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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Merhi, Vania Aparecida Leandro"). One record found.

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1. Gobato, Amanda Oliva, 1985-. Esteatose hepática em crianças e adolescentes com fibrose cística: Hepatic steatosis in children and adolescents with cystic fibrosis.

Degree: 2019, Universidade Estadual de Campinas

Abstract: Cystic fibrosis (CF), is an autosomal recessive genetic disorder characterized by the dysfunction of the cystic fibrosis transmembrane conductance regulator gene (CFTR). It is considered a potentially lethal and multisystemic disease because it affects sweat glands, pancreas, lungs, liver, intestine and Wolff's ducts. Recently, attention has been paid to hepatic involvement in cystic fibrosis (CF), since it is the third leading cause of death after respiratory failure and complications related to lung transplant. Objectives: To determine the prevalence of hepatic steatosis (HS) in children and adolescents with CF and to associate it with the nutritional status. To associate HS and the nutritional status with the metabolic profile in children and adolescents with cystic fibrosis. Methods: Cross-sectional study in children and adolescents with CF diagnosis. Weight and height were checked for the calculation of BMI/age and classification of the nutritional status classified according to the cut-off points of the WHO and the International Consensus of CF. Arm circumference (AC), triceps skinfold (TSF) and arm muscle circumference (AMC) were used to evaluate body composition. Abdominal ultrasonography was performed for the diagnosis of HS. The metabolic profile was assessed by aminotransferase activity, lipid profile, triglycerides, fasting glycemia and basal insulin for calculating the HOMA index. The statistical tests used were the Student's t-test, Mann-Whitney, Chi-square and Anova, with a significance level of 5%. Results: Of the 50 patients evaluated, between the ages of 2 and 19 y.o. (incomplete) (12.28 ± 4.96), 18 (36%) presented HS (Group A) and 32 (64%) without HS. For the mean age (Group A = 13.3 ± 5.0 years and Group B = 11.7 ± 5.0 years), BMI (Group A = 18.0 ± 4.1 and Group B = 15.7 ± 3 , 8) and TSF (Group A = 8.4mm ± 3.5 and Group B = 7.0mm ± 2.5), there was no significant difference between the groups. Mean AC and AMC differed significantly between the groups, being higher in the group with HS with a respective p value of 0.047 and 0.043. Patients in group A presented a higher mean aspartate aminotransferase (AST) (p 0.034) and 61.1% of this group had elevated levels of alkaline phosphatase (ALP) (p 0.012). In this same group, mean total cholesterol and HDL were decreased (p = 0.029 and 0.018, respectively. The association between nutritional status classification and metabolic profile was not significant. Conclusion: The frequency of HS is high in patients with CF and is not related to malnutrition according to the parameters of BMI, TSF and AMC. AC and AMC values indicated a greater reserve of muscle mass in patients with HS. HS and metabolic profile in CF patients were not associated with nutritional status. HS was associated with elevation of ALP and AST. In the HS group, the patients presented lower mean HDL-cholesterol and total cholesterol Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Hessel, Gabriel, 1960- (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Saúde da Criança e do Adolescente (nameofprogram), Mendes, Roberto Teixeira (committee member), Toro, Adyléia Aparecida Dalbo Contrera (committee member), Merhi, Vania Aparecida Leandro (committee member), Saron, Margareth Lopes Galvão (committee member).

Subjects/Keywords: Fibrose cística; Fígado gorduroso; Estado nutricional; Cystic fibrosis; Hepatic steatosis; Nutricional status

…Pesquisa da Faculdade de Ciências Médicas (FCM) da Universidade Estadual de Campinas… …Fibrose Cística do Hospital de Clinicas da Universidade Estadual de Campinas (UNICAMP)… …Ambulatório de Fibrose Cística do Hospital de Clinicas da Universidade Estadual de Campinas (… …association with nutritional status Amanda Oliva Gobato: Universidade Estadual de Campinas… …Campinas, SP, Brasil Ana Carolina Junqueira Vasques: Universidade Estadual de Campinas, Campinas… 

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APA (6th Edition):

Gobato, Amanda Oliva, 1. (2019). Esteatose hepática em crianças e adolescentes com fibrose cística: Hepatic steatosis in children and adolescents with cystic fibrosis. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/333752

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Gobato, Amanda Oliva, 1985-. “Esteatose hepática em crianças e adolescentes com fibrose cística: Hepatic steatosis in children and adolescents with cystic fibrosis.” 2019. Thesis, Universidade Estadual de Campinas. Accessed December 04, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/333752.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Gobato, Amanda Oliva, 1985-. “Esteatose hepática em crianças e adolescentes com fibrose cística: Hepatic steatosis in children and adolescents with cystic fibrosis.” 2019. Web. 04 Dec 2020.

Vancouver:

Gobato, Amanda Oliva 1. Esteatose hepática em crianças e adolescentes com fibrose cística: Hepatic steatosis in children and adolescents with cystic fibrosis. [Internet] [Thesis]. Universidade Estadual de Campinas; 2019. [cited 2020 Dec 04]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/333752.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gobato, Amanda Oliva 1. Esteatose hepática em crianças e adolescentes com fibrose cística: Hepatic steatosis in children and adolescents with cystic fibrosis. [Thesis]. Universidade Estadual de Campinas; 2019. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/333752

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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