+publisher:"Universidade Estadual de Campinas" +contributor:("Ribeiro, Marcelo Lima")

Universidade Estadual de Campinas

1. Arçari, Demétrius Paiva, 1978-. Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling.

Degree: 2011, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317039

► Abstract: Obesity is a problem of public health, mainly because it is associated with many conditions such especially insulin resistance (IR). Currently, several strategies have… (more)

▼ Abstract: Obesity is a problem of public health, mainly because it is associated with many conditions such especially insulin resistance (IR). Currently, several strategies have been used in order to reduce the total body weight, among these there is a growing evidence supporting the use of products of plant origin, including the Ilex paraguariensis, whose common name is yerba mate. Various studies have shown that the compounds found in yerba mate has several biological functions, such as antioxidant, anti-inflammatory, immunomodulatory, anticancer, modification of cholesterol metabolism and others. Although several studies highlight the biological functions of yerba mate, there are lack of evidence providing their ability to modulate expression of genes related to obesity and its effect on the insulin signaling pathway. Thus, the aim of this study was to evaluate the effects of yerba mate in gene expression that regulate adipogenesis and insulin signaling pathway. Our data showed yerba mate (1,0 g/kg) in animals subjected to high fat diet, increased different gene expression responsible for the activation of the AKT, reduction of FOXO1 and NF-kB nuclear translocation, reduction gene expression of PEPCK and G6Pase involved in gluconeogenesis process in liver. The effects of yerba mate in insulin signaling was confirmed by IRS-1, IRS-2 and AKT protein analysis, reduction in insulin test tolerance by KITT and reduction in glucose. Our data also showed in 3T3-L1 cell culture that yerba mate and some of its major bioactive compounds (chlorogenic acid, rutin and quercetin), act in an early stage of adipocyte differentiation and modulate different gene expression that regulate adipogenesis. Additionally, yerba mate can act in vitro and ex vivo in WNT pathway, seen by the increased expression of different genes in this pathway resulting in a significant repression of C/EBP'alfa' and PPARy2, the most important transcription factors essencial for the occurrence of adipocyte differentiation. This findings collaborate to elucidate the reduction of body weight and epididymal fat observed in animals subjected to high fat diet treated with yerba mate for 60 days, which reduces the production of cytokines, particularly TNF-'alfa', contributing partially to the improvement in insulin signaling observed after intervention Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Ribeiro, Marcelo Lima (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Genética e Biologia Molecular (nameofprogram), Sartorato, Edi Lúcia (committee member), Cintra, Dennys Esper (committee member), Ong, Thomas Prates (committee member), Rogero, Marcelo Macedo (committee member).

Subjects/Keywords: Erva-mate; Adipogenia; Insulina; Obesidade; Yerba de mate; Ilex paraguariensis; Adipogenesis; Insulin; Obesity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Arçari, Demétrius Paiva, 1. (2011). Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/317039

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arçari, Demétrius Paiva, 1978-. “Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling.” 2011. Thesis, Universidade Estadual de Campinas. Accessed March 07, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317039.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arçari, Demétrius Paiva, 1978-. “Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling.” 2011. Web. 07 Mar 2021.

Vancouver:

Arçari, Demétrius Paiva 1. Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling. [Internet] [Thesis]. Universidade Estadual de Campinas; 2011. [cited 2021 Mar 07]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317039.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arçari, Demétrius Paiva 1. Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling. [Thesis]. Universidade Estadual de Campinas; 2011. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317039

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

2. Santos, Juliana Carvalho, 1987-. Determinação do perfil epigenético relacionado aos sistemas de reparo ao DNA influenciados pela infecção por "Helicobacter pylori" = Evaluation of epigenetic profile associated with DNA repair systems induced by "Helicobacter pylori": Evaluation of epigenetic profile associated with DNA repair systems induced by "Helicobacter pylori".

Degree: 2016, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317037

► Abstract: Although thousands of DNA damaging events occur in each cell every day, efficient DNA repair pathways have evolved to counteract them. The DNA repair… (more)

▼ Abstract: Although thousands of DNA damaging events occur in each cell every day, efficient DNA repair pathways have evolved to counteract them. The DNA repair machinery plays a key role in maintaining genomic stability by avoiding the maintenance of mutations. The DNA repair enzymes continuously monitor the DNA to correct any damage that is caused by exogenous and endogenous mutagens. In addition to mutations, which can be either inherited or somatically acquired, epigenetic changes in DNA repair genes has been associated with carcinogenesis. Gastric cancer (GC) represents the second highest cause of cancer mortality worldwide. The disease develops from the accumulation of several genetic and epigenetic changes during the lifetime. Among the risk factors, "Helicobacter pylori" ("H. pylori") infection is considered the main driving factor to gastric cancer development. This bacteria induces the loss of key features of epithelial differentiation, the transition to a mesenchymal phenotype, endorses the transformation of gastric stem cells and therefore tumor formation. These cells with self-renewal properties (called cancer stem cells, CSCs) are also resistant to GC therapy and subsequently responsible for tumor recurrence and metastasis. Therefore, the determination of the mechanisms of CSCs regulation and maintenance are essential for understanding the pathobiology of GC. Thus, the current study analyzed the role of "H. pylori" infection on the epigenetic regulation of DSB and BER DNA repair systems in epithelial and CSCs. In this work we have identified that H. pylori infection stimulates key features of the development of cancer, such as cell proliferation, nuclear translocation of 'beta'-catenin, DNA damage and consequent induction of DNA repair genes response in a virulence factors dependent manner. In addition, it was determined that the induction of DNA repair is mediated by H3 and H4 hyperacetylation and hypomethylation of promoter region of certain genes. it was determined that SOX9 is essential for maintenance of CSCs and stimulate gastric key processes such as tumor cell proliferation, nuclear translocation 'beta'-catenin, chemoresistance, decreased apoptosis and senescence. In addition, we found a regulatory interaction loop between SOX9 and 'beta'-catenin. Interestingly, it was demonstrated that SOX9 is induced in response to "H. pylori" both in gastric epithelial cells as CSCs. Finally, it was observed that CSCs are regulated by ATM and there is an ATM increase in CSCs in response to H. pylori. From these results, we concluded that the DNA repair induction occurs in response to "H. pylori" to prevent or reduce chromosome aberrations. Our findings provide novel epigenetic mechanism associated to DNA damage caused by "H. pylori" infection Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Ribeiro, Marcelo Lima (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Genética e Biologia Molecular (nameofprogram), Burbano, Rommel Mario Rodríguez (committee member), Salvadori, Daisy Maria (committee member), Derchain, Sophie Françoise Mauricette (committee member), Carvalheira, José Barreto (committee member).

Subjects/Keywords: Helicobacter pylori; Reparo do DNA; Epigenética; Neoplasias gástricas; Helicobacter pylori; DNA repair; Epigenetics; Stomach neoplasms

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Santos, Juliana Carvalho, 1. (2016). Determinação do perfil epigenético relacionado aos sistemas de reparo ao DNA influenciados pela infecção por "Helicobacter pylori" = Evaluation of epigenetic profile associated with DNA repair systems induced by "Helicobacter pylori": Evaluation of epigenetic profile associated with DNA repair systems induced by "Helicobacter pylori". (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/317037

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Santos, Juliana Carvalho, 1987-. “Determinação do perfil epigenético relacionado aos sistemas de reparo ao DNA influenciados pela infecção por "Helicobacter pylori" = Evaluation of epigenetic profile associated with DNA repair systems induced by "Helicobacter pylori": Evaluation of epigenetic profile associated with DNA repair systems induced by "Helicobacter pylori".” 2016. Thesis, Universidade Estadual de Campinas. Accessed March 07, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317037.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Santos, Juliana Carvalho, 1987-. “Determinação do perfil epigenético relacionado aos sistemas de reparo ao DNA influenciados pela infecção por "Helicobacter pylori" = Evaluation of epigenetic profile associated with DNA repair systems induced by "Helicobacter pylori": Evaluation of epigenetic profile associated with DNA repair systems induced by "Helicobacter pylori".” 2016. Web. 07 Mar 2021.

Vancouver:

Santos, Juliana Carvalho 1. Determinação do perfil epigenético relacionado aos sistemas de reparo ao DNA influenciados pela infecção por "Helicobacter pylori" = Evaluation of epigenetic profile associated with DNA repair systems induced by "Helicobacter pylori": Evaluation of epigenetic profile associated with DNA repair systems induced by "Helicobacter pylori". [Internet] [Thesis]. Universidade Estadual de Campinas; 2016. [cited 2021 Mar 07]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317037.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Santos, Juliana Carvalho 1. Determinação do perfil epigenético relacionado aos sistemas de reparo ao DNA influenciados pela infecção por "Helicobacter pylori" = Evaluation of epigenetic profile associated with DNA repair systems induced by "Helicobacter pylori": Evaluation of epigenetic profile associated with DNA repair systems induced by "Helicobacter pylori". [Thesis]. Universidade Estadual de Campinas; 2016. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317037

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

3. Faria, Aline Macedo, 1980-. No diabetes mellitus o chá verde melhora o desacoplamento da áxido nítrico sintase renal por restabelecer os valores de tetrahidrobiopterina = Uncoupling endothelial nitric oxid synthase is ameliorated by green tea in experimental diabetes mellitus by reestablishing tetrahydrobiopterin levels: Uncoupling endothelial nitric oxid synthase is ameliorated by green tea in experimental diabetes mellitus by reestablishing tetrahydrobiopterin levels.

Degree: 2012, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/313607

► Abstract: The aim of the present study was to investigate the potential of green tea (GT) to improve uncoupling endothelial nitric oxide synthase (eNOS) in… (more)

Subjects/Keywords: Nefropatias; Polifenóis; Óxido nítrico; Nephoropaty; Polyphenols; Nitric oxide

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Faria, Aline Macedo, 1. (2012). No diabetes mellitus o chá verde melhora o desacoplamento da áxido nítrico sintase renal por restabelecer os valores de tetrahidrobiopterina = Uncoupling endothelial nitric oxid synthase is ameliorated by green tea in experimental diabetes mellitus by reestablishing tetrahydrobiopterin levels: Uncoupling endothelial nitric oxid synthase is ameliorated by green tea in experimental diabetes mellitus by reestablishing tetrahydrobiopterin levels. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/313607

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Faria, Aline Macedo, 1980-. “No diabetes mellitus o chá verde melhora o desacoplamento da áxido nítrico sintase renal por restabelecer os valores de tetrahidrobiopterina = Uncoupling endothelial nitric oxid synthase is ameliorated by green tea in experimental diabetes mellitus by reestablishing tetrahydrobiopterin levels: Uncoupling endothelial nitric oxid synthase is ameliorated by green tea in experimental diabetes mellitus by reestablishing tetrahydrobiopterin levels.” 2012. Thesis, Universidade Estadual de Campinas. Accessed March 07, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313607.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Faria, Aline Macedo, 1980-. “No diabetes mellitus o chá verde melhora o desacoplamento da áxido nítrico sintase renal por restabelecer os valores de tetrahidrobiopterina = Uncoupling endothelial nitric oxid synthase is ameliorated by green tea in experimental diabetes mellitus by reestablishing tetrahydrobiopterin levels: Uncoupling endothelial nitric oxid synthase is ameliorated by green tea in experimental diabetes mellitus by reestablishing tetrahydrobiopterin levels.” 2012. Web. 07 Mar 2021.

Vancouver:

Faria, Aline Macedo 1. No diabetes mellitus o chá verde melhora o desacoplamento da áxido nítrico sintase renal por restabelecer os valores de tetrahidrobiopterina = Uncoupling endothelial nitric oxid synthase is ameliorated by green tea in experimental diabetes mellitus by reestablishing tetrahydrobiopterin levels: Uncoupling endothelial nitric oxid synthase is ameliorated by green tea in experimental diabetes mellitus by reestablishing tetrahydrobiopterin levels. [Internet] [Thesis]. Universidade Estadual de Campinas; 2012. [cited 2021 Mar 07]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/313607.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Faria, Aline Macedo 1. No diabetes mellitus o chá verde melhora o desacoplamento da áxido nítrico sintase renal por restabelecer os valores de tetrahidrobiopterina = Uncoupling endothelial nitric oxid synthase is ameliorated by green tea in experimental diabetes mellitus by reestablishing tetrahydrobiopterin levels: Uncoupling endothelial nitric oxid synthase is ameliorated by green tea in experimental diabetes mellitus by reestablishing tetrahydrobiopterin levels. [Thesis]. Universidade Estadual de Campinas; 2012. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/313607

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

4. Alvarez, Marisa Claudia, 1966-. Análise da influência da infecção por Helicobacter pylori no padrão de metilação de genes envolvidos na carcinogênese gástrica: Analysis of the influence of Helicobacter pylori infection on the methylation pattern of genes related to gastric carcinogenesis.

Degree: 2012, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317038

► Abstract: Helicobacter pylori infection is usually acquired in childhood and persists into adulthood if untreated. It is known that the bacterium induces a chronic inflammatory… (more)

▼ Abstract: Helicobacter pylori infection is usually acquired in childhood and persists into adulthood if untreated. It is known that the bacterium induces a chronic inflammatory response, which is associated with epigenetic alterations in oncogenes, tumor suppressor genes and DNA repair genes. The aim of this study was to evaluate the influence of Helicobacter pylori infection on the methylation pattern of genes related to gastric carcinogenesis. The methylation pattern of 106 genes was characterized in gastric biopsies samples from 5 adult patients (1 H. pylori negative, 3 chronic gastritis infected with strains of different toxicities, and 1 gastric cancer) and DNA extracted from co – cultured cells infected with H. pylori. These analyses were performed with Promoter methylation array system, and Gastric Cancer Methyl – Profiler DNA PCR Array. The results showed that 20 % of genes were methylated in gastric cancer mucosa and 16% were hyper methylated in the mucosa of the chronic gastritis patients. The comparative analysis showed that 8,5 % of genes were methylated in both samples. The results from the co culture showed that 12% of genes were methylated. Among them the following genes were selected: THBS1, HIC1, GATA – 4, GATA – 5 e MLH1 e MGMT and evaluated in 239 gastric biopsies samples from 50 children and 97 adults infected or uninfected by H. pylori, and 92 adults with gastric cancer. The methylation pattern was analyzed by methylation specific PCR (MSP – PCR). The results from pediatric samples showed no methylation for MLH1, MGMT and HIC1 genes, independent of the infection status. Among the infected adults samples the higher levels of methylation were observed for GATA – 4 e THBS1 (p<0.05), MGMT e GATA – 5 (p<0.001). Higher levels of methylation were observed for MGMT e GATA – 5 (p<0.05, p<0.001, respectively) in gastric cancer samples. It was observed an increase in microsatellite instability among gastric cancer samples, related to hyper methylation of MLH1. The expression levels of GATA – 5 and TFF1 was analyzed in vitro. The results from infected cells showed an up regulation at 6, 24, and 48 for GATA-5 and at 48 h for TFF1. This increase was independent of cagPAI status. In an animal model an up regulation of GATA – 5 was observed after six months of infection. A decrease in TFF1 mRNA levels was observed in infected children and adults samples methylated in GATA – 5 promoter region. These data suggest that promoter hyper methylation occurs in gastric mucosa of children in association with H. pylori infection, however for some loci as MGMT and MLH1 this event seems to be dependent on the time of exposure. Furthermore it was observed an increase in methylation frequencies in adults samples compared to pediatric samples suggesting that the duration of the infection is related to methylation levels Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Ribeiro, Marcelo Lima (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Genética e Biologia Molecular (nameofprogram), Yunes, José Andrés (committee member), Zeitune, José Murilo Robilotta (committee member), Rocha, Gifone Aguiar (committee member), Mendonça, Sergio de (committee member).

Subjects/Keywords: Helicobacter pylori; Metilação; Gastrite; Neoplasias gástricas; Helicobacter pylori; Methylation; Gastritis; Stomach neoplasms

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alvarez, Marisa Claudia, 1. (2012). Análise da influência da infecção por Helicobacter pylori no padrão de metilação de genes envolvidos na carcinogênese gástrica: Analysis of the influence of Helicobacter pylori infection on the methylation pattern of genes related to gastric carcinogenesis. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/317038

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alvarez, Marisa Claudia, 1966-. “Análise da influência da infecção por Helicobacter pylori no padrão de metilação de genes envolvidos na carcinogênese gástrica: Analysis of the influence of Helicobacter pylori infection on the methylation pattern of genes related to gastric carcinogenesis.” 2012. Thesis, Universidade Estadual de Campinas. Accessed March 07, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317038.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alvarez, Marisa Claudia, 1966-. “Análise da influência da infecção por Helicobacter pylori no padrão de metilação de genes envolvidos na carcinogênese gástrica: Analysis of the influence of Helicobacter pylori infection on the methylation pattern of genes related to gastric carcinogenesis.” 2012. Web. 07 Mar 2021.

Vancouver:

Alvarez, Marisa Claudia 1. Análise da influência da infecção por Helicobacter pylori no padrão de metilação de genes envolvidos na carcinogênese gástrica: Analysis of the influence of Helicobacter pylori infection on the methylation pattern of genes related to gastric carcinogenesis. [Internet] [Thesis]. Universidade Estadual de Campinas; 2012. [cited 2021 Mar 07]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317038.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alvarez, Marisa Claudia 1. Análise da influência da infecção por Helicobacter pylori no padrão de metilação de genes envolvidos na carcinogênese gástrica: Analysis of the influence of Helicobacter pylori infection on the methylation pattern of genes related to gastric carcinogenesis. [Thesis]. Universidade Estadual de Campinas; 2012. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317038

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Baptista, Marcella Bergamini de, 1988-. Gangliosidose GM1 : proposta de estudo em modelo animal utilizando o Danio rerio: GM1 gangliosidosis : proposal of an animal model study using Danio rerio.

Degree: 2017, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/325642

► Abstract: GM1 gangliosidosis is a rare autosomal recessive lysosomal storage disorder with high prevalence in Brazil (1:17 000). The decreased enzymatic activity of ß-galactosidase leads… (more)

Subjects/Keywords: Gangliosidose GM1; Zebrafish; Morfolinos; Beta-galactosidase; Gangliosidosis, GM1; Zebrafish; Morpholinos; Beta-galactosidase

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APA (6^th Edition):

Baptista, Marcella Bergamini de, 1. (2017). Gangliosidose GM1 : proposta de estudo em modelo animal utilizando o Danio rerio: GM1 gangliosidosis : proposal of an animal model study using Danio rerio. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/325642

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Baptista, Marcella Bergamini de, 1988-. “Gangliosidose GM1 : proposta de estudo em modelo animal utilizando o Danio rerio: GM1 gangliosidosis : proposal of an animal model study using Danio rerio.” 2017. Thesis, Universidade Estadual de Campinas. Accessed March 07, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/325642.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Baptista, Marcella Bergamini de, 1988-. “Gangliosidose GM1 : proposta de estudo em modelo animal utilizando o Danio rerio: GM1 gangliosidosis : proposal of an animal model study using Danio rerio.” 2017. Web. 07 Mar 2021.

Vancouver:

Baptista, Marcella Bergamini de 1. Gangliosidose GM1 : proposta de estudo em modelo animal utilizando o Danio rerio: GM1 gangliosidosis : proposal of an animal model study using Danio rerio. [Internet] [Thesis]. Universidade Estadual de Campinas; 2017. [cited 2021 Mar 07]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/325642.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Baptista, Marcella Bergamini de 1. Gangliosidose GM1 : proposta de estudo em modelo animal utilizando o Danio rerio: GM1 gangliosidosis : proposal of an animal model study using Danio rerio. [Thesis]. Universidade Estadual de Campinas; 2017. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/325642

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Souza, Bruno Batista, 1983-. Aspectos genéticos do glaucoma primário de ângulo fechado: Genetic aspects of primary angle closure glaucoma.

Degree: 2017, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/330469

► Abstract: Glaucoma is the leading cause of irreversible blindness worldwide, affecting approximately 70 million individuals, with at least 6.8 million people presenting bilateral blindness. The… (more)

▼ Abstract: Glaucoma is the leading cause of irreversible blindness worldwide, affecting approximately 70 million individuals, with at least 6.8 million people presenting bilateral blindness. The most common forms are primary open-angle glaucoma (POAG), followed by primary angle-closure glaucoma (PACG). Primary angle-closure glaucoma is characterized by an anatomical alteration in the peripheral iris, which leads to blockage of the aqueous humor outflow and consequent elevation of intraocular pressure (IOP). Its clinical forms include acute attacks, typically unilateral, more aggressive and symptomatic process, leading to severe eye pain, headaches, blurred vision, nausea and vomiting, and chronic angle closure, a process that is painless and asymptomatic. A number of predisposing factors are extensively studied in an attempt to explain geographic and racial variations in the prevalence of PACG. In addition to factors such as sex, age and ethnicity, anatomical factors such as 1) basal iris position, 2) differential pressure measurement, and 3) iris-lens resistance may also contribute to the development of the disease. Ethnical and gender-specific predispositions as well as family history suggest a genetic basis for the development of PACG. In an attempt to better comprehend the genetic aspects of PACG in a sample of the Brazilian population, two strategies have been used. A replication study was conducted in order to verify the frequency of rs11024102, rs3753841 and rs1015213 in PACG cases and controls as well as to determine their association with the disease and its clinical characteristics. These loci have been associated with the disease in two previous studies. Simultaneously, the evaluation of two informative families harboring PACG has been performed through exome sequencing. Our results showed no association between rs11024102, rs3753841 and rs1015213 with PACG development, as well as with its clinical forms. The exome study could not detect which gene might be responsible for the development of the disease in both studied families Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Melo, Mônica Barbosa de, 1968- (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Genética e Biologia Molecular (nameofprogram), Paula, Mônica de Cássia Alves de (committee member), Maurer-Morelli, Cláudia Vianna (committee member), Ribeiro, Marcelo Lima (committee member), Kasahara, Niro (committee member).

Subjects/Keywords: Glaucoma; Exoma; Glaucoma; Exome

…dos tipos de Glaucoma no Hospital das Clínicas da Universidade Estadual de Campinas…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Souza, Bruno Batista, 1. (2017). Aspectos genéticos do glaucoma primário de ângulo fechado: Genetic aspects of primary angle closure glaucoma. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/330469

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Souza, Bruno Batista, 1983-. “Aspectos genéticos do glaucoma primário de ângulo fechado: Genetic aspects of primary angle closure glaucoma.” 2017. Thesis, Universidade Estadual de Campinas. Accessed March 07, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/330469.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Souza, Bruno Batista, 1983-. “Aspectos genéticos do glaucoma primário de ângulo fechado: Genetic aspects of primary angle closure glaucoma.” 2017. Web. 07 Mar 2021.

Vancouver:

Souza, Bruno Batista 1. Aspectos genéticos do glaucoma primário de ângulo fechado: Genetic aspects of primary angle closure glaucoma. [Internet] [Thesis]. Universidade Estadual de Campinas; 2017. [cited 2021 Mar 07]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/330469.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Souza, Bruno Batista 1. Aspectos genéticos do glaucoma primário de ângulo fechado: Genetic aspects of primary angle closure glaucoma. [Thesis]. Universidade Estadual de Campinas; 2017. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/330469

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Dos Santos, Tanila Wood, 1987-. Efeitos das erva-mate (Ilex paraguariensis) na modulação do metabolismo energético mitocondrial associado à obesidade : Effects of yerba mate (Ilex paraguariensis) on modulation of mitochondrial energetic metabolism associated with obesity: Effects of yerba mate (Ilex paraguariensis) on modulation of mitochondrial energetic metabolism associated with obesity.

Degree: 2018, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332434

► Abstract: Obesity is a major risk factor for the development of chronic diseases and premature death. From the strategies currently used for the reduction and… (more)

▼ Abstract: Obesity is a major risk factor for the development of chronic diseases and premature death. From the strategies currently used for the reduction and control of body weight, the use of natural compounds has demonstrated potential effects in both weight reduction and metabolic profile. In this sense, previous results published by our team demonstrated that YM presented promising effects concerning the modulation of adipogenesis and obesity in vitro and in vivo, respectively, as well as thermogenic activity. However, the regulatory mechanisms exercises by YM in the control of obesity remain unclear. Thus, the present study investigated the possible effects of YM on mitochondrial function. For this, in vitro analyzes were performed using a C2C12 cell line previously treated with YM, in which was measured the OCR, indicative of cellular metabolism. Additionally, genes involved in the pathways of mitochondrial biogenesis and thermogenesis were investigated. In vivo analyzes were conducted in high fat diet- induced obese mice, submitted to 8 weeks of daily YM intervention. The food intake was monitored weekly and respirometric tests were performed. At the end of the treatment, analyzes of the expression of genes involved in mitochondrial biogenesis and thermogenesis were developed in BAT and skeletal muscle. The results showed that YM effectively stimulated mitochondrial energy metabolism in C2C12 cells, through the activation of genes involved in mitochondrial biogenesis (Ampk, Mttfa, Nrf1) and thermogenesis (Ucp-1 and Ucp-3), as well as increased OCR, suggesting an improvement in mitochondrial function in this lineage. In vivo, data showed that regular intake of YM reduced the body weight of the HFD + YM group when compared to the HFD group. The weight loss observed in this group was not related to the reduction in food intake. Additionally, the anthropometric data indicated a significant reduction in epididymal, perirenal, subcutaneous and mesenteric fat and liver weights, in relation to the HFD group. In addition, respirometric tests indicated a significant increase in VO2, VCO2, RER and EE parameters in the HFD + YM group, suggesting that YM was able to stimulate energy expenditure. Gene expression data in BAT and skeletal muscle showed increased expression of Ucp-1 and Ucp-3 in animals treated with YM suggesting thermogenic effect. In addition, there were indications of mitochondrial biogenesis stimulation as well as enhancement of oxidative phosphorylation activity as evidenced by increased of Nrf-1, Mttfa, Pgc-1alpha and Sirt-1 and SIRT-1, p- AMPK, UCP-1, UCP-3 and OXPHOS in both tissues of animals of the HFD + YM group. Briefly, the results of this study reaffirm YM as an excellent candidate in the strategy to obesity management. In addition to its anti-adipogenic potential, previously proven, the present study confirmed its efficacy on mitochondrial imbalances observed in obesity, through the restoration of mitochondrial function and consequent improvement in energy metabolism, benefits that evidently… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Ribeiro, Marcelo Lima (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Genética e Biologia Molecular (nameofprogram), Velloso, Licio Augusto (committee member), Ortega, Manoela Marques (committee member), Sartorato, Edi Lúcia (committee member), Ferraz, Lucio Fabio Caldas (committee member).

Subjects/Keywords: Obesidade; Erva-mate; Polifenóis; Biogênese de organelas; Termogenese; Obesity; Mate plant; Polyphenols; Organelle biogenesis; Thermogenesis

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APA (6^th Edition):

Dos Santos, Tanila Wood, 1. (2018). Efeitos das erva-mate (Ilex paraguariensis) na modulação do metabolismo energético mitocondrial associado à obesidade : Effects of yerba mate (Ilex paraguariensis) on modulation of mitochondrial energetic metabolism associated with obesity: Effects of yerba mate (Ilex paraguariensis) on modulation of mitochondrial energetic metabolism associated with obesity. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/332434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dos Santos, Tanila Wood, 1987-. “Efeitos das erva-mate (Ilex paraguariensis) na modulação do metabolismo energético mitocondrial associado à obesidade : Effects of yerba mate (Ilex paraguariensis) on modulation of mitochondrial energetic metabolism associated with obesity: Effects of yerba mate (Ilex paraguariensis) on modulation of mitochondrial energetic metabolism associated with obesity.” 2018. Thesis, Universidade Estadual de Campinas. Accessed March 07, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/332434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dos Santos, Tanila Wood, 1987-. “Efeitos das erva-mate (Ilex paraguariensis) na modulação do metabolismo energético mitocondrial associado à obesidade : Effects of yerba mate (Ilex paraguariensis) on modulation of mitochondrial energetic metabolism associated with obesity: Effects of yerba mate (Ilex paraguariensis) on modulation of mitochondrial energetic metabolism associated with obesity.” 2018. Web. 07 Mar 2021.

Vancouver:

Dos Santos, Tanila Wood 1. Efeitos das erva-mate (Ilex paraguariensis) na modulação do metabolismo energético mitocondrial associado à obesidade : Effects of yerba mate (Ilex paraguariensis) on modulation of mitochondrial energetic metabolism associated with obesity: Effects of yerba mate (Ilex paraguariensis) on modulation of mitochondrial energetic metabolism associated with obesity. [Internet] [Thesis]. Universidade Estadual de Campinas; 2018. [cited 2021 Mar 07]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dos Santos, Tanila Wood 1. Efeitos das erva-mate (Ilex paraguariensis) na modulação do metabolismo energético mitocondrial associado à obesidade : Effects of yerba mate (Ilex paraguariensis) on modulation of mitochondrial energetic metabolism associated with obesity: Effects of yerba mate (Ilex paraguariensis) on modulation of mitochondrial energetic metabolism associated with obesity. [Thesis]. Universidade Estadual de Campinas; 2018. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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