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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Delella, Flavia Karina"). Showing records 1 – 2 of 2 total matches.

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Universidade Estadual de Campinas

1. Pytlowanciv, Eloísa Zanin, 1987-. Efeitos da exposição ao ambiente obesogênico em diferentes fases do desenvolvimento sobre a morfofisiologia da próstata de ratos Wistar = The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats: The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats.

Degree: 2015, Universidade Estadual de Campinas

Abstract: Experimental data indicate that the high-fat diet (HFD) affects the proliferative activity and prostate health. However, the consequences of maternal obesity and obesogenic environment (OE) by lipids excess in the diet for the prostate remain inconclusive. This study investigated the effects of the exposure to OE at different developmental phases on prostate morphophysiology of Wistar rats at adulthood and the possible correlations with the metabolic status and regulation by sex steroids. Male Wistar rats (19 weeks-old; n=15) were fed with balanced chow (C; 3% fat, 3.5Kcal/g) or HFD (20% fat, 4.9Kcal/g) during gestation (G), gestation and lactation (GL), from post-weaning to adulthood (WA), from lactation to adulthood (LA) and from gestation to adulthood (GA). The OE during pregnancy included previous induction of maternal obesity by feeding with HFD for 15 weeks. OE led to insulin resistance in all groups, overweight in GL, obesity and decrease in circulating testosterone levels in the WA, LA and GA groups and increased estrogen levels in GA. Moreover, there was an increase in triglycerides and decrease in HDL levels in the obese groups. Regardless the developmental phase, the OE leads to ventral prostate hypertrophy which, except for the G group, also presented an increase in epithelial proliferation activity. The increase in cell proliferation in these groups was concurrent with the decrease in immunopositive cells frequency of androgen receptor, estrogen receptor ? and liver X receptor ? and increase in estrogen receptor ? and peroxisome proliferator-activated receptor ?. Therefore, the increase in cell proliferation induced by the OE is independent of the androgen receptor signaling. The OE increases cell death by desquamation, in acinar epithelium of ventral prostate, in the groups exposed during gestation and/or lactation and to a greater degree in the group exposed throughout life. The morphological changes in the prostate that characterize the earliest, intermediate and final stages of this kind of death were established. Loss of epithelial AR plays a key role in this process. OE exposure before weaning, increased atrophic lesions foci on the ventral prostate, and the exposure after weaning, increased hyperplasia and intraepithelial neoplasia foci, as indicated by the lesions multiplicity analysis. The longer the exposure period to OE, more serious were the lesions found in the ventral lobe. The OE did not promote pronounced alterations on the dorsal and lateral prostate histology, as indicated by microscopic and stereological analyses. Nor alters the androgen receptor frequency, showing that these lobes are less susceptible to the OE exposure and androgen fall, as compared with the ventral lobes. In conclusion, the OE exposure at different developmental phases interferes with ventral prostate morphophysiology proportionally with metabolic impairment and androgen decline, leading to a hypertrophic and hyperproliferative state associated with increased pathological lesions and collective loss of… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Góes, Rejane Maira (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Biologia Celular e Estrutural (nameofprogram), Ramos, Cristiane da Fonte (committee member), Delella, Flavia Karina (committee member), Junior, Luis Antonio Justulin (committee member), Scarano, Wellerson Rodrigo (committee member).

Subjects/Keywords: Prostata; Ambiente obesogênico; Receptores nucleares; Proliferação celular; Morte celular; Alterações histopatológicas; Prostate; Obesogenic environment; Nuclear receptors; Cell proliferation; Cell death; Histopathological alterations

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Pytlowanciv, Eloísa Zanin, 1. (2015). Efeitos da exposição ao ambiente obesogênico em diferentes fases do desenvolvimento sobre a morfofisiologia da próstata de ratos Wistar = The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats: The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/317894

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Pytlowanciv, Eloísa Zanin, 1987-. “Efeitos da exposição ao ambiente obesogênico em diferentes fases do desenvolvimento sobre a morfofisiologia da próstata de ratos Wistar = The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats: The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats.” 2015. Thesis, Universidade Estadual de Campinas. Accessed October 22, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317894.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Pytlowanciv, Eloísa Zanin, 1987-. “Efeitos da exposição ao ambiente obesogênico em diferentes fases do desenvolvimento sobre a morfofisiologia da próstata de ratos Wistar = The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats: The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats.” 2015. Web. 22 Oct 2020.

Vancouver:

Pytlowanciv, Eloísa Zanin 1. Efeitos da exposição ao ambiente obesogênico em diferentes fases do desenvolvimento sobre a morfofisiologia da próstata de ratos Wistar = The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats: The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats. [Internet] [Thesis]. Universidade Estadual de Campinas; 2015. [cited 2020 Oct 22]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317894.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pytlowanciv, Eloísa Zanin 1. Efeitos da exposição ao ambiente obesogênico em diferentes fases do desenvolvimento sobre a morfofisiologia da próstata de ratos Wistar = The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats: The effects os exposure to obesogenic environment at different developmental phases on prostate morphophysiology os Wistar rats. [Thesis]. Universidade Estadual de Campinas; 2015. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/317894

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Silva, Diego Augusto Lopes da, 1987-. Efeitos do fitoterápico Tribulus terrestris sobre a próstata do gerbilo da Mongólia (Meriones unguiculatus) : Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus): Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus).

Degree: 2017, Universidade Estadual de Campinas

Abstract: The plant Tribulus terrestris (TT) is used to treat numerous health problems in many traditional medicines. One of the most frequent indication of use is for the treatment of sexual dysfunction, because of its supposed ability to interfere with androgenic metabolism. Because of this, TT became popular among individuals of various ages, having been used as a natural and legal alternative for anabolics. However, the use of substances that interfere with hormonal balance can have negative consequences for prostate histophysiology, since the prostate is an organ that is the target of androgen action and sensitive to hormonal changes. On the other hand, data from the literature indicate a possible chemoprotective action of some of the major components of TT, the saponins, which would be able to attenuate deleterious effects of age and exposure to toxic agents. Thus, this work has proposed to present an extensive review of the literature on the role of this herbal medicine in aspects of reproductive biology (Chapter I) and to evaluate the effects of the use of TT extract on testosterone levels and its consequences on the histophysiology of the prostate in intact Mongolian gerbil, or those exposed to the carcinogen N-methyl-N-nitrosourea (MNU). To evaluate the effects of short-term exposure (Chapter II), 24 males were divided into four groups: experimental control, control of carcinogenic induction (50 mg/kg of MNU in a single dose on the 180º day), control of TT effects (11 mg/kg, in daily doses from 180º to 270º day) and treatment after induction (11 mg/kg of TT, in daily doses from 180º to 270º day, after a single dose of 50 mg/kg of MNU on the 180º day). To evaluate the effects of long-term exposure (Chapter III), 24 males were divided into four groups: experimental control, carcinogenic induction control (50 mg/kg MNU, in a single dose on the 180º day), control of prolonged use of TT (11 mg/kg in daily doses from 90º to 270º day) and prolonged treatment associated with induction (11 mg/kg of TT, in daily doses from 90º to 270º day, with a single dose of 50 mg/kg of MNU on the 180º day). TT was not able to raise serum testosterone levels and did not cause biometric changes in androgen-sensitive organs, which indicates low anabolic potential at the dose and periods administered. In addition, the herbal medicine may have contributed to the chemoprotection of the prostate as it has delayed the onset of malignant lesions in the gland. There was a specific action of TT in reducing the activity of the canonical androgenic pathway (decrease of androgen receptors and proliferation of epithelial cells), reproducing, in vivo, the protection against the tumor activity already observed in vitro. However, in spite of repressing the onset of malignant lesions, TT was not able to prevent the onset of premalignant lesions, especially when the use started in young individuals. Thus, the effects of TT on the prostate need to be better understood and phytotherapeutic use still requires caution Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Taboga, Sebastião Roberto (advisor), Santos, Fernanda Cristina Alcântara dos (coadvisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Biologia Celular e Estrutural (nameofprogram), Borges, Luciano de Figueiredo (committee member), Augusto, Taize Machado (committee member), Oliveira, Silvia Borges Pimentel de (committee member), Delella, Flavia Karina (committee member).

Subjects/Keywords: Tribulus terrestris; Prostata; Cancer - Quimioprevenção; Gerbilos; Testosterona; Tribulus terrestris; Prostate; Cancer - Chemoprevetion; Gerbils; Testosterone

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Silva, Diego Augusto Lopes da, 1. (2017). Efeitos do fitoterápico Tribulus terrestris sobre a próstata do gerbilo da Mongólia (Meriones unguiculatus) : Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus): Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus). (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/332303

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Silva, Diego Augusto Lopes da, 1987-. “Efeitos do fitoterápico Tribulus terrestris sobre a próstata do gerbilo da Mongólia (Meriones unguiculatus) : Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus): Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus).” 2017. Thesis, Universidade Estadual de Campinas. Accessed October 22, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/332303.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Silva, Diego Augusto Lopes da, 1987-. “Efeitos do fitoterápico Tribulus terrestris sobre a próstata do gerbilo da Mongólia (Meriones unguiculatus) : Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus): Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus).” 2017. Web. 22 Oct 2020.

Vancouver:

Silva, Diego Augusto Lopes da 1. Efeitos do fitoterápico Tribulus terrestris sobre a próstata do gerbilo da Mongólia (Meriones unguiculatus) : Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus): Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus). [Internet] [Thesis]. Universidade Estadual de Campinas; 2017. [cited 2020 Oct 22]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332303.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Silva, Diego Augusto Lopes da 1. Efeitos do fitoterápico Tribulus terrestris sobre a próstata do gerbilo da Mongólia (Meriones unguiculatus) : Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus): Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus). [Thesis]. Universidade Estadual de Campinas; 2017. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332303

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.