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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Mussi-Pinhata, Marisa Marcia"). One record found.

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Universidade Estadual de Campinas

1. Mazzola, Taís Nitsch, 1982-. Viremia na infecção vertical pelo vírus da imunodeficiência humana e resposta imunológica adaptativa: Cellular immune responses to Bacillus Calmette-Guerin vaccine from health and human immunodeficiency virus-exposed.

Degree: 2013, Universidade Estadual de Campinas

Abstract: The aim of this study was to evaluate if there was an association of Human Immunodeficiency Virus (HIV) plasma viremia and the development of adaptative immune responses from vertically-HIV-1 infected children and adolescents under combination Antirretroviral Therapy (cART). The individuals were recruited at the Pediatric Immunodeficiency Outpatient Unit at the University of Campinas Clinical Hospital (UNICAMP, Campinas) and at the Center for Orientation and Serologic Support (COAS, Jundiaí), in São Paulo State, Brazil. They were separated in two groups, according to HIV RNA plasma viral load (VL): one had sustained undetectable VL (UVL, with VL < 50 copies of RNA/mL) for at least one year before blood collection; the other had VL > 1,000 copies/mL. Healthy children and adolescents participated in the study as controls. Aldrithiol-2-inactivated HIV-1-stimulated peripheral blood mononuclear cells were cultured to evaluate HIV-specific lymphoproliferation by flow cytometry and IL-2, IL-4, IL-5, IL-10, IFN-?, IFN-?, TNF-? and TGF-?1 concentration by Cytometric Bead Array and Enzyme-Linked Immunosorbent Assay. Adaptative immunity was also evaluated with T CD4+, T CD8+, total and memory B cell counts by flow cytometry, immunoglobulin dosage by nephelometry, Chemiluminescent Microparticle Immunoassay to antibodies anti-hepatitis B and anti-rubella and Toxin Binding Inhibiton test to anti-tetanus and anti-diphtheria were carried out to humoral response evaluation. Kruskal-Wallis, Wilcoxon, Mann-Whitney, Fisher's exact, Nonparametric Multiple Comparisons and Spearman Correlation tests were used, with a p value < 0.05. There was no difference in T CD8, total and memory B cell counts between the groups of patients. T CD4 cell numbers were decreased in the viremic group at the time humoral immunity was performed. Greater memory B cell counts were observed among patients with UVL who were younger at cART beginning. IgM and IgG levels were higher in viremic patients in comparison to control and patients with UVL, which had increased levels of IgA in comparison to controls. There was no difference in the proportion of responders for tetanus, diphtheria, rubella and hepatitis B vaccines between the two groups of patients; nevertheless, the group with UVL showed higher titers of anti-hepatitis B, anti-rubella and anti-tetanus than the viremic group. Controls showed higher frequency of responders to diphtheria, rubella and hepatitis B and titers to anti-hepatitis B, anti-rubella and anti-tetanus in comparison to patients. Patients with UVL showed higher HIV-1-specific T lymphocyte proliferation and IL-2 and IFN-? production in comparison to viremic patients. Greater time since the start of successful cART in patients with UVL was associated with higher proliferation and IFN-? and IL-2 levels in cultures with HIV. Among viremic patients, HIV-specific proliferation was lower in individuals who started ART after one year of age, and IFN-? concentration was inversely correlated with VL. We concluded that sustained HIV-1… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Vilela, Maria Marluce dos Santos, 1947- (advisor), Silva, Marcos Tadeu Nolasco da, 1960- (coadvisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Saúde da Criança e do Adolescente (nameofprogram), Riccetto, Adriana Gut Lopes (committee member), Pedro, Rogerio de Jesus (committee member), Mussi-Pinhata, Marisa Marcia (committee member), Oshiro, Telma Miyuki (committee member).

Subjects/Keywords: HIV; Crianças; Adolescentes; Imunidade celular; Vacinas; HIV; Child; Adolescent; Cellular immunity; Vaccines

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APA (6th Edition):

Mazzola, Taís Nitsch, 1. (2013). Viremia na infecção vertical pelo vírus da imunodeficiência humana e resposta imunológica adaptativa: Cellular immune responses to Bacillus Calmette-Guerin vaccine from health and human immunodeficiency virus-exposed. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/311091

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Mazzola, Taís Nitsch, 1982-. “Viremia na infecção vertical pelo vírus da imunodeficiência humana e resposta imunológica adaptativa: Cellular immune responses to Bacillus Calmette-Guerin vaccine from health and human immunodeficiency virus-exposed.” 2013. Thesis, Universidade Estadual de Campinas. Accessed December 03, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311091.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Mazzola, Taís Nitsch, 1982-. “Viremia na infecção vertical pelo vírus da imunodeficiência humana e resposta imunológica adaptativa: Cellular immune responses to Bacillus Calmette-Guerin vaccine from health and human immunodeficiency virus-exposed.” 2013. Web. 03 Dec 2020.

Vancouver:

Mazzola, Taís Nitsch 1. Viremia na infecção vertical pelo vírus da imunodeficiência humana e resposta imunológica adaptativa: Cellular immune responses to Bacillus Calmette-Guerin vaccine from health and human immunodeficiency virus-exposed. [Internet] [Thesis]. Universidade Estadual de Campinas; 2013. [cited 2020 Dec 03]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/311091.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mazzola, Taís Nitsch 1. Viremia na infecção vertical pelo vírus da imunodeficiência humana e resposta imunológica adaptativa: Cellular immune responses to Bacillus Calmette-Guerin vaccine from health and human immunodeficiency virus-exposed. [Thesis]. Universidade Estadual de Campinas; 2013. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/311091

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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