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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Ramos, Cristiane da Fonte"). One record found.

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Universidade Estadual de Campinas

1. Pytlowanciv, Eloísa Zanin, 1987-. Efeitos da exposição ao ambiente obesogênico em diferentes fases do desenvolvimento sobre a morfofisiologia da próstata de ratos Wistar = The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats: The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats.

Degree: 2015, Universidade Estadual de Campinas

Abstract: Experimental data indicate that the high-fat diet (HFD) affects the proliferative activity and prostate health. However, the consequences of maternal obesity and obesogenic environment (OE) by lipids excess in the diet for the prostate remain inconclusive. This study investigated the effects of the exposure to OE at different developmental phases on prostate morphophysiology of Wistar rats at adulthood and the possible correlations with the metabolic status and regulation by sex steroids. Male Wistar rats (19 weeks-old; n=15) were fed with balanced chow (C; 3% fat, 3.5Kcal/g) or HFD (20% fat, 4.9Kcal/g) during gestation (G), gestation and lactation (GL), from post-weaning to adulthood (WA), from lactation to adulthood (LA) and from gestation to adulthood (GA). The OE during pregnancy included previous induction of maternal obesity by feeding with HFD for 15 weeks. OE led to insulin resistance in all groups, overweight in GL, obesity and decrease in circulating testosterone levels in the WA, LA and GA groups and increased estrogen levels in GA. Moreover, there was an increase in triglycerides and decrease in HDL levels in the obese groups. Regardless the developmental phase, the OE leads to ventral prostate hypertrophy which, except for the G group, also presented an increase in epithelial proliferation activity. The increase in cell proliferation in these groups was concurrent with the decrease in immunopositive cells frequency of androgen receptor, estrogen receptor ? and liver X receptor ? and increase in estrogen receptor ? and peroxisome proliferator-activated receptor ?. Therefore, the increase in cell proliferation induced by the OE is independent of the androgen receptor signaling. The OE increases cell death by desquamation, in acinar epithelium of ventral prostate, in the groups exposed during gestation and/or lactation and to a greater degree in the group exposed throughout life. The morphological changes in the prostate that characterize the earliest, intermediate and final stages of this kind of death were established. Loss of epithelial AR plays a key role in this process. OE exposure before weaning, increased atrophic lesions foci on the ventral prostate, and the exposure after weaning, increased hyperplasia and intraepithelial neoplasia foci, as indicated by the lesions multiplicity analysis. The longer the exposure period to OE, more serious were the lesions found in the ventral lobe. The OE did not promote pronounced alterations on the dorsal and lateral prostate histology, as indicated by microscopic and stereological analyses. Nor alters the androgen receptor frequency, showing that these lobes are less susceptible to the OE exposure and androgen fall, as compared with the ventral lobes. In conclusion, the OE exposure at different developmental phases interferes with ventral prostate morphophysiology proportionally with metabolic impairment and androgen decline, leading to a hypertrophic and hyperproliferative state associated with increased pathological lesions and collective loss of… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Góes, Rejane Maira (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Biologia Celular e Estrutural (nameofprogram), Ramos, Cristiane da Fonte (committee member), Delella, Flavia Karina (committee member), Junior, Luis Antonio Justulin (committee member), Scarano, Wellerson Rodrigo (committee member).

Subjects/Keywords: Prostata; Ambiente obesogênico; Receptores nucleares; Proliferação celular; Morte celular; Alterações histopatológicas; Prostate; Obesogenic environment; Nuclear receptors; Cell proliferation; Cell death; Histopathological alterations

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APA (6th Edition):

Pytlowanciv, Eloísa Zanin, 1. (2015). Efeitos da exposição ao ambiente obesogênico em diferentes fases do desenvolvimento sobre a morfofisiologia da próstata de ratos Wistar = The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats: The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/317894

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Pytlowanciv, Eloísa Zanin, 1987-. “Efeitos da exposição ao ambiente obesogênico em diferentes fases do desenvolvimento sobre a morfofisiologia da próstata de ratos Wistar = The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats: The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats.” 2015. Thesis, Universidade Estadual de Campinas. Accessed October 21, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317894.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Pytlowanciv, Eloísa Zanin, 1987-. “Efeitos da exposição ao ambiente obesogênico em diferentes fases do desenvolvimento sobre a morfofisiologia da próstata de ratos Wistar = The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats: The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats.” 2015. Web. 21 Oct 2020.

Vancouver:

Pytlowanciv, Eloísa Zanin 1. Efeitos da exposição ao ambiente obesogênico em diferentes fases do desenvolvimento sobre a morfofisiologia da próstata de ratos Wistar = The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats: The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats. [Internet] [Thesis]. Universidade Estadual de Campinas; 2015. [cited 2020 Oct 21]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317894.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pytlowanciv, Eloísa Zanin 1. Efeitos da exposição ao ambiente obesogênico em diferentes fases do desenvolvimento sobre a morfofisiologia da próstata de ratos Wistar = The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats: The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats. [Thesis]. Universidade Estadual de Campinas; 2015. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317894

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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