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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Burdman, Emanuel de Almeida"). Showing records 1 – 2 of 2 total matches.

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Universidade Estadual de Campinas

1. Lutaif, Nelson Afonso. Contribuição renal para a homeostase corporal em ratos : função da inervação renal: Renal contributions to corporal homeostasis in rats : role of renal innervation.

Degree: 2007, Universidade Estadual de Campinas

Abstract: Introduction: Human kidneys are responsible for 10% of whole oxygen consumed in 24 hours as a result may have a great contribution in human global thermogenesis. Global thermogenesis which is related with mitochondrial oxygen consumption. We assumed that renal injuries necessarily promotes disturbances on global thermogenesis and consequently promote a re-adaptation on facultative and obligatory thermogenesis. To investigate the renal contribution on maintenance of internal temperature, we studied Sprague Dawley rats with: (Nx) mass reduction, (Dx) denervation and (Ox) urinary tract obstruction and two controls group: sham and (Non) no-operative. Methods: The study was performed after animals¿ immersions in warm water to avoid temperature dissipation and rectal temperature was recorded. Obligatory thermogenesis was evaluated through mitochondria respiratory chain and ADP/0 ratio in hepatocytes. The UCP1 and pathways associated with glucose captation (IRS1, PI3K, AKT1 and ERK1,2) protein expression in brow adipose tissue was studied by western blot method. Results: The Nx group presented significant initial lower temperature than Dx group: 36.14±0.8083°C x 37.15±0.9601 °C, with p<0.05. After thirty minutes, Dx group presented significant higher temperature (40.38 °C) than Sham (39.09±0.21°C), Nx (36.14±0.8083°C) and Ox (37.22±0.4338°C), groups with p<0.05. The Dx group showed significant higher thermal slope curve values (0.05836±0.07683) than Sham (0.04238±0.006312), Non (0.05182 ± 0.05546) and Ox (0.04516±0.005107) with p<0.05. Also, the area under curve presented Nx group with significant higher values (57.05 ± 17.82) than Ox (35.61±7.792), Sham (41.03 ± 3.06) and Non (39.82 ± 5.848) with p<0.001. No statistical difference was observed between all groups when the mitochondrial oxygen consumption and ADP/0 ratio were studied. The Dx and Nx groups showed increase in UCP1 and AKT1 activities. Conclusions: These results suggest that kidneys may play important function on body thermoregulation, contributing to thermal generation with own metabolic activities. We also concluded that renal nerves activity plays a role in thermic homeostase control, working associated with central nervous system and brown adipose tissue Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Gontijo, Jose Antonio Rocha, 1956- (advisor), Gontijo, José Antonio da Rocha (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Fisiopatologia Médica (nameofprogram), Barros, Rui Toledo de (committee member), Burdman, Emanuel de Almeida (committee member), Rocha, Eduardo Melani (committee member), Homsi, Eduardo (committee member).

Subjects/Keywords: Termogenese; Proteinas desacopladoras; Homeostase; Insuficiência renal; Thermogenesis; Uncoupling proteins; Energy transfer; Renal insuficiency

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lutaif, N. A. (2007). Contribuição renal para a homeostase corporal em ratos : função da inervação renal: Renal contributions to corporal homeostasis in rats : role of renal innervation. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/309922

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lutaif, Nelson Afonso. “Contribuição renal para a homeostase corporal em ratos : função da inervação renal: Renal contributions to corporal homeostasis in rats : role of renal innervation.” 2007. Thesis, Universidade Estadual de Campinas. Accessed September 21, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309922.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lutaif, Nelson Afonso. “Contribuição renal para a homeostase corporal em ratos : função da inervação renal: Renal contributions to corporal homeostasis in rats : role of renal innervation.” 2007. Web. 21 Sep 2020.

Vancouver:

Lutaif NA. Contribuição renal para a homeostase corporal em ratos : função da inervação renal: Renal contributions to corporal homeostasis in rats : role of renal innervation. [Internet] [Thesis]. Universidade Estadual de Campinas; 2007. [cited 2020 Sep 21]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/309922.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lutaif NA. Contribuição renal para a homeostase corporal em ratos : função da inervação renal: Renal contributions to corporal homeostasis in rats : role of renal innervation. [Thesis]. Universidade Estadual de Campinas; 2007. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/309922

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Universidade Estadual de Campinas

2. Menegon, Leonardo Fantinato, 1974-. Efeito da administração intracerebroventricular de insulina sobre a excreção urinaria de sodio e vias de sinalização da insulina em hipotalamo de ratos hipertensos: Effective of intracerebroventricular insulin microinjection on renal sodium handling in spontaneous hypertensive rats.

Degree: 2007, Universidade Estadual de Campinas

Abstract: Chronic elevated plasma insulin levels and resistance to the hypoglycemic effect of insulin have been associated with increased blood pressure in human and animal models of hypertension. This observation has led to the speculation that insulin may play a role in the development of increased blood pressure. Although authors have shown that the peripheral action of insulin reduces urinary sodium excretion, suggesting an attractive reciprocal link between insulin¿s renal effect, urinary sodium excretion and the development or maintenance of hypertension, studies from our laboratory have indicated that acute intracerebroventricular injection of insulin significantly increases the output of sodium. Thus, we hypothesized that central resistance to the natriuretic effect of intracerebroventricular administration of insulin could lead to an inability of renal tubules to handle the hydroelectrolyte balance. To test this hypothesis, we investigated the effects of acute intracerebroventricular insulin administration on sodium tubular handling in SHR and WKy, and characterized the direct actions of insulin on the PI 3-kinase and MAP-kinase in the hypothalamus of these rats. Furthermore, we investigated the long-term effect of intracerebroventricular administration of insulin on sodium tubular handling and arterial pressure of normotensive rats. We demonstrated that chronic intracerebroventricular insulin injection attenuated urinary sodium excretion. However, this altered response did not simultaneously change the arterial blood pressure at this time. We functionally characterized the MAPK-ERK-1/2 as the intracellular hypothalamic pathway responsible for insulin-mediated natriuresis in rats. On the other hand, our results show that central insulin administration is less effective in inducing activation of the MAPK pathway and natriuresis in SHR rats, characterizing these rats as centrally resistant to insulin-mediated natriuresis. Thus, central resistance to the natriuretic effect of insulin could lead to an inability of renal tubules to handle the hydroelectrolyte balance, possibly contributing to the development or maintenance of hypertension Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Gontijo, Jose Antonio Rocha, 1956- (advisor), Gontijo, José Antonio da Rocha (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Fisiopatologia Médica (nameofprogram), Homsi, Eduardo (committee member), Figueiredo, Jose Francisco (committee member), Burdman, Emanuel de Almeida (committee member), Boim, Mirian Aparecida (committee member).

Subjects/Keywords: Hipertensão; Natriurese; Insulina; Hipotálamo; Arterial hypertension; Natriuresis; Insulin; Hypothalamus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Menegon, Leonardo Fantinato, 1. (2007). Efeito da administração intracerebroventricular de insulina sobre a excreção urinaria de sodio e vias de sinalização da insulina em hipotalamo de ratos hipertensos: Effective of intracerebroventricular insulin microinjection on renal sodium handling in spontaneous hypertensive rats. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/312400

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Menegon, Leonardo Fantinato, 1974-. “Efeito da administração intracerebroventricular de insulina sobre a excreção urinaria de sodio e vias de sinalização da insulina em hipotalamo de ratos hipertensos: Effective of intracerebroventricular insulin microinjection on renal sodium handling in spontaneous hypertensive rats.” 2007. Thesis, Universidade Estadual de Campinas. Accessed September 21, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312400.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Menegon, Leonardo Fantinato, 1974-. “Efeito da administração intracerebroventricular de insulina sobre a excreção urinaria de sodio e vias de sinalização da insulina em hipotalamo de ratos hipertensos: Effective of intracerebroventricular insulin microinjection on renal sodium handling in spontaneous hypertensive rats.” 2007. Web. 21 Sep 2020.

Vancouver:

Menegon, Leonardo Fantinato 1. Efeito da administração intracerebroventricular de insulina sobre a excreção urinaria de sodio e vias de sinalização da insulina em hipotalamo de ratos hipertensos: Effective of intracerebroventricular insulin microinjection on renal sodium handling in spontaneous hypertensive rats. [Internet] [Thesis]. Universidade Estadual de Campinas; 2007. [cited 2020 Sep 21]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312400.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Menegon, Leonardo Fantinato 1. Efeito da administração intracerebroventricular de insulina sobre a excreção urinaria de sodio e vias de sinalização da insulina em hipotalamo de ratos hipertensos: Effective of intracerebroventricular insulin microinjection on renal sodium handling in spontaneous hypertensive rats. [Thesis]. Universidade Estadual de Campinas; 2007. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312400

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.