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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Damasceno, Alfredo"). Showing records 1 – 2 of 2 total matches.

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Universidade Estadual de Campinas

1. Lopes, Tátila Martins, 1985-. Avaliação de linguagem em epilepsia de lobo temporal mesial = correlações com neuroimagem estrutural e funcional = Language assessment in mesial temporal lobe epilepsy: correlations with structural and functional neuroimaging: Language assessment in mesial temporal lobe epilepsy : correlations with structural and functional neuroimaging.

Degree: 2017, Universidade Estadual de Campinas

Abstract: Temporal lobe epilepsy is the most common type of epilepsy in adults and is also associated with cognitive comorbidities, such as memory and language impairments, especially in temporal lobe epilepsy (TLE). In this population, a higher incidence of people with atypical language lateralization (ALL) is expected; 20% against 5% of the healthy people. Some factors are pointed as predictors: manual dominance, left-hand familial history, as well as early insult and left hemisphere lesion. Language in these patients has been studied for decades. Lately functional magnetic resonance (fMRI) technique has been replacing the WADA test and has provided new methods and paradigms to study this function in vivo, including in healthy volunteers. Therefore, the objective of this study was to delineate the language aspects in TLE with left (LHA) and right (RHA) hippocampal atrophy and patients without hippocampal atrophy (nonAH), comparing them to controls. The results were set out in two manuscripts. The first, showed the translation of a well-established language fMRI paradigm based on semantic decision and comparison of two versions: easy and complex task in 24 healthy subjects. Both versions were effective, but the complex version produced more robust results for the evaluation of the language in our patients. Therefore, complex version was chosen to conduct the study with TLE patients. The second result was presented in the manuscript which compared patients with RHA (n=31), LHA (n=32), nonHA (n=30) and controls (n=101). In this paper analyzes were performed to investigate the impact of HA on language to obtain a profile of the language in different subtypes of TLE. Analyzes were conducted to acquire the incidence of language lateralization, predictive factors and correlation with fMRI activation pattern in regions associated with language; comparison between groups regarding language activation pattern and functional connectivity, as well as a comparison of performance on the Boston naming test and its correlation with the task activation pattern. The results pointed to a similar frequency of ALL in all groups and only manual dominance as a predictor of hemispheric dominance for language. However, each group was different according to the specific regions of interest. Language activation pattern and ROI-to-ROI analysis showed that LHA presented reduced activation compared with controls and nonHA groups. Seed-based-voxel analysis showed that all groups of patients had reduced functional connectivity in relation to controls, as well as differences among patients. The higher scores on naming performance was correlated with greater activation in language areas only in RHA and nonHA groups. We concluded that patients with LHA presented worse performance in naming, activation and functional connectivity, followed by RHA, and nonHA patients were more similar to controls. This thesis shows that despite of several language fMRI studies, further investigations using different methodologies and paradigms are necessary for better… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Cendes, Fernando, 1962- (advisor), Balthazar, Marcio Luiz Figueredo, 1975- (coadvisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Fisiopatologia Médica (nameofprogram), Amaro Junior, Edson (committee member), Rosset, Sara Regina Escorsi (committee member), Damasceno, Alfredo (committee member).

Subjects/Keywords: Linguagem; Imagem por ressônancia magnética; Epilepsia; Languag; Magnetic resonance imaging; Epilepsy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lopes, Tátila Martins, 1. (2017). Avaliação de linguagem em epilepsia de lobo temporal mesial = correlações com neuroimagem estrutural e funcional = Language assessment in mesial temporal lobe epilepsy: correlations with structural and functional neuroimaging: Language assessment in mesial temporal lobe epilepsy : correlations with structural and functional neuroimaging. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/321824

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lopes, Tátila Martins, 1985-. “Avaliação de linguagem em epilepsia de lobo temporal mesial = correlações com neuroimagem estrutural e funcional = Language assessment in mesial temporal lobe epilepsy: correlations with structural and functional neuroimaging: Language assessment in mesial temporal lobe epilepsy : correlations with structural and functional neuroimaging.” 2017. Thesis, Universidade Estadual de Campinas. Accessed October 31, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/321824.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lopes, Tátila Martins, 1985-. “Avaliação de linguagem em epilepsia de lobo temporal mesial = correlações com neuroimagem estrutural e funcional = Language assessment in mesial temporal lobe epilepsy: correlations with structural and functional neuroimaging: Language assessment in mesial temporal lobe epilepsy : correlations with structural and functional neuroimaging.” 2017. Web. 31 Oct 2020.

Vancouver:

Lopes, Tátila Martins 1. Avaliação de linguagem em epilepsia de lobo temporal mesial = correlações com neuroimagem estrutural e funcional = Language assessment in mesial temporal lobe epilepsy: correlations with structural and functional neuroimaging: Language assessment in mesial temporal lobe epilepsy : correlations with structural and functional neuroimaging. [Internet] [Thesis]. Universidade Estadual de Campinas; 2017. [cited 2020 Oct 31]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/321824.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lopes, Tátila Martins 1. Avaliação de linguagem em epilepsia de lobo temporal mesial = correlações com neuroimagem estrutural e funcional = Language assessment in mesial temporal lobe epilepsy: correlations with structural and functional neuroimaging: Language assessment in mesial temporal lobe epilepsy : correlations with structural and functional neuroimaging. [Thesis]. Universidade Estadual de Campinas; 2017. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/321824

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Universidade Estadual de Campinas

2. Takazaki, Karen Antonia Girotto, 1979-. Avaliação da função autonômica e da cardiomiopatia na Ataxia de Friedreich : Assessment of autonomic function and cardiomyopathy in Friedreich's Ataxia: Assessment of autonomic function and cardiomyopathy in Friedreich's Ataxia.

Degree: 2019, Universidade Estadual de Campinas

Abstract: Friedreich ataxia (FRDA) is the most frequent autosomal recessive ataxia worldwide. Caused by homozygous GAA expansions at FXN that ultimately lead to mitochondrial dysfunction. Manifestations such cardiac damage and autonomic dysfunction have not been properly explored. Therefore, the objectives of this thesis are: (a) To determine the frequency and profile of autonomic manifestations in FRDA and (b) to characterize FRDA-related cardiomyopathy using cardiac magnetic resonance (CMR). In the first part of the study (a), we have performed clinical and detailed electrophysiological autonomic evaluation of 28 patients with molecular confirmation of FRDA and 24 healthy controls matched by age and gender. We used the FARS scale (Friedreich¿s Ataxia Rating Scale) and the SCOPA-AUT questionnare (Scales for Outcomes in Parkinson¿s Disease ¿ Autonomic Questionnaire) to quantify ataxic and dysautonomic manifestations. We also studied the heart rate variability at rest, during the orthostatic challenge, during the Valsalva maneuver and deep breathing. We included in our study the quantitative sudomotor axonal reflex, QSART. In the FRDA group, there were 11 men and mean age was 31.5±11.1 years. Mean SCOPA-AUT score was 15.1±8.1. Analyses of the variability of RR intervals were all similar between patients and controls (p>0.05), except for minimum RR intervals at rest, which were smaller in patients than controls (Median 649.5, IQR 98.0 x 724.0, IQR 98.0ms, p<0.001). Sweat responses were significantly reduced in patients for all sites tested (forearm 0.389, IQR 0.783 x1.309, IQR 0.842 µL; proximal leg 0.406, IQR 1.050 x1.107, IQR 1.011 µL; distal leg 0.491, IQR 1.191 x 1.232, IQR 1.01 µL; foot 0.265, IQR 0.763 x 0.708, IQR 0.416µL; p value?0.05). Sweat volumes correlated with FARS scores. In the second part of the study (b), we scanned twenty-seven FRDA patients (mean age 26.6±9.3years, 15 female)- without full blown heart failure in a 3T device. T1 mapping was used to assess myocardial extracellular volume fraction (ECV) and intracellular lifetime of water (?ic), a measure of cardiomyocyte hypertrophy. FARS score was used to measure disease severity in FRDA. Ten healthy volunteers (mean age 34.9±8.5, 4 female) also underwent CMR for comparison. FRDA patients hd significant increased LV mass-index (LVMASSi) compared to healthy controls (LVEF: 67%±11.5 vs. 63.9±9.0, P=NS; LVMASSi 62.7±23 vs. 45.1±6.8 g/m2, p<0.01). Both ECV and intracellular lifetime of water (?ic) were notably higher in FRDA patients (ECV: 0.36 ± 0.05 vs. 0.25±0.01, p<0.0001; ?ic: 0.13±0.07 vs. 0.06±0.02, p=0.001). ECV demonstrated a negative association with left ventricular end diastolic index (LVEDV-index), r=-0.5, P<0.001. ?ic was negatively associated with FARS scores (r=-0.55, P=0.02), FARS was positively associated with time since diagnosis/onset (r=-0.68, P<0.001), suggesting that the progression of FRDA in the heart may result in regression of cardiomyocyte hypertrophy. In conclusion, results of both studies reveal that (a) sudomotor, but not… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), França Junior, Marcondes Cavalcante, 1976- (advisor), Nucci, Anamarli, 1947- (coadvisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Ciências Médicas (nameofprogram), Schmidt, André (committee member), Heise, Carlos Otto (committee member), Nadruz Junior, Wilson (committee member), Damasceno, Alfredo (committee member).

Subjects/Keywords: Ataxia de Friedreich; Friedreich Ataxia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Takazaki, Karen Antonia Girotto, 1. (2019). Avaliação da função autonômica e da cardiomiopatia na Ataxia de Friedreich : Assessment of autonomic function and cardiomyopathy in Friedreich's Ataxia: Assessment of autonomic function and cardiomyopathy in Friedreich's Ataxia. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/333949

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Takazaki, Karen Antonia Girotto, 1979-. “Avaliação da função autonômica e da cardiomiopatia na Ataxia de Friedreich : Assessment of autonomic function and cardiomyopathy in Friedreich's Ataxia: Assessment of autonomic function and cardiomyopathy in Friedreich's Ataxia.” 2019. Thesis, Universidade Estadual de Campinas. Accessed October 31, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/333949.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Takazaki, Karen Antonia Girotto, 1979-. “Avaliação da função autonômica e da cardiomiopatia na Ataxia de Friedreich : Assessment of autonomic function and cardiomyopathy in Friedreich's Ataxia: Assessment of autonomic function and cardiomyopathy in Friedreich's Ataxia.” 2019. Web. 31 Oct 2020.

Vancouver:

Takazaki, Karen Antonia Girotto 1. Avaliação da função autonômica e da cardiomiopatia na Ataxia de Friedreich : Assessment of autonomic function and cardiomyopathy in Friedreich's Ataxia: Assessment of autonomic function and cardiomyopathy in Friedreich's Ataxia. [Internet] [Thesis]. Universidade Estadual de Campinas; 2019. [cited 2020 Oct 31]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/333949.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Takazaki, Karen Antonia Girotto 1. Avaliação da função autonômica e da cardiomiopatia na Ataxia de Friedreich : Assessment of autonomic function and cardiomyopathy in Friedreich's Ataxia: Assessment of autonomic function and cardiomyopathy in Friedreich's Ataxia. [Thesis]. Universidade Estadual de Campinas; 2019. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/333949

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.