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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Calich, Vera Lucia Garcia"). One record found.

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Universidade Estadual de Campinas

1. Mamoni, Ronei Luciano. Caracterização da paracoccidioidomicose-infecção como a forma de resistencia da paracoccidioidomicose humana : comparação com as formas juvenil e adulta da doença.

Degree: 2005, Universidade Estadual de Campinas

Abstract: Paracoccidioidomycosis (PCM) presents three major forms: PCM-infection (PI); adult form (AF) and juvenile form (JF). The aim of this study was to compare the immunological response in these groups through the analysis of the kinectics of mRNA expression of some cytokines and chemokines (IL-2, IL-4, IL-5, IL-6, IL-lO, IFN-y, TGF p, TNF-a, CXCLS, CXCL9 and CXCLlO) by RT-PCR, as well as, to characterize the phenotype of the cytokines producing cells by flow cytometry. The results showed that PI individuaIs express earlier and higher levels of mRNA for IFN-y, TNF-a, CXCL9 and CXCLIO when compared to JF patients and similar levels of CXCLlO and IFN-y and higher levels of CXCL9 and TNF -a when compared to AF ones. On the other hand, the mRNA expression ofTh2 cytokines (IL-4, IL-IO, IL-5 and TGF-P) was higher and earlier in JF and AF groups when compared to PI individuaIs. In relation to protein expression, we observed that PI group presents a higher percentage of cells producing IFN-y, TNF-a, IL-2, CXCL9 and CXCLIO when compared to both groups ofpatients. The production ofIFN-y was predominantIy done by CD3+CDS+ T cells, whereas IL-2 and TNF-a production was higher in CD3+CD4+ cells. Monocytes ofPI individuaIs also presented higher expression of CDSO and lower expression of CDS6 and CD54 when compared to JF and AF patients, and higher expression of HLA-DR and CDIIa only when compared to JF patients. These results indicate that the differential kinetic of mRNA expression of ThI or Th2 cytokines observed in the different forms of PCM may modulate the immunological response resulting in the different outcomes observed in this disease Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Blotta, Maria Heloisa de Souza Lima, 1953- (advisor), Blotta, Maria Heloisa Souza Lima (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), -Yasuda, Maria Aparecida Shikanai (committee member), Calich, Vera Lucia Garcia (committee member), Verinaud, Liana Maria Cardoso (committee member), Trabasso, Plinio (committee member).

Subjects/Keywords: Paracoccidioidomicose; Citocinas; Quimiocinas; Imunologia celular

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APA (6th Edition):

Mamoni, R. L. (2005). Caracterização da paracoccidioidomicose-infecção como a forma de resistencia da paracoccidioidomicose humana : comparação com as formas juvenil e adulta da doença. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/313406

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Mamoni, Ronei Luciano. “Caracterização da paracoccidioidomicose-infecção como a forma de resistencia da paracoccidioidomicose humana : comparação com as formas juvenil e adulta da doença.” 2005. Thesis, Universidade Estadual de Campinas. Accessed March 03, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313406.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Mamoni, Ronei Luciano. “Caracterização da paracoccidioidomicose-infecção como a forma de resistencia da paracoccidioidomicose humana : comparação com as formas juvenil e adulta da doença.” 2005. Web. 03 Mar 2021.

Vancouver:

Mamoni RL. Caracterização da paracoccidioidomicose-infecção como a forma de resistencia da paracoccidioidomicose humana : comparação com as formas juvenil e adulta da doença. [Internet] [Thesis]. Universidade Estadual de Campinas; 2005. [cited 2021 Mar 03]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/313406.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mamoni RL. Caracterização da paracoccidioidomicose-infecção como a forma de resistencia da paracoccidioidomicose humana : comparação com as formas juvenil e adulta da doença. [Thesis]. Universidade Estadual de Campinas; 2005. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/313406

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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