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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Mesquita, Suzana de Fatima Paccola"). One record found.

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Universidade Estadual de Campinas

1. Garcia, Patrick Vianna, 1978-. Alterações morfométricas, estereológicas e funcionais no epidídimo e parâmetros de fertilidade em ratos tratados com finasterida: Morphometric-stereological and functional epididymal alterations and fertility parameters in rats treated with finasteride.

Degree: 2012, Universidade Estadual de Campinas

Abstract: During epididymal maturation, proteins secreted by epididymis functionally interact with the spermatozoa modifying it. About 75% of the proteins that participate in the epididymal maturation are secreted by the epithelial cells of the initial segment and caput of the epididymis and 48% of the synthesis is dependent on dihydrotestosterone (DHT), which is synthesized from testosterone by the action of the enzyme 5 ? reductase.The DHT is extremely important for the physiology of the male reproductive system. High levels of DHT in adulthood may predispose to various disorders such as androgenic alopecia. In order to minimize the effects of DHT, medications were produced with the purpose of inhibit the action of 5 ?-reductase and among those medications the finasteride was the first 5 ? reductase inhibitor that received clinical approval for the treatment of these disorders. A public increasingly young uses finasteride as a preventive and palliative method and against androgenic alopecia, in this way; studies of the effects of finasteride in the male reproductive system are of clinical and commercial interest. The aim of this study was to evaluate the possible alterations in the caput epididymis and sperm quality in animals submitted to acute (15 days) and chronic (56 days) treatment and animals with 30 days post- treatment. Acute administration of finasteride in rats (15 days) was observed reduction in sperm membrane integrity. Chronic administration of finasteride in rats (56 days), leads to changes in the epididymis, such as weight reduction, morphometric-stereological changes, decreased transit time of sperm, motility of the sperm membrane integrity and consequently in fertility parameters of these animals. Even with the interruption of treatment with finasteride (30 days) sperm quality remains committed. Thus, further studies should be performed to complement the existing knowledge on the physiology of the epididymis after DHT depletion, on the time that is needed for the recovery of fertility parameters after interruption of finasteride treatment, and if it these parameters can be fully recovered Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Pereira, Luis Antonio Violin Dias, 1968- (advisor), Mesquita, Suzana de Fatima Paccola (coadvisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Biologia Celular e Estrutural (nameofprogram), Fernandes, Galura Scantamburlo Alves (committee member), Junior, Odair Aguiar (committee member), Quitete, Valeria Helena Cagnon (committee member), Scarano, Wellerson Rodrigo (committee member).

Subjects/Keywords: Epidídimo; Finasterida; Espermatozóides; Fertilidade; Epididymis; Finasteride; Sperm; Fertility

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APA (6th Edition):

Garcia, Patrick Vianna, 1. (2012). Alterações morfométricas, estereológicas e funcionais no epidídimo e parâmetros de fertilidade em ratos tratados com finasterida: Morphometric-stereological and functional epididymal alterations and fertility parameters in rats treated with finasteride. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/317694

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Garcia, Patrick Vianna, 1978-. “Alterações morfométricas, estereológicas e funcionais no epidídimo e parâmetros de fertilidade em ratos tratados com finasterida: Morphometric-stereological and functional epididymal alterations and fertility parameters in rats treated with finasteride.” 2012. Thesis, Universidade Estadual de Campinas. Accessed October 19, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317694.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Garcia, Patrick Vianna, 1978-. “Alterações morfométricas, estereológicas e funcionais no epidídimo e parâmetros de fertilidade em ratos tratados com finasterida: Morphometric-stereological and functional epididymal alterations and fertility parameters in rats treated with finasteride.” 2012. Web. 19 Oct 2020.

Vancouver:

Garcia, Patrick Vianna 1. Alterações morfométricas, estereológicas e funcionais no epidídimo e parâmetros de fertilidade em ratos tratados com finasterida: Morphometric-stereological and functional epididymal alterations and fertility parameters in rats treated with finasteride. [Internet] [Thesis]. Universidade Estadual de Campinas; 2012. [cited 2020 Oct 19]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317694.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Garcia, Patrick Vianna 1. Alterações morfométricas, estereológicas e funcionais no epidídimo e parâmetros de fertilidade em ratos tratados com finasterida: Morphometric-stereological and functional epididymal alterations and fertility parameters in rats treated with finasteride. [Thesis]. Universidade Estadual de Campinas; 2012. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317694

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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