group of structurally distinct bacterial polysaccharides able to activate T cells in vivo and in vitro. They present a zwitterionic charge motif distributed along the chain and, for this reason, they are called zwitterionic polysaccharides (ZPSs). This zwitterionic charge motif is believed to be responsible for their particular immunological behavior. The integrity of the zwitterionic motif is essential for the biological activity of ZPS. However, it must be clarified if the introduction of the zwitterionic motif into a naturally non-zwitterionic polysaccharide confers to the resulting ZPS the ability to activate T cells without protein conjugation. To this end, zwitterionic oligomers must be obtained by chemical modification of fully synthetic, non-zwitterionic polysaccharide fragments. With these compounds in hand it would be possible to correlate structural and conformational properties of the ZPS with their biological activity, in terms of charge pattern and minimum molecular weight required for immunogenicity. For this purpose the capsular polysaccharide (CPS) of Salmonella typhi was chosen as a suitable model for our investigation. S. typhi is an encapsulated Gram-negative bacterium that causes typhoid fever. Its CPS, commonly named Vi antigen, is an anionic polymer composed of alpha-(1-4)-linked N-acetylgalactosaminuronic acid repeating units predominantly O-acetylated at position 3. Recent studies indicated the importance of the acetylation for the immunogenicity. The structure of the Vi antigen makes it an ideal candidate for our investigation, since its fragments can be easily converted into zwitterionic derivatives by formal N-deacetylation, without introducing huge structural modifications. We designed a flexible synthetic strategy in order to obtain, from common building blocks, two distinct series of oligomers: the ones corresponding to the natural structure and their zwitterionic derivatives. Moreover, the role of 3-O-acetylation will be investigated by the synthesis of both fully 3-O-acetylated and fully 3-non-O-acetylated oligosaccharides. We selected N-phenyltrifluoroacetimidate moieties as the best leaving group in the glycosyl donors. Moreover, all the oligomers were endowed with a suitable linker at the anomeric position of the reducing end in order to facilitate subsequent conjugation to multivalent scaffolds. In the first part of the work the synthesis of oligomers non acetylated at position 3 is described. The glycosyl donor and acceptor were obtained from commercially available D-galactosamine… Advisors/Committee Members: tutor: L. Lay, coordinator: E. Licandro, LAY, LUIGI, LICANDRO, EMANUELA.

Subjects/Keywords: oligosaccharide-based vaccines; glycoconjugate vaccines; zwitterionic polysaccharides; ZPS; Vi antigen; Salmonella typhi; typhoid fever; oligosaccharides; chemical synthesis; alpha-stereoselective glycosylations; disaccharide donors; ELISA competitive assay; Settore CHIM/06 - Chimica Organica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fusari, M. (2014). SYNTHESIS OF FRAGMENTS OF SALMONELLA TYPHI CAPSULAR POLYSACCHARIDE AND THEIR ZWITTERIONIC ANALOGUES. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/243479

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fusari, M.M.. “SYNTHESIS OF FRAGMENTS OF SALMONELLA TYPHI CAPSULAR POLYSACCHARIDE AND THEIR ZWITTERIONIC ANALOGUES.” 2014. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/243479.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fusari, M.M.. “SYNTHESIS OF FRAGMENTS OF SALMONELLA TYPHI CAPSULAR POLYSACCHARIDE AND THEIR ZWITTERIONIC ANALOGUES.” 2014. Web. 15 Jan 2021.

Vancouver:

Fusari M. SYNTHESIS OF FRAGMENTS OF SALMONELLA TYPHI CAPSULAR POLYSACCHARIDE AND THEIR ZWITTERIONIC ANALOGUES. [Internet] [Thesis]. Università degli Studi di Milano; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/243479.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fusari M. SYNTHESIS OF FRAGMENTS OF SALMONELLA TYPHI CAPSULAR POLYSACCHARIDE AND THEIR ZWITTERIONIC ANALOGUES. [Thesis]. Università degli Studi di Milano; 2014. Available from: http://hdl.handle.net/2434/243479

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. I. Guzzetti. INTEGRIN AND CADHERIN LIGANDS: INTERACTION STUDIES BY COMPUTATIONAL METHODS AND BIOAFFINITY NMR ON INTACT CELLS.

Degree: 2014, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/243616

► On a molecular level protein – ligand interactions are central to a number of biological processes, but their investigation is inherently difficult due to several… (more)

▼ On a molecular level protein – ligand interactions are central to a number of biological processes, but their investigation is inherently difficult due to several problems, especially for membrane proteins. The study of this type of interactions poses a whole set of challenges, including the characterization of the dynamic behaviour and of the conformational properties of the ligands in complex with the target macromolecules. A variety of biophysical methods have been developed to study protein – ligand interactions and several NMR spectroscopic techniques have emerged as powerful methods to identify and characterize the binding of ligands with receptor proteins. Ligand-based methods do not require labeled protein, since only the ligand NMR signals are detected and only a small amount of protein is required. These techniques are particularly useful in the medium–low affinity range and, therefore they have been adopted to detect ligand interactions in various systems. Among the ligand-based NMR techniques, Saturation Transfer Difference (STD) and transferred-NOE focus on the NMR signals of the ligand and utilize NOE effects between protein and ligand. They are used for: i) the definition of the bioactive conformation of the ligand in the bound state (tr-NOESY), ii) the identification and characterization of the binding mode of the ligand to the receptor with epitope mapping of the ligand itself (STD). The use of the technique is limited to molecules that exhibit a dissociation constant Kd between 10-3 M and 10-7 M. During my PhD, I had the highly qualifying opportunity to grasp these new potent NMR methods, and to apply them for assessing the interactions of cell surface proteins with peptidomimetics. Since membrane proteins, such as integrins, change their conformation if extracted from their environment, it is clear the importance of working in the biophysical neighbourhood of the membrane itself and not in an isotropic extracellular medium. For this reason, when appropriate to the project, I have carried out NMR experiments using intact cells overexpressing the proteins of interest. Specifically, two main topics have been addressed: 1. The first and second year of my PhD have been mainly focused on the conformational study of peptidomimetic integrin ligands and on the investigation of their interaction with platelets and cancer cell overexpressing integrins on their membrane. This study has been developed within the framework of a PRIN project (MIUR-PRIN project 2010NRREPL “Synthesis and Biomedical Applications of Tumor-Targeting Peptidomimetics”) in collaboration with the research groups of Proff. Gennari and Piarulli (University of Insubria) as regards the synthetic activities and with the group of Dr. Belvisi as regards the computational and design studies. 2. The second part of my PhD was mainly focused on cadherins, a class of cell adhesion proteins that promote homophilic interactions. This work is at an early stage and has been developed within the framework of a FIRB project coordinated by Dr. Civera… Advisors/Committee Members: tutor: D. Potenza, coordinatore: E. Licandro, POTENZA, DONATELLA, LICANDRO, EMANUELA.

Subjects/Keywords: STD-NMR; ligand - protein interactions; tr-NOESY; integrins; cadherins; peptidomimetic ligands; RGD ligands; Settore CHIM/06 - Chimica Organica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Guzzetti, I. (2014). INTEGRIN AND CADHERIN LIGANDS: INTERACTION STUDIES BY COMPUTATIONAL METHODS AND BIOAFFINITY NMR ON INTACT CELLS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/243616

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Guzzetti, I.. “INTEGRIN AND CADHERIN LIGANDS: INTERACTION STUDIES BY COMPUTATIONAL METHODS AND BIOAFFINITY NMR ON INTACT CELLS.” 2014. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/243616.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Guzzetti, I.. “INTEGRIN AND CADHERIN LIGANDS: INTERACTION STUDIES BY COMPUTATIONAL METHODS AND BIOAFFINITY NMR ON INTACT CELLS.” 2014. Web. 15 Jan 2021.

Vancouver:

Guzzetti I. INTEGRIN AND CADHERIN LIGANDS: INTERACTION STUDIES BY COMPUTATIONAL METHODS AND BIOAFFINITY NMR ON INTACT CELLS. [Internet] [Thesis]. Università degli Studi di Milano; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/243616.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Guzzetti I. INTEGRIN AND CADHERIN LIGANDS: INTERACTION STUDIES BY COMPUTATIONAL METHODS AND BIOAFFINITY NMR ON INTACT CELLS. [Thesis]. Università degli Studi di Milano; 2014. Available from: http://hdl.handle.net/2434/243616

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. F. Riboni. PHOTOCATALYTIC REACTIONS FOR ENERGY CONVERSION.

Degree: 2014, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/244319

► General upward trends in fossil fuel consumption and CO2 emissions, along with the accepted belief that global chemistry substantially influences climate, require that scientific research… (more)

▼ General upward trends in fossil fuel consumption and CO2 emissions, along with the accepted belief that global chemistry substantially influences climate, require that scientific research provides efficient remedies and/or alternatives to the present scenario. Photocatalysis is often proposed as one of the most promising technique to achieve these purposes. This PhD thesis is mainly focused on the investigation of TiO2-based systems for the photocatalytic oxidation of formic acid in aqueous suspension, as well as for H2 production by methanol photo steam reforming in the gas phase. Two different approaches were adopted to minimize the drawbacks usually characterizing TiO2 photocatalysts: i) TiO2-WO3 mixed oxide photocatalysts were prepared with the aim of reducing the recombination rate of photopromoted electron/hole pairs. The superior photocatalytic performance of the mixed oxide system was mainly attributed to the positive effect induced by W in efficiently trapping the photopromoted electron from the conduction band of TiO2, ensuring extended charge carriers separation. Even better results were obtained upon the surface modification with Pt nanoparticles which, by virtue of the metal high work function, further enhanced e-/h+ separation. ii) surface modification of TiO2 with Au nanoparticles, possessing a Localized Surface Plasmon Resonance (LSPR) at λ = 530 nm was proved to be an efficient way to promote TiO2 photoactivity under visible light irradiation. By selecting three titania samples (i.e., a stoichiometric, nearly non defective TiO2, a N-doped TiO2 and a oxygen vacancy-rich TiO2), evidence of two different plasmonic photoactivity mechanisms was provided, with the so-called hot electron transfer promoting plasmonic photoactivity in the stoichiometric TiO2 and Plasmon Resonance Energy Transfer accounting for the observed plasmonic visible light photoactivity of doped samples. Being the abatement of CO2 through (photo)electrochemical reduction very challenging (E0(CO2/CO2-* = -2.14 V)), an alternative way has been studied: pyridinyl radicals (1-PyH*), photogenerated by irradiating a pyridine (Py) solution, were found to efficiently react with CO2 yielding a carbamic species (HPy-1-COOH), triggered by a stepwise mechanism where electron transfer from 1-PyH* precedes proton transfer. Formate (HCOO-) was also obtained, demonstrating that photoexcited pyridine does catalyze the 2e—reduction of CO2. Finally, Fenton oxidation of gaseous isoprene on the surface of aqueous Fe2+ droplets, yielding carboxylic acids, polyols and carbonyl compounds, detected in situ through ElectroSpray Ionization Mass Spectrometry, accounted for alternative routes for the conversion of organic gases into secondary organic aerosol, occurring under tropospheric conditions, and may be incorporated into present atmospheric chemistry models. Advisors/Committee Members: tutor: E. Selli, coordinator: E. Licandro, SELLI, ELENA, LICANDRO, EMANUELA.

Subjects/Keywords: Photocatalysis; Localized Surface Plasmon Resonance; H2 production; CO2 photoreduction; Secondary Organic Aerosol; Settore CHIM/02 - Chimica Fisica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Riboni, F. (2014). PHOTOCATALYTIC REACTIONS FOR ENERGY CONVERSION. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/244319

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Riboni, F.. “PHOTOCATALYTIC REACTIONS FOR ENERGY CONVERSION.” 2014. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/244319.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Riboni, F.. “PHOTOCATALYTIC REACTIONS FOR ENERGY CONVERSION.” 2014. Web. 15 Jan 2021.

Vancouver:

Riboni F. PHOTOCATALYTIC REACTIONS FOR ENERGY CONVERSION. [Internet] [Thesis]. Università degli Studi di Milano; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/244319.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Riboni F. PHOTOCATALYTIC REACTIONS FOR ENERGY CONVERSION. [Thesis]. Università degli Studi di Milano; 2014. Available from: http://hdl.handle.net/2434/244319

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. S. Checchia. DISORDER AT THE NANOSCALE IN PEROVSKITE TITANATES AND DOPED CERIA: MULTIPLE APPROACHES TO MODELLING TOTAL SCATTERING DATA.

Degree: 2017, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/489036

► Crystal structures can take a number of forms and their relationship with the physics of a solid lends itself to an even greater number of… (more)

▼ Crystal structures can take a number of forms and their relationship with the physics of a solid lends itself to an even greater number of interpretations. Ferroelectricity, for example, can be predicted to occur in certain symmetries, but sometimes it can be hidden in the response to an electric field, in a peculiar electron- or nuclear-spin resonance, in the unfolding of a phase transition, or else. In any of these cases, the emergence of ferroelectricity is intimately related to subtle changes in the atomic positions with respect to a high-symmetry parent structure. As is the case with many other physical properties, this often implies that the crystal structure is disordered locally (as opposed to on average or long-range), but the magnitude and the time- and length-scales of disorder can vary dramatically between different materials. This work combines multiple X-ray and neutron powder diffraction techniques to try to capture the most of the structural complexity hidden in the bulk of materials. First, reciprocal-space analysis by the Rietveld method allowed drawing the crystallographic phase diagram of a novel perovskite solid solution, praseodymium-doped strontium titanate (SPTO). SPTO is a perovskite that combines a centrosymmetric antiferrodistortive (AFD) structure and a large, diffuse dielectric response at room temperature, prompting the question of whether AFD and ferroelectric (FE) distortions coexist in the material. Subsequently, the Pair Distribution Function (PDF) of SPTO, representing the instantaneous spatial arrangement of the atoms in the material, was analysed using multiple approaches. X-ray PDF was fitted with structural models obtained by evaluating possible polar and rotational distortions of the cubic perovskite phase. The most accurate, a tetragonal structure derived from the long-range phase, showed a huge AFD distortion that could also be consistent with a local FE mode. To get a better insight into the local structure, neutron PDF data were collected and modelled by i) fitting the distorted tetragonal model over successive ranges in real space (`box-car� refinements) and ii) atomistic simulations using the Reverse Monte Carlo (RMC) method. This led to a model in which FE distortion caused by Pr-doping at the perovskite A-site spreads to the AFD framework of octahedra, resulting in distorted coordination of both A and B cations. Neutron PDF data of undoped strontium titanate was also used in the development of another approach to PDF modelling, in which structural models representing a unique soft-mode distortion are evaluated statistically against the experimental neutron PDF. This symmetry-adapted approach evidenced that four soft modes among those suggested by theoretical phonon dispersion are active distortions in SrTiO3, and have signatures in the local structure determined experimentally. This approach is aimed at obtaining an unbiased local structural model of strontium titanate, in that symmetry lowerings are inferred directly from the amplitudes of the individual soft modes… Advisors/Committee Members: supervisor: M. Scavini, coordinator: E. Licandro, SCAVINI, MARCO, LICANDRO, EMANUELA.

Subjects/Keywords: Settore CHIM/02 - Chimica Fisica; Settore CHIM/03 - Chimica Generale e Inorganica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Checchia, S. (2017). DISORDER AT THE NANOSCALE IN PEROVSKITE TITANATES AND DOPED CERIA: MULTIPLE APPROACHES TO MODELLING TOTAL SCATTERING DATA. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/489036

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Checchia, S.. “DISORDER AT THE NANOSCALE IN PEROVSKITE TITANATES AND DOPED CERIA: MULTIPLE APPROACHES TO MODELLING TOTAL SCATTERING DATA.” 2017. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/489036.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Checchia, S.. “DISORDER AT THE NANOSCALE IN PEROVSKITE TITANATES AND DOPED CERIA: MULTIPLE APPROACHES TO MODELLING TOTAL SCATTERING DATA.” 2017. Web. 15 Jan 2021.

Vancouver:

Checchia S. DISORDER AT THE NANOSCALE IN PEROVSKITE TITANATES AND DOPED CERIA: MULTIPLE APPROACHES TO MODELLING TOTAL SCATTERING DATA. [Internet] [Thesis]. Università degli Studi di Milano; 2017. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/489036.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Checchia S. DISORDER AT THE NANOSCALE IN PEROVSKITE TITANATES AND DOPED CERIA: MULTIPLE APPROACHES TO MODELLING TOTAL SCATTERING DATA. [Thesis]. Università degli Studi di Milano; 2017. Available from: http://hdl.handle.net/2434/489036

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. M. Pasquini. FULLY QUANTUM DYNAMICAL STUDIES OF ELEY-RIDEAL H2 RECOMBINATION ON GRAPHITE.

Degree: 2018, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/545870

► The formation of molecular hydrogen in the InterStellar Medium (ISM) is an important topic for astrochemistry and astrophysics: H2 is the most abundant molecular species… (more)

▼ The formation of molecular hydrogen in the InterStellar Medium (ISM) is an important topic for astrochemistry and astrophysics: H2 is the most abundant molecular species in the entire universe, but the mechanism leading to its formation is not completely understood yet. The scientific community now agrees that the reaction occurs on the graphitic surface of the interstellar dust grains, which act as catalysts facilitating the collision between the reactants and dissipating the excess of energy. Moreover, the substrate is crucial in determining the ro-vibrational excitation of the newly formed molecule, whose energy can be exploited in subsequent reactive processes involving H2. In this PhD project, the H2 formation on graphite through the Eley-Rideal mechanism has been investigated with quantum dynamical methods, using specific implementations and models, that overcome the limitations imposed by traditional approaches. In the first part of the project, we addressed the problem of the isotope effect in the Eley-Rideal H2 formation on graphite; in particular, we focused on hydrogen-deuterium substitutions and on the collision energy regime relevant for the chemistry of the ISM. We employed a reduced dimensionality dynamical model, where the surface is considered as rigid and flat, and the calculations were performed using a Time-Dependent WavePacket (TDWP) method. We employed a specific implementation of the TDWP approach, developed within our research group, that allows us to obtain reliable results at collision energies down to 10-4 eV, which would be very challenging with standard methodologies. Our results show a strong isotope effect in the reaction probabilities obtained from simulations of collinear collisions and almost no isotope effect when the full dimensionality of the problem is considered. This suggests that the process is not as direct as previously believed and that the mechanism proceeds through glancing collisions. On the other side, the trapping process is strongly influenced by the involved masses and, in particular, by the mass of the projectile atom. Indeed, when the reactant coming from the gas phase is heavier, more physisorption bound states are available, so that the trapping is favored. We also investigated the ro-vibrational populations of the products, which are found to be vibrationally "hot" and rotationally "cold". In the second part of the project, we investigated the role of the graphitic surface in both reaction dynamics and energy partitioning of the Eley-Rideal H2 formation on graphite within a fully quantum approach. In order to include the coupling to phonons in our quantum dynamical simulations, we resorted to a system-bath model, in which the two hydrogen atoms and the binding carbon are the main reactive system, while the rest of the graphitic lattice is represented as a ensemble of independent harmonic oscillators (HOs), the so-called "bath". Each HO is bilinearly coupled to the main system through the C atom and the bath is characterized so that it reproduces the… Advisors/Committee Members: tutor: R. Martinazzo, M. Bonfanti, coordinatore: E. Licandro, LICANDRO, EMANUELA.

Subjects/Keywords: quantum dynamics; graphite; molecular hydrogen; eley-rideal; Settore CHIM/02 - Chimica Fisica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pasquini, M. (2018). FULLY QUANTUM DYNAMICAL STUDIES OF ELEY-RIDEAL H2 RECOMBINATION ON GRAPHITE. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/545870

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pasquini, M.. “FULLY QUANTUM DYNAMICAL STUDIES OF ELEY-RIDEAL H2 RECOMBINATION ON GRAPHITE.” 2018. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/545870.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pasquini, M.. “FULLY QUANTUM DYNAMICAL STUDIES OF ELEY-RIDEAL H2 RECOMBINATION ON GRAPHITE.” 2018. Web. 15 Jan 2021.

Vancouver:

Pasquini M. FULLY QUANTUM DYNAMICAL STUDIES OF ELEY-RIDEAL H2 RECOMBINATION ON GRAPHITE. [Internet] [Thesis]. Università degli Studi di Milano; 2018. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/545870.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pasquini M. FULLY QUANTUM DYNAMICAL STUDIES OF ELEY-RIDEAL H2 RECOMBINATION ON GRAPHITE. [Thesis]. Università degli Studi di Milano; 2018. Available from: http://hdl.handle.net/2434/545870

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. S. Ordanini. PSEUDO-GLYCODENDRIMERS CONTAINING A MOLECULAR ROD CORE: SYNTHESIS, CHARACTERIZATION AND DC-SIGN ANTAGONISM.

Degree: 2015, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/267153

► Human immunodeficiency virus (HIV) is still a huge health problem, causing the death of over 1 million people per year. The search for HIV-entry inhibitors… (more)

Subjects/Keywords: HIV; DC-SIGN; multivalency; glycomimetic; Settore CHIM/06 - Chimica Organica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ordanini, S. (2015). PSEUDO-GLYCODENDRIMERS CONTAINING A MOLECULAR ROD CORE: SYNTHESIS, CHARACTERIZATION AND DC-SIGN ANTAGONISM. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/267153

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ordanini, S.. “PSEUDO-GLYCODENDRIMERS CONTAINING A MOLECULAR ROD CORE: SYNTHESIS, CHARACTERIZATION AND DC-SIGN ANTAGONISM.” 2015. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/267153.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ordanini, S.. “PSEUDO-GLYCODENDRIMERS CONTAINING A MOLECULAR ROD CORE: SYNTHESIS, CHARACTERIZATION AND DC-SIGN ANTAGONISM.” 2015. Web. 15 Jan 2021.

Vancouver:

Ordanini S. PSEUDO-GLYCODENDRIMERS CONTAINING A MOLECULAR ROD CORE: SYNTHESIS, CHARACTERIZATION AND DC-SIGN ANTAGONISM. [Internet] [Thesis]. Università degli Studi di Milano; 2015. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/267153.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ordanini S. PSEUDO-GLYCODENDRIMERS CONTAINING A MOLECULAR ROD CORE: SYNTHESIS, CHARACTERIZATION AND DC-SIGN ANTAGONISM. [Thesis]. Università degli Studi di Milano; 2015. Available from: http://hdl.handle.net/2434/267153

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. G. Goti. GLYCOMIMETIC ANTAGONISTS OF C-TYPE LECTINS: IMPROVING LIGAND POTENCY AND MULTIVALENT PRESENTATION.

Degree: 2017, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/483585

► Le lectine di tipo C sono recettori calcio dipendenti in grado di riconoscere in modo selettivo e di legarsi a carboidrati esposti da patogeni e… (more)

Subjects/Keywords: C-type lectins; glycomimetics; multivalency; glycoconjugates; glycan microarrays; Settore CHIM/06 - Chimica Organica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Goti, G. (2017). GLYCOMIMETIC ANTAGONISTS OF C-TYPE LECTINS: IMPROVING LIGAND POTENCY AND MULTIVALENT PRESENTATION. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/483585

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Goti, G.. “GLYCOMIMETIC ANTAGONISTS OF C-TYPE LECTINS: IMPROVING LIGAND POTENCY AND MULTIVALENT PRESENTATION.” 2017. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/483585.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Goti, G.. “GLYCOMIMETIC ANTAGONISTS OF C-TYPE LECTINS: IMPROVING LIGAND POTENCY AND MULTIVALENT PRESENTATION.” 2017. Web. 15 Jan 2021.

Vancouver:

Goti G. GLYCOMIMETIC ANTAGONISTS OF C-TYPE LECTINS: IMPROVING LIGAND POTENCY AND MULTIVALENT PRESENTATION. [Internet] [Thesis]. Università degli Studi di Milano; 2017. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/483585.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Goti G. GLYCOMIMETIC ANTAGONISTS OF C-TYPE LECTINS: IMPROVING LIGAND POTENCY AND MULTIVALENT PRESENTATION. [Thesis]. Università degli Studi di Milano; 2017. Available from: http://hdl.handle.net/2434/483585

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. L. Veronese. OPTOELECTRONICALLY ACTIVE DINUCLEAR RHENIUM(I) AND MANGANESE(I) COMPLEXES: FROM DESIGN TO APPLICATIONS.

Degree: 2017, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/481733

► Energy is definitely the most important resource for mankind, and sunlight is without any doubt the ultimate energy source.[1] Unfortunately, solar energy is not useful… (more)

▼ Energy is definitely the most important resource for mankind, and sunlight is without any doubt the ultimate energy source.[1] Unfortunately, solar energy is not useful for mankind unless converted into the final usable forms: heat, electricity, and fuels. Conversion of solar energy into heat is straightforward, but conversion of solar energy into electricity or fuel poses several problems, strongly limiting the conversion efficiency.[2] Since we cannot modify the solar spectrum, we need to find materials capable of exploiting sunlight through the threshold mechanism with the highest possible efficiency. Taking into account the average spectral distribution of solar energy, the most favorable threshold is about 885 nm (1.4 eV), which, in principle, allows 33% of energy conversion efficiency.[3] Summing up, the amount of energy we can actually get from the average solar power striking the surface of the earth depends on our capacity of developing the conversion and storage devices we need with the materials we have on our planet. In the last five years, the photovoltaic systems worldwide have undergone substantial development in terms of manufacturing distribution (largely shifted from Europe to Asia), global deployment, and even new photoactive materials.[4] Over 90% of today commercial solar cells are still based on the very same material and basic concepts developed in the 50’s at the Bell Laboratories: light-induced charge separation at a p–n junction between two wafers of p- and n-doped silicon in either single-crystal or polycrystalline form (sc-Si and poly-Si, respectively). The global share of Si PV has increased from 80% in 2009 to over 90% in 2014, because the main competitors, the so called “2nd generation solar cells”, thin film technologies like cadmium telluride (CdTe), copper-gallium-indium selenide (CIGS), and amorphous silicon (a-Si) have grown at a much lower rate.[4] Indeed, Silicon is the second most abundant and uniformly distributed element on the earth’s crust and there is no risk of shortage in any foreseeable future. By contrast, In, Ga, Se, Te, and Cd exhibit a way smaller crustal abundance and, accordingly, they are collected only as byproducts of minerals containing mostly other elements (Cu, Zn, and Al).[5] The third wave of PV technologies entering the market should be based on DSSC and OPV. Expectations for their market debut have been high for years,[6-8] but so far they have materialized only to a very small extent. At present, the market share of these two technologies is still virtually zero, despite a few flagship demonstration projects, which support technical feasibility.[9-10] Compared to the already established technologies, DSSC and OPV can offer easier building integration, in windows and facades, good performances also in non-standard illumination and temperature conditions, and lower requirements in terms of quantity and quality of raw materials. They can be manufactured at smaller economic and energetic cost and their energy payback times are estimated to be shorter than… Advisors/Committee Members: tutor: M. Panigati,

Subjects/Keywords: Settore CHIM/03 - Chimica Generale e Inorganica; Settore CHIM/02 - Chimica Fisica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Veronese, L. (2017). OPTOELECTRONICALLY ACTIVE DINUCLEAR RHENIUM(I) AND MANGANESE(I) COMPLEXES: FROM DESIGN TO APPLICATIONS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/481733

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Veronese, L.. “OPTOELECTRONICALLY ACTIVE DINUCLEAR RHENIUM(I) AND MANGANESE(I) COMPLEXES: FROM DESIGN TO APPLICATIONS.” 2017. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/481733.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Veronese, L.. “OPTOELECTRONICALLY ACTIVE DINUCLEAR RHENIUM(I) AND MANGANESE(I) COMPLEXES: FROM DESIGN TO APPLICATIONS.” 2017. Web. 15 Jan 2021.

Vancouver:

Veronese L. OPTOELECTRONICALLY ACTIVE DINUCLEAR RHENIUM(I) AND MANGANESE(I) COMPLEXES: FROM DESIGN TO APPLICATIONS. [Internet] [Thesis]. Università degli Studi di Milano; 2017. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/481733.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Veronese L. OPTOELECTRONICALLY ACTIVE DINUCLEAR RHENIUM(I) AND MANGANESE(I) COMPLEXES: FROM DESIGN TO APPLICATIONS. [Thesis]. Università degli Studi di Milano; 2017. Available from: http://hdl.handle.net/2434/481733

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. L. Rimoldi. NANOSTRUCTURED OXIDES AS LEADING ACTORS FOR ENVIRONMENTAL REMEDIATION, SMART SURFACES AND ENERGY APPLICATIONS.

Degree: 2019, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/612084

► In the last decades, metal oxides have been widely employed in the field of nanotechnology, thanks to their physicochemical characteristics. In fact, oxidic compounds can… (more)

▼ In the last decades, metal oxides have been widely employed in the field of nanotechnology, thanks to their physicochemical characteristics. In fact, oxidic compounds can be exploited for manifold applications due to their chemical, thermal and mechanical stability, the low-cost, the low- or non-toxicity. Moreover, the possibility to easily obtain metal oxides as nano or nanostructured powders together with their high reactivity, mainly due to the presence of polar hydroxyl groups populating the surface, have always attracted the scientific community interested in the field connected to catalysis. Among the most adopted metal oxide in materials science, titanium dioxide (TiO2), tungsten oxide (WO3), silicon dioxide (SiO2) and aluminium oxide (Al2O3) can be mentioned. Actually, the properties of the metal oxides strictly depend on their electronic structure. Some of them are semiconductors (e.g. TiO2 and WO3), while others are insulators (e.g. SiO2 and Al2O3), in dependence on the width of the energy gap between the valence and the conduction bands. Semiconductors, thanks to the relatively small band gap with respect to insulators, can be exploited for a wide number of recently developed applications in chemistry, physics and materials science. One of these applications exploited light with suitable wavelength for the promotion of electrons from the valence band to the conduction band, in order to promote reduction or oxidation reactions. This field of the physical chemistry is called photocatalysis and is the main focus of this Thesis. Photocatalysis, especially if titanium dioxide-based, can be useful for promoting a wide range of chemical reactions, e.g. hydrogen and fuels production, CO2 reduction, metal reduction/oxidation. In the last decades, photocatalysis was also proposed as an innovative and effective environmental remediation technique for the oxidative degradation of organic compounds constituting atmospheric or water pollution. In fact, photocatalysis can be able, differently from traditional remediation techniques (e.g. biological treatments, adsorption by activated carbon, …), to completely degrade the pollutants and their oxidation intermediates and by-products to harmless compounds (water, CO2, and, in case, inorganic salts). Nonetheless, photocatalysis suffers from critical issues which, nowadays, still prevent its use on a large utility-scale. Among these, the low quantum yields and, thus, efficiency of the photocatalytic process with respect to the light irradiation adopted to activate the photocatalyst, the need of UV light to activate large band gap semiconductors, such as TiO2, and the high costs for the removal of the photocatalyst from the polluted effluent once the remediation treatment has been performed. This Thesis is divided into three different parts, on the grounds of the materials studied and their final application. In Part I (Chapters 1–7), TiO2-based materials for photocatalysis, variably modified and engineered by adopting different strategies for the promotion of specific… Advisors/Committee Members: tutor: S. Ardizzone, coordinatore: E. Licandro, ARDIZZONE, SILVIA, LICANDRO, EMANUELA.

Subjects/Keywords: Settore CHIM/02 - Chimica Fisica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rimoldi, L. (2019). NANOSTRUCTURED OXIDES AS LEADING ACTORS FOR ENVIRONMENTAL REMEDIATION, SMART SURFACES AND ENERGY APPLICATIONS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/612084

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rimoldi, L.. “NANOSTRUCTURED OXIDES AS LEADING ACTORS FOR ENVIRONMENTAL REMEDIATION, SMART SURFACES AND ENERGY APPLICATIONS.” 2019. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/612084.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rimoldi, L.. “NANOSTRUCTURED OXIDES AS LEADING ACTORS FOR ENVIRONMENTAL REMEDIATION, SMART SURFACES AND ENERGY APPLICATIONS.” 2019. Web. 15 Jan 2021.

Vancouver:

Rimoldi L. NANOSTRUCTURED OXIDES AS LEADING ACTORS FOR ENVIRONMENTAL REMEDIATION, SMART SURFACES AND ENERGY APPLICATIONS. [Internet] [Thesis]. Università degli Studi di Milano; 2019. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/612084.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rimoldi L. NANOSTRUCTURED OXIDES AS LEADING ACTORS FOR ENVIRONMENTAL REMEDIATION, SMART SURFACES AND ENERGY APPLICATIONS. [Thesis]. Università degli Studi di Milano; 2019. Available from: http://hdl.handle.net/2434/612084

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. C. Damiano. HYBRID CATALYSTS FOR CARBENE AND NITRENE TRANSFER REACTIONS.

Degree: 2020, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/703333

► The chemical industry is ever more focused on the development of sustainable and selective procedures for the synthesis of high-added value fine chemicals, in order… (more)

▼ The chemical industry is ever more focused on the development of sustainable and selective procedures for the synthesis of high-added value fine chemicals, in order to meet the demand in society for environment-friendly chemical processes. The metal-catalysed carbene and nitrene transfer reactions have proved to be an excellent strategy to achieve the goal, due to their ability to form C-C, C-N and C heteroatom bonds with high stereo- and regioselectivities. In addition, the good choice of the carbene and nitrene precursors can increase the reaction sustainability and the atom efficiency, as when diazo compounds and azides were used as starting materials thanks to the formation of molecular nitrogen as the only by product of the reaction. Among all the metal catalysed carbene and nitrene transfer reactions, the formation of three-membered ring compounds, such as cyclopropanes and aziridines, is a very attractive topic due to their use as building blocks in organic chemistry and their biological and/or pharmaceutical activity. Considering the catalytic activity of metal porphyrin complexes in promoting cyclopropanation and aziridination reactions of alkenes, the following PhD thesis aims to develop a new class of hybrid catalysts which are able to mediate carbene and nitrene transfer reactions under mild experimental conditions. In order to confer chiral recognition properties and modulate the catalyst properties, the conjugation of metal porphyrin complexes with bio scaffolds such as carbohydrates, amino acids, cellulose and β-lactoglobulins was studied. Carbohydrates are natural chiral, polyhydroxylated compounds which play critical roles in several biological processes, including the energy storage, cellular communications and recognitions, and the immune system maintenance. Glycoporphyrins, derived from the conjugation of porphyrin rings with sugar units, are efficient photosensitizers extensively used in photodynamic therapy (PDT) and they are desirable ligands for organometallic synthesis. To assess how different glycosylated porphyrin ligands can influence the catalytic activity of corresponding ruthenium and iron complexes, different meso glycosyl-conjugated porphyrins were synthesised. The number and position of carbohydrate units on the porphyrin skeleton play an important role in determining the ligand chemo-physical properties. Mono and tetra-glycosylated porphyrins were synthesized and the corresponding iron and ruthenium complexes were tested as catalysts of cyclopropanation and aziridination reactions. In the model cyclopropanation reaction between α-methylstyrene and EDA, Fe(III)(porphyrin)OMe complexes showed higher activity then Ru(II)(porphyrin)CO derivatives and obtained data indicated the strong dependence of the reaction diastereoselectivity on the ligand structure. Among all the iron complexes which were tested as cyclopropanation catalysts, Fe(15)OMe complex was chosen to study the reaction scope by testing different styrenes in view of the good compromise between the synthetic accessibility of… Advisors/Committee Members: tutor: E. Gallo, coordinatore: E. Licandro, GALLO, EMMA, LICANDRO, EMANUELA.

Subjects/Keywords: carbene transfer; nitrene transfer; hybrid catalysts; porphyrins; bio-scaffolds; sugars; aminoacids; cellulose; proteins; cyclopropanes; aziridines; CO2; cyclic carbonates; oxoazolidinones; Settore CHIM/03 - Chimica Generale e Inorganica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Damiano, C. (2020). HYBRID CATALYSTS FOR CARBENE AND NITRENE TRANSFER REACTIONS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/703333

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Damiano, C.. “HYBRID CATALYSTS FOR CARBENE AND NITRENE TRANSFER REACTIONS.” 2020. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/703333.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Damiano, C.. “HYBRID CATALYSTS FOR CARBENE AND NITRENE TRANSFER REACTIONS.” 2020. Web. 15 Jan 2021.

Vancouver:

Damiano C. HYBRID CATALYSTS FOR CARBENE AND NITRENE TRANSFER REACTIONS. [Internet] [Thesis]. Università degli Studi di Milano; 2020. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/703333.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Damiano C. HYBRID CATALYSTS FOR CARBENE AND NITRENE TRANSFER REACTIONS. [Thesis]. Università degli Studi di Milano; 2020. Available from: http://hdl.handle.net/2434/703333

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. G. Soliveri. PATTERNING AND MODULATION OF OXIDE SURFACE PROPERTIES.

Degree: 2015, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/329471

► Most of the topics dealt with in this thesis belong to surface science. The starting point was the fundamental understanding of phenomena at the oxide-gas… (more)

▼ Most of the topics dealt with in this thesis belong to surface science. The starting point was the fundamental understanding of phenomena at the oxide-gas interface and the effect of its modification. Such knowhow was then used to solve (or, at least, to attempt to solve) issues of critical impact in everyday life: the increasing lifetime of building materials employed in low-impact smart houses; the fouling prevention in electroanalytical sensors for neurotransmitter detection; the unspecialized laboratories accessibility to microlithography, critical to device miniaturization. These challenges might seem not related, but they actually share deep scientific and technological foundations. The physicochemical modification of oxide surfaces, the creation of organic/inorganic hybrids and the exploiting / the enhancing of semiconductor peculiar properties allowed us, starting from the foundation, the realization of proof-of-concept protocols and devices, ready for the pre-commercial development. The Leitmotif of my research was the synthesis and the modification of titanium dioxide surfaces. TiO2 has been the main character in physico, physicochemical and material science researches of the last 50 years. Biocompatibility and low cost make it engaging for many applications. Its (near-UV active) semiconductor features, well known and abundantly investigated by the scientific community, are acquiring central interest also in many markets with the development of self cleaning coatings, windows and asphalts, anti-fogging mirrors and self-sterilizing surgery rooms and instrumentations. New generation batteries and solar cells are going to be developed as commercial prototypes. One of the biggest challenges in the titania fundamental research is the enhancement of activity in the solar spectrum. First, the most recent aspects in titania doping and promotion were touched. While, in the last twenty years, great effort has been made in the mono-atomic doping of titania and in the understanding of the influence of the dopant position in the titania lattice and its electronic behavior, the most recent literature describes the co-promotion of the material by two (or more) atoms doping. The metal/non-metal codoping seems especially promising; the synergetic effect of the two atoms in the TiO2 lattice was both theoretically and experimentally proved. In this contest, the N/Nb codoping was analyzed, investigating the effect of the atoms in the lattice from morphological (surface area, porosity and crystallographic structure) and electronic point of view (EXAFS, UV-Vis absorption and EPR analyses). N/Nb codoping was compared with N/Ta co-doped samples, synthesized by two different procedures. The photoactivity of the two sample families was tested by a model reaction (the degradation of ethanol, throughout acetaldehyde intermediate) both under UV and solar simulated irradiation. Then, a different approach in the modification of surfaces was tested. The assembly of organic/inorganic hybrids was tested; thanks to the formation of… Advisors/Committee Members: tutor: S. Ardizzone, co-tutor: R. Annunziata, coordinator: E. Licandro, ARDIZZONE, SILVIA, LICANDRO, EMANUELA.

Subjects/Keywords: silicon dioxide; titanium dioxide; photocatalytic lithography; patterned polymer brushes; self-assembled monolayer; dopamine detection; self-cleaning cyclo voltammetric sensors; codoping; superhydrophobic coatings; hydrophobic siloxanes; electrochemically assisted deposition; thin TiO2 films; Ag nanoparticles films; Settore CHIM/02 - Chimica Fisica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Soliveri, G. (2015). PATTERNING AND MODULATION OF OXIDE SURFACE PROPERTIES. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/329471

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Soliveri, G.. “PATTERNING AND MODULATION OF OXIDE SURFACE PROPERTIES.” 2015. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/329471.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Soliveri, G.. “PATTERNING AND MODULATION OF OXIDE SURFACE PROPERTIES.” 2015. Web. 15 Jan 2021.

Vancouver:

Soliveri G. PATTERNING AND MODULATION OF OXIDE SURFACE PROPERTIES. [Internet] [Thesis]. Università degli Studi di Milano; 2015. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/329471.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Soliveri G. PATTERNING AND MODULATION OF OXIDE SURFACE PROPERTIES. [Thesis]. Università degli Studi di Milano; 2015. Available from: http://hdl.handle.net/2434/329471

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. M. Orlandi. DESIGN OF NEW CHIRAL BRØNSTED ACID CATALYSTS AND RATIONALIZATION OF H-BOND MEDIATED REACTIONS.

Degree: 2015, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/330245

► The present thesis work is mainly focused on the study of the influence of the Brønsted acid-base interaction on different chemical systems. In the first… (more)

▼ The present thesis work is mainly focused on the study of the influence of the Brønsted acid-base interaction on different chemical systems. In the first chapter an overview of chiral Brønsted catalysis is provided. Due to the recent publication of exhaustive reviews,1-3 this introductory chapter assumes a conceptual role, avoiding the listing of the numerous published papers on the topic. Indeed, after an overview on the synthesis of the most common acidic catalysts, only the most significant examples of their application are reported, which represent the most known modes of activation involved in this kind of catalysis. In particular, few examples of mono, dual and bifunctional activation of imines by chiral phosphoric acids are presented. The reasons for the development of other acidic functional groups are then illustrated, and an overview on the activation of other electrophiles is reported. As last part of this first chapter, the few published chemico-physical works on the topic are summarized, introducing the reader to the state of the art about: (i) the establishment of pKa scales of acidic catalysts in organic solvents; (ii) the study of the acid-base interaction through NMR techniques; (iii) the study of the nature of the interactions responsible for the stereoselectivity in chiral Brønsted acid catalysis. In chapter 2, several chemico-physical studies performed in our laboratories are presented. The exploration of the use of the NMR as an easily available and suitable tool for the assessment of pKa scales of Brønsted acids is presented. Low temperature NMR studies on acid-base pairs are then reported, which allowed to provide new insight in the understanding of the mechanism involved in the Brønsted acid activation of imines (typical substrates for chiral Brønsted acid catalysis). In the second part of chapter 2, investigations about the Brønsted catalysis law via kinetic experiments are reported. Specifically, the importance of the influence of steric effects on the catalytic activity of Brønsted acids is proved by taking into account the Friedel-Craft alkylation of N-tosylimines, a classical reaction where we have found a counterintuitive violation of the Brønsted catalysis law. Chapter 3 is centered on the synthesis of new chiral phosphoric acids. Since the development of chiral Brønsted acid catalysis, the most existing catalysts rely on the BINOL or SPINOL scaffolds. Despite their huge use and high efficiency, these catalysts are expensive and, sometimes, difficult to synthesize. On the basis of a geometry analysis, new compounds supposed to be similarly hindered to BINOL and SPINOL catalysts have been designed, and seven derivatives of a new (R,R)-diaminocyclohexane-based class of compounds have been synthesized. The obtained catalysts have been tested in two typical reactions providing promising results. On the basis of the reaction outcome, a structural analysis of the tested compounds was performed. In chapters 4 and 5 two projects that lie outside the field of Brønsted acid catalysis are… Advisors/Committee Members: tutor: F. Cozzi, cotutor: M. Ceotto, coordinatrice: E. Licandro, COZZI, FRANCO, LICANDRO, EMANUELA.

Subjects/Keywords: Organocatalysis; Bronsted acids; trichlorosilane; computational studies; proline catalyzed aldol reaction; nitro groups reduction; Settore CHIM/06 - Chimica Organica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Orlandi, M. (2015). DESIGN OF NEW CHIRAL BRØNSTED ACID CATALYSTS AND RATIONALIZATION OF H-BOND MEDIATED REACTIONS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/330245

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Orlandi, M.. “DESIGN OF NEW CHIRAL BRØNSTED ACID CATALYSTS AND RATIONALIZATION OF H-BOND MEDIATED REACTIONS.” 2015. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/330245.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Orlandi, M.. “DESIGN OF NEW CHIRAL BRØNSTED ACID CATALYSTS AND RATIONALIZATION OF H-BOND MEDIATED REACTIONS.” 2015. Web. 15 Jan 2021.

Vancouver:

Orlandi M. DESIGN OF NEW CHIRAL BRØNSTED ACID CATALYSTS AND RATIONALIZATION OF H-BOND MEDIATED REACTIONS. [Internet] [Thesis]. Università degli Studi di Milano; 2015. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/330245.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Orlandi M. DESIGN OF NEW CHIRAL BRØNSTED ACID CATALYSTS AND RATIONALIZATION OF H-BOND MEDIATED REACTIONS. [Thesis]. Università degli Studi di Milano; 2015. Available from: http://hdl.handle.net/2434/330245

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. S. Marzorati. PT-FREE NANO- AND MICRO-STRUCTURED CARBONS FOR ELECTROCHEMICAL OXYGEN REDUCTION REACTION.

Degree: 2015, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/332529

► Oxygen reduction reaction (ORR) catalysts are of crucial importance in developing low- and medium-temperature fuel cells, as PEMFCs (Polymer Electrolyte Membrane Fuel Cells), from which… (more)

▼ Oxygen reduction reaction (ORR) catalysts are of crucial importance in developing low- and medium-temperature fuel cells, as PEMFCs (Polymer Electrolyte Membrane Fuel Cells), from which sizeable energy saving and reduction of greenhouse gas emission are expected in comparison with the use of coal and oil based fuels in thermal engines. The same electrochemical oxygen reduction reaction takes place in oxygen depolarized cathodes (ODC) in chlor-alkali electrolysis, replacing the conventional hydrogen evolving cathode, gaining about 30% energy consumption reduction in the overall process. At present carbon-supported Pt and Pt-rich alloys are best credited to the ORR purpose. However, Pt-based catalysts are not free from certain drawbacks, such as oxide formation and Pt particle coarsening through Ostwald ripening, that decrease the overall cell energy conversion efficiency. Furthermore, attendant problems concerning natural availability, geographic distribution and cost of platinum, render platinum supply strategic and fuel cells hardly scalable to mass production. At present, projections on platinum usage for PEMFCs are estimated at ~15 ton y-1 in addition to the current ones, at a cost of ~40 $ g-1. Therefore, non-precious metal catalysts are actively searched for, such as to meet already established operational benchmarks for conventional platinum PEMFC vehicular requirements (0.5 W cm-2; 5500 h durability) with the additional target of significant cost reduction. Several papers on non-precious ORR catalysts have been published after a first report by Jasinski in 1964 demonstrating the ORR activity of metal substitutes-phthalocyanines. Then, research on metal-nitrogen macrocycles significantly expanded, leading to the picture that ORR catalytic activity can be related to N4-Me and N2-Me moieties. However, for precursors cost and unsatisfactory lifetime performance, research was steered toward more simple nitrogen-containing reactants and preparation procedures. Significant steps in this direction were obtained by Dodelet et al. who demonstrated that ORR overpotentials almost linearly decrease with increasing nitrogen content in carbon. Positive results were obtained on a series of samples prepared by high temperature treatment of carbon precursors in NH3/H2/N2 mixtures; doping of these modified carbons with iron rather than cobalt salts was shown to be preferable for better efficiency in oxygen reduction, even though still lower than that of platinum. Further improvements both in terms of incipient ORR potentials and currents were obtained by Maruyama et al. using carbons from hemoglobin and adenine-glucose pyrolysis in the presence of added Fe(II) and Cu(II)/Fe(II) mixtures, respectively. The ORR promoting role of nitrogen in carbon was independently demonstrated both theoretically and experimentally. Indeed, it was found that substitutional nitrogen at a few, specific, peripheral positions of graphene layers in well-ordered carbon nanostructures is in itself able to promote ORR activity even in the absence of… Advisors/Committee Members: tutor: M. Longhi, co-tutor: L. Formaro, coordinator: E. Licandro, LONGHI, MARIANGELA, LICANDRO, EMANUELA.

Subjects/Keywords: Oxygen Reduction Reaction; Pt-free catalysts; Mesoporous Carbons; Nanostructures; N-doping; Carbon Nanotubes; Carbon Nanocubes; Carbon Microspheres; RDE and RRDE; Ultraspray Pyrolysis Method; Charge Transfer; Settore CHIM/02 - Chimica Fisica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Marzorati, S. (2015). PT-FREE NANO- AND MICRO-STRUCTURED CARBONS FOR ELECTROCHEMICAL OXYGEN REDUCTION REACTION. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/332529

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Marzorati, S.. “PT-FREE NANO- AND MICRO-STRUCTURED CARBONS FOR ELECTROCHEMICAL OXYGEN REDUCTION REACTION.” 2015. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/332529.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Marzorati, S.. “PT-FREE NANO- AND MICRO-STRUCTURED CARBONS FOR ELECTROCHEMICAL OXYGEN REDUCTION REACTION.” 2015. Web. 15 Jan 2021.

Vancouver:

Marzorati S. PT-FREE NANO- AND MICRO-STRUCTURED CARBONS FOR ELECTROCHEMICAL OXYGEN REDUCTION REACTION. [Internet] [Thesis]. Università degli Studi di Milano; 2015. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/332529.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Marzorati S. PT-FREE NANO- AND MICRO-STRUCTURED CARBONS FOR ELECTROCHEMICAL OXYGEN REDUCTION REACTION. [Thesis]. Università degli Studi di Milano; 2015. Available from: http://hdl.handle.net/2434/332529

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. M. Casartelli. POINT DEFECTS AND ADATOMS AT SURFACES:CHALLENGES AND OPPORTUNITIES.

Degree: 2014, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/229252

► In many occasions defects have been proved to be an opportunity more than a limit, as they may be used to tailor the properties of… (more)

▼ In many occasions defects have been proved to be an opportunity more than a limit, as they may be used to tailor the properties of a given material. To this end, a practical route to introduce a controlled amount of defects as well as a deep knowledge of the defect nature is always desirable. As well, recombinative and dissociative processes involving gas molecules are well known to likely occur on metal surfaces, that may then be used in a number of industrial applications. In this thesis I report on both the isolated carbon atom vacancy, that is a common lattice defect in graphene, and the Eley-Rideal formation of H2 molecules in the limit of an single adsorbed atom on the Ag(111) surface. In the first part of this thesis I consider the details of the electronic structure in the neighbourhoods of a carbon atom vacancy in graphene by employing magnetisation-constrained density-functional theory on periodic slabs, and spin-exact, multi-reference, second-order perturbation theory on a finite cluster. The picture that emerges is that of two local magnetic moments (one sigma-like and one pi-like) decoupled from the pi-band and coupled to each other. The ground state is identified as a triplet with a planar equilibrium geometry resulting upon a Jahn-Teller distortion, in which an apical C atom opposes a pentagonal ring. This state lies 0.2 eV lower in energy than the open-shell singlet with one spin flipped, which is a bistable system with two equivalent equilibrium lattice configurations (for the apical C atom above or below the lattice plane) and a barrier 0.1 eV high separating them. Accordingly, a bare carbon-atom vacancy is predicted to be a spin-one paramagnetic species, but spin-half paramagnetism can be accommodated if binding to foreign species, ripples, coupling to a substrate, or doping are taken into account. In the second part, I study by DFT means the process of hydrogenation of the carbon vacancy, starting from the bare defect atom up to the case of six hydrogen atoms chemisorbed onto its nearest neighbours. I initially consider the formation of a mono-hydrogenated vacancy, finding a binding energy of 4.2 eV and no activation barrier to the adsorption. As well, I study a variety of possible mutual arrangements of the adsorbates at higher coverages discussing their reactivity and local magnetic moments. In this way the overall hydrogenation process turns out to be thermodynamically favoured and exothermic with respect to both atomic and molecular hydrogen gas sources at least up to four H atoms. This follows from the fact that the driving force in this process is the saturation of the (3sigma + 1pi) unpaired electrons at the vacancy. Moreover, these DFT energies are used to build a phase diagram in a broad range of temperatures and H2 partial pressures, thus finding that at room T and p conditions, the magnetic (M = 1muB) 3H-anti structure is the most stable in agreement with recent magnetic measurements. In addition, by considering the stable phase at TEM conditions, it seems reasonable… Advisors/Committee Members: tutor: R. Martinazzo, co-tutor: G. F. Tantardini, coordinatore: E. Licandro, MARTINAZZO, ROCCO, LICANDRO, EMANUELA.

Subjects/Keywords: graphene; vacancy; spin coupling; hydrogenated vacancy; Eley-Rideal; Ag(111); Settore CHIM/02 - Chimica Fisica

10 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Casartelli, M. (2014). POINT DEFECTS AND ADATOMS AT SURFACES:CHALLENGES AND OPPORTUNITIES. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/229252

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Casartelli, M.. “POINT DEFECTS AND ADATOMS AT SURFACES:CHALLENGES AND OPPORTUNITIES.” 2014. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/229252.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Casartelli, M.. “POINT DEFECTS AND ADATOMS AT SURFACES:CHALLENGES AND OPPORTUNITIES.” 2014. Web. 15 Jan 2021.

Vancouver:

Casartelli M. POINT DEFECTS AND ADATOMS AT SURFACES:CHALLENGES AND OPPORTUNITIES. [Internet] [Thesis]. Università degli Studi di Milano; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/229252.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Casartelli M. POINT DEFECTS AND ADATOMS AT SURFACES:CHALLENGES AND OPPORTUNITIES. [Thesis]. Università degli Studi di Milano; 2014. Available from: http://hdl.handle.net/2434/229252

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. F. Airaghi. SYNTHESIS, STRUCTURAL INVESTIGATION AND BIOLOGICAL EVALUATION OF CONFORMATIONALLY CONSTRAINED PEPTIDOMIMETICS.

Degree: 2013, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/214952

► This Ph.D. thesis is located in the medicinal chemistry research field. Peptides are among the most studied entities as potential drug candidates, due to their… (more)

Subjects/Keywords: opioid receptors; endomorphin-2; peptidomimetics; prolyl oligopeptidase; conformational analysis; Settore CHIM/06 - Chimica Organica; Settore CHIM/08 - Chimica Farmaceutica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Airaghi, F. (2013). SYNTHESIS, STRUCTURAL INVESTIGATION AND BIOLOGICAL EVALUATION OF CONFORMATIONALLY CONSTRAINED PEPTIDOMIMETICS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/214952

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Airaghi, F.. “SYNTHESIS, STRUCTURAL INVESTIGATION AND BIOLOGICAL EVALUATION OF CONFORMATIONALLY CONSTRAINED PEPTIDOMIMETICS.” 2013. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/214952.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Airaghi, F.. “SYNTHESIS, STRUCTURAL INVESTIGATION AND BIOLOGICAL EVALUATION OF CONFORMATIONALLY CONSTRAINED PEPTIDOMIMETICS.” 2013. Web. 15 Jan 2021.

Vancouver:

Airaghi F. SYNTHESIS, STRUCTURAL INVESTIGATION AND BIOLOGICAL EVALUATION OF CONFORMATIONALLY CONSTRAINED PEPTIDOMIMETICS. [Internet] [Thesis]. Università degli Studi di Milano; 2013. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/214952.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Airaghi F. SYNTHESIS, STRUCTURAL INVESTIGATION AND BIOLOGICAL EVALUATION OF CONFORMATIONALLY CONSTRAINED PEPTIDOMIMETICS. [Thesis]. Università degli Studi di Milano; 2013. Available from: http://hdl.handle.net/2434/214952

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. F. Ferretti. HOMOGENEOUS CATALYTIC REDUCTIVE CARBONYLATION OF ORGANIC NITRO COMPOUNDS: BIDENTATE NITROGEN LIGANDS AS A KEY POINT.

Degree: 2013, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/214936

► The reductive carbonylation of nitro compounds is a process with a high potential synthetic and industrial interest, since many products can be obtained from nitro… (more)

Subjects/Keywords: homogeneous catalysis; reductive carbonylation; indoles; carbamates; palladium catalyst; nitrogen ligands; phenanthroline; Settore CHIM/03 - Chimica Generale e Inorganica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ferretti, F. (2013). HOMOGENEOUS CATALYTIC REDUCTIVE CARBONYLATION OF ORGANIC NITRO COMPOUNDS: BIDENTATE NITROGEN LIGANDS AS A KEY POINT. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/214936

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ferretti, F.. “HOMOGENEOUS CATALYTIC REDUCTIVE CARBONYLATION OF ORGANIC NITRO COMPOUNDS: BIDENTATE NITROGEN LIGANDS AS A KEY POINT.” 2013. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/214936.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ferretti, F.. “HOMOGENEOUS CATALYTIC REDUCTIVE CARBONYLATION OF ORGANIC NITRO COMPOUNDS: BIDENTATE NITROGEN LIGANDS AS A KEY POINT.” 2013. Web. 15 Jan 2021.

Vancouver:

Ferretti F. HOMOGENEOUS CATALYTIC REDUCTIVE CARBONYLATION OF ORGANIC NITRO COMPOUNDS: BIDENTATE NITROGEN LIGANDS AS A KEY POINT. [Internet] [Thesis]. Università degli Studi di Milano; 2013. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/214936.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ferretti F. HOMOGENEOUS CATALYTIC REDUCTIVE CARBONYLATION OF ORGANIC NITRO COMPOUNDS: BIDENTATE NITROGEN LIGANDS AS A KEY POINT. [Thesis]. Università degli Studi di Milano; 2013. Available from: http://hdl.handle.net/2434/214936

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. C. Carrara. SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES (SPIONS): DESIGN AND SYNTHESIS OF NEW NANOCONJUGATES.

Degree: 2013, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/214973

► Superparamagnetic Iron Oxide Nanoparticles (SPIONs) have demonstrated great promise for diagnostic and therapeutic applications. Thanks to their magnetic properties and to their size, comparable to… (more)

Subjects/Keywords: SPIONs; iron oxide nanoparticles; linker; isocyanate; carbamate bond; PNA; melting temperature; bionanoconjugates; Settore CHIM/06 - Chimica Organica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carrara, C. (2013). SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES (SPIONS): DESIGN AND SYNTHESIS OF NEW NANOCONJUGATES. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/214973

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carrara, C.. “SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES (SPIONS): DESIGN AND SYNTHESIS OF NEW NANOCONJUGATES.” 2013. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/214973.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carrara, C.. “SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES (SPIONS): DESIGN AND SYNTHESIS OF NEW NANOCONJUGATES.” 2013. Web. 15 Jan 2021.

Vancouver:

Carrara C. SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES (SPIONS): DESIGN AND SYNTHESIS OF NEW NANOCONJUGATES. [Internet] [Thesis]. Università degli Studi di Milano; 2013. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/214973.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carrara C. SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES (SPIONS): DESIGN AND SYNTHESIS OF NEW NANOCONJUGATES. [Thesis]. Università degli Studi di Milano; 2013. Available from: http://hdl.handle.net/2434/214973

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. R. Colombo. SYNTHESIS AND BIOLOGICAL EVALUATION OF POTENT INTEGRIN LIGANDS CONTAINING A DIKETOPIPERAZINE SCAFFOLD, AND OF THEIR CONJUGATES WITH CYTOTOXIC AGENTS.

Degree: 2013, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/214953

► A library of eight bifunctional 2,5-diketopiperazine (DKP) scaffolds, which are formally derived from 2,3-diaminopropionic acid and aspartic acid (DKP1 - DKP7) or glutamic acid (DKP8)… (more)

▼ A library of eight bifunctional 2,5-diketopiperazine (DKP) scaffolds, which are formally derived from 2,3-diaminopropionic acid and aspartic acid (DKP1 - DKP7) or glutamic acid (DKP8) was designed and synthesized. The scaffolds differ for the configuration at the two stereocenters and the substitution at the diketopiperazinic nitrogens. The bifunctional diketopiperazines were introduced into eight cyclic peptidomimetics containing the Arg-Gly-Asp (RGD) sequence. The resulting RGD-peptidomimetics were screened for their ability to inhibit biotinylated vitronectin binding to the purified integrins alphaVbeta3 and alphaVbeta5, which are involved in tumor angiogenesis. Nanomolar values were obtained for the RGD-peptidomimetics derived from trans DKP scaffolds (DKP2 - DKP8). Conformational studies of the cyclic RGD-peptidomimetics by 1H-NMR experiments (VT-NMR and NOESY) in aqueous solution and Monte Carlo – Stochastic Dynamics (MC-SD) simulations revealed that the highest affinity ligands display well-defined preferred conformations featuring intramolecular hydrogen-bonded turn motifs and an extended arrangement of the RGD sequence [Cbeta(Arg)-Cbeta(Asp) average distance ≥ 8.8 A]. Docking studies were performed, starting from the representative conformations obtained from the MC/SD simulations and taking as a reference model the crystal structure of the extracellular segment of integrin alphaVbeta3 complexed with the cyclic pentapeptide Cilengitide. The highest affinity ligands produced top-ranked poses conserving all the important interactions of the X-ray complex. Since alphaV integrins, which can be internalized by cells, are involved in tumor angiogenesis and are overexpressed on the surface of cancer cells, integrin ligands can be usefully employed as tumor homing peptidomimetics for site-directed delivery of cytotoxic drugs. A small library of integrin ligand - Paclitaxel conjugates 90-93 was synthesized with the aim of using the tumor-homing cyclo[DKP-RGD] peptidomimetics for site-directed delivery of the cytotoxic drug. All the Paclitaxel-RGD constructs 90-93 inhibited biotinylated vitronectin binding to the purified alphaVbeta3 integrin receptor at low nanomolar concentration and showed in vitro cytotoxic activity against a panel of human tumor cell lines similar to that of Paclitaxel. Among the cell lines, the cisplatin-resistant IGROV-1/Pt1 cells expressed high levels of integrin alphaVbeta3, making them attractive to be tested in in vivo models. Cyclo[DKP-f3-RGD]-PTX 91 displayed sufficient stability in physiological solution and in both human and murine plasma to be a good candidate for in vivo testing. In tumor-targeting experiments against the IGROV-1/Pt1 human ovarian carcinoma xenotransplanted in nude mice, compound 91 exhibited a superior activity than Paclitaxel, despite the lower (ca. half) molar dosage used. Advisors/Committee Members: tutor: C. Gennari, co-tutor: U. Piarulli, coordinator: E. Licandro, GENNARI, CESARE MARIO ARTURO, LICANDRO, EMANUELA.

Subjects/Keywords: angiogenesis; integrins; RGD; diketopiperazines; peptidomimetics; paclitaxel; tumor homing; targeted drug; paclitaxel conjugates; RGD conjugates; Settore CHIM/06 - Chimica Organica; Settore CHIM/08 - Chimica Farmaceutica; Settore BIO/14 - Farmacologia

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Colombo, R. (2013). SYNTHESIS AND BIOLOGICAL EVALUATION OF POTENT INTEGRIN LIGANDS CONTAINING A DIKETOPIPERAZINE SCAFFOLD, AND OF THEIR CONJUGATES WITH CYTOTOXIC AGENTS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/214953

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Colombo, R.. “SYNTHESIS AND BIOLOGICAL EVALUATION OF POTENT INTEGRIN LIGANDS CONTAINING A DIKETOPIPERAZINE SCAFFOLD, AND OF THEIR CONJUGATES WITH CYTOTOXIC AGENTS.” 2013. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/214953.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Colombo, R.. “SYNTHESIS AND BIOLOGICAL EVALUATION OF POTENT INTEGRIN LIGANDS CONTAINING A DIKETOPIPERAZINE SCAFFOLD, AND OF THEIR CONJUGATES WITH CYTOTOXIC AGENTS.” 2013. Web. 15 Jan 2021.

Vancouver:

Colombo R. SYNTHESIS AND BIOLOGICAL EVALUATION OF POTENT INTEGRIN LIGANDS CONTAINING A DIKETOPIPERAZINE SCAFFOLD, AND OF THEIR CONJUGATES WITH CYTOTOXIC AGENTS. [Internet] [Thesis]. Università degli Studi di Milano; 2013. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/214953.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Colombo R. SYNTHESIS AND BIOLOGICAL EVALUATION OF POTENT INTEGRIN LIGANDS CONTAINING A DIKETOPIPERAZINE SCAFFOLD, AND OF THEIR CONJUGATES WITH CYTOTOXIC AGENTS. [Thesis]. Università degli Studi di Milano; 2013. Available from: http://hdl.handle.net/2434/214953

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. A. Alekseeva. COMBINED NMR/LC-MS APPROACH FOR STRUCTURAL CHARACTERIZATION OF HEPARINS AND NON-ANTICOAGULANT GLYCOL-SPLIT HEPARINS.

Degree: 2014, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/243373

► Heparin is a sulfated polysaccharide extracted from animal organs, which is successfully used since more than fifty years in clinics as anticoagulant and antithrombotic drug.… (more)

▼ Heparin is a sulfated polysaccharide extracted from animal organs, which is successfully used since more than fifty years in clinics as anticoagulant and antithrombotic drug. There is also a growing interest in investigating and exploiting “new” activities of heparin, especially for cancer therapy. Nowadays, a number of non-anticoagulant glycol-split (gs) heparins, obtained by periodate oxidation/borohydride reduction are being considered as potential anticancer due to a potent inhibitory effect on heparanase, overexpressed by tumors. Additionally, the majority of their biological properties are preserved upon glycol-splitting. It is also worth noting that glycol-splitting of glucuronic acid within antithrombin binding region (ATBR) causes a drastic decrease of heparin anticoagulant activity, helping avoiding undesirable effects when being used for clinical therapy. Gs-derivatives of low molecular weight heparins (LMWHs) are of higher interest due to their better bioavailability. In spite of the numerous studies on their biological activity, detailed structural analysis of gs heparins as well as structure–activity relationship have not been reported yet. Their structural characterization remains a very challenging task, firstly, due to the high microheterogeneity of the starting heparin (significantly depending on tissue and animal sources), and to the various side reactions that can occur under sometimes uncontrolled reaction conditions. In the case of more bioavailable and, consequently, more pharmacologically attractive, low molecular weight heparins (LMWHs) used as starting material, the end groups introduced by the depolymerisation processes induce additional heterogeneity of the corresponding gs-derivatives. Evidently, an appropriate analytical approach is required for a pharmaceutical development of these potential drugs. The present study is focused on the development and application of an efficient analytical approach combining advanced techniques, such as NMR and LC-MS methods, for structural characterization of various gs-heparins and gs-LMWHs. The structural information obtained for gs-samples was expected to provide structural details about the sequences of the parent heparin/LMWH material. The long-term aim of this project includes the exploration of structural basis of heparin-related gs-oligosaccharide sequences for their optimal binding motif with heparanase and other target proteins. In Chapter I the state-of-art of the present topic is overviewed. Structural features, biosynthesis and interaction with proteins of heparin and HS as well as structure and bioactivity of LMWHs are discussed. The potential anticancer and anti-inflammation activity of gs-heparins/gs-LMWHs and the main problems in their preparation and structural analysis are also highlighted. In the last part of the Chapter I the main analytical techniques used for analysis of heparin-related samples (NMR, LC-MS, SEC-TDA) are reviewed. The overall goal of the study and the short-term objectives are described in Chapter II. … Advisors/Committee Members: tutor: L. Lay, co-tutor: A. Naggi, coordinator: E. Licandro, LAY, LUIGI, LICANDRO, EMANUELA.

Subjects/Keywords: Glycol-split heparins; non-anticoagulant; ion pair reversed phase liquid chromatography; mass spectrometry; NMR; heparanase; Settore CHIM/06 - Chimica Organica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alekseeva, A. (2014). COMBINED NMR/LC-MS APPROACH FOR STRUCTURAL CHARACTERIZATION OF HEPARINS AND NON-ANTICOAGULANT GLYCOL-SPLIT HEPARINS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/243373

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alekseeva, A.. “COMBINED NMR/LC-MS APPROACH FOR STRUCTURAL CHARACTERIZATION OF HEPARINS AND NON-ANTICOAGULANT GLYCOL-SPLIT HEPARINS.” 2014. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/243373.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alekseeva, A.. “COMBINED NMR/LC-MS APPROACH FOR STRUCTURAL CHARACTERIZATION OF HEPARINS AND NON-ANTICOAGULANT GLYCOL-SPLIT HEPARINS.” 2014. Web. 15 Jan 2021.

Vancouver:

Alekseeva A. COMBINED NMR/LC-MS APPROACH FOR STRUCTURAL CHARACTERIZATION OF HEPARINS AND NON-ANTICOAGULANT GLYCOL-SPLIT HEPARINS. [Internet] [Thesis]. Università degli Studi di Milano; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/243373.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alekseeva A. COMBINED NMR/LC-MS APPROACH FOR STRUCTURAL CHARACTERIZATION OF HEPARINS AND NON-ANTICOAGULANT GLYCOL-SPLIT HEPARINS. [Thesis]. Università degli Studi di Milano; 2014. Available from: http://hdl.handle.net/2434/243373

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. S. Arnaboldi. CHIRAL ELECTROCHEMISTRY IN IONIC LIQUIDS.

Degree: 2014, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/244316

► This thesis has been initially conceived as a study of molecular electrochemistry and electrocatalysis in ionic liquids, emerging media for safe and environmentally friendly chemical… (more)

▼ This thesis has been initially conceived as a study of molecular electrochemistry and electrocatalysis in ionic liquids, emerging media for safe and environmentally friendly chemical and electrochemical processes, particularly focusing on the combined effects of the ionic liquid molecular structure and the nature of the electrode surface, and considering two model processes: • the electroreductive cleavage of the carbon-halogen bond in organic halides, of high interest in the synthetic, analytical and environmental fields; • the electrooxidative coupling of thiophene-based monomers, resulting in electrodeposition of conducting films for applications in photovoltaic, optoelectronic and sensor devices. Both processes are thus of great applicative interest and, at the same time, two convenient model cases for electron transfer studies in ionic liquids, one reductive (via radical anion) and one oxidative (via radical cation), on which the cation and the anion of the ionic liquid should be more determining, respectively. However, the 3-year research results actually went well beyond these initial targets, with the discovery of the outstanding properties of inherently chiral electroactive thiophene-based oligomers, on which we then concentrated most of our efforts. In particular: • electrooligomerization in ionic liquids of "inherently chiral" thiophene-based monomers developed by Professor Sannicolò's partner group afforded the preparation of enantiopure chiral electrodes of new concept and unprecedented enantiodiscrimination ability, resulting for the first time in a neat separation of voltammetry peaks for the enantiomers of a series of different chiral probes, also of pharmaceutical interest, in different media and operating conditions; • such inherently chiral electroactive oligomers turned out to be mostly cyclic, idealizing chiral conducting polymers without ends, and displaying a pool of extraordinary properties, both as racemates (promising performance in organic solar cells, photoactivity, electrochromism, possibility to complex other semiconductors, outstanding oligomerization ability...) and as enantiopure antipodes (chirality tunable with electric potential, unprecedented enantiodiscrimination ability as electrodes, circularly polarized luminescence, possibility of preparation as self-supported membranes...). Such properties prompted a patent application for the new molecule class. Furthermore, having verified the general validity and effectiveness of the inherent chirality concept, and considering our concern for ionic liquid media, we have started, again in cooperation with Professor Sannicolò's group, a further research line, aimed to the implementation of inherent chirality in new-concept ionic liquids, with the target of obtaining new, attractive media for chemical and electrochemical processes, possibly of cheap and simple synthesis, affording safe, mild and environmentally friendly operating conditions, intrinsic to the ionic liquid class, combined with powerful chirality manifestations. Three… Advisors/Committee Members: tutor: P. R. Mussini, cotutor: A. Gennaro, school director: E. Licandro, MUSSINI, PATRIZIA ROMANA, LICANDRO, EMANUELA.

Subjects/Keywords: chirality; inherent chirality; enantioselectivity; chiral macrocycles; optoelectronic; chiral sensor; ionic liquids; chiral ionic liquids; conducting polymer; breathing chirality; chloride abatement; Settore CHIM/02 - Chimica Fisica; Settore CHIM/05 - Scienza e Tecnologia dei Materiali Polimerici; Settore CHIM/06 - Chimica Organica; Settore CHIM/01 - Chimica Analitica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Arnaboldi, S. (2014). CHIRAL ELECTROCHEMISTRY IN IONIC LIQUIDS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/244316

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arnaboldi, S.. “CHIRAL ELECTROCHEMISTRY IN IONIC LIQUIDS.” 2014. Thesis, Università degli Studi di Milano. Accessed January 15, 2021. http://hdl.handle.net/2434/244316.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arnaboldi, S.. “CHIRAL ELECTROCHEMISTRY IN IONIC LIQUIDS.” 2014. Web. 15 Jan 2021.

Vancouver:

Arnaboldi S. CHIRAL ELECTROCHEMISTRY IN IONIC LIQUIDS. [Internet] [Thesis]. Università degli Studi di Milano; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2434/244316.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arnaboldi S. CHIRAL ELECTROCHEMISTRY IN IONIC LIQUIDS. [Thesis]. Università degli Studi di Milano; 2014. Available from: http://hdl.handle.net/2434/244316

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations