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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Coimbra, Terezila Machado"). Showing records 1 – 3 of 3 total matches.

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Universidade Estadual de Campinas

1. Ciampone, Silmara, 1972-. Estudo da resposta metabólica, receptores da angiotensina e a pressão arterial em ratas androgenizadas em estro persistente : efeito do exercício físico aeróbio programado: Study of metabolic response, angiotensin receptor and blood pressure in androgenized rats in persistent estrus : effect of aerobic exercise shedule.

Degree: 2016, Universidade Estadual de Campinas

Abstract: The polycystic ovary syndrome (PCOS) is an endocrine heterogeneous disease with unknown etiology. It affects about 8% of women in reproductive age. Among the main features of this disease is the hyperandrogenism, infertility and chronic anovulation. The PCOS also have high prevalence of disorders that lead to the metabolic syndrome, such as obesity, insulin resistance, hyperinsulinemia, hyperlipidemia, hypertension and diabetes mellitus type 2. The pharmacological measures, such as diet and physical exercise, have been considered as a first-line strategic on disease prevention and treatment of that. Regarding this presented situation, the aim of this study was to assessusing an animal model of androgenization, PCOS relationship between metabolic syndrome and aerobic exercise effects on the chronic treatment of these disorders. The animals groups were sedentary PCOS (PCOSsed), PCOS exercise (PCOSexe), sedentary control (SEDcon) and exercise control (EXEcon). The animals had free access to water and food. The training methodology was swimming with pleasant water temperature, during 1 hour per day, 5 times a week, over 8 weeks with progressive overload. The anthropometric, metabolic, cardiovascular, renal and intracellularly analysis were carried out considering measures such as body mass ratings, blood pressure, heart rate, lipid profile, glycemic profile, insulin analyses, glomerular filtration, renal sodium handling and intracellular signaling pathways. In the skeletal muscle was evaluated intracellular signaling through the proteins IR, IRS-1, Akt, GLUT-4 and Angiotensin II receptors (AT1R and AT2R) in kidneys. The PCOSsed animals showed the parameters obesity, glucose intolerance, hyperinsulinemia, hypertension, and increased heart rate significantly higher than trained groups, after 8 weeks of experiments. The obesity, insulin resistance and hypertension results were positively correlated with high cholesterol, triglycerides and HDL-C levels. For the kidney function¿s test, the trained groups (PCOSexe and EXEcon) showed lower renal sodium excretion than sedentary groups. However, only in PCOSexe animals the decrease occurred primarily by reducing excretion in the proximal portion, which was offset by an increase in sodium excretion in the distal portion. Another renal response in animals PCOSexe observed was a decrease in renal excretion of potassium. Natriuretic reduction in trained animals may have occurred due to the homeostatic mechanism for compensatory reduction in blood pressure and heart rate. The analysis of AT1R and AT2R, PCOSsed animals have showed less expression of these receptors. On the other hand, the PCOSexe group has presented a significant increase in the expression of AT2R when compared to PCOSsed, which have influenced in the elevation of the reason AT1R/AT2R. The intracellular analysis of insulin pathways in skeletal muscle, PCOSsed animals showed changes in signal transduction pathways of insulin through the significant decrease of the expression of IRS-1 and GLUT-4 of suggesting a… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Gontijo, Jose Antonio Rocha, 1956- (advisor), Boer, Patricia Aline (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Fisiopatologia Médica (nameofprogram), Torsoni, Marcio Alberto (committee member), Silva, Benedito Borges da (committee member), Coimbra, Terezila Machado (committee member), Negrão, Carlos Eduardo (committee member).

Subjects/Keywords: Síndrome do ovário policístico; Virilismo; Infertilidade; Modelos animais; Estro; Polycystic ovary syndrome; Estrus; Virilism; Infertility; Models, Animal

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Ciampone, Silmara, 1. (2016). Estudo da resposta metabólica, receptores da angiotensina e a pressão arterial em ratas androgenizadas em estro persistente : efeito do exercício físico aeróbio programado: Study of metabolic response, angiotensin receptor and blood pressure in androgenized rats in persistent estrus : effect of aerobic exercise shedule. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/312744

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Ciampone, Silmara, 1972-. “Estudo da resposta metabólica, receptores da angiotensina e a pressão arterial em ratas androgenizadas em estro persistente : efeito do exercício físico aeróbio programado: Study of metabolic response, angiotensin receptor and blood pressure in androgenized rats in persistent estrus : effect of aerobic exercise shedule.” 2016. Thesis, Universidade Estadual de Campinas. Accessed October 28, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312744.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Ciampone, Silmara, 1972-. “Estudo da resposta metabólica, receptores da angiotensina e a pressão arterial em ratas androgenizadas em estro persistente : efeito do exercício físico aeróbio programado: Study of metabolic response, angiotensin receptor and blood pressure in androgenized rats in persistent estrus : effect of aerobic exercise shedule.” 2016. Web. 28 Oct 2020.

Vancouver:

Ciampone, Silmara 1. Estudo da resposta metabólica, receptores da angiotensina e a pressão arterial em ratas androgenizadas em estro persistente : efeito do exercício físico aeróbio programado: Study of metabolic response, angiotensin receptor and blood pressure in androgenized rats in persistent estrus : effect of aerobic exercise shedule. [Internet] [Thesis]. Universidade Estadual de Campinas; 2016. [cited 2020 Oct 28]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312744.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ciampone, Silmara 1. Estudo da resposta metabólica, receptores da angiotensina e a pressão arterial em ratas androgenizadas em estro persistente : efeito do exercício físico aeróbio programado: Study of metabolic response, angiotensin receptor and blood pressure in androgenized rats in persistent estrus : effect of aerobic exercise shedule. [Thesis]. Universidade Estadual de Campinas; 2016. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312744

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Universidade Estadual de Campinas

2. Roza, Noemí Angélica Vieira, 1980-. Estudo da morfologia e função renal na prole de ratas submetidas à ingestão crônica de dieta hiperlipídica : efeito do Tempol: Morphology study and renal function in offspring of female rats submitted to long term high fat diet intake : tempol effect.

Degree: 2016, Universidade Estadual de Campinas

Abstract: Considering that there is a significant increase in processed foods rich in saturated fat intake, mainly in Western populations, is important to study the effect of this change in the incidence of diseases. Obesity, hyperglycemia and hypertension have been associated with high circulating levels of oxidizing metabolites, such as superoxides. It is known that both maternal and paternal diets, maternal stress and intrauterine ischemia have epigenetic effects that may alter the gene expression of fetuses leading to increased predisposition to diseases in adult life. In this context, the present study aims to analyze maternal long-term consumption of hyperlipidic diet (HFD), associated with the use of the antioxidant Tempol on the mothers and offspring male rats. Sprague-Dawley rats were fed a HFD (60% of calories from lipids), added to Tempol for 6 weeks prior to pregnancy and throughout gestation and lactation. HFD dams showed significantly lower water and food consumption, with an increase in caloric intake and a consequent increase in body mass. HFD added the antioxidant group (DTempol) had a decrease in weight gain during pregnancy and changes in potassium excretion at the end of the lactation period. HFD offspring with or without Tempol (Diet and Dtempol) had a lower birth weight compared to the Control group. After 16 weeks HFD offspring had a reduction in HDL levels and a surprising decrease in the adiposity index, which was normalized by the antioxidant consume. There was an increase in blood pressure in both groups from HFD dams. Glucose and insulin metabolism were altered HFD offspring, with decreased insulin secretion. DTempol also presented a drop in glomerular filtration and modifications in the sodium and potassium renal manipulation at the 16th week. Maternal long term HFD consumption induced a decrease in nephron number in offspring at 12 days, but with normalization in adulthood (16 weeks of life). In addition, offspring of HFD dams presented important renal morphological changes characterized by: inflammatory infiltrate, increased renal collagen deposition, and elevated renal expression of mesenchymal epithelial transition markers such as desmin and vimentin. These changes were accompanied by elevation in urinary protein excretion and appear to be linked to reduced SOD expression and elevated NADPH expression. Also, HFD with Tempol dams treatment promoted a significant attenuation of the described inflammatory and morphological changes. Thus, the study showed that HFD intake can promote fetal programming in male offspring rats with future renal changes characterized by expression of glomerular proteins that suggest that these kidneys are subject to the epithelial-mesenchymal transition. All these changes appear to be at least in part due to modifications of the oxide-reduction system Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Gontijo, Jose Antonio Rocha, 1956- (advisor), Boer, Patricia Aline (coadvisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Clínica Médica (nameofprogram), Coimbra, Terezila Machado (committee member), Boim, Mirian Aparecida (committee member), Oliveira, Rodrigo Bueno de (committee member), Vieira, Andre Schwambach (committee member).

Subjects/Keywords: Dieta hiperlipídica; Feto - Desenvolvimento; Rim; Estresse oxidativo; Inflamação; Diet, High-fat; Fetal development; Kidney; Oxidative stress; Inflamation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Roza, Noemí Angélica Vieira, 1. (2016). Estudo da morfologia e função renal na prole de ratas submetidas à ingestão crônica de dieta hiperlipídica : efeito do Tempol: Morphology study and renal function in offspring of female rats submitted to long term high fat diet intake : tempol effect. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/321776

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Roza, Noemí Angélica Vieira, 1980-. “Estudo da morfologia e função renal na prole de ratas submetidas à ingestão crônica de dieta hiperlipídica : efeito do Tempol: Morphology study and renal function in offspring of female rats submitted to long term high fat diet intake : tempol effect.” 2016. Thesis, Universidade Estadual de Campinas. Accessed October 28, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/321776.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Roza, Noemí Angélica Vieira, 1980-. “Estudo da morfologia e função renal na prole de ratas submetidas à ingestão crônica de dieta hiperlipídica : efeito do Tempol: Morphology study and renal function in offspring of female rats submitted to long term high fat diet intake : tempol effect.” 2016. Web. 28 Oct 2020.

Vancouver:

Roza, Noemí Angélica Vieira 1. Estudo da morfologia e função renal na prole de ratas submetidas à ingestão crônica de dieta hiperlipídica : efeito do Tempol: Morphology study and renal function in offspring of female rats submitted to long term high fat diet intake : tempol effect. [Internet] [Thesis]. Universidade Estadual de Campinas; 2016. [cited 2020 Oct 28]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/321776.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Roza, Noemí Angélica Vieira 1. Estudo da morfologia e função renal na prole de ratas submetidas à ingestão crônica de dieta hiperlipídica : efeito do Tempol: Morphology study and renal function in offspring of female rats submitted to long term high fat diet intake : tempol effect. [Thesis]. Universidade Estadual de Campinas; 2016. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/321776

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Universidade Estadual de Campinas

3. Belline, Paula. Ação de angiotensina II sobre macrofagos peritoneais de camundongos normais e diabeticos.

Degree: 2001, Universidade Estadual de Campinas

Abstract: The Renin Angiotensin System (RAS) is an important regulatory mechanism of cardiovascular homeostasis in normal and hypertensive subjects. Recently, several reports have been showed the existence of a local RAS in different cells and tissues, inclusive immunological cells. The aim of this study was evaluated in culture the effect of Angiotensin II (AII) on peritoneal mice macrophages (BALB/c and Non Obese Diabetic - NOD). The dose response curve of AII on phagocytic activity was determined during 1 and 3 hours of treatment and the stimulant dose of the phagocytosis was AII 10-12 M. To verify if this stimulus was obtained through AT1 receptor, the dose response curve of DuP 753 was determined. The protocol with DuP 753 was realized in the presence and absence of AII. The results showed that the inhibition of the phagocytic activity occurred in different concentrations of DuP, but the higher inhibition, in normal and diabetic animals, it was with 10-6 M. In order to evaluate the cytotoxic effect of DuP 753 and to show that the inhibition effect was not caused by an alteration of the cellular viability, were realized 3 cytotoxic assays: MTT reduction, analysis of nucleic acid content (NAC) and lactate dehydrogenase release (LDH). All assays indicated that cell viability was maintained afier treatment with DuP 753 in concentrations used. In addition of the phagocytic activity, the effect of AII and DuP 753 in production of superoxide anions was also investigate through the ferricytochrome c reduction. The results demonstrated that the phagocytic stimulant dose of AII (10-12 M) and the inhibition phagocytic dose of DuP (10-6 M) did not influence the superoxide production of macrophages. These results showed that the phagocytic function and superoxide production are probably activated by different concentrations of AII. Finally, an immunofluorescence study was performed in order to identify the type of AII receptors are present in BALB/c and NOD macrophages. The treatment of the cells with AII and DuP changed the immunoreactive of AT1 and AT2 receptors. This shows the influence of RAS on the function and metabolism of lmmunological Cell System Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Figueiredo, Jose Francisco, 1942- (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Biologia Funcional e Molecular (nameofprogram), Ferreira, Carmen Veríssima (committee member), Gadelha, Fernanda Ramos (committee member), Gontijo, Antonio Rocha (committee member), Coimbra, Terezila Machado (committee member).

Subjects/Keywords: Macrofagos; Angiotensina; Diabetes Mellitus; Fagocitose

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Belline, P. (2001). Ação de angiotensina II sobre macrofagos peritoneais de camundongos normais e diabeticos. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/314389

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Belline, Paula. “Ação de angiotensina II sobre macrofagos peritoneais de camundongos normais e diabeticos.” 2001. Thesis, Universidade Estadual de Campinas. Accessed October 28, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314389.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Belline, Paula. “Ação de angiotensina II sobre macrofagos peritoneais de camundongos normais e diabeticos.” 2001. Web. 28 Oct 2020.

Vancouver:

Belline P. Ação de angiotensina II sobre macrofagos peritoneais de camundongos normais e diabeticos. [Internet] [Thesis]. Universidade Estadual de Campinas; 2001. [cited 2020 Oct 28]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/314389.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Belline P. Ação de angiotensina II sobre macrofagos peritoneais de camundongos normais e diabeticos. [Thesis]. Universidade Estadual de Campinas; 2001. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/314389

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.