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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Lamano, Teresa Lucia Colussi"). Showing records 1 – 2 of 2 total matches.

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Universidade Estadual de Campinas

1. Perobelli, Juliana Elaine, 1985-. Morfofisiologia do sistema genital masculino de ratos púberes e adultos após privação androgênica durante a pré-puberdade: Morphophysiology of male reproductive system of adult and pubertal rats after androgen deprivation during prepuberty.

Degree: 2012, Universidade Estadual de Campinas

Abstract: Endocrine disrupters are chemicals that can act as agonists or antagonists of endogenous hormones, interfering with the homeostasis of the organism. Since the endocrine system plays a critical role in the development and function of the male reproductive system, this is an especially vulnerable target of potential endocrine perturbations. The literature presents data on exposure to antiandrogens during the prenatal life and adulthood and its consequences on the male reproductive function. However, few studies have investigated the possible effects on the male reproductive system of rats after androgen deprivation during prepuberty. The prepubertal period comprehends the phase in which the epididymis, male reproductive organ responsible for the sperm maturation and storage, undergoes significant morphofunctional changes, besides being a period of more vulnerability to endocrine disrupters, possibly due to hormonal imprinting. The aim of this study was to evaluate the possible consequences of androgen deprivation during the prepuberty on morphophysiology of male reproductive system of pubertal and adult rats, focusing on the epididymis and sperm quality. The choice of an antiandrogen agent was due to extensive environmental and occupational exposure of the general population to this group of contaminants. For this purpose, Wistar male rats were divided into flutamide group (flutamide 25mg/Kg/day, orally, from postnatal day 21 to 44) and control group (corn oil, orally, during the same period). The animals were evaluated at 50 days and 75 days of age. At both ages it was evaluated the serum sexual hormone levels, intra-testicular testosterone levels, organ weights, testicular and epididymal histopathology, immunohistochemistry for androgen receptor (AR), sperm protein 22 (SP22), calmodulin (CALM) and Rab11A in epididymal tissue, besides immunostaining for CALM and Rab11A in the testis and Western blot for AR in the epididymis. Furthermore, additional parameters were assessed in 75-day-old animals, such as sexual behavior, fertility after natural mating and after artificial insemination, sperm motility and morphology, sperm counts in the testis and epididymis, proteomic of sperm membrane by bi-dimensional electrophoresis and Sertoli cells counts. Pubertal animals showed reduced reproductive organs weight, probably due to a decrease in serum testosterone and changes in the pattern of immunostaining for AR and CALM in the epididymis. The other parameters were comparable between the groups. In animals at 75 days old changes in the pattern of immunostaining for AR, CALM and Rab11A in the epididymis, decreased fertility potential after artificial insemination, impaired sperm motility, decrease in the sperm numbers in the caput/corpus and cauda epididymis, acceleration of sperm transit time through these epididymal regions, and modifications in three proteins of sperm membrane were observed. Other parameters were similar between the groups. The results show that androgen deprivation during prepuberty impairs sperm… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Kempinas, Wilma De Grava (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Biologia Celular e Estrutural (nameofprogram), Lamano, Teresa Lucia Colussi (committee member), Camargo, João Lauro Viana de (committee member), Pereira, Luis Antonio Violin Dias (committee member), Pinheiro, Patricia Fernanda Felipe (committee member).

Subjects/Keywords: Ratos Wistar; Receptores androgênicos - Antagonistas e inibidores; Epidídimo; Pré-puberdade; Aparelho genital masculino; Wistar rats; Androgen receptors - Antagonists and inhibitors; Epididymis; Prepuberty; Male genitalia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Perobelli, Juliana Elaine, 1. (2012). Morfofisiologia do sistema genital masculino de ratos púberes e adultos após privação androgênica durante a pré-puberdade: Morphophysiology of male reproductive system of adult and pubertal rats after androgen deprivation during prepuberty. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/316201

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Perobelli, Juliana Elaine, 1985-. “Morfofisiologia do sistema genital masculino de ratos púberes e adultos após privação androgênica durante a pré-puberdade: Morphophysiology of male reproductive system of adult and pubertal rats after androgen deprivation during prepuberty.” 2012. Thesis, Universidade Estadual de Campinas. Accessed October 30, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316201.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Perobelli, Juliana Elaine, 1985-. “Morfofisiologia do sistema genital masculino de ratos púberes e adultos após privação androgênica durante a pré-puberdade: Morphophysiology of male reproductive system of adult and pubertal rats after androgen deprivation during prepuberty.” 2012. Web. 30 Oct 2020.

Vancouver:

Perobelli, Juliana Elaine 1. Morfofisiologia do sistema genital masculino de ratos púberes e adultos após privação androgênica durante a pré-puberdade: Morphophysiology of male reproductive system of adult and pubertal rats after androgen deprivation during prepuberty. [Internet] [Thesis]. Universidade Estadual de Campinas; 2012. [cited 2020 Oct 30]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/316201.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Perobelli, Juliana Elaine 1. Morfofisiologia do sistema genital masculino de ratos púberes e adultos após privação androgênica durante a pré-puberdade: Morphophysiology of male reproductive system of adult and pubertal rats after androgen deprivation during prepuberty. [Thesis]. Universidade Estadual de Campinas; 2012. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/316201

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Universidade Estadual de Campinas

2. Fernandes, Glaura Scantamburlo Alves. Relação entre estresse oxidativo e desordens reprodutivas em ratos machos hiperglicemicos = potencial antioxidante das vitaminas C e E: Oxidative stress and reproductive disorders in hyperglycemic male rats : antioxidant potencial of vitamins C and E.

Degree: 2009, Universidade Estadual de Campinas

Abstract: The hyperglycemia is related to disorders in the male reproductive system. When induced chemically, it can reduce the sexual hormones' level, reproductive organs' weight, sperm concentration, and fertility as well as the male rat sexual behavior. In men, the hyperglycemia can lead to sexual impotence, libido and spermatogenesis reduction. However, the main factors that are responsible for these alterations are still controversial. One of the possible causes for this would be the increase of the oxidative stress, which can cause lipid peroxidation in the biological membranes, hyperglycemic neuropathies, injury in the DNA molecule and to compromise the cellular communication. However, there is a lack of information related to the increased oxidative stress effect with the morphophysiology from the male reproductive system in hyperglycemic subjects. In this sense, the aim of the present study was to evaluate if the treatment with antioxidants (vitamins C and/or E), lowering the oxidative stress, could somehow attenuate the damages caused by hyperglycemia in the male rat reproductive system. Therefore the hyperglycemia was induced chemically using a single dose of streptozotocin antibiotic in male adult rats (90 days old; 9 or 10/experimental group). These animals were divided into experimental groups that received vitamin C or E (isolated or in association), or only the vehicles (normoglycemic group) during thirty consecutive days orally. At the 31st day from the experimental period, after the euthanasia of the rats, blood was collected to evaluate biomarkers of oxidative stress and hormonal levels, and reproductive organs to evaluate the permatic parameters and the noradrenergic response of vas deferens. The experimental design described above was applied in another amount of animals for the accomplishment of histopathological and morphometric analysis from testis and epididymis. The results showed that hyperglycemia caused significant increase in the oxidative stress and in the sensibility of noradrenergic a1 receptors, decrease in the body mass and in the reproductive organs' weights, reduction on the sperm motility, on epididymal tissue, in the testosterone level, an increase in the malformed sperm number and a rearrangement in the epididymal tissue components. The vitamins reduced significantly the level of oxidative stress and the number of malformed sperm, but in both cases vitamin C was more effective. These vitamins also reduced partly the sensibility to noradrenalin in the a receptors. In relation to the injuries in the sperm motility, the vitamin C alone attenuated partly these alterations. In addition, the vitamin C alone also prevented the reduction of the epididymal compartimental. Besides that, the vitamin C alone and in association to vitamin E reestablished partly the testosterone levels. Meanwhile, the association of the vitamins caused a significant reduction in the LH levels. Nonetheless, the daily sperm production, the transit time by epididymis, the histological aspect of the testes and… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Kempinas, Wilma De Grava (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Biologia Celular e Estrutural (nameofprogram), Lamano, Teresa Lucia Colussi (committee member), Lazari, Maria de Fatima Magalhães (committee member), Godinho, Antonio Francisco (committee member), Scarano, Wellerson Rodrigo (committee member).

Subjects/Keywords: Estresse oxidativo; Hiperglicemia; Reprodução; Vitamina C; Vitamina E; Oxidative stress; Hyperglycemia; Reproduction; Vitamin C; Vitamin E

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Fernandes, G. S. A. (2009). Relação entre estresse oxidativo e desordens reprodutivas em ratos machos hiperglicemicos = potencial antioxidante das vitaminas C e E: Oxidative stress and reproductive disorders in hyperglycemic male rats : antioxidant potencial of vitamins C and E. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/318037

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Fernandes, Glaura Scantamburlo Alves. “Relação entre estresse oxidativo e desordens reprodutivas em ratos machos hiperglicemicos = potencial antioxidante das vitaminas C e E: Oxidative stress and reproductive disorders in hyperglycemic male rats : antioxidant potencial of vitamins C and E.” 2009. Thesis, Universidade Estadual de Campinas. Accessed October 30, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/318037.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Fernandes, Glaura Scantamburlo Alves. “Relação entre estresse oxidativo e desordens reprodutivas em ratos machos hiperglicemicos = potencial antioxidante das vitaminas C e E: Oxidative stress and reproductive disorders in hyperglycemic male rats : antioxidant potencial of vitamins C and E.” 2009. Web. 30 Oct 2020.

Vancouver:

Fernandes GSA. Relação entre estresse oxidativo e desordens reprodutivas em ratos machos hiperglicemicos = potencial antioxidante das vitaminas C e E: Oxidative stress and reproductive disorders in hyperglycemic male rats : antioxidant potencial of vitamins C and E. [Internet] [Thesis]. Universidade Estadual de Campinas; 2009. [cited 2020 Oct 30]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/318037.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fernandes GSA. Relação entre estresse oxidativo e desordens reprodutivas em ratos machos hiperglicemicos = potencial antioxidante das vitaminas C e E: Oxidative stress and reproductive disorders in hyperglycemic male rats : antioxidant potencial of vitamins C and E. [Thesis]. Universidade Estadual de Campinas; 2009. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/318037

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.