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You searched for +publisher:"Universidade do Rio Grande do Norte" +contributor:("Soares, Marco Antonio Botelho"). Showing records 1 – 2 of 2 total matches.

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Universidade do Rio Grande do Norte

1. Queiroz, Dinalva Brito de. Biolipídio B2: desenvolvimento de um veículo estável para reposição hormonal transdérmica nanoestruturada .

Degree: 2013, Universidade do Rio Grande do Norte

The hormone administration by the oral route is frequently related with different many side effects. The aim of this study was to evaluate the safety and efficacy of a new product intended to transdermal hormone replacement nanostructured (TRHN) therapy, based on a patented under No. US 2013/0123220A1 formulation. This formulation was able to restore serum levels of estradiol (0.1%) + estradiol (0.25%) in 122 postmenopausal women with a mean age of 56.88 (± 6.27). The assessment is part of a longitudinal prospective study. Clinical parameters, including the degree of satisfaction with symptom relief, serum concentrations of estradiol, weight, blood pressure, were compared between the beginning and the end of treatment. The findings show that BIOLIPÍDEO B2® was safe and effective in restoring hormonal serum levels without side effects. The satisfaction with treatment was 92%. Serum concentrations of estradiol was significantly higher after treatment (p <0.05). Weight and systolic and diastolic blood pressure showed no significant differences (p> 0.05) during treatment. No vaginal bleeding was observed. Evaluation of bilateral breast mammography treatment found normal results in all women. This study shows for the first time the effectiveness of a transdermal formulation nanostructured in the transdermal delivery of estradiol and estriol measured in vivo using Confocal Raman Spectroscopy. The formulation of BIOLIPÍDEO/B2® is safe and effective in restoring serum estradiol levels and alleviates menopausal symptoms. The formulation can serve as a good choice for hormone replacement therapy to protect against post-menopausal symptoms. Advisors/Committee Members: Soares, Marco Antonio Botelho (advisor), 41030150397 (advisor), http://lattes.cnpq.br/0151660833349474 (advisor).

Subjects/Keywords: Biotecnologia; Nanotecnologia; Menopausa; Estradiol; Estriol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Queiroz, D. B. d. (2013). Biolipídio B2: desenvolvimento de um veículo estável para reposição hormonal transdérmica nanoestruturada . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/19809

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Queiroz, Dinalva Brito de. “Biolipídio B2: desenvolvimento de um veículo estável para reposição hormonal transdérmica nanoestruturada .” 2013. Thesis, Universidade do Rio Grande do Norte. Accessed June 04, 2020. http://repositorio.ufrn.br/handle/123456789/19809.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Queiroz, Dinalva Brito de. “Biolipídio B2: desenvolvimento de um veículo estável para reposição hormonal transdérmica nanoestruturada .” 2013. Web. 04 Jun 2020.

Vancouver:

Queiroz DBd. Biolipídio B2: desenvolvimento de um veículo estável para reposição hormonal transdérmica nanoestruturada . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2013. [cited 2020 Jun 04]. Available from: http://repositorio.ufrn.br/handle/123456789/19809.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Queiroz DBd. Biolipídio B2: desenvolvimento de um veículo estável para reposição hormonal transdérmica nanoestruturada . [Thesis]. Universidade do Rio Grande do Norte; 2013. Available from: http://repositorio.ufrn.br/handle/123456789/19809

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Universidade do Rio Grande do Norte

2. Queiroz, Dinalva Brito de. Biolipídio B2: desenvolvimento de um veículo estável para reposição hormonal transdérmica nanoestruturada .

Degree: 2013, Universidade do Rio Grande do Norte

The hormone administration by the oral route is frequently related with different many side effects. The aim of this study was to evaluate the safety and efficacy of a new product intended to transdermal hormone replacement nanostructured (TRHN) therapy, based on a patented under No. US 2013/0123220A1 formulation. This formulation was able to restore serum levels of estradiol (0.1%) + estradiol (0.25%) in 122 postmenopausal women with a mean age of 56.88 (± 6.27). The assessment is part of a longitudinal prospective study. Clinical parameters, including the degree of satisfaction with symptom relief, serum concentrations of estradiol, weight, blood pressure, were compared between the beginning and the end of treatment. The findings show that BIOLIPÍDEO B2® was safe and effective in restoring hormonal serum levels without side effects. The satisfaction with treatment was 92%. Serum concentrations of estradiol was significantly higher after treatment (p <0.05). Weight and systolic and diastolic blood pressure showed no significant differences (p> 0.05) during treatment. No vaginal bleeding was observed. Evaluation of bilateral breast mammography treatment found normal results in all women. This study shows for the first time the effectiveness of a transdermal formulation nanostructured in the transdermal delivery of estradiol and estriol measured in vivo using Confocal Raman Spectroscopy. The formulation of BIOLIPÍDEO/B2® is safe and effective in restoring serum estradiol levels and alleviates menopausal symptoms. The formulation can serve as a good choice for hormone replacement therapy to protect against post-menopausal symptoms. Advisors/Committee Members: Soares, Marco Antonio Botelho (advisor), 41030150397 (advisor), http://lattes.cnpq.br/0151660833349474 (advisor).

Subjects/Keywords: Biotecnologia; Nanotecnologia; Menopausa; Estradiol; Estriol

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Queiroz, D. B. d. (2013). Biolipídio B2: desenvolvimento de um veículo estável para reposição hormonal transdérmica nanoestruturada . (Doctoral Dissertation). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/19809

Chicago Manual of Style (16th Edition):

Queiroz, Dinalva Brito de. “Biolipídio B2: desenvolvimento de um veículo estável para reposição hormonal transdérmica nanoestruturada .” 2013. Doctoral Dissertation, Universidade do Rio Grande do Norte. Accessed June 04, 2020. http://repositorio.ufrn.br/handle/123456789/19809.

MLA Handbook (7th Edition):

Queiroz, Dinalva Brito de. “Biolipídio B2: desenvolvimento de um veículo estável para reposição hormonal transdérmica nanoestruturada .” 2013. Web. 04 Jun 2020.

Vancouver:

Queiroz DBd. Biolipídio B2: desenvolvimento de um veículo estável para reposição hormonal transdérmica nanoestruturada . [Internet] [Doctoral dissertation]. Universidade do Rio Grande do Norte; 2013. [cited 2020 Jun 04]. Available from: http://repositorio.ufrn.br/handle/123456789/19809.

Council of Science Editors:

Queiroz DBd. Biolipídio B2: desenvolvimento de um veículo estável para reposição hormonal transdérmica nanoestruturada . [Doctoral Dissertation]. Universidade do Rio Grande do Norte; 2013. Available from: http://repositorio.ufrn.br/handle/123456789/19809

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