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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Quintilho, Eder Carlos Rocha"). One record found.

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Universidade Estadual de Campinas

1. Dorighello, Gabriel Gabriel, 1982-. Efeitos da restrição calórica e do 2,4 dinitrofenol sobre o metabolismo e desenvolvimento da aterosclerose em camundongos hipercolesterolêmicos: Effects of caloric restriction and 2,4-dinitrophenol on the metabolism and development of atherosclerosis in hypercholesterolemic mice.

Degree: 2013, Universidade Estadual de Campinas

Abstract: Cardiovascular diseases (CVD) are the major cause of death in the occidental world. Atherosclerosis is the main process responsible for the pathogenesis of these diseases. Metabolic disturbances such as dyslipidemias, hypertension, insulin resistance and obesity are well established atherosclerosis risk factors. Currently, different pharmacological and dietetic interventions have been used to reduce and avoid CVD. Caloric restriction is one of these strategies, which is associated with increases in life span and reductions of age related chronic diseases. The mitochondrial uncoupler 2,4 dinitrophenol (DNP) has been considered as a caloric restriction mimetic tool. We have demonstrated that a mouse model of human familial hypercholesterolemia exhibits metabolic and redox disturbances highly relevant for metabolic syndrome and atherosclerosis. Thus, the aim of this study was to evaluate the effects of caloric restriction and mild mitochondrial uncoupling induced by DNP on the metabolism and atherosclerosis development in hypercholesterolemic LDL receptor deficient mice (R0). Thus, R0 mice were compared after 3 months in three conditions: R0 fed ad libitum (control), R0 under caloric restriction (R0-RC) obtained by providing food in alternate days, and R0-DNP fed ad libitum and treated with DNP 1 mg/L in the drinking water. The caloric restriction regimen, despite reducing food intake, induced unexpected adverse metabolic effects, namely, increased plasma total-, VLDL- and LDL-cholesterol, and increased visceral and subcutaneous adipose tissue masses. In addition, R0-RC mice became hyperglycemic, hyperinsulinemic, glucose intolerant and insulin resistant. Moreover, R0-RC mice presented elevated plasma levels of the inflammatory markers TNF? and C-reactive protein. Some benefits regarding systemic and tissue redox state were observed in R0-RC, however, atherosclerosis lesion areas were increased about 3 fold in R0-RC mice. DNP treatment had minimal effects on the lipid and glucose metabolism of R0-DNP mice. It decreased plasma free fatty acids, but did not change other plasma lipids, inflammatory markers, glucose homeostasis, and the size of adipose depots. On the other hand, marked effects of DNP treatment on the tissue redox state were observed, namely, reduction in the generation of mitochondrial oxidative reactive species and in the liver content of carbonyl protein. The spontaneous atherosclerosis development was significantly reduced in the R0-DNP mice, independently other well established risk factors such as plasma cholesterol and inflammatory mediators. Therefore, the caloric restriction regimen is not indicated for the condition of familial hypercholesterolemia due to LDL receptor deficiency. On the other hand, DNP treatment, possibly via mild mitochondrial uncoupling, evidences the relevance of mitochondrial source of reactive oxygen for the atherosclerosis development independently of other risk factors Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Oliveira, Helena Coutinho Franco de, 1958- (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Biologia Funcional e Molecular (nameofprogram), Davel, Ana Paula Couto (committee member), Castilho, Roger Frigério (committee member), Amaral, Maria Esmeria Corezola do (committee member), Quintilho, Eder Carlos Rocha (committee member).

Subjects/Keywords: Hipercolesterolemia; Aterosclerose; Restrição calórica; Diabetes Mellitus; Hypercholesterolemia; Atherosclerosis; Caloric restriction; Diabetes

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APA (6th Edition):

Dorighello, Gabriel Gabriel, 1. (2013). Efeitos da restrição calórica e do 2,4 dinitrofenol sobre o metabolismo e desenvolvimento da aterosclerose em camundongos hipercolesterolêmicos: Effects of caloric restriction and 2,4-dinitrophenol on the metabolism and development of atherosclerosis in hypercholesterolemic mice. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/314294

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Dorighello, Gabriel Gabriel, 1982-. “Efeitos da restrição calórica e do 2,4 dinitrofenol sobre o metabolismo e desenvolvimento da aterosclerose em camundongos hipercolesterolêmicos: Effects of caloric restriction and 2,4-dinitrophenol on the metabolism and development of atherosclerosis in hypercholesterolemic mice.” 2013. Thesis, Universidade Estadual de Campinas. Accessed January 24, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314294.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Dorighello, Gabriel Gabriel, 1982-. “Efeitos da restrição calórica e do 2,4 dinitrofenol sobre o metabolismo e desenvolvimento da aterosclerose em camundongos hipercolesterolêmicos: Effects of caloric restriction and 2,4-dinitrophenol on the metabolism and development of atherosclerosis in hypercholesterolemic mice.” 2013. Web. 24 Jan 2021.

Vancouver:

Dorighello, Gabriel Gabriel 1. Efeitos da restrição calórica e do 2,4 dinitrofenol sobre o metabolismo e desenvolvimento da aterosclerose em camundongos hipercolesterolêmicos: Effects of caloric restriction and 2,4-dinitrophenol on the metabolism and development of atherosclerosis in hypercholesterolemic mice. [Internet] [Thesis]. Universidade Estadual de Campinas; 2013. [cited 2021 Jan 24]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/314294.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dorighello, Gabriel Gabriel 1. Efeitos da restrição calórica e do 2,4 dinitrofenol sobre o metabolismo e desenvolvimento da aterosclerose em camundongos hipercolesterolêmicos: Effects of caloric restriction and 2,4-dinitrophenol on the metabolism and development of atherosclerosis in hypercholesterolemic mice. [Thesis]. Universidade Estadual de Campinas; 2013. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/314294

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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