+publisher:"Universidade do Rio Grande do Norte" +contributor:("15603016434")

Universidade do Rio Grande do Norte

1. Castro, Patricia Ingrid Macêdo de. Receptores de citocinas proinflamatórias na pré-eclâmpsia .

Degree: 2015, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/21095

► Preeclampsia is a disease specific of human pregnancy that affects 3-8% of pregnant women, and it is one of the three leading causes of maternal… (more)

▼ Preeclampsia is a disease specific of human pregnancy that affects 3-8% of pregnant women, and it is one of the three leading causes of maternal mortality and morbidity. The disease is characterized by hypertension and proteinuria after the 20th week of gestation. The risk factors for this disease are not completely understood but appear to include dysregulation of the immune response arising from defects in placentation, environmental and genetic factors. This study aimed to determine whether the variation in the amount of proinflammatory cytokine receptors IL-1R2, IL-6R and TNF-αR1 would be involved in preeclampsia. They were recruited women with preeclampsia (n=24) and women who evolved during pregnancy without changes in blood pressure (n=12) were recruited. Clinical and laboratory data were collected. The cytokine receptors (IL-1R2, TNF-αR1 and IL-6R) were assessed in mononuclear cells isolated from peripheral blood using flow cytometry (Control = 8; PE = 24). C-reactive protein (CRP) was determined by CRP ultrasensitive method (Control = 7; PE = 18) was performed using sera pregnant women. Women with preeclampsia had higher weight at the beginning of the pregnancy (p=0.0171) and lower gestational age at delivery (0.0008). Classical monocytes were decreased in preeclampsia but not intermediate or non-classical monocytes. The frequency of IL-1R2 pro inflammatory cytokine receptors is decreased in women with PE only in the subpopulation of non-classical monocytes (p = 0.0011). TNF-αR1 receptor and IL-6R, had a decreased frequency in the three subpopulations of monocyte (classic, intermediate and non-classical) when compared to women with normal pregnancy. An increase in IL-1R2 receptor in TCD4+ lymphocytes, but a decrease in TNF-receptor and IL-6R in women with preeclampsia were found. No differences in the frequency of those receptors in CD3+/CD8+ in preeclampsia. There was no difference in C-reactive protein in preeclampsia. The reduction in the amount of IL-1R2, TNF- αR1 and IL-6R monocytes and lymphocytes can be involved in the regulation of inflammation observed in preeclampsia, contributing to disease. Advisors/Committee Members: Jerônimo, Selma Maria Bezerra (advisor), 15603016434 (advisor).

Subjects/Keywords: Pré-eclâmpsia; Receptor de citocinas; IL-1R2; TNF-αR1; IL-6R; Inflamação

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APA (6^th Edition):

Castro, P. I. M. d. (2015). Receptores de citocinas proinflamatórias na pré-eclâmpsia . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/21095

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Castro, Patricia Ingrid Macêdo de. “Receptores de citocinas proinflamatórias na pré-eclâmpsia .” 2015. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/21095.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Castro, Patricia Ingrid Macêdo de. “Receptores de citocinas proinflamatórias na pré-eclâmpsia .” 2015. Web. 10 Apr 2021.

Vancouver:

Castro PIMd. Receptores de citocinas proinflamatórias na pré-eclâmpsia . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2015. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/21095.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Castro PIMd. Receptores de citocinas proinflamatórias na pré-eclâmpsia . [Thesis]. Universidade do Rio Grande do Norte; 2015. Available from: http://repositorio.ufrn.br/handle/123456789/21095

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

2. Rodrigues Neto, João Firmino. Moléculas coestimulatórias na leishmaniose visceral .

Degree: 2015, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/19910

► Visceral leishmaniasis (VL) is endemic in many countries, including Brazil. The protozoan Leishmania infantum, is the etiological agent of VL, and is transmitted by the… (more)

Subjects/Keywords: Resposta imune; Moléculas coestimulatórias; Leishmaniose visceral

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APA (6^th Edition):

Rodrigues Neto, J. F. (2015). Moléculas coestimulatórias na leishmaniose visceral . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/19910

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rodrigues Neto, João Firmino. “Moléculas coestimulatórias na leishmaniose visceral .” 2015. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/19910.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rodrigues Neto, João Firmino. “Moléculas coestimulatórias na leishmaniose visceral .” 2015. Web. 10 Apr 2021.

Vancouver:

Rodrigues Neto JF. Moléculas coestimulatórias na leishmaniose visceral . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2015. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/19910.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rodrigues Neto JF. Moléculas coestimulatórias na leishmaniose visceral . [Thesis]. Universidade do Rio Grande do Norte; 2015. Available from: http://repositorio.ufrn.br/handle/123456789/19910

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

3. Ferreira, Leonardo Capistrano. Determinantes genéticos e ambientais das doenças hipertensivas da gravidez .

Degree: 2014, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/19554

► The development of complex diseases such as preeclampsia are determined by both environmental and genetic factors, but there is also interaction among these factors. Preeclampsia… (more)

Subjects/Keywords: Pré-eclâmpsia; Fatores de risco; Associação genética; SNP

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APA (6^th Edition):

Ferreira, L. C. (2014). Determinantes genéticos e ambientais das doenças hipertensivas da gravidez . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/19554

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ferreira, Leonardo Capistrano. “Determinantes genéticos e ambientais das doenças hipertensivas da gravidez .” 2014. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/19554.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ferreira, Leonardo Capistrano. “Determinantes genéticos e ambientais das doenças hipertensivas da gravidez .” 2014. Web. 10 Apr 2021.

Vancouver:

Ferreira LC. Determinantes genéticos e ambientais das doenças hipertensivas da gravidez . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2014. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/19554.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ferreira LC. Determinantes genéticos e ambientais das doenças hipertensivas da gravidez . [Thesis]. Universidade do Rio Grande do Norte; 2014. Available from: http://repositorio.ufrn.br/handle/123456789/19554

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

4. Galvão, Joanna Gardel Valverde. Perfil imunológico associado à susceptibilidade, resistência e cura na infecção por Leishmania ( Leishmania ) infantum .

Degree: 2014, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/19591

► Visceral Leishmaniasis (VL) is endemic in Brazil and the northeast region had the highest incidence of the disease , despite, in the last 30 years,… (more)

▼ Visceral Leishmaniasis (VL) is endemic in Brazil and the northeast region had the highest incidence of the disease , despite, in the last 30 years, it has spread to all geographic regions of the country. Leishmania infantum is the m ain etiological agent of VL in Latin America, Europe and North Africa. However, not all infected individuals develop the disease; in fact, the majority present spontaneous re solution of infection without symptoms. The evaluation of the immunological profil e has been mostly conducted stimulating, with Leishmania spp. antigen, peripheral blood mononuclear cells isolated from subjects with VL. These studies showed that VL patients had an inhibition of both, lymphocyte proliferation and proinflammatory response to Leishmania spp. antigen. Our study aimed to evaluate the immune response in active LV, cured post treatment and asymptomatic infection. To reach this aim, we analyzed immunophenotypic features related to activation, Treg and memory lymphocytes, by flow cytometry, as well as, evaluation of cytokine production, in ex vivo or in whole blood culture. In active VL volunteers, a longitu dinal study was conducted with reassessment at 4 and 14 months after clinical cure. The control group included individuals th at live d in endemic region and were either Positive Control, consisting of individuals with positive anti - L eishmania spp. serology and/or positive PCR for Leishmania  spp. and Negative Control composed by individuals with negative anti - Leishmania antibodie s serology and negative PCR for Leishmania . During VL, CD4 lymphocytes showed greater activation and memory profile s and were the major source of cytokines in culture when compared to CD8 lymphocytes , and these were not Leishmania specific. There were act ivated lymphocytes during VL (CD4 + CD69 + :4.9%) when compared to control groups, Positive (CD4 + CD69 + :1.96%, p=0.0045) and Negative (CD4 + CD69 + :1.35%, p=0.006), on the other hand, this was non - specific activation. The lymphocyte activation profile remain ed el evated even 14 months post treatmen t. A fter clinical cure , the activation was Leishmania specific (CD4 + CD25 + absence of SLA: 8.4%, and presence of SLA: 10.7% p=0.0279). CD8 + CD25 + lymphocytes were able to produce Leishmania specific IFN - γ in both, Positive Controls (absence of SLA 5.2% and presence of SLA: 9.5%, p=0.0391) and Cured 4 month (absence of SLA: 3.9%; presence of SLA: 10.7% p=0.0098). Whole blood culture cells, of VL patients, were able to produce IFN - γ, by SLA stimulation (absence of SLA: 28.0 pg ∕mL, and presence: 44.3 pg∕mL p=0.0020) as well as recovered groups (absence of SLA 2.3 pg∕mL… Advisors/Committee Members: Jerônimo, Selma Maria Bezerra (advisor), 15603016434 (advisor), http://lattes.cnpq.br/7120263570947836 (advisor).

Subjects/Keywords: Leishmaniose visceral; Resposta imunológica; Cura; Resistência

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APA (6^th Edition):

Galvão, J. G. V. (2014). Perfil imunológico associado à susceptibilidade, resistência e cura na infecção por Leishmania ( Leishmania ) infantum . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/19591

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Galvão, Joanna Gardel Valverde. “Perfil imunológico associado à susceptibilidade, resistência e cura na infecção por Leishmania ( Leishmania ) infantum .” 2014. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/19591.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Galvão, Joanna Gardel Valverde. “Perfil imunológico associado à susceptibilidade, resistência e cura na infecção por Leishmania ( Leishmania ) infantum .” 2014. Web. 10 Apr 2021.

Vancouver:

Galvão JGV. Perfil imunológico associado à susceptibilidade, resistência e cura na infecção por Leishmania ( Leishmania ) infantum . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2014. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/19591.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Galvão JGV. Perfil imunológico associado à susceptibilidade, resistência e cura na infecção por Leishmania ( Leishmania ) infantum . [Thesis]. Universidade do Rio Grande do Norte; 2014. Available from: http://repositorio.ufrn.br/handle/123456789/19591

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

5. Dourado Júnior, Mário Emílio Teixeira. Síndrome de Guillain-Barré: epidemiologia, prognóstico e fatores de risco .

Degree: 2015, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/20220

► Introduction. Guillain-Barré syndrome (GBS) is an immune-mediated polyneuropathy and the principal cause of acute neuromuscular paralysis. The most prominent GBS subtypes are: acute inflammatory demyelinating… (more)

▼ Introduction. Guillain-Barré syndrome (GBS) is an immune-mediated polyneuropathy and the principal cause of acute neuromuscular paralysis. The most prominent GBS subtypes are: acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor-sensory axonal neuropathy (AMSAN) and Fisher syndrome (FS). Differences in geographical distribution of variants have been reported. In Brazil, there are few studies describing the characteristics of GBS, but none on the frequency of GBS variants and their clinical manifestations. Infection-induced aberrant immune response resulting from molecular mimicry and formation of cross-reacting antibodies, contribute to complement activation. Functional biallelic polymorphism in immunoglobulin receptors that influence the affinity of IgG subclasses and the type of immune response have been described, suggesting genetic susceptibility to developing disease. It remains unclear whether individuals carrying different FCGR alleles have differential risk for GBS and⁄or disease severity. The goals of this study were: (1) To characterize GBS and describe the clinical findings in a cohort of patients with GBS from the state of Rio Grande do Norte, Brazil; (2) to determine whether polymorphism in FCGR were associated with development of GBS, and (3) to tease out whether the global gene expression studies could be a tool to identify pathways and transcriptional networks which could be regulated and decrease the time of disease. Methods. Clinical and laboratory data for 149 cases of GBS diagnosed from 1994 to 2013 were analyzed. Genomic DNA and total RNA were extracted from whole blood. Antigangliosides antibodies were determined in the sera. In addition, we also assessed whether FCGR polymorphism are present in GBS (n=141) and blood donors (n=364), and global gene expressions were determined for 12 participants with GBS. Blood samples were collected at the diagnosis and post-recovery. Results. AIDP was the most frequent variant (81.8%) of GBS, followed by AMAN (14.7%) and AMSAN (3.3%). The incidence of GBS was 0.3 ⁄ 100,000 people for the state of Rio Grande do Norte and cases occurred at a younger age. GBS was preceded by infections, with the axonal variant associated with episodes of diarrhea (P = 0.025). Proximal weakness was more frequent in AIDP, and distal weakness predominant in the axonal variant. Compared to 42.4% of cases with AIDP (P<0.0001), 84.6% of cases with the axonal variant had nadir in <10 days. Individuals with the axonal variant took longer to recover deambulation (P<0.0001). The mortality of GBS was 5.3%. A worse outcome was related to an axonal variant (OR17.063; P=0.03) and time required to improve one point in the Hughes functional scale (OR 1.028; P=0.03). The FCGR genotypes and allele frequencies did not differ significantly between the patients with GBS and the controls (FCGR2A p=0.367 and FCGR3A p=0.2430). Global gene expression using RNAseq showed variation in transcript coding for protein… Advisors/Committee Members: Jerônimo, Selma Maria Bezerra (advisor), 15603016434 (advisor), http://lattes.cnpq.br/7120263570947836 (advisor).

Subjects/Keywords: Síndrome Guillain Barré; Neuroepidemiologia; Neuroimunologia; FcyR; Polimorfismo; Transcriptoma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dourado Júnior, M. E. T. (2015). Síndrome de Guillain-Barré: epidemiologia, prognóstico e fatores de risco . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/20220

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dourado Júnior, Mário Emílio Teixeira. “Síndrome de Guillain-Barré: epidemiologia, prognóstico e fatores de risco .” 2015. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/20220.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dourado Júnior, Mário Emílio Teixeira. “Síndrome de Guillain-Barré: epidemiologia, prognóstico e fatores de risco .” 2015. Web. 10 Apr 2021.

Vancouver:

Dourado Júnior MET. Síndrome de Guillain-Barré: epidemiologia, prognóstico e fatores de risco . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2015. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/20220.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dourado Júnior MET. Síndrome de Guillain-Barré: epidemiologia, prognóstico e fatores de risco . [Thesis]. Universidade do Rio Grande do Norte; 2015. Available from: http://repositorio.ufrn.br/handle/123456789/20220

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

6. Cabral, Angela Pardo. Influência de fatores ambientais na Leishmaniose visceral no Rio Grande do Norte .

Degree: 2007, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/12534

► The Visceral Leishmaniose (LV) disease is endemic in some places in Brazil. It is caused by the protozoa Leishmania chagasi, being transmitted for vector, the… (more)

Subjects/Keywords: Fatores de risco; Fatores ambientais; Leishmaniose visceral; Ambient factors of risk; Factors; Visceral Leishmanises

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APA (6^th Edition):

Cabral, A. P. (2007). Influência de fatores ambientais na Leishmaniose visceral no Rio Grande do Norte . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/12534

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cabral, Angela Pardo. “Influência de fatores ambientais na Leishmaniose visceral no Rio Grande do Norte .” 2007. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/12534.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cabral, Angela Pardo. “Influência de fatores ambientais na Leishmaniose visceral no Rio Grande do Norte .” 2007. Web. 10 Apr 2021.

Vancouver:

Cabral AP. Influência de fatores ambientais na Leishmaniose visceral no Rio Grande do Norte . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2007. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/12534.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cabral AP. Influência de fatores ambientais na Leishmaniose visceral no Rio Grande do Norte . [Thesis]. Universidade do Rio Grande do Norte; 2007. Available from: http://repositorio.ufrn.br/handle/123456789/12534

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

7. Nascimento, Paulo Ricardo Porfirio do. O papel modulatório do ferro sobre a resposta imune na Leishmaniose Visceral .

Degree: 2012, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/12592

► Iron is an essential element for many cellular functions, including the immune response against intracellular pathogens. In this study, we aimed evaluate the effect of… (more)

Subjects/Keywords: Ferro; Leishmaniose visceral; Resposta imune; Immune response; Iron metabolism; Visceral leishmaniasis

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APA (6^th Edition):

Nascimento, P. R. P. d. (2012). O papel modulatório do ferro sobre a resposta imune na Leishmaniose Visceral . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/12592

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nascimento, Paulo Ricardo Porfirio do. “O papel modulatório do ferro sobre a resposta imune na Leishmaniose Visceral .” 2012. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/12592.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nascimento, Paulo Ricardo Porfirio do. “O papel modulatório do ferro sobre a resposta imune na Leishmaniose Visceral .” 2012. Web. 10 Apr 2021.

Vancouver:

Nascimento PRPd. O papel modulatório do ferro sobre a resposta imune na Leishmaniose Visceral . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2012. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/12592.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nascimento PRPd. O papel modulatório do ferro sobre a resposta imune na Leishmaniose Visceral . [Thesis]. Universidade do Rio Grande do Norte; 2012. Available from: http://repositorio.ufrn.br/handle/123456789/12592

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

8. Lacerda, Hênio Godeiro. Determinantes envolvidos na resposta imune celular humana à infecção por Leishmania infantum chagasi .

Degree: 2011, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/13247

► Visceral leishmaniasis (VL) is a disease caused by protozoa of the Leishmania donovani complex, whose infection has clinical spectrum ranging from asymptomatic infection to active… (more)

▼ Visceral leishmaniasis (VL) is a disease caused by protozoa of the Leishmania donovani complex, whose infection has clinical spectrum ranging from asymptomatic infection to active disease characterized by fever, cachexia, hepatosplenomegaly, and immunosuppression. The healing or protective immunity require an antigen-specific type 1. The Montenegro skin test (DTH) has been interpreted as a marker of protective immunity. However, there is no known correlation between the DTH response to type 1 and DTH and immunity of type 1 are maintained in the long term. Thus, a longitudinal study of 8 years, nested in a cohort family held in Brazil, documented the status of DTH and cytokine production by peripheral blood mononuclear cells in response to antigen-specific stimulation. This study was the interdisciplinary approach of physicians, biochemists, nutritionists, veterinary medicine, biology and statistics. The results show that 46.2% of subjects were analyzed DTH positive at baseline. The prevalence of positive and DTH induration size increased with age (p = 0.0021). 15.7% of individuals positive DTH "retro-converted" the negative and 50.4% (64) of individuals negative DTH became positive. The size of DTH induration was correlated significantly with the antigen-induced production of IFN-γ (r = 0.6186, p = 0.0001). IL-6 was secreted at higher levels in peripheral blood mononuclear cells of individuals who "retro-converted" DTH positive to negative than individuals who remained stable DTH status (p = 0.005). Thus, IFN-γ produced by peripheral blood mononuclear cells, may be a surrogate marker for protective immunity instead of the DTH response. In addition, differences in innate immune response may determine whether individuals maintain or eliminate the infection by Leishmania infantum chagasi in asymptomatic patients Advisors/Committee Members: CPF:15603016434 (advisor), do%3Fid%3DK4785584A3%26dataRevisao%3Dnull%22%29&pagesize-30">http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785584A3&dataRevisao=null (advisor).

Subjects/Keywords: leishmaniose visceral; imunidade protetor; infecção assintomática; Visceral leishmaniasis; protective immunity; asymptomatic infection

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lacerda, H. G. (2011). Determinantes envolvidos na resposta imune celular humana à infecção por Leishmania infantum chagasi . (Doctoral Dissertation). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/13247

Chicago Manual of Style (16^th Edition):

Lacerda, Hênio Godeiro. “Determinantes envolvidos na resposta imune celular humana à infecção por Leishmania infantum chagasi .” 2011. Doctoral Dissertation, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/13247.

MLA Handbook (7^th Edition):

Lacerda, Hênio Godeiro. “Determinantes envolvidos na resposta imune celular humana à infecção por Leishmania infantum chagasi .” 2011. Web. 10 Apr 2021.

Vancouver:

Lacerda HG. Determinantes envolvidos na resposta imune celular humana à infecção por Leishmania infantum chagasi . [Internet] [Doctoral dissertation]. Universidade do Rio Grande do Norte; 2011. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/13247.

Council of Science Editors:

Lacerda HG. Determinantes envolvidos na resposta imune celular humana à infecção por Leishmania infantum chagasi . [Doctoral Dissertation]. Universidade do Rio Grande do Norte; 2011. Available from: http://repositorio.ufrn.br/handle/123456789/13247

Universidade do Rio Grande do Norte

9. Pereira, Flavio Venício Marinho. Fatores de risco individuais e familiares no desenvolvimento da pré-eclâmpia .

Degree: 2010, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/13220

► Preeclampsia is a spectral disease, with different clinical forms which can evolve with severe multisystemic complications. This present study aimed to determine the risk factors… (more)

▼ Preeclampsia is a spectral disease, with different clinical forms which can evolve with severe multisystemic complications. This present study aimed to determine the risk factors associated with preeclampsia (PE); to validate the existence of aggregation of hypertensive disease in families of women with preeclampsia and verify the existence of association between polymorphisms in the VEGF gene and level of VEGF and its soluble receptor (sFlt1). A case-control study was performed (n = 851). Genotyping of VEGF was performed and serum levels of VEGF and sFlt1 were measured by ELISA. It was observed that 38% of mothers (173, 455) of a case of preeclampsia and 30.8% (78 of 361) of controls had history of hypertension (p <0.0001). Similarly, when examining the history of maternal preeclampsia, we observed that 14.6% (48 of 328) of mothers of women with preeclampsia and 9.6% (12 of 294) of mothers of controls had a history of preeclampsia (p = 0.0001). As for maternal history of preeclampsia, we found that 5.1% (15 of 295) of cases and 3.6% (7 of 314) of controls had a history of preeclampsia (p = 0.0568). Sisters of women with preeclampsia also had a history of hypertensive disease in 9% (41 of 455) versus 6.6% (13 of 361), p = 0.002. Similarly when examining the history of preeclampsia in sisters, it was observed that 22.7% (57 of 251) of a sister of case versus 11.4% (26 of 228) of controls had a history of preeclampsia (P = 0.0011). We observed a decrease in free VEGF in the serum of patients (P <0.05) and increased soluble VEGF receptor. There was no association between polymorphisms in the VEGF gene and preeclampsia. The data obtained in this work validate that hypertensive disease in mothers and sisters with preeclampsia are risk factors for preeclampsia. The risk of illness in the family is higher according to disease severity. High incidence of preeclampsia can be assumed by the high incidence of this disease among the controls. Significant differences between the frequency of preeclampsia in mothers of cases and controls indicate familial factors. Work is being conducted with the to eventually perform genome wide association studies to identify susceptibility loci Advisors/Committee Members: CPF:15603016434 (advisor), do%3Fid%3DK4785584A3%26dataRevisao%3Dnull%22%29&pagesize-30">http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785584A3&dataRevisao=null (advisor).

Subjects/Keywords: Pre-eclâmpsia; Eclâmpsia; Síndrome HELLP; Fatores de risco

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pereira, F. V. M. (2010). Fatores de risco individuais e familiares no desenvolvimento da pré-eclâmpia . (Doctoral Dissertation). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/13220

Chicago Manual of Style (16^th Edition):

Pereira, Flavio Venício Marinho. “Fatores de risco individuais e familiares no desenvolvimento da pré-eclâmpia .” 2010. Doctoral Dissertation, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/13220.

MLA Handbook (7^th Edition):

Pereira, Flavio Venício Marinho. “Fatores de risco individuais e familiares no desenvolvimento da pré-eclâmpia .” 2010. Web. 10 Apr 2021.

Vancouver:

Pereira FVM. Fatores de risco individuais e familiares no desenvolvimento da pré-eclâmpia . [Internet] [Doctoral dissertation]. Universidade do Rio Grande do Norte; 2010. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/13220.

Council of Science Editors:

Pereira FVM. Fatores de risco individuais e familiares no desenvolvimento da pré-eclâmpia . [Doctoral Dissertation]. Universidade do Rio Grande do Norte; 2010. Available from: http://repositorio.ufrn.br/handle/123456789/13220

Universidade do Rio Grande do Norte

10. Teixeira, Diego Gomes. Diversidade genômica de isolados com origem clínica distinta de Leishmania infantum do Estado do Rio Grande do Norte .

Degree: 2015, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/20327

► Leishmaniasis is a complex of diseases with no preventable or therapeutic vaccine available. There is only a small set of drugs for treatment of these… (more)

▼ Leishmaniasis is a complex of diseases with no preventable or therapeutic vaccine available. There is only a small set of drugs for treatment of these diseases, which evolve with distinct clinical outcomes from skin ulcers, to mucosal involvement or visceralization. The type of clinical presentation usually is associated with the infecting species of Leishmania. Leishmania infantum is the visceralizing species, causing visceral leishmaniasis, in Latin America, Europe and northern Africa and was introduced in the Americas by Europeans during colonization. Visceral leishmaniasis used to be a sporadic disease found in rural areas Northeast of Brazil, however with urbanization, outbreaks have been reported in periurban areas of major cities. L. infantum infection can evolve with control of the parasite without apparent clinical symptoms, with only a minority developing symptomatic disease. The reasons why one evolve with selfresolution and others develop full blown disease is not entirely understood, but seems to include host genetic susceptibility, comorbidity, sand fly exposure and potentially genetic variation in the infecting Leishmania species. Our ongoing study, have shown structural genome variations in several clinical Leishmania isolates obtained from people infected in the State of Rio Grande do Norte. Despite the different clinical patterns, the isolates´ genomes showed a high identity degree to each other, even the ones isolated from the 90 compared with the latest. However, the few found changes were sufficient for the isolation of the distinct groups by a principal component analysis, showing that the isolates from more recent years are more homogeneous among the population. Phylogenetic analyzes using Bayesian reconstruction methods have been made and supported the grouping patterns already seen in the foregoing results. Moreover by an Expanded Bayesian Skyline Plot it was possible to observe the growth of the genomic population of L. infantum compared with the 1990s. Changes were observed in the number of chromosome copies in all strains, but only chromosome 31 is presented as exclusively trisomic. This work presents evidence on patterns of L. infantum isolated genomes relating them to clinical characteristics of their hosts. Advisors/Committee Members: Lima, João Paulo Matos Santos (advisor), 79332021368 (advisor), http://lattes.cnpq.br/3289758851760692 (advisor), Jerônimo, Selma Maria Bezerra (advisor), 15603016434 (advisor), http://lattes.cnpq.br/7120263570947836 (advisor).

Subjects/Keywords: Doença infecciosa; Leishmania infantum; Genoma; Evolução; Ploidia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Teixeira, D. G. (2015). Diversidade genômica de isolados com origem clínica distinta de Leishmania infantum do Estado do Rio Grande do Norte . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/20327

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Teixeira, Diego Gomes. “Diversidade genômica de isolados com origem clínica distinta de Leishmania infantum do Estado do Rio Grande do Norte .” 2015. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/20327.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Teixeira, Diego Gomes. “Diversidade genômica de isolados com origem clínica distinta de Leishmania infantum do Estado do Rio Grande do Norte .” 2015. Web. 10 Apr 2021.

Vancouver:

Teixeira DG. Diversidade genômica de isolados com origem clínica distinta de Leishmania infantum do Estado do Rio Grande do Norte . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2015. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/20327.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Teixeira DG. Diversidade genômica de isolados com origem clínica distinta de Leishmania infantum do Estado do Rio Grande do Norte . [Thesis]. Universidade do Rio Grande do Norte; 2015. Available from: http://repositorio.ufrn.br/handle/123456789/20327

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

11. Araújo, Sérgio Ricardo Fernandes de. Determinantes genéticos da hanseníase em uma população do Rio Grande do Norte .

Degree: 2008, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/12539

► Background: Leprosy can cause severe disability and disfigurement and is still a major health in different parts of the world. Only a subset of those… (more)

▼ Background: Leprosy can cause severe disability and disfigurement and is still a major health in different parts of the world. Only a subset of those individuals exposed to the pathogen will go on to develop clinical disease and there is a broad clinical spectrum amongst leprosy patients. The outcome of infection is in part due to host genes that influence control of the initial infection and the host´s immune response to that infection. Aim: Evaluate if polymorphisms type SNP in the 17q118q21 chromosomic region contribute to development of leprosy in Rio Grande do Norte population. Material and methods: A sample composed of 215 leprosy patients and 229 controls drawn from the same population were genotyped by using a Snapshot assay for eight genes (NOS2A, CCL18, CRLF3, CCL23, TNFAIP1, STAT5B, CCR7 and CSF3) located in chromosomic region 17q118q21. The genotype and allele frequency were measured and statistical analysis was performed by chi-square in SPSS version 15 and graph prism pad version 4 software. Results: Ours results indicated that the markers NOS2A8277, NOS2A8rs16949, CCR78rs11574663 and CSF38rs2227322 presented strong association with leprosy and their risk genotype were GG, TT, AA and GG respectively. The risk genotypes for all markers associated to leprosy presented recessive inheritance standard. When we compared the interaction among the markers in different combination we find that the marker NOS2A8277 associated with CCR78rs11574663 presented highest risk probability to development of leprosy. When we evaluated the haplotype of the risk markers it was found a haplotype associated with increase of the protection (CSF38rs22273228CC, CCR78 rs115746638GA, NOS2A8rs169498CT and NOS2A82778GA). The association of the clinical forms paucibacilary and multibacilary with markers showed that to the markers NOS2A8 2778GG, CCR78rs115746638AA and CSF38rs22273228GG there were a strong influence to migration to multibacilary pole and to marker NOS2A8rs169498TT the high proportion was found to the paucibacilary form. Conclusions: Changes in the genes NOS2A, CCR7 and CSF3 can influence the immune response against Mycobacterium leprae. The combination among these polymorphisms alters the risk probability to develop leprosy. The markers type SNP associated to development of the leprosy also are linked to clinical forms and its severity being the polymorphism NOS2A8rs169498TT associated with paucibacilar form and the polymorphisms NOS2A82778GG, CCR78rs115746638AA and CSF38rs22273228GG associated to multibacilar form Advisors/Committee Members: Jerônimo, Selma Maria Bezerra (advisor), CPF:15603016434 (advisor), do%3Fid%3DK4785584A3%26dataRevisao%3Dnull%22%29&pagesize-30">http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785584A3&dataRevisao=null (advisor).

Subjects/Keywords: Polimorfismos; Hanseníase; SNP; Susceptibilidade genética; Polymorphisms; Genetic; Susceptibility; Leprosy; SNP

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Araújo, S. R. F. d. (2008). Determinantes genéticos da hanseníase em uma população do Rio Grande do Norte . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/12539

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Araújo, Sérgio Ricardo Fernandes de. “Determinantes genéticos da hanseníase em uma população do Rio Grande do Norte .” 2008. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/12539.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Araújo, Sérgio Ricardo Fernandes de. “Determinantes genéticos da hanseníase em uma população do Rio Grande do Norte .” 2008. Web. 10 Apr 2021.

Vancouver:

Araújo SRFd. Determinantes genéticos da hanseníase em uma população do Rio Grande do Norte . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2008. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/12539.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Araújo SRFd. Determinantes genéticos da hanseníase em uma população do Rio Grande do Norte . [Thesis]. Universidade do Rio Grande do Norte; 2008. Available from: http://repositorio.ufrn.br/handle/123456789/12539

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

12. Ferreira, Leonardo Capistrano. Genes candidatos de suscetibilidade a pré-eclampsia: estudo de associação .

Degree: 2010, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/12565

► Preeclampsia is a multifactorial disease of unknown etiology that features with wide clinical symptoms, ranging from mild preeclampsia to severe forms, as eclampsia and HELLP… (more)

Subjects/Keywords: Pré-eclâmpsia; Associação genética; SNP

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ferreira, L. C. (2010). Genes candidatos de suscetibilidade a pré-eclampsia: estudo de associação . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/12565

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ferreira, Leonardo Capistrano. “Genes candidatos de suscetibilidade a pré-eclampsia: estudo de associação .” 2010. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/12565.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ferreira, Leonardo Capistrano. “Genes candidatos de suscetibilidade a pré-eclampsia: estudo de associação .” 2010. Web. 10 Apr 2021.

Vancouver:

Ferreira LC. Genes candidatos de suscetibilidade a pré-eclampsia: estudo de associação . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2010. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/12565.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ferreira LC. Genes candidatos de suscetibilidade a pré-eclampsia: estudo de associação . [Thesis]. Universidade do Rio Grande do Norte; 2010. Available from: http://repositorio.ufrn.br/handle/123456789/12565

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

13. Maciel, Bruna Leal Lima. Estado nutricional e efeito da vitamina A na resposta imune frente à infecção por Leishmania Infantum .

Degree: 2013, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/12575

► Nutritional status is an important determinant to the response against Leishmania infection, although few studies have characterized the molecular basis for the association found between… (more)

▼ Nutritional status is an important determinant to the response against Leishmania infection, although few studies have characterized the molecular basis for the association found between malnutrition and the disease. Vitamin A supplementation has long been used in developing countries to prevent mortality by diarrheal and respiratory diseases, but there are no studies on the role of vitamin A in Leishmania infection, although we and others have found vitamin A deficiency in visceral Leishmaniasis (VL). Regulatory T cells are induced in vitro by vitamin A metabolites and are considered important cells implicated T CD4+ cell suppression in human VL. This work aimed to examine the correlation of nutritional status and the effect of vitamin A in the response against Leishmania infantum infection. A total of 179 children were studied: 31 had active VL, 33 VL history, 44 were DTH+ and 71 were DTH- and had negative antibody to Leishmania (DTH-/Ac-). Peripheral blood monuclear cells were isolated in a subgroup of 10 active VL and 16 DTH-/Ac- children and cultivated for 20h under 5 different conditions: 1) Medium, 2) Soluble promastigote L. infantum antigens (SLA), 3) All-trans retinoic acid (ATRA), 4) SLA + ATRA and 5) Concanavalin A. T CD4+CD25highFoxp3+, T CD4+CD25-Foxp3- and CD14+ monocytes were stained and studied by flow cytometry for IL-10, TGF-β and IL-17 production. Nutritional status was compromised in VL children, which presented lower BMI/Age and retinol concentrations when compared to healthy controls. We found a negative correlation between nutritional status (measured by BMI/Age and serum retinol) and anti-Leishmania antibodies and acute phase proteins. There was no correlation between nutritional status and parasite load. ATRA presented a dual effect in Treg cells and monocytes: In healthy children (DTH-/Ac-), it induced a regulatory response, increasing IL-10 and TGF-β production; in VL children it modulated the immune response, preventing increased IL-10 production after SLA stimulation. Furthermore, we found a positive correlation between BMI/Age and IL-17 production and negative correlation between serum retinol and IL-10 and TGF-β production in T CD4+CD25highFoxp3+ cells after SLA stimulus. Our results show a potential dual role of vitamin A in the immune system: improvement of regulatory profile during homeostasis and down modulation of IL-10 in Treg cells and monocytes during symptomatic VL. Therefore, the use of vitamin A concomitant to VL therapy might improve recovery from disease status in Leishmania infantum infection Advisors/Committee Members: Jerônimo, Selma Maria Bezerra (advisor), CPF:15603016434 (advisor), do%3Fid%3DK4785584A3%26dataRevisao%3Dnull%22%29&pagesize-30">http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785584A3&dataRevisao=null (advisor).

Subjects/Keywords: Leishmaniose visceral. Ácido all-trans retinóico. IL-10; Visceral leishmaniasis. All-trans retinoic acid. IL-10

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maciel, B. L. L. (2013). Estado nutricional e efeito da vitamina A na resposta imune frente à infecção por Leishmania Infantum . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/12575

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Maciel, Bruna Leal Lima. “Estado nutricional e efeito da vitamina A na resposta imune frente à infecção por Leishmania Infantum .” 2013. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/12575.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Maciel, Bruna Leal Lima. “Estado nutricional e efeito da vitamina A na resposta imune frente à infecção por Leishmania Infantum .” 2013. Web. 10 Apr 2021.

Vancouver:

Maciel BLL. Estado nutricional e efeito da vitamina A na resposta imune frente à infecção por Leishmania Infantum . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2013. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/12575.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Maciel BLL. Estado nutricional e efeito da vitamina A na resposta imune frente à infecção por Leishmania Infantum . [Thesis]. Universidade do Rio Grande do Norte; 2013. Available from: http://repositorio.ufrn.br/handle/123456789/12575

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

14. Ottoni, Cristina Iglesias. A infecção por Leishmania infantum chagasi altera o metabolismo lipídico do hospedeiro .

Degree: 2012, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/12590

► American visceral leishmaniasis (AVL), caused by Leishmania infantum chagasi (L.i.chagasi), stands as a public health problem in Brazil, with human and canine cases related in… (more)

▼ American visceral leishmaniasis (AVL), caused by Leishmania infantum chagasi (L.i.chagasi), stands as a public health problem in Brazil, with human and canine cases related in all states..Lipid metabolism can be modified in several status of infection. For example, experimental studies show that the cholesterol is necessary to internalization and replication of L.i.chagasi in macrophages through caveolar domains. Patients with AVL present low levels of cholesterol and a visible triglycerides increase. This work aimed to evaluate the lipid metabolism in several post-infection status by L.i.chagasi, including individuals with symptomatic infection (AVL), and asymptomatic. The levels of cholesterol, triglycerides, HDL and reactive C protein, were measured. Individuals with AVL were compared with individuals with assymptomatic infection and presented low levels of total cholesterol (128 ± 6.180 mg/dL vs. 158 ±5.733 mg/dL, p=0.0001), HDL (29 ± 1.746 mg/dL vs. 37 ± 1.647 mg/dL, p=0.0001), increased levels of triglycerides (149.5 mg/dL ± 12.72 vs. 78.00 ± 10.43 mg/dL, p=0.0095) and higher levels of reactive C protein (1.750± 0.4939 mg/dL vs. 0.40 ± 0.1707 mg/dL; p=0.0001). The expression of genes related to lipid metabolism, such as LXR-a, LXR-b, PPAR-a, PPAR-d, PPAR-g and APOE was evaluated by real time PCR. A reduction in the expression of those genes was found in the group of AVL patients corroborating the serum levels of the metabolites earlier quantified. Our findings suggest a modulation of metabolism of lipids, in the chronic phase of AVL, this could facilitate the survival of leishmania, due to the known reduction on the ability of macrophages in presenting antigens efficiently to the T cells due to the reduction in the cholesterol available, it results in a subversion of the host immunity. Advisors/Committee Members: Jerônimo, Selma Maria Bezerra (advisor), CPF:15603016434 (advisor), do%3Fid%3DK4785584A3%26dataRevisao%3Dnull%22%29&pagesize-30">http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785584A3&dataRevisao=null (advisor).

Subjects/Keywords: Leishmania chagasi; Metabolismo lipídico.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ottoni, C. I. (2012). A infecção por Leishmania infantum chagasi altera o metabolismo lipídico do hospedeiro . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/12590

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ottoni, Cristina Iglesias. “A infecção por Leishmania infantum chagasi altera o metabolismo lipídico do hospedeiro .” 2012. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/12590.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ottoni, Cristina Iglesias. “A infecção por Leishmania infantum chagasi altera o metabolismo lipídico do hospedeiro .” 2012. Web. 10 Apr 2021.

Vancouver:

Ottoni CI. A infecção por Leishmania infantum chagasi altera o metabolismo lipídico do hospedeiro . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2012. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/12590.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ottoni CI. A infecção por Leishmania infantum chagasi altera o metabolismo lipídico do hospedeiro . [Thesis]. Universidade do Rio Grande do Norte; 2012. Available from: http://repositorio.ufrn.br/handle/123456789/12590

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

15. Andrade, Ion Garcia Mascarenhas de. Determinantes socioeconômicos e ambientais do declínio das hospitalizações por diarréias em lactentes no Rio Grande do Norte - 1992 a 2001 .

Degree: 2008, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/13139

► There was a significant decline in hospitalizations for acute diarrhea in children younger than 1 year of age in Brazil between 1992 to 2001. The… (more)

Subjects/Keywords: Diarréia; Mortalidade infantil; Inflação; Analfabetismo; Saneamento básico; Baixa renda; Pobreza; Diarrhoea; Infant mortality; Inflation; Illiteracy; Sanitation; Low income; Poverty,; Hospitalization

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Andrade, I. G. M. d. (2008). Determinantes socioeconômicos e ambientais do declínio das hospitalizações por diarréias em lactentes no Rio Grande do Norte - 1992 a 2001 . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/13139

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Andrade, Ion Garcia Mascarenhas de. “Determinantes socioeconômicos e ambientais do declínio das hospitalizações por diarréias em lactentes no Rio Grande do Norte - 1992 a 2001 .” 2008. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/13139.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Andrade, Ion Garcia Mascarenhas de. “Determinantes socioeconômicos e ambientais do declínio das hospitalizações por diarréias em lactentes no Rio Grande do Norte - 1992 a 2001 .” 2008. Web. 10 Apr 2021.

Vancouver:

Andrade IGMd. Determinantes socioeconômicos e ambientais do declínio das hospitalizações por diarréias em lactentes no Rio Grande do Norte - 1992 a 2001 . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2008. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/13139.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Andrade IGMd. Determinantes socioeconômicos e ambientais do declínio das hospitalizações por diarréias em lactentes no Rio Grande do Norte - 1992 a 2001 . [Thesis]. Universidade do Rio Grande do Norte; 2008. Available from: http://repositorio.ufrn.br/handle/123456789/13139

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

16. Nascimento, Eliana Lúcia Tomaz do. Periurbanização da leishmaniose visceral e emergência da coinfecção HIV/leishimania, no Rio Grande do Norte .

Degree: 2009, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/13189

► Visceral leishmaniasis (VL) has undergone changes in terms of clinical and epidemiological presentation worldwide. Urbanization has been described in different regions of Brazil and the… (more)

▼ Visceral leishmaniasis (VL) has undergone changes in terms of clinical and epidemiological presentation worldwide. Urbanization has been described in different regions of Brazil and the world, as well as in the state of Rio Grande do Norte. These changes have impacted in the clinical outcome of Leishmania infection. A new clinical entity called co-infection of HIV/Leishmania has been described as a consequence of overlapping areas of occurrence of VL and HIV / AIDS in different countries including Brazil. The aim of this study was to define the process of periurbanization of the LV and describe a case series of co-infection HIV / Leishmania in Rio Grande do Norte. A new demographic pattern of VL was detected, with an increase in the number VL adult male subjects. Analysis of spatial distribution of VL in the state of Rio Grande do Norte showed that in the past 20 years VL tends to occur in larger cities and therefore the highest risk disease is greater in the eastern and western regions. The first region included Natal, the state capital, where the process of suburbanization began in 1990, and more recently the city of Mossoró, the second largest state, where periurbanization began in the last five years. In 1990, the emergence of co-infection HIV/Leishmania in the state was observed. Case-control study revealed that the new clinical entity affects adult males, who acquired HIV through sexual intercourse, 40% of those with a preivous history of leishmania infection Relapse and death from LV is increased in HIV positive compared with HIV-negative patients matched by sex and age. This pattern is similar to the observed in Europe, except of the route of transmission, where in Europe occured concomitantly, by parenteral route in drug users. Analysis of spatial distribution identified overlapping new areas of occurrence of HIV / AIDS and LV potentially signaling to increased risk of this new clinical entity as described above. Therefore, epidemiological surveillance for co-infection HIV / Leishmania should be adopted in all areas of risk of VL. At the same time, it is necessary to evaluate drug resistance currently used in the treatment of VL, as well as parenteral transmission of L infantum/ chagasi in areas where drug dependence is a risk factor for HIV acquisition Advisors/Committee Members: Jerônimo, Selma Maria Bezerra (advisor), CPF:15603016434 (advisor), do%3Fid%3DK4785584A3%26dataRevisao%3Dnull%22%29&pagesize-30">http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785584A3&dataRevisao=null (advisor).

Subjects/Keywords: Calazar (Leishimaniose visceral); Leishmania chagasi; Periurbanização; Infecção subclínica; Co-infecção-HIV/Leishmania

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nascimento, E. L. T. d. (2009). Periurbanização da leishmaniose visceral e emergência da coinfecção HIV/leishimania, no Rio Grande do Norte . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/13189

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nascimento, Eliana Lúcia Tomaz do. “Periurbanização da leishmaniose visceral e emergência da coinfecção HIV/leishimania, no Rio Grande do Norte .” 2009. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/13189.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nascimento, Eliana Lúcia Tomaz do. “Periurbanização da leishmaniose visceral e emergência da coinfecção HIV/leishimania, no Rio Grande do Norte .” 2009. Web. 10 Apr 2021.

Vancouver:

Nascimento ELTd. Periurbanização da leishmaniose visceral e emergência da coinfecção HIV/leishimania, no Rio Grande do Norte . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2009. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/13189.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nascimento ELTd. Periurbanização da leishmaniose visceral e emergência da coinfecção HIV/leishimania, no Rio Grande do Norte . [Thesis]. Universidade do Rio Grande do Norte; 2009. Available from: http://repositorio.ufrn.br/handle/123456789/13189

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

17. Queiroz, José Wilton de. Sistemas de informação geográfica e análise espacial de dados como ferramentas para determinação de agregação espacial de doenças: a hanseníase como modelo .

Degree: 2009, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/13192

► This work demonstrates the importance of using tools used in geographic information systems (GIS) and spatial data analysis (SDA) for the study of infectious diseases.… (more)

Subjects/Keywords: Hanseníase; Análise espacial; Sistema de informação geográfica; Área de risco; Agregação espacial; Spatial analysis of data; Infectious diseases; Spatial aggregation; Risk area

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Queiroz, J. W. d. (2009). Sistemas de informação geográfica e análise espacial de dados como ferramentas para determinação de agregação espacial de doenças: a hanseníase como modelo . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/13192

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Queiroz, José Wilton de. “Sistemas de informação geográfica e análise espacial de dados como ferramentas para determinação de agregação espacial de doenças: a hanseníase como modelo .” 2009. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/13192.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Queiroz, José Wilton de. “Sistemas de informação geográfica e análise espacial de dados como ferramentas para determinação de agregação espacial de doenças: a hanseníase como modelo .” 2009. Web. 10 Apr 2021.

Vancouver:

Queiroz JWd. Sistemas de informação geográfica e análise espacial de dados como ferramentas para determinação de agregação espacial de doenças: a hanseníase como modelo . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2009. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/13192.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Queiroz JWd. Sistemas de informação geográfica e análise espacial de dados como ferramentas para determinação de agregação espacial de doenças: a hanseníase como modelo . [Thesis]. Universidade do Rio Grande do Norte; 2009. Available from: http://repositorio.ufrn.br/handle/123456789/13192

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

18. Maciel, Bruna Leal Lima. Associação entre fatores nutricionais e a resposta frente à infecção por Leishmania chagasi .

Degree: 2008, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/13207

► Leishmania chagasi infection presents a wide spectrum of clinical outcomes, ranging from asymptomatic self resolving infection to disease, visceral leishmaniasis (VL). The exact mechanisms that… (more)

▼ Leishmania chagasi infection presents a wide spectrum of clinical outcomes, ranging from asymptomatic self resolving infection to disease, visceral leishmaniasis (VL). The exact mechanisms that lead the evolution of infection to disease are not understood. It is believed that malnutrition is a risk factor associated with VL development, although there are few human studies in the area. We aimed to assess the nutritional factors associated with the response to L. chagasi infection in Rio Grande do Norte. The study was conducted from December 2006 to January 2008. 149 children were assessed: 20 active VL cases, 33 children with VL history, 40 DTH+ asymptomatic children and 56 DTH-. Nutritional status was assessed using z scores for Weight/Age, Weight/Height, Height/Age, Body Mass Index (BMI), and mid-upper arm circumference/height (MUAC/height). Vitamin A status was determined by serum retinol concentrations and the modified-relative-dose-esponse test (MRDR). Breastfeeding time and birth weight were also evaluated. VL children presented compromised nutritional status when compared to the other groups using BMI and MUAC/age, with means -1,53 ± 1,10 and -1,48 ± 1,28 z scores, respectively (ANOVA, p < 0,05). VL children also showed lower vitamin A levels: 43% presented serum retinol < 20 µg/dL and 15% MRDR > 0,060. Birth weight was inverserly associated with the risk to belong the VL group (β = -0,00; OR = 0,84; 95% CI 0,73 - 0,99; p = 0,047), whereas more breastfeeding time was directly associated with the risk to belong to the DTH+ group (β = 0,02; OD = 1,16; 95% CI 1,01 - 1,33; p = 0,036). The nutritional variables evaluated were associated with the response to the L. chagasi infection, with malnutrition and compromised vitamin A status as markers of children who present with VL. Higher birth weight was associated with protection to disease, and higher breastfeeding time was associated with increased likelihood of an asymptomatic infection. The results show that modifiable nutritional aspects in the study population are associated with the response to the L. chagasi infection Advisors/Committee Members: Jerônimo, Selma Maria Bezerra (advisor), CPF:15603016434 (advisor), do%3Fid%3DK4785584A3%26dataRevisao%3Dnull%22%29&pagesize-30">http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785584A3&dataRevisao=null (advisor).

Subjects/Keywords: Leishmaniose visceral; Estado nutricional; Vitamina A

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maciel, B. L. L. (2008). Associação entre fatores nutricionais e a resposta frente à infecção por Leishmania chagasi . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/13207

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Maciel, Bruna Leal Lima. “Associação entre fatores nutricionais e a resposta frente à infecção por Leishmania chagasi .” 2008. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/13207.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Maciel, Bruna Leal Lima. “Associação entre fatores nutricionais e a resposta frente à infecção por Leishmania chagasi .” 2008. Web. 10 Apr 2021.

Vancouver:

Maciel BLL. Associação entre fatores nutricionais e a resposta frente à infecção por Leishmania chagasi . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2008. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/13207.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Maciel BLL. Associação entre fatores nutricionais e a resposta frente à infecção por Leishmania chagasi . [Thesis]. Universidade do Rio Grande do Norte; 2008. Available from: http://repositorio.ufrn.br/handle/123456789/13207

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

19. Pereira, Flavio Venício Marinho. Fatores de risco individuais e familiares no desenvolvimento da pré-eclâmpia .

Degree: 2010, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/13220

► Preeclampsia is a spectral disease, with different clinical forms which can evolve with severe multisystemic complications. This present study aimed to determine the risk factors… (more)

▼ Preeclampsia is a spectral disease, with different clinical forms which can evolve with severe multisystemic complications. This present study aimed to determine the risk factors associated with preeclampsia (PE); to validate the existence of aggregation of hypertensive disease in families of women with preeclampsia and verify the existence of association between polymorphisms in the VEGF gene and level of VEGF and its soluble receptor (sFlt1). A case-control study was performed (n = 851). Genotyping of VEGF was performed and serum levels of VEGF and sFlt1 were measured by ELISA. It was observed that 38% of mothers (173, 455) of a case of preeclampsia and 30.8% (78 of 361) of controls had history of hypertension (p <0.0001). Similarly, when examining the history of maternal preeclampsia, we observed that 14.6% (48 of 328) of mothers of women with preeclampsia and 9.6% (12 of 294) of mothers of controls had a history of preeclampsia (p = 0.0001). As for maternal history of preeclampsia, we found that 5.1% (15 of 295) of cases and 3.6% (7 of 314) of controls had a history of preeclampsia (p = 0.0568). Sisters of women with preeclampsia also had a history of hypertensive disease in 9% (41 of 455) versus 6.6% (13 of 361), p = 0.002. Similarly when examining the history of preeclampsia in sisters, it was observed that 22.7% (57 of 251) of a sister of case versus 11.4% (26 of 228) of controls had a history of preeclampsia (P = 0.0011). We observed a decrease in free VEGF in the serum of patients (P <0.05) and increased soluble VEGF receptor. There was no association between polymorphisms in the VEGF gene and preeclampsia. The data obtained in this work validate that hypertensive disease in mothers and sisters with preeclampsia are risk factors for preeclampsia. The risk of illness in the family is higher according to disease severity. High incidence of preeclampsia can be assumed by the high incidence of this disease among the controls. Significant differences between the frequency of preeclampsia in mothers of cases and controls indicate familial factors. Work is being conducted with the to eventually perform genome wide association studies to identify susceptibility loci Advisors/Committee Members: Jerônimo, Selma Maria Bezerra (advisor), CPF:15603016434 (advisor), do%3Fid%3DK4785584A3%26dataRevisao%3Dnull%22%29&pagesize-30">http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785584A3&dataRevisao=null (advisor).

Subjects/Keywords: Pre-eclâmpsia; Eclâmpsia; Síndrome HELLP; Fatores de risco

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pereira, F. V. M. (2010). Fatores de risco individuais e familiares no desenvolvimento da pré-eclâmpia . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/13220

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pereira, Flavio Venício Marinho. “Fatores de risco individuais e familiares no desenvolvimento da pré-eclâmpia .” 2010. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/13220.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pereira, Flavio Venício Marinho. “Fatores de risco individuais e familiares no desenvolvimento da pré-eclâmpia .” 2010. Web. 10 Apr 2021.

Vancouver:

Pereira FVM. Fatores de risco individuais e familiares no desenvolvimento da pré-eclâmpia . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2010. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/13220.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pereira FVM. Fatores de risco individuais e familiares no desenvolvimento da pré-eclâmpia . [Thesis]. Universidade do Rio Grande do Norte; 2010. Available from: http://repositorio.ufrn.br/handle/123456789/13220

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

20. Lacerda, Hênio Godeiro. Determinantes envolvidos na resposta imune celular humana à infecção por Leishmania infantum chagasi .

Degree: 2011, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/13247

► Visceral leishmaniasis (VL) is a disease caused by protozoa of the Leishmania donovani complex, whose infection has clinical spectrum ranging from asymptomatic infection to active… (more)

▼ Visceral leishmaniasis (VL) is a disease caused by protozoa of the Leishmania donovani complex, whose infection has clinical spectrum ranging from asymptomatic infection to active disease characterized by fever, cachexia, hepatosplenomegaly, and immunosuppression. The healing or protective immunity require an antigen-specific type 1. The Montenegro skin test (DTH) has been interpreted as a marker of protective immunity. However, there is no known correlation between the DTH response to type 1 and DTH and immunity of type 1 are maintained in the long term. Thus, a longitudinal study of 8 years, nested in a cohort family held in Brazil, documented the status of DTH and cytokine production by peripheral blood mononuclear cells in response to antigen-specific stimulation. This study was the interdisciplinary approach of physicians, biochemists, nutritionists, veterinary medicine, biology and statistics. The results show that 46.2% of subjects were analyzed DTH positive at baseline. The prevalence of positive and DTH induration size increased with age (p = 0.0021). 15.7% of individuals positive DTH "retro-converted" the negative and 50.4% (64) of individuals negative DTH became positive. The size of DTH induration was correlated significantly with the antigen-induced production of IFN-γ (r = 0.6186, p = 0.0001). IL-6 was secreted at higher levels in peripheral blood mononuclear cells of individuals who "retro-converted" DTH positive to negative than individuals who remained stable DTH status (p = 0.005). Thus, IFN-γ produced by peripheral blood mononuclear cells, may be a surrogate marker for protective immunity instead of the DTH response. In addition, differences in innate immune response may determine whether individuals maintain or eliminate the infection by Leishmania infantum chagasi in asymptomatic patients Advisors/Committee Members: Jerônimo, Selma Maria Bezerra (advisor), CPF:15603016434 (advisor), do%3Fid%3DK4785584A3%26dataRevisao%3Dnull%22%29&pagesize-30">http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785584A3&dataRevisao=null (advisor).

Subjects/Keywords: leishmaniose visceral; imunidade protetor; infecção assintomática; Visceral leishmaniasis; protective immunity; asymptomatic infection

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lacerda, H. G. (2011). Determinantes envolvidos na resposta imune celular humana à infecção por Leishmania infantum chagasi . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/13247

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lacerda, Hênio Godeiro. “Determinantes envolvidos na resposta imune celular humana à infecção por Leishmania infantum chagasi .” 2011. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/13247.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lacerda, Hênio Godeiro. “Determinantes envolvidos na resposta imune celular humana à infecção por Leishmania infantum chagasi .” 2011. Web. 10 Apr 2021.

Vancouver:

Lacerda HG. Determinantes envolvidos na resposta imune celular humana à infecção por Leishmania infantum chagasi . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2011. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/13247.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lacerda HG. Determinantes envolvidos na resposta imune celular humana à infecção por Leishmania infantum chagasi . [Thesis]. Universidade do Rio Grande do Norte; 2011. Available from: http://repositorio.ufrn.br/handle/123456789/13247

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

21. Lima, Iraci Duarte de. Aspectos ambientais e sociais envolvidos na transmissão da L. chagasi no município de Parnamirim/RN .

Degree: 2009, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/13274

► Visceral leishmaniasis hás adapted in the past 20 years to periurban and urban areas, and in Natal, Rio Grande do Norte, it became endemic. Thid… (more)

▼ Visceral leishmaniasis hás adapted in the past 20 years to periurban and urban areas, and in Natal, Rio Grande do Norte, it became endemic. Thid study aimed to evaluate the environmental and social aspectsof Leishmania chagasi infection and its epidemiologic transmission chain in an urban, periurban and rural area of Parnamirim-RN. A study with three sections was conducted: Section 1: Sectional study of the human and canine infection by L. chagasi and its environmental and social determinants. Section 2: Observational longitudinal cohort to evaluate the dynamics of the canine infection. Section 3: Longitudinal study to evaluate the behavior of Lu. Longipalpis vector and the seasonal factors related to its dynamics. To include in the study the hauses were randomly selected and georreferenciated. Montenegro skin test was done in the human population and blood samples were collected for anti-Leishmania antibody detection. The canine population was examinated for L. chagasi infection by RIFI, ELISA and ELISA for rK39. An entomologic surveillance was monthly done with CDC light trapsin 10 houses of each locality. Quantitative and qualitative analyses was done using STATISC 6.0. Probality and prediction maps were done using ArcGis 9.0 model. In the human population L. chagasi infection was associated with the area of the hause, age, sex, population densyti, vegetation, kind of the floor of thr hause, water and resides destiny. In the canine population L. chagasi infection was associated with the breed, size, time of living in the hause, presence of dogs in the neighborhood, presence of horses and donkeys in the neighborhood, vegetation, kind of the floor and walls of the hause. The human infection was associated with canine infction only when analyzed taking into account the locality. In the prospective study, serum conversion and antibody lost observed in 30,8% and 22% of the animals examined, respectively. The human infection rate by L. chagasi was 24,6%, by the presence of anti-Leishmania antibody and 38,6% by the Montenegro skin test. The canine infection rate 32,5% by the presence of anti-Leishmania antibody. The vector Lu longipalpis showed an atypical behavior. These results indicate that environmental and social factors are important variables associated with L. chagasi infection in humans and canines, with punctual association of thr last two. Control measures of the infection on the studied points are necessary, in the aim to reduce the endemic focus of the disease in the study area. This research was carried out in a multidisciplinary involving the categories of: doctor, biologist, veterinarian, statistical, pharmaceutical and biochemical Advisors/Committee Members: Jerônimo, Selma Maria Bezerra (advisor), CPF:15603016434 (advisor), do%3Fid%3DK4785584A3%26dataRevisao%3Dnull%22%29&pagesize-30">http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785584A3&dataRevisao=null (advisor).

Subjects/Keywords: Leishmania chagasi; Leishmaniose; DTH; Leishmaniose visceral canina; Anticorpo; Lu; longipalpis; Leishmania chagasi; Leishmaniasis; DTH; Antibody; Canine visceral leishmaniasis; Lu; longipalpis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lima, I. D. d. (2009). Aspectos ambientais e sociais envolvidos na transmissão da L. chagasi no município de Parnamirim/RN . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/13274

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lima, Iraci Duarte de. “Aspectos ambientais e sociais envolvidos na transmissão da L. chagasi no município de Parnamirim/RN .” 2009. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/13274.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lima, Iraci Duarte de. “Aspectos ambientais e sociais envolvidos na transmissão da L. chagasi no município de Parnamirim/RN .” 2009. Web. 10 Apr 2021.

Vancouver:

Lima IDd. Aspectos ambientais e sociais envolvidos na transmissão da L. chagasi no município de Parnamirim/RN . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2009. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/13274.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lima IDd. Aspectos ambientais e sociais envolvidos na transmissão da L. chagasi no município de Parnamirim/RN . [Thesis]. Universidade do Rio Grande do Norte; 2009. Available from: http://repositorio.ufrn.br/handle/123456789/13274

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

22. Maciel, Bruna Leal Lima. Estado nutricional e efeito da vitamina A na resposta imune frente à infecção por Leishmania Infantum .

Degree: 2013, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/12575

► Nutritional status is an important determinant to the response against Leishmania infection, although few studies have characterized the molecular basis for the association found between… (more)

▼ Nutritional status is an important determinant to the response against Leishmania infection, although few studies have characterized the molecular basis for the association found between malnutrition and the disease. Vitamin A supplementation has long been used in developing countries to prevent mortality by diarrheal and respiratory diseases, but there are no studies on the role of vitamin A in Leishmania infection, although we and others have found vitamin A deficiency in visceral Leishmaniasis (VL). Regulatory T cells are induced in vitro by vitamin A metabolites and are considered important cells implicated T CD4+ cell suppression in human VL. This work aimed to examine the correlation of nutritional status and the effect of vitamin A in the response against Leishmania infantum infection. A total of 179 children were studied: 31 had active VL, 33 VL history, 44 were DTH+ and 71 were DTH- and had negative antibody to Leishmania (DTH-/Ac-). Peripheral blood monuclear cells were isolated in a subgroup of 10 active VL and 16 DTH-/Ac- children and cultivated for 20h under 5 different conditions: 1) Medium, 2) Soluble promastigote L. infantum antigens (SLA), 3) All-trans retinoic acid (ATRA), 4) SLA + ATRA and 5) Concanavalin A. T CD4+CD25highFoxp3+, T CD4+CD25-Foxp3- and CD14+ monocytes were stained and studied by flow cytometry for IL-10, TGF-β and IL-17 production. Nutritional status was compromised in VL children, which presented lower BMI/Age and retinol concentrations when compared to healthy controls. We found a negative correlation between nutritional status (measured by BMI/Age and serum retinol) and anti-Leishmania antibodies and acute phase proteins. There was no correlation between nutritional status and parasite load. ATRA presented a dual effect in Treg cells and monocytes: In healthy children (DTH-/Ac-), it induced a regulatory response, increasing IL-10 and TGF-β production; in VL children it modulated the immune response, preventing increased IL-10 production after SLA stimulation. Furthermore, we found a positive correlation between BMI/Age and IL-17 production and negative correlation between serum retinol and IL-10 and TGF-β production in T CD4+CD25highFoxp3+ cells after SLA stimulus. Our results show a potential dual role of vitamin A in the immune system: improvement of regulatory profile during homeostasis and down modulation of IL-10 in Treg cells and monocytes during symptomatic VL. Therefore, the use of vitamin A concomitant to VL therapy might improve recovery from disease status in Leishmania infantum infection Advisors/Committee Members: Jerônimo, Selma Maria Bezerra (advisor), CPF:15603016434 (advisor), do%3Fid%3DK4785584A3%26dataRevisao%3Dnull%22%29&pagesize-30">http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785584A3&dataRevisao=null (advisor).

Subjects/Keywords: Leishmaniose visceral. Ácido all-trans retinóico. IL-10; Visceral leishmaniasis. All-trans retinoic acid. IL-10

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maciel, B. L. L. (2013). Estado nutricional e efeito da vitamina A na resposta imune frente à infecção por Leishmania Infantum . (Doctoral Dissertation). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/12575

Chicago Manual of Style (16^th Edition):

Maciel, Bruna Leal Lima. “Estado nutricional e efeito da vitamina A na resposta imune frente à infecção por Leishmania Infantum .” 2013. Doctoral Dissertation, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/12575.

MLA Handbook (7^th Edition):

Maciel, Bruna Leal Lima. “Estado nutricional e efeito da vitamina A na resposta imune frente à infecção por Leishmania Infantum .” 2013. Web. 10 Apr 2021.

Vancouver:

Maciel BLL. Estado nutricional e efeito da vitamina A na resposta imune frente à infecção por Leishmania Infantum . [Internet] [Doctoral dissertation]. Universidade do Rio Grande do Norte; 2013. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/12575.

Council of Science Editors:

Maciel BLL. Estado nutricional e efeito da vitamina A na resposta imune frente à infecção por Leishmania Infantum . [Doctoral Dissertation]. Universidade do Rio Grande do Norte; 2013. Available from: http://repositorio.ufrn.br/handle/123456789/12575

Universidade do Rio Grande do Norte

23. Gomes, Carlos Eduardo Maia. Fatores genéticos e étnicos relacionados à evolução da infecção por Leishmania infantum .

Degree: 2012, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/13243

Subjects/Keywords: Leishmania; Leishmaniose visceral; Etnia; Varredura de genoma; Análise de associação.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gomes, C. E. M. (2012). Fatores genéticos e étnicos relacionados à evolução da infecção por Leishmania infantum . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/13243

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gomes, Carlos Eduardo Maia. “Fatores genéticos e étnicos relacionados à evolução da infecção por Leishmania infantum .” 2012. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/13243.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gomes, Carlos Eduardo Maia. “Fatores genéticos e étnicos relacionados à evolução da infecção por Leishmania infantum .” 2012. Web. 10 Apr 2021.

Vancouver:

Gomes CEM. Fatores genéticos e étnicos relacionados à evolução da infecção por Leishmania infantum . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2012. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/13243.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gomes CEM. Fatores genéticos e étnicos relacionados à evolução da infecção por Leishmania infantum . [Thesis]. Universidade do Rio Grande do Norte; 2012. Available from: http://repositorio.ufrn.br/handle/123456789/13243

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

24. Amaral, Cleia Teixeira do. Efeitos da deficiência de vitamina A na função pulmonar de crianças após infecção respiratória viral .

Degree: 2011, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/13371

Subjects/Keywords: Deficiência de vitamina A; MRDR; Função pulmonar; Sibilância; Resistência respiratória

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Amaral, C. T. d. (2011). Efeitos da deficiência de vitamina A na função pulmonar de crianças após infecção respiratória viral . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/13371

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Amaral, Cleia Teixeira do. “Efeitos da deficiência de vitamina A na função pulmonar de crianças após infecção respiratória viral .” 2011. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/13371.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Amaral, Cleia Teixeira do. “Efeitos da deficiência de vitamina A na função pulmonar de crianças após infecção respiratória viral .” 2011. Web. 10 Apr 2021.

Vancouver:

Amaral CTd. Efeitos da deficiência de vitamina A na função pulmonar de crianças após infecção respiratória viral . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2011. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/13371.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Amaral CTd. Efeitos da deficiência de vitamina A na função pulmonar de crianças após infecção respiratória viral . [Thesis]. Universidade do Rio Grande do Norte; 2011. Available from: http://repositorio.ufrn.br/handle/123456789/13371

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

25. Lima, Josane Regina de. Influência do vírus da hepatite G (GBV-C) na resposta imune frente à infecção por Leishmania chagasi .

Degree: 2001, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/12519

► GB virus type C (GBV-C) appears to promote a Th1 response and is associated with prolonged survival in HIV-infected people. L. chagasi causes a spectrum… (more)

Subjects/Keywords: Hepatite G; Leishmania chagasi; Leishmania chagasi

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lima, J. R. d. (2001). Influência do vírus da hepatite G (GBV-C) na resposta imune frente à infecção por Leishmania chagasi . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/12519

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lima, Josane Regina de. “Influência do vírus da hepatite G (GBV-C) na resposta imune frente à infecção por Leishmania chagasi .” 2001. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/12519.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lima, Josane Regina de. “Influência do vírus da hepatite G (GBV-C) na resposta imune frente à infecção por Leishmania chagasi .” 2001. Web. 10 Apr 2021.

Vancouver:

Lima JRd. Influência do vírus da hepatite G (GBV-C) na resposta imune frente à infecção por Leishmania chagasi . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2001. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/12519.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lima JRd. Influência do vírus da hepatite G (GBV-C) na resposta imune frente à infecção por Leishmania chagasi . [Thesis]. Universidade do Rio Grande do Norte; 2001. Available from: http://repositorio.ufrn.br/handle/123456789/12519

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

26. Araújo, Sérgio Ricardo Fernandes de. Polimorfismos nos genes ERBB2 e PARK2/PACRG e sua associação com a hanseníase em populações do Rio Grande do Norte e Pará .

Degree: 2013, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/12577

Subjects/Keywords: Rio Grande do Norte. Hanseníase. Genotipagem. Susceptibilidade. Patogênese. M. leprae; Rio Grande do Norte. Leprosy. Susceptibility. Pathogenesis. M. leprae

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Araújo, S. R. F. d. (2013). Polimorfismos nos genes ERBB2 e PARK2/PACRG e sua associação com a hanseníase em populações do Rio Grande do Norte e Pará . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/12577

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Araújo, Sérgio Ricardo Fernandes de. “Polimorfismos nos genes ERBB2 e PARK2/PACRG e sua associação com a hanseníase em populações do Rio Grande do Norte e Pará .” 2013. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/12577.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Araújo, Sérgio Ricardo Fernandes de. “Polimorfismos nos genes ERBB2 e PARK2/PACRG e sua associação com a hanseníase em populações do Rio Grande do Norte e Pará .” 2013. Web. 10 Apr 2021.

Vancouver:

Araújo SRFd. Polimorfismos nos genes ERBB2 e PARK2/PACRG e sua associação com a hanseníase em populações do Rio Grande do Norte e Pará . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2013. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/12577.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Araújo SRFd. Polimorfismos nos genes ERBB2 e PARK2/PACRG e sua associação com a hanseníase em populações do Rio Grande do Norte e Pará . [Thesis]. Universidade do Rio Grande do Norte; 2013. Available from: http://repositorio.ufrn.br/handle/123456789/12577

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

27. Costa, Magda Fabiana Dantas da. Co-infecção pelo vírus da hepatite G em pacientes infectados pelo Leihsmania chagasi .

Degree: 2005, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/12605

Subjects/Keywords: Leishmaniose visceral; GBV-C; HIV; Co-infecção

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Costa, M. F. D. d. (2005). Co-infecção pelo vírus da hepatite G em pacientes infectados pelo Leihsmania chagasi . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/12605

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Costa, Magda Fabiana Dantas da. “Co-infecção pelo vírus da hepatite G em pacientes infectados pelo Leihsmania chagasi .” 2005. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/12605.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Costa, Magda Fabiana Dantas da. “Co-infecção pelo vírus da hepatite G em pacientes infectados pelo Leihsmania chagasi .” 2005. Web. 10 Apr 2021.

Vancouver:

Costa MFDd. Co-infecção pelo vírus da hepatite G em pacientes infectados pelo Leihsmania chagasi . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2005. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/12605.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Costa MFDd. Co-infecção pelo vírus da hepatite G em pacientes infectados pelo Leihsmania chagasi . [Thesis]. Universidade do Rio Grande do Norte; 2005. Available from: http://repositorio.ufrn.br/handle/123456789/12605

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

28. Monteiro, Glória Regina de Goes. Efetividade da doxiciclina na profilaxia contra letptospirose .

Degree: 2003, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/12622

► Leptospirosis is a worldwide zoonosis of considerable medical and economical importance that affects humans in both urban and rural contexts, as well as domestic animals… (more)

▼ Leptospirosis is a worldwide zoonosis of considerable medical and economical importance that affects humans in both urban and rural contexts, as well as domestic animals and wild fauna. Leptospira interrogans is the causative agent and is transmitted to humans by indirect contact with contaminated soil or water. The clinical syndromes include sub clinical infection, self-limited anicteric febrile illness, and severe and potentially fatal illness, known as Weil´s syndrome. In developed countries, leptospirosis is related to occupational or recreational activities while in developing countries, outbreaks occur during floods. In those regions, traditional strategies to prevent the transmission are difficulties to be implemented because of costs and lack of community acceptance. In addition, no efficient vaccine is available for human use. Several studies have suggested that chemoprophylaxis with doxycycline pre and post-exposure may be effective to prevent leptospirosis. Leptospirosis has been reported in rural areas of the State of Rio Grande do Norte, Brazil since 1985 in rice farmers who present the anicteric illness. The disease cause great social and economics impact. The study was conducted in São Miguel where an epidemic of leptospirosis in rice farmers was reported. The main objective was to determine the efficacy of doxycycline in preventing Leptospira exposure. A taxa de soroprevalência de leptospirose na população estudada antes e após a colheita foi de 14,2% (n=22) e de 16.6% (n=27) respectivamente. Anti-Leptospira serology was determined for 61 subjects in two instances, pre and post-exposure to potential contaminated water. There was an increased risk of 29.0 per cent in acquiring infection for individuals that did not use doxycycline. In addition, an increased risk of 30.0 % observed in farmers who did not use protection when exposed to Leptospira. The adhesion to preventive chemoprophylaxis was 55.7%. Therefore doxycycline, under specific circunstances appears to be an effective alternative to protect against leptosprirosis infection. A large sample composed of individuals to adhere to preventive therapy is needed to define time, dosage and length of use of doxycycline in this area Advisors/Committee Members: Jerônimo, Selma Maria Bezerra (advisor), CPF:15603016434 (advisor), do%3Fid%3DK4785584A3%26dataRevisao%3Dnull%22%29&pagesize-30">http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785584A3&dataRevisao=null (advisor).

Subjects/Keywords: Zoonoses; Efetividade da doxiciclina na profilaxia contra letptospirose; Epidemiologia; Doxiciclina; Profilaxia; Leptospirose; Zoonosis; Effectiveness of the doxiciclina in the Prophylaxis against letptospirose; Epidemiology; Doxycycline; Prophylaxis; Leptospirosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Monteiro, G. R. d. G. (2003). Efetividade da doxiciclina na profilaxia contra letptospirose . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/12622

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Monteiro, Glória Regina de Goes. “Efetividade da doxiciclina na profilaxia contra letptospirose .” 2003. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/12622.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Monteiro, Glória Regina de Goes. “Efetividade da doxiciclina na profilaxia contra letptospirose .” 2003. Web. 10 Apr 2021.

Vancouver:

Monteiro GRdG. Efetividade da doxiciclina na profilaxia contra letptospirose . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2003. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/12622.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Monteiro GRdG. Efetividade da doxiciclina na profilaxia contra letptospirose . [Thesis]. Universidade do Rio Grande do Norte; 2003. Available from: http://repositorio.ufrn.br/handle/123456789/12622

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

29. Salha, Daniella Regina Arantes Martins. Antígenos da forma amastigota de Leishmania chagasi identificados por dupla varredura da biblioteca de cDNA .

Degree: 2006, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/13112

► Control of human visceral leishmaniasis in endemic regions is hampered in part by the lack of knowledge with respect of the role reservoirs and vector.… (more)

▼ Control of human visceral leishmaniasis in endemic regions is hampered in part by the lack of knowledge with respect of the role reservoirs and vector. In addition, there is not yet an understanding of how non-symptomatic subclinical infection might influence the maintenance of infection in a particular locality. Of worrisome is the limited accessibility to medical care in places with emerging drug resistance. There is still no available protective vaccine either for humans or other reservoirs. Leishmania species are protozoa that express multiple antigens which are recognized by the vertebrate immune system. Since there is not one immunodominant epitope recognized by most hosts, strategies must be developed to optimize selection of antigens for prevention and immunodiagnosis. For this reason, we generated a cDNA library from the intracellular amastigote form of Leishmania chagasi, the causative agent of South American visceral leishmaniasis. We employed a two-step expression screen of the library to systematically identify T and T-dependent B cell antigens. The first step was aimed at identifying the largest possible number of clones producing an epitope-containing polypeptide with a pool of sera from Brazilians with documented visceral leishmaniasis. After removal of clones encoding heat shock proteins, positive clones underwent a second step screen for their ability to cause proliferation and IFN-γ responses of T cells from immune mice. Six unique clones were selected from the second screen for further analysis. The clones encoded part of the coding sequence of glutamine synthetase, transitional endoplasmic reticulum ATPase, elongation factor 1γ, kinesin K-39, repetitive protein A2, and a hypothetical conserved protein. Humans naturally infected with L. chagasi mounted both cellular and antibody responses to these protein Preparations containing multiple antigens may be optimal for immunodiagnosis and protective vaccines against Leishmania Advisors/Committee Members: Jerônimo, Selma Maria Bezerra (advisor), CPF:15603016434 (advisor), do%3Fid%3DK4785584A3%26dataRevisao%3Dnull%22%29&pagesize-30">http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785584A3&dataRevisao=null (advisor).

Subjects/Keywords: Leishmaniose Visceral; Leishmania chagasi; Antígeno recombinante; Citocinas; Visceral leishmaniasis; Leishmania chagasi

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Salha, D. R. A. M. (2006). Antígenos da forma amastigota de Leishmania chagasi identificados por dupla varredura da biblioteca de cDNA . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/13112

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Salha, Daniella Regina Arantes Martins. “Antígenos da forma amastigota de Leishmania chagasi identificados por dupla varredura da biblioteca de cDNA .” 2006. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/13112.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Salha, Daniella Regina Arantes Martins. “Antígenos da forma amastigota de Leishmania chagasi identificados por dupla varredura da biblioteca de cDNA .” 2006. Web. 10 Apr 2021.

Vancouver:

Salha DRAM. Antígenos da forma amastigota de Leishmania chagasi identificados por dupla varredura da biblioteca de cDNA . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2006. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/13112.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Salha DRAM. Antígenos da forma amastigota de Leishmania chagasi identificados por dupla varredura da biblioteca de cDNA . [Thesis]. Universidade do Rio Grande do Norte; 2006. Available from: http://repositorio.ufrn.br/handle/123456789/13112

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

30. Queiroz, Paula Viviane de Sousa. Aspectos clínicos e imunológicos da infecção por Leishmania Infantum Chagasi em cães do Rio Grande do Norte / Paula Vivianne Souza de Queiroz. Natal/RN .

Degree: 2011, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/13257

Subjects/Keywords: cães; leishmaniose visceral; subclasses de imunoglobulinas

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Queiroz, P. V. d. S. (2011). Aspectos clínicos e imunológicos da infecção por Leishmania Infantum Chagasi em cães do Rio Grande do Norte / Paula Vivianne Souza de Queiroz. Natal/RN . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/13257

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Queiroz, Paula Viviane de Sousa. “Aspectos clínicos e imunológicos da infecção por Leishmania Infantum Chagasi em cães do Rio Grande do Norte / Paula Vivianne Souza de Queiroz. Natal/RN .” 2011. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/13257.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Queiroz, Paula Viviane de Sousa. “Aspectos clínicos e imunológicos da infecção por Leishmania Infantum Chagasi em cães do Rio Grande do Norte / Paula Vivianne Souza de Queiroz. Natal/RN .” 2011. Web. 10 Apr 2021.

Vancouver:

Queiroz PVdS. Aspectos clínicos e imunológicos da infecção por Leishmania Infantum Chagasi em cães do Rio Grande do Norte / Paula Vivianne Souza de Queiroz. Natal/RN . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2011. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/13257.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Queiroz PVdS. Aspectos clínicos e imunológicos da infecção por Leishmania Infantum Chagasi em cães do Rio Grande do Norte / Paula Vivianne Souza de Queiroz. Natal/RN . [Thesis]. Universidade do Rio Grande do Norte; 2011. Available from: http://repositorio.ufrn.br/handle/123456789/13257

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations