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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Vigani, Aline Gonzalez"). Showing records 1 – 2 of 2 total matches.

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Universidade Estadual de Campinas

1. Miotto, Noelle, 1986-. Antivirais de ação direta no tratamento de pacientes cronicamente infectados pelo vírus da hepatite C : avaliação da interrupção do esquema terapêutico e da resposta virológico sustentada = Treatment of patients chronically infected with hepatitis C virus using direct antiviral agents: evaluation of treatment discontinuation and sustained virological response: Treatment of patients chronically infected with hepatitis C virus using direct antiviral agents : evaluation of treatment discontinuation and sustained virological response.

Degree: 2018, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332297 

Abstract: Hepatitis C virus (HCV) is one of the major causes of liver diseases, including cirrhosis and hepatocellular carcinoma. The main reason to treat HCV infection is to eradicate the virus and prevent complications related to the chronic infection. The first study evaluated the rates of sustained virological response (SVR) , treatment discontinuation (TD) due to adverse events (AE), and severe anemia (hemoglobin >8.5g/dL) in patients with chronic HCV infection treated with triple therapy based on first generation protease inhibitors (PI). We included 203 patients: 132 treated with telaprevir (TVR) and 71 with boceprevir (BOC). TD rate due to AE was 19.2% and anemia was the mains reason (38.5%). Risk factors for TD were higher Charlson's comorbidity Index [(CCI) OR 1.85, CI 1.05-3.25)] for BOC, and higher bilirubin count (OR 1.02, CI 1.01-1.04) and lower body mass index (OR 0.98, CI 0.96-0.99) for TVR. Severe anemia occurred 17.2% of the patients. Risk factors for this outcome were lower estimated glomerular filtration rate (eGFR) (OR 0.95, CI 0.91-0.98) for patients treated with TVR and higher CCI (OR 2.21, CI 1.04-4.67) and higher ribavirin (RBV) dosage (OR 0.84, CI 0.72-0.99) for those patients treated with BOC. SVR rates for patients treated with TVR and BOC were 57.3% and 27.3%, respectively. The second study evaluated the TD rates and its risk factors among patients with advanced liver fibrosis treated with all-oral direct antiviral agents (DAA). We included 214 patients: 180 were treated with sofosbuvir (SOF) + daclatasvir (DCV) ± RBV; 31 received SOF + simeprevir (SMV) ± RBV e 3 had SOF + RBV. TD rate was 8.9% and liver decompensation (42%) was the main reason. Among patients with Child-Pugh B or C cirrhosis (31), 10 (32.2%) prematurely interrupted treatment. Risk factors for TD in univariate analysis were higher age (p=0.0252), higher CCI (p= 0.0078), higher Model for end stage liver disease (MELD) (p<0.0001), higher FIB-4 index (p=0.0122), and lower hemoglobin (p=0.0185) at baseline. Multivariate analysis demonstrated that higher age (OR 1.1, CI 1.02-1.19) and higher MELD (OR 1.27, CI 1.03-1.56) were associated with premature treatment interruption. The third study evaluated SVR rates and its associated factors in patients treated with all-oral DAA. We included 527 patients: 51,6% were cirrhotic, 76,8% were infected with genotype (GT) 1, 20,7% had GT3, and 2,5% had GT2. Most patients used SOF + DCV + RBV (60,7%) or SOF + SMV (25,6%). Global SVR rate by intention-to-treat was 90.5%. SVR rate was higher in patients with GT1 (92.1%), followed by GT2 (84.6%), and GT3 (84.4%). SVR rate was higher in non-cirrhotic (94.2%) compared to cirrhotic patients (87.1%; p=0.0071). Lower CCI was associated with SVR (p=0.0014). Among cirrhotic patients, RVS rate was higher in those with Child-Pugh A (88.7%) compared to Child-Pugh B or C (80%). At baseline, lower MELD (p=0.0258), higher albumin (p=0.0015) and higher eGFR (p=0.0366) were associated with SVR in cirrhotic patients. Based on the first study, we concluded… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Stucchi, Raquel Silveira Bello, 1958- (advisor), Vigani, Aline Gonzalez (coadvisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Clínica Médica (nameofprogram), Ferraz, Maria Lucia Cardoso Gomes (committee member), Peribanez Gonzalez, Mario (committee member), Sevá-Pereira, Tiago (committee member), Mazo, Daniel Ferraz de Campos (committee member).

Subjects/Keywords: Hepatite C crônica; Inibidores de proteases; Anticorpos anti-hepatite C; Resposta viral sustentada; Hepatitis C, Chronic; Protease inhibitors; Hepatitis C antibodies; Sustained virologic response

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Miotto, Noelle, 1. (2018). Antivirais de ação direta no tratamento de pacientes cronicamente infectados pelo vírus da hepatite C : avaliação da interrupção do esquema terapêutico e da resposta virológico sustentada = Treatment of patients chronically infected with hepatitis C virus using direct antiviral agents: evaluation of treatment discontinuation and sustained virological response: Treatment of patients chronically infected with hepatitis C virus using direct antiviral agents : evaluation of treatment discontinuation and sustained virological response. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/332297

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Miotto, Noelle, 1986-. “Antivirais de ação direta no tratamento de pacientes cronicamente infectados pelo vírus da hepatite C : avaliação da interrupção do esquema terapêutico e da resposta virológico sustentada = Treatment of patients chronically infected with hepatitis C virus using direct antiviral agents: evaluation of treatment discontinuation and sustained virological response: Treatment of patients chronically infected with hepatitis C virus using direct antiviral agents : evaluation of treatment discontinuation and sustained virological response.” 2018. Thesis, Universidade Estadual de Campinas. Accessed February 28, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/332297.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Miotto, Noelle, 1986-. “Antivirais de ação direta no tratamento de pacientes cronicamente infectados pelo vírus da hepatite C : avaliação da interrupção do esquema terapêutico e da resposta virológico sustentada = Treatment of patients chronically infected with hepatitis C virus using direct antiviral agents: evaluation of treatment discontinuation and sustained virological response: Treatment of patients chronically infected with hepatitis C virus using direct antiviral agents : evaluation of treatment discontinuation and sustained virological response.” 2018. Web. 28 Feb 2021.

Vancouver:

Miotto, Noelle 1. Antivirais de ação direta no tratamento de pacientes cronicamente infectados pelo vírus da hepatite C : avaliação da interrupção do esquema terapêutico e da resposta virológico sustentada = Treatment of patients chronically infected with hepatitis C virus using direct antiviral agents: evaluation of treatment discontinuation and sustained virological response: Treatment of patients chronically infected with hepatitis C virus using direct antiviral agents : evaluation of treatment discontinuation and sustained virological response. [Internet] [Thesis]. Universidade Estadual de Campinas; 2018. [cited 2021 Feb 28]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332297.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Miotto, Noelle 1. Antivirais de ação direta no tratamento de pacientes cronicamente infectados pelo vírus da hepatite C : avaliação da interrupção do esquema terapêutico e da resposta virológico sustentada = Treatment of patients chronically infected with hepatitis C virus using direct antiviral agents: evaluation of treatment discontinuation and sustained virological response: Treatment of patients chronically infected with hepatitis C virus using direct antiviral agents : evaluation of treatment discontinuation and sustained virological response. [Thesis]. Universidade Estadual de Campinas; 2018. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332297

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Universidade Estadual de Campinas

2. Mendes, Leandro César, 1984-. Performance diagnóstica da elastografia transitória para o estadiamento de fibrose e esteatose em pacientes com hepatite C crônica : Diagnostic performance of transient elastography for fibrosis and steatosis staging in chronic hepatitis C: Diagnostic performance of transient elastography for fibrosis and steatosis staging in chronic hepatitis C.

Degree: 2018, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332467 

Abstract: Vibration controlled transient elastography (VCTE) is one of the most validated noninvasive test modalities for liver fibrosis staging and steatosis grading in chronic hepatitis C (CHC), however, diagnostic performance indicators may have been hampered by an imperfect gold standard. Considerable inter and intraobserver variability may hinder the accuracy for liver biopsy and, therefore, its comparators. Moreover, VCTE results are internally validated solely on the basis of variability and success rate and lack reproducible quality indicators. In this study we aimed to evaluate different aspects regarding diagnostic performance of VCTE and factors associated with accuracy. Adult patients with CHC were prospectively enrolled from an outpatient university hospital viral hepatitis clinic for consecutive liver biopsy and VCTE. Anthropomorphic, clinical and biochemical data were analysed along with technical factors for possible association with accuracy, including elastogram quality. Liver biopsies underwent both conventional histological examination by an experienced hepatopathologist and digital morphometric analysis. Controlled Attenuation Parameter results from VCTE measurements were recorded and studied in comparison with digital morphometric quantification in liver biopsy fragments and for possible association with elastogram quality. In a preliminary analysis, 182 adult patients with a median age of 55 years and median body mass index of 26.71 kg/m2 were analyzed. On conventional histological examination of LB, 56% of patients had significant levels of fibrosis... The abstract is available with the full electronic document Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Stucchi, Raquel Silveira Bello, 1958- (advisor), Vigani, Aline Gonzalez (coadvisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Clínica Médica (nameofprogram), Ferraz, Maria Lucia Cardoso Gomes (committee member), Carvalho Filho, Roberto José de (committee member), Sevá-Pereira, Tiago (committee member), Mazo, Daniel Ferraz de Campos (committee member).

Subjects/Keywords: Hepatite C; Técnicas de imagem por elasticidade; Fibrose; Fígado gorduroso; Diagnóstico; Hepatitis C; Elasticity imaging techniques; Fibrosis; Fatty liver; Diagnosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Mendes, Leandro César, 1. (2018). Performance diagnóstica da elastografia transitória para o estadiamento de fibrose e esteatose em pacientes com hepatite C crônica : Diagnostic performance of transient elastography for fibrosis and steatosis staging in chronic hepatitis C: Diagnostic performance of transient elastography for fibrosis and steatosis staging in chronic hepatitis C. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/332467

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Mendes, Leandro César, 1984-. “Performance diagnóstica da elastografia transitória para o estadiamento de fibrose e esteatose em pacientes com hepatite C crônica : Diagnostic performance of transient elastography for fibrosis and steatosis staging in chronic hepatitis C: Diagnostic performance of transient elastography for fibrosis and steatosis staging in chronic hepatitis C.” 2018. Thesis, Universidade Estadual de Campinas. Accessed February 28, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/332467.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Mendes, Leandro César, 1984-. “Performance diagnóstica da elastografia transitória para o estadiamento de fibrose e esteatose em pacientes com hepatite C crônica : Diagnostic performance of transient elastography for fibrosis and steatosis staging in chronic hepatitis C: Diagnostic performance of transient elastography for fibrosis and steatosis staging in chronic hepatitis C.” 2018. Web. 28 Feb 2021.

Vancouver:

Mendes, Leandro César 1. Performance diagnóstica da elastografia transitória para o estadiamento de fibrose e esteatose em pacientes com hepatite C crônica : Diagnostic performance of transient elastography for fibrosis and steatosis staging in chronic hepatitis C: Diagnostic performance of transient elastography for fibrosis and steatosis staging in chronic hepatitis C. [Internet] [Thesis]. Universidade Estadual de Campinas; 2018. [cited 2021 Feb 28]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332467.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mendes, Leandro César 1. Performance diagnóstica da elastografia transitória para o estadiamento de fibrose e esteatose em pacientes com hepatite C crônica : Diagnostic performance of transient elastography for fibrosis and steatosis staging in chronic hepatitis C: Diagnostic performance of transient elastography for fibrosis and steatosis staging in chronic hepatitis C. [Thesis]. Universidade Estadual de Campinas; 2018. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332467

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.