Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Rogero, Marcelo Macedo"). One record found.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


Universidade Estadual de Campinas

1. Arçari, Demétrius Paiva, 1978-. Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling.

Degree: 2011, Universidade Estadual de Campinas

Abstract: Obesity is a problem of public health, mainly because it is associated with many conditions such especially insulin resistance (IR). Currently, several strategies have been used in order to reduce the total body weight, among these there is a growing evidence supporting the use of products of plant origin, including the Ilex paraguariensis, whose common name is yerba mate. Various studies have shown that the compounds found in yerba mate has several biological functions, such as antioxidant, anti-inflammatory, immunomodulatory, anticancer, modification of cholesterol metabolism and others. Although several studies highlight the biological functions of yerba mate, there are lack of evidence providing their ability to modulate expression of genes related to obesity and its effect on the insulin signaling pathway. Thus, the aim of this study was to evaluate the effects of yerba mate in gene expression that regulate adipogenesis and insulin signaling pathway. Our data showed yerba mate (1,0 g/kg) in animals subjected to high fat diet, increased different gene expression responsible for the activation of the AKT, reduction of FOXO1 and NF-kB nuclear translocation, reduction gene expression of PEPCK and G6Pase involved in gluconeogenesis process in liver. The effects of yerba mate in insulin signaling was confirmed by IRS-1, IRS-2 and AKT protein analysis, reduction in insulin test tolerance by KITT and reduction in glucose. Our data also showed in 3T3-L1 cell culture that yerba mate and some of its major bioactive compounds (chlorogenic acid, rutin and quercetin), act in an early stage of adipocyte differentiation and modulate different gene expression that regulate adipogenesis. Additionally, yerba mate can act in vitro and ex vivo in WNT pathway, seen by the increased expression of different genes in this pathway resulting in a significant repression of C/EBP'alfa' and PPARy2, the most important transcription factors essencial for the occurrence of adipocyte differentiation. This findings collaborate to elucidate the reduction of body weight and epididymal fat observed in animals subjected to high fat diet treated with yerba mate for 60 days, which reduces the production of cytokines, particularly TNF-'alfa', contributing partially to the improvement in insulin signaling observed after intervention Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Ribeiro, Marcelo Lima (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Genética e Biologia Molecular (nameofprogram), Sartorato, Edi Lúcia (committee member), Cintra, Dennys Esper (committee member), Ong, Thomas Prates (committee member), Rogero, Marcelo Macedo (committee member).

Subjects/Keywords: Erva-mate; Adipogenia; Insulina; Obesidade; Yerba de mate; Ilex paraguariensis; Adipogenesis; Insulin; Obesity

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Arçari, Demétrius Paiva, 1. (2011). Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/317039

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Arçari, Demétrius Paiva, 1978-. “Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling.” 2011. Thesis, Universidade Estadual de Campinas. Accessed January 18, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317039.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Arçari, Demétrius Paiva, 1978-. “Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling.” 2011. Web. 18 Jan 2021.

Vancouver:

Arçari, Demétrius Paiva 1. Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling. [Internet] [Thesis]. Universidade Estadual de Campinas; 2011. [cited 2021 Jan 18]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317039.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arçari, Demétrius Paiva 1. Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling. [Thesis]. Universidade Estadual de Campinas; 2011. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317039

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.