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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Ong, Thomas Prates"). Showing records 1 – 3 of 3 total matches.

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Universidade Estadual de Campinas

1. Arçari, Demétrius Paiva, 1978-. Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling.

Degree: 2011, Universidade Estadual de Campinas

Abstract: Obesity is a problem of public health, mainly because it is associated with many conditions such especially insulin resistance (IR). Currently, several strategies have been used in order to reduce the total body weight, among these there is a growing evidence supporting the use of products of plant origin, including the Ilex paraguariensis, whose common name is yerba mate. Various studies have shown that the compounds found in yerba mate has several biological functions, such as antioxidant, anti-inflammatory, immunomodulatory, anticancer, modification of cholesterol metabolism and others. Although several studies highlight the biological functions of yerba mate, there are lack of evidence providing their ability to modulate expression of genes related to obesity and its effect on the insulin signaling pathway. Thus, the aim of this study was to evaluate the effects of yerba mate in gene expression that regulate adipogenesis and insulin signaling pathway. Our data showed yerba mate (1,0 g/kg) in animals subjected to high fat diet, increased different gene expression responsible for the activation of the AKT, reduction of FOXO1 and NF-kB nuclear translocation, reduction gene expression of PEPCK and G6Pase involved in gluconeogenesis process in liver. The effects of yerba mate in insulin signaling was confirmed by IRS-1, IRS-2 and AKT protein analysis, reduction in insulin test tolerance by KITT and reduction in glucose. Our data also showed in 3T3-L1 cell culture that yerba mate and some of its major bioactive compounds (chlorogenic acid, rutin and quercetin), act in an early stage of adipocyte differentiation and modulate different gene expression that regulate adipogenesis. Additionally, yerba mate can act in vitro and ex vivo in WNT pathway, seen by the increased expression of different genes in this pathway resulting in a significant repression of C/EBP'alfa' and PPARy2, the most important transcription factors essencial for the occurrence of adipocyte differentiation. This findings collaborate to elucidate the reduction of body weight and epididymal fat observed in animals subjected to high fat diet treated with yerba mate for 60 days, which reduces the production of cytokines, particularly TNF-'alfa', contributing partially to the improvement in insulin signaling observed after intervention Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Ribeiro, Marcelo Lima (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Genética e Biologia Molecular (nameofprogram), Sartorato, Edi Lúcia (committee member), Cintra, Dennys Esper (committee member), Ong, Thomas Prates (committee member), Rogero, Marcelo Macedo (committee member).

Subjects/Keywords: Erva-mate; Adipogenia; Insulina; Obesidade; Yerba de mate; Ilex paraguariensis; Adipogenesis; Insulin; Obesity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Arçari, Demétrius Paiva, 1. (2011). Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/317039

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Arçari, Demétrius Paiva, 1978-. “Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling.” 2011. Thesis, Universidade Estadual de Campinas. Accessed January 17, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317039.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Arçari, Demétrius Paiva, 1978-. “Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling.” 2011. Web. 17 Jan 2021.

Vancouver:

Arçari, Demétrius Paiva 1. Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling. [Internet] [Thesis]. Universidade Estadual de Campinas; 2011. [cited 2021 Jan 17]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317039.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arçari, Demétrius Paiva 1. Avaliação da erva-mate (Ilex paraguariensis) na adipogênese e sinalização da insulina: Effects of yerba mate (Ilex paraguariensis) in adipogenesis and insulin signaling. [Thesis]. Universidade Estadual de Campinas; 2011. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317039

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Universidade Estadual de Campinas

2. Faria, Juliana de Almeida. O consumo de frutose restrito a fase clara do ciclo e suas implicações para a ativação da AMPK hipotalâmica, a produção de melatonina e o metabolismo glicídico = Light phase restricted fructose consumption and its implications on hypothalamic AMPK activation, melatonin production and glucose metabolism: Light phase restricted fructose consumption and its implications on hypothalamic AMPK activation, melatonin production and glucose metabolism.

Degree: 2016, Universidade Estadual de Campinas

Abstract: A high fructose diet exerts a known modulation which is characterized by peripheral resistance to the insulin action, increased gluconeogenesis and hepatic steatosis on glucose metabolism. The exact mechanisms by which fructose triggers such actions are in continuous elucidation however it is known that the increased gluconeogenesis and the hyperphagia stimulation both result from activation of hypothalamic AMPK protein. Among several endocrine modulations, fructose promotes a reduction on nocturnal melatonin production. Melatonin, a hormone produced by pineal gland in a circadian manner, has the ability to synchronize the energetic metabolism by increasing insulin sensitivity and reducing gluconeogenesis. As melatonin production, it is known that hypothalamic AMPK activity has a circadian rhythm with increased values during the night phase. It has been shown recently that increased hypothalamic AMPK activity through pharmacologic activators is able to reduce nocturnal melatonin production. Interestingly, fructose consumption only during the light phase of the light / dark cycle results in metabolic changes similar to those described above, while fructose intake exclusively during the dark phase appears to exert milder metabolic effects. This study presents the results arising from the research of metabolic changes resulting from fructose intake at different phases of light / dark cycle; and in this context, we have assessed whether such changes are dependent on hypothalamic AMPK activity patterns and corticosterone production Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Anhê, Gabriel Forato, 1980- (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Farmacologia (nameofprogram), Esteves, Andrea Maculano (committee member), Ong, Thomas Prates (committee member), Júnior, José Donato (committee member), Souza, Gabriela Freitas Pereira de (committee member).

Subjects/Keywords: Frutose; Ingestão fora de fase; Hipotálamo; Proteínas quinases ativadas por AMP; Corticosterona; Melatonina; Fructose; Out-of-phase feeding; Hypothalamus; AMP-Activated protein kinase; Corticosterone; Melatonin

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APA (6th Edition):

Faria, J. d. A. (2016). O consumo de frutose restrito a fase clara do ciclo e suas implicações para a ativação da AMPK hipotalâmica, a produção de melatonina e o metabolismo glicídico = Light phase restricted fructose consumption and its implications on hypothalamic AMPK activation, melatonin production and glucose metabolism: Light phase restricted fructose consumption and its implications on hypothalamic AMPK activation, melatonin production and glucose metabolism. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/319208

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Faria, Juliana de Almeida. “O consumo de frutose restrito a fase clara do ciclo e suas implicações para a ativação da AMPK hipotalâmica, a produção de melatonina e o metabolismo glicídico = Light phase restricted fructose consumption and its implications on hypothalamic AMPK activation, melatonin production and glucose metabolism: Light phase restricted fructose consumption and its implications on hypothalamic AMPK activation, melatonin production and glucose metabolism.” 2016. Thesis, Universidade Estadual de Campinas. Accessed January 17, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/319208.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Faria, Juliana de Almeida. “O consumo de frutose restrito a fase clara do ciclo e suas implicações para a ativação da AMPK hipotalâmica, a produção de melatonina e o metabolismo glicídico = Light phase restricted fructose consumption and its implications on hypothalamic AMPK activation, melatonin production and glucose metabolism: Light phase restricted fructose consumption and its implications on hypothalamic AMPK activation, melatonin production and glucose metabolism.” 2016. Web. 17 Jan 2021.

Vancouver:

Faria JdA. O consumo de frutose restrito a fase clara do ciclo e suas implicações para a ativação da AMPK hipotalâmica, a produção de melatonina e o metabolismo glicídico = Light phase restricted fructose consumption and its implications on hypothalamic AMPK activation, melatonin production and glucose metabolism: Light phase restricted fructose consumption and its implications on hypothalamic AMPK activation, melatonin production and glucose metabolism. [Internet] [Thesis]. Universidade Estadual de Campinas; 2016. [cited 2021 Jan 17]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/319208.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Faria JdA. O consumo de frutose restrito a fase clara do ciclo e suas implicações para a ativação da AMPK hipotalâmica, a produção de melatonina e o metabolismo glicídico = Light phase restricted fructose consumption and its implications on hypothalamic AMPK activation, melatonin production and glucose metabolism: Light phase restricted fructose consumption and its implications on hypothalamic AMPK activation, melatonin production and glucose metabolism. [Thesis]. Universidade Estadual de Campinas; 2016. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/319208

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Universidade Estadual de Campinas

3. Santos, Lilia Zago Ferreira dos. Suplementação com acido linoleico conjugado : influencia sobre a oxidação dos lipides biologicos e conteudo de lipides hepaticos de ratos Wistar saudaveis em crescimento: Conjugates linoleic acid supplementation : influence on biological lipid oxidation and hepatic lipid content in healthy growing Wistar rats.

Degree: 2007, Universidade Estadual de Campinas

Abstract: Conjugated linoleic acid (CLA) is a set of geometrical and positional isomers of the linoleic acid, found in milk, meats and their products. Since its identification as an anticarcinogenic agent, other effects have been attributed to it since, among them an antioxidant action  – a rather intriguing claim in view of the fact that CLA is a conjugated diene, i.e., a fatty acid in an early stage of autoxidation, but with one of its conjugated double bonds in the trans form. The objective of this Thesis was to assess the effect of CLA supplementation, both in the presence and in the absence of an antioxidant, on: (a) the process of biological lipid autoxidation, (b) the total lipid content, and (c) the hepatic morphology of healthy growing Wistar rats. A biological assay on sixty rats divided into six groups (n=10) was realized: C (control), CE (control + vitamin E), AE (AdvantEdge® CLA), AEE (AdvantEdge® CLA + Vitamin E), CO (CLA One®), and COE (CLA One®+ vitamin E). Control groups C and CE received linoleic acid, and supplemented groups AE, AEE, CO and COE received commercial CLA mixtures with a mean CLA content 76.17% and similar proportions of trans-10, cis-12 and cis-9, trans-11 isomers. A preliminary assay was conducted in order to standardize supplementation conditions; its results indicated that the best CLA concentration for administration, taking into account operational aspects and biological response, was 2% of diet intake. Rats were supplemented with that concentration of CLA by orogastric intubation for 42 days. For animals receiving vitamin E in combination with CLA, alpha-tocopherol acetate in the concentration of 30 mg/day was used. Peroxide index (IP), malondialdehyde (MDA), 8-iso-PGF2 alpha isoprostane, and catalase activity were determined as lipid autoxidation indicators. Total liver lipid content was determined, and organ morphology was examined by transmission electronic microscopy (TEM). Results demonstrated that the influence of CLA on the process of biological lipid oxidation depends on supplement type, on the chosen indicator, and on whether it is determined in a tissue or in a body fluid. Serum values of MDA (AE: 1.80±0.67 mg MDA / kg; CO: 2.43±0.61 mg MDA / kg) and catalase serum activity (AE: 4734.23±107893 kU / L; CO: 5916.06±2490.71 kU / L) were significantly lower (P <0,05) than in the controls (MDA: 3.85±0.24 mg MDA / kg; catalase: 10496.52±5121.84 kU / L), whereas 8-iso-PGF2 alpha isoprostane were higher (P <0.05) for AE (urina: 95.13±20.26 pg / mL; plasma: 18.86±3.41 pg / mL) than in the controls (urina: 69.46±16.65 pg / mL; plasma: 13.84±3.55 pg / mL). IP values were higher (P<0,05) for CO (84,.38±1097mEq / kg) than in the control (54.75±9.70 mEq / kg). Regarding the combination of alpha-tocopherol acetate and CLA supplementation, the presence of this antioxidant influenced the action of CLA on biological lipid oxidation as indicated by catalase, hepatic MDA and urinary 8-iso-PGF2 alpha isoprostane. Total hepatic lipid content did not increase in rats receiving CLA (C:… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Oliveira, Admar Costa de, 1949- (advisor), Universidade Estadual de Campinas. Faculdade de Engenharia de Alimentos (institution), Programa de Pós-Graduação em Alimentos e Nutrição (nameofprogram), Miyasaka, Celio Kenji (committee member), Pastore, Glaucia Maria (committee member), Saad, Mario José Abdalla (committee member), Domene, Semiramis Martins Alvares (committee member), Ong, Thomas Prates (committee member).

Subjects/Keywords: Acido linoleico conjugado; Lipides hepaticos; Ratos Wistar; Conjugated linoleic-acid; Hepatic lipids; Lipid autoxidation; Rats

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Santos, L. Z. F. d. (2007). Suplementação com acido linoleico conjugado : influencia sobre a oxidação dos lipides biologicos e conteudo de lipides hepaticos de ratos Wistar saudaveis em crescimento: Conjugates linoleic acid supplementation : influence on biological lipid oxidation and hepatic lipid content in healthy growing Wistar rats. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/256175

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Santos, Lilia Zago Ferreira dos. “Suplementação com acido linoleico conjugado : influencia sobre a oxidação dos lipides biologicos e conteudo de lipides hepaticos de ratos Wistar saudaveis em crescimento: Conjugates linoleic acid supplementation : influence on biological lipid oxidation and hepatic lipid content in healthy growing Wistar rats.” 2007. Thesis, Universidade Estadual de Campinas. Accessed January 17, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256175.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Santos, Lilia Zago Ferreira dos. “Suplementação com acido linoleico conjugado : influencia sobre a oxidação dos lipides biologicos e conteudo de lipides hepaticos de ratos Wistar saudaveis em crescimento: Conjugates linoleic acid supplementation : influence on biological lipid oxidation and hepatic lipid content in healthy growing Wistar rats.” 2007. Web. 17 Jan 2021.

Vancouver:

Santos LZFd. Suplementação com acido linoleico conjugado : influencia sobre a oxidação dos lipides biologicos e conteudo de lipides hepaticos de ratos Wistar saudaveis em crescimento: Conjugates linoleic acid supplementation : influence on biological lipid oxidation and hepatic lipid content in healthy growing Wistar rats. [Internet] [Thesis]. Universidade Estadual de Campinas; 2007. [cited 2021 Jan 17]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/256175.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Santos LZFd. Suplementação com acido linoleico conjugado : influencia sobre a oxidação dos lipides biologicos e conteudo de lipides hepaticos de ratos Wistar saudaveis em crescimento: Conjugates linoleic acid supplementation : influence on biological lipid oxidation and hepatic lipid content in healthy growing Wistar rats. [Thesis]. Universidade Estadual de Campinas; 2007. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/256175

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.