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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Matsubara, Luiz Shiguero"). One record found.

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Universidade Estadual de Campinas

1. Ozaki, Michiko Regina, 1962-. Evolução e involução da aterosclerose estudo experimental em coelhos hipercolesterolêmicos: Evolution and involution of atherosclerosis experimental study in hypercholesterolemic rabbits.

Degree: 2011, Universidade Estadual de Campinas

Abstract: Regression of atherosclerosis is still a very broad field to be searched, with mechanisms to be explored, the rabbit is an animal used internationally for research in this area. This work was carried out aiming at checking the progress and regression of atherosclerosis in hypercholesterolemic rabbits and its relation to endothelial function, lipid peroxidation and plasma and tissue. We used 30 New Zealand white rabbits initially weighing 3.0 to 3.5 kg and divided into six groups (n=5): G1: not hypercholesterolemic animals, G2: hypercholesterolemic animals, G3: hypercholesterolemic animals, followed by four months of not hypercholesterolemic diet; G4: hypercholesterolemic rats, followed by a month of not hypercholesterolemic diet and treatment with rosuvastatin (5.0mg/animal/day), G5: hypercholesterolemic rabbits, followed by two months of diet does not hypercholesterolemic and treatment with rosuvastatin (5.0mg/animal/day) G6: hypercholesterolemic animals, followed by four months of diet does not hypercholesterolemic and treatment with rosuvastatin. (5.0mg/animal/day). The animals in groups G2 to G6 were fed a hypercholesterolemic diet composed by 0.5% cholesterol and 10% coconut oil for a period of four months. At the end of the experiment were measured in plasma: total cholesterol, triglycerides and HDL-C. The LDL-C was estimated by the Friedwald formula. In aortic segments dosed 0cholesterol and MDA, as well as measured endothelial function through curves of concentration-effect with acetylcholine. Quantification of atherosclerosis in the aorta was observed macroscopically stained sudam IV, and microscopic fragments stained with hematoxylin-eosin and studied by light microscopy. Quantification was performed by specific software. The values of total cholesterol, LDL-C, HDL-C, triglycerides, cholesterol and tissue peroxidation in different groups of animals were examined by nonparametric statistical test Kruskal-Walls, followed by multiple comparison test of Dunn. The curves expressing endothelial function were compared by analysis of variance (ANOVA) for repeated measures. Considering the significant values "p"<0.05. The parameters, both biochemical and tissue were increased for G2 compared to G1. The suspension of the hypercholesterolemic diet was not enough parameters to return the tissue to the G1. The groups treated with rosuvastatin G4, G5 and G6, plasma lipids were significantly decreased, but in relation to cholesterol peroxidation and tissue in animals only significant decrease in the G6. Regarding the endothelial function, only the animals of the G6 group showed significant improvement. Only the suspension of the diet was not effective for improving the tissue values of cholesterol, lipid peroxidation, endothelial function and regress atherosclerosis. Prolonged treatment with rosuvastatin, besides the suspension of hypercholesterolemic diet decreased cholesterol and tissue lipid peroxidation, improved endothelial function and produced regression of atherosclerosis Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Almeida, Eros Antonio de, 1951- (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Clínica Médica (nameofprogram), Matsubara, Luiz Shiguero (committee member), Okoshi, Marina Politi (committee member), Bonon, Sandra Helena Alves (committee member), Fagian, Marcia Marilia (committee member).

Subjects/Keywords: Aterosclerose; Coelho; Endotelio; Óxido nítrico; Peroxidação lipidica; Atherosclerosis; Rabbits; Endothelium; Nitric oxide; Lipid peroxidation

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APA (6th Edition):

Ozaki, Michiko Regina, 1. (2011). Evolução e involução da aterosclerose estudo experimental em coelhos hipercolesterolêmicos: Evolution and involution of atherosclerosis experimental study in hypercholesterolemic rabbits. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/309178

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Ozaki, Michiko Regina, 1962-. “Evolução e involução da aterosclerose estudo experimental em coelhos hipercolesterolêmicos: Evolution and involution of atherosclerosis experimental study in hypercholesterolemic rabbits.” 2011. Thesis, Universidade Estadual de Campinas. Accessed December 01, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309178.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Ozaki, Michiko Regina, 1962-. “Evolução e involução da aterosclerose estudo experimental em coelhos hipercolesterolêmicos: Evolution and involution of atherosclerosis experimental study in hypercholesterolemic rabbits.” 2011. Web. 01 Dec 2020.

Vancouver:

Ozaki, Michiko Regina 1. Evolução e involução da aterosclerose estudo experimental em coelhos hipercolesterolêmicos: Evolution and involution of atherosclerosis experimental study in hypercholesterolemic rabbits. [Internet] [Thesis]. Universidade Estadual de Campinas; 2011. [cited 2020 Dec 01]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/309178.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ozaki, Michiko Regina 1. Evolução e involução da aterosclerose estudo experimental em coelhos hipercolesterolêmicos: Evolution and involution of atherosclerosis experimental study in hypercholesterolemic rabbits. [Thesis]. Universidade Estadual de Campinas; 2011. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/309178

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.