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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Lomazi, Elizete Aparecida, 1957-"). One record found.

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Universidade Estadual de Campinas

1. Davanço, Taciana. Doença de Crohn = efeito de um concentrado de proteínas do soro de leite bovino enriquecido com tgf-ß na nutrição e inflamação de pacientes sob terapia com imunossupressor: Crohn's disease : effect of a concentrated whey protein enriched with TGF-ß in nutrition and inflammation in patients under immunosupressive therapy.

Degree: 2011, Universidade Estadual de Campinas

Abstract: Crohn's disease (AD) is a chronic inflammatory bowel disorder, with evidence of transmural granulomatous inflammation of the mucosa. There is increased intestinal permeability, reduced the activity of the ciliary mucus, changes in epithelial junctions, and trace element deficiency to severe malnutrition. The etiopathogenesis remains an enigma, but there are hypotheses about the genetics of disease and changes in regulation of the mucosal immune response to intestinal microbiota. The diagnosis is established by the symptoms and signs, endoscopy and radiology images, and histology of the intestinal tissue. The objective of this research was to investigate the role of a protein concentrate of whey enriched with TGF-? on inflammation and nutritional status of patients with Crohn's disease under treatment with azathioprine alone or combined with anti-TNF (infliximab). The study design is prospective and intervention orally for sixteen weeks with a protein concentrate of whey enriched with TGF-?. Were analyzed for chemical composition, degree of hydrolysis, solubility and total amino acid determination of protein supplementation of whey. Dietary intake and nutritional status were evaluated before and after intervention. To supplement the sensory evaluation test was applied for acceptance facial hedonic scale of 9 points. Inflammation was assessed before, during and after the intervention by measuring the index of disease activity and dosage of the oxidant system H2O2 by granulocytes and erythrocyte antioxidant enzyme glutathione (GSH). The total group of patients with Crohn's disease had, in most cases, adequate intake of carbohydrates and lipids, and protein consumption was higher than recommended in more than half of patients. It was found inadequate intake of vitamins A, C, D, E, fiber, calcium, folate, iron and zinc. Protein intake of whey resulted in improved body composition of patients. The sensory evaluation showed that about 30% of individuals liked the supplement with respect to all attributes, since half of them did not like and 20% classified it as "more or less". The clinical activity index for Crohn's disease (CDAI), showed that nutritional supplementation in patients under azathioprine and infliximab combination therapy significantly reduced the IADC revealed by the improvement of clinical symptoms of patients. The group of patients who presented with the DC milder symptoms were being treated with AZA alone and showed production of GSH similar to healthy control. However, the AZA group under combined therapy + anti-TNF-? (infliximab) had GSH values significantly higher than healthy controls before (p = 0.023) and after supplementation (p <0.01). Similarly, significantly higher values of GSH in the combined therapy group before (p = 0.048) and after supplementation was observed when compared to the AZA group. Highest levels of GSH in the combined therapy group can be interpreted as an effect of this therapy, combined, since there was no significant difference when comparing the values before and… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Lomazi, Elizete Aparecida, 1957- (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Saúde da Criança e do Adolescente (nameofprogram), Pacheco, Maria Teresa Bertoldo (committee member), Merhi, Vania Aparecida Leandro (committee member), Silva, Luciano Bruno de Carvalho (committee member), Coy, Claudio Saddy Rodrigues (committee member).

Subjects/Keywords: Doença de Crohn; Estado nutricional; Azatioprina; Infliximab; Suplementos dieteticos; Crohn's disease; Nutritional status; Azathioprine; Infliximab; Suplementation

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APA (6th Edition):

Davanço, T. (2011). Doença de Crohn = efeito de um concentrado de proteínas do soro de leite bovino enriquecido com tgf-ß na nutrição e inflamação de pacientes sob terapia com imunossupressor: Crohn's disease : effect of a concentrated whey protein enriched with TGF-ß in nutrition and inflammation in patients under immunosupressive therapy. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/309099

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Davanço, Taciana. “Doença de Crohn = efeito de um concentrado de proteínas do soro de leite bovino enriquecido com tgf-ß na nutrição e inflamação de pacientes sob terapia com imunossupressor: Crohn's disease : effect of a concentrated whey protein enriched with TGF-ß in nutrition and inflammation in patients under immunosupressive therapy.” 2011. Thesis, Universidade Estadual de Campinas. Accessed December 05, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309099.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Davanço, Taciana. “Doença de Crohn = efeito de um concentrado de proteínas do soro de leite bovino enriquecido com tgf-ß na nutrição e inflamação de pacientes sob terapia com imunossupressor: Crohn's disease : effect of a concentrated whey protein enriched with TGF-ß in nutrition and inflammation in patients under immunosupressive therapy.” 2011. Web. 05 Dec 2020.

Vancouver:

Davanço T. Doença de Crohn = efeito de um concentrado de proteínas do soro de leite bovino enriquecido com tgf-ß na nutrição e inflamação de pacientes sob terapia com imunossupressor: Crohn's disease : effect of a concentrated whey protein enriched with TGF-ß in nutrition and inflammation in patients under immunosupressive therapy. [Internet] [Thesis]. Universidade Estadual de Campinas; 2011. [cited 2020 Dec 05]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/309099.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Davanço T. Doença de Crohn = efeito de um concentrado de proteínas do soro de leite bovino enriquecido com tgf-ß na nutrição e inflamação de pacientes sob terapia com imunossupressor: Crohn's disease : effect of a concentrated whey protein enriched with TGF-ß in nutrition and inflammation in patients under immunosupressive therapy. [Thesis]. Universidade Estadual de Campinas; 2011. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/309099

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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