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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Godinho, Antonio Francisco"). One record found.

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Universidade Estadual de Campinas

1. Fernandes, Glaura Scantamburlo Alves. Relação entre estresse oxidativo e desordens reprodutivas em ratos machos hiperglicemicos = potencial antioxidante das vitaminas C e E: Oxidative stress and reproductive disorders in hyperglycemic male rats : antioxidant potencial of vitamins C and E.

Degree: 2009, Universidade Estadual de Campinas

Abstract: The hyperglycemia is related to disorders in the male reproductive system. When induced chemically, it can reduce the sexual hormones' level, reproductive organs' weight, sperm concentration, and fertility as well as the male rat sexual behavior. In men, the hyperglycemia can lead to sexual impotence, libido and spermatogenesis reduction. However, the main factors that are responsible for these alterations are still controversial. One of the possible causes for this would be the increase of the oxidative stress, which can cause lipid peroxidation in the biological membranes, hyperglycemic neuropathies, injury in the DNA molecule and to compromise the cellular communication. However, there is a lack of information related to the increased oxidative stress effect with the morphophysiology from the male reproductive system in hyperglycemic subjects. In this sense, the aim of the present study was to evaluate if the treatment with antioxidants (vitamins C and/or E), lowering the oxidative stress, could somehow attenuate the damages caused by hyperglycemia in the male rat reproductive system. Therefore the hyperglycemia was induced chemically using a single dose of streptozotocin antibiotic in male adult rats (90 days old; 9 or 10/experimental group). These animals were divided into experimental groups that received vitamin C or E (isolated or in association), or only the vehicles (normoglycemic group) during thirty consecutive days orally. At the 31st day from the experimental period, after the euthanasia of the rats, blood was collected to evaluate biomarkers of oxidative stress and hormonal levels, and reproductive organs to evaluate the permatic parameters and the noradrenergic response of vas deferens. The experimental design described above was applied in another amount of animals for the accomplishment of histopathological and morphometric analysis from testis and epididymis. The results showed that hyperglycemia caused significant increase in the oxidative stress and in the sensibility of noradrenergic a1 receptors, decrease in the body mass and in the reproductive organs' weights, reduction on the sperm motility, on epididymal tissue, in the testosterone level, an increase in the malformed sperm number and a rearrangement in the epididymal tissue components. The vitamins reduced significantly the level of oxidative stress and the number of malformed sperm, but in both cases vitamin C was more effective. These vitamins also reduced partly the sensibility to noradrenalin in the a receptors. In relation to the injuries in the sperm motility, the vitamin C alone attenuated partly these alterations. In addition, the vitamin C alone also prevented the reduction of the epididymal compartimental. Besides that, the vitamin C alone and in association to vitamin E reestablished partly the testosterone levels. Meanwhile, the association of the vitamins caused a significant reduction in the LH levels. Nonetheless, the daily sperm production, the transit time by epididymis, the histological aspect of the testes and… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Kempinas, Wilma De Grava (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Biologia Celular e Estrutural (nameofprogram), Lamano, Teresa Lucia Colussi (committee member), Lazari, Maria de Fatima Magalhães (committee member), Godinho, Antonio Francisco (committee member), Scarano, Wellerson Rodrigo (committee member).

Subjects/Keywords: Estresse oxidativo; Hiperglicemia; Reprodução; Vitamina C; Vitamina E; Oxidative stress; Hyperglycemia; Reproduction; Vitamin C; Vitamin E

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APA (6th Edition):

Fernandes, G. S. A. (2009). Relação entre estresse oxidativo e desordens reprodutivas em ratos machos hiperglicemicos = potencial antioxidante das vitaminas C e E: Oxidative stress and reproductive disorders in hyperglycemic male rats : antioxidant potencial of vitamins C and E. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/318037

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Fernandes, Glaura Scantamburlo Alves. “Relação entre estresse oxidativo e desordens reprodutivas em ratos machos hiperglicemicos = potencial antioxidante das vitaminas C e E: Oxidative stress and reproductive disorders in hyperglycemic male rats : antioxidant potencial of vitamins C and E.” 2009. Thesis, Universidade Estadual de Campinas. Accessed October 22, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/318037.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Fernandes, Glaura Scantamburlo Alves. “Relação entre estresse oxidativo e desordens reprodutivas em ratos machos hiperglicemicos = potencial antioxidante das vitaminas C e E: Oxidative stress and reproductive disorders in hyperglycemic male rats : antioxidant potencial of vitamins C and E.” 2009. Web. 22 Oct 2020.

Vancouver:

Fernandes GSA. Relação entre estresse oxidativo e desordens reprodutivas em ratos machos hiperglicemicos = potencial antioxidante das vitaminas C e E: Oxidative stress and reproductive disorders in hyperglycemic male rats : antioxidant potencial of vitamins C and E. [Internet] [Thesis]. Universidade Estadual de Campinas; 2009. [cited 2020 Oct 22]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/318037.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fernandes GSA. Relação entre estresse oxidativo e desordens reprodutivas em ratos machos hiperglicemicos = potencial antioxidante das vitaminas C e E: Oxidative stress and reproductive disorders in hyperglycemic male rats : antioxidant potencial of vitamins C and E. [Thesis]. Universidade Estadual de Campinas; 2009. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/318037

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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