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You searched for +publisher:"Universidade Estadual de Campinas" +contributor:("Adde, Fabiola Villac"). Showing records 1 – 2 of 2 total matches.

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Universidade Estadual de Campinas

1. Bonadia, Luciana Cardoso, 1977-. Correlação entre aspectos clínicos, moleculares e fisiológicos de pacientes adultos com hipótese diagnóstica de fibrose cística de um centro de referência no Brasil: Correlation between clinical, molecular and physiological aspects of adult patients with diagnostic hypothesis of cystic fibrosis in a Brazilian reference Center.

Degree: 2011, Universidade Estadual de Campinas

Abstract: Cystic Fibrosis (CF) is a lethal autosomal recessive disease with high incidence in Southeast Brazil. It is caused by mutations in the CFTR gene, which encodes a protein that is located in the apical membrane of epithelial cells of airway tract, pancreas, salivary and sweat glands, intestine and reproductive system, forming a chloride channel. The increasing of the viscosity of extracellular mucus is responsible for most clinical complications related to CF, with pulmonary impairment as a major cause of morbidity and mortality. More than 1500 mutations have been associated with CF, divided in six different classes according to the effect on CFTR protein production and activity, F508del being the most common type. With the increase of early diagnosis and improved therapeutic approach, more and more patients reach adulthood. The patient care should follow the demographic shift regarding the specific needs of the age are clinical, psychological or social. The aim of this study was to characterize a sample of adult CF patients with diagnosis of CF and to correlate the clinical, molecular and physiological features. Clinical characterization was obtained from archived medical records. Molecular characterization was performed by genotyping methods such as DHPLC, MLPA and sequencing and physiological characterization was performed by intestinal current measurements by micro-Ussing chamber. It was observed that patients in whom the CFTR channel does not show any residual activity tend to be diagnosed earlier. There was an association between the classes of CFTR mutation and the activity of the channel and a relationship of mutation severity/inactivity of CFTR with the age at diagnosis, lung function and severity score assessed by Shwachman-Kulczycki. There was an association between chronic colonization by Pseudomonas aeruginosa and pulmonary obstruction. The main contributions of this study were: implementation of a method pioneered in Brazil that serves as a diagnostic tool and has been used in researching new drugs for treatment of specifics mutation and clinical, physiological and molecular characterization of adults with cystic fibrosis, a growing group in medical care Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Bertuzzo, Carmen Sílvia, 1963- (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Ciências Médicas (nameofprogram), Gonçalves, Marilda de Souza (committee member), Adde, Fabiola Villac (committee member), Torres, Fabio Rossi (committee member), Ribeiro, José Dirceu (committee member), Guerra, Andrea Trevas Maciel (committee member).

Subjects/Keywords: Regulador de condutância transmembrana em fibrose cística; Genótipo; Fenótipo; Adulto; Cystic Fibrosis transmembrane conductance regulator; Genotype; Phenotype; Adult

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Bonadia, Luciana Cardoso, 1. (2011). Correlação entre aspectos clínicos, moleculares e fisiológicos de pacientes adultos com hipótese diagnóstica de fibrose cística de um centro de referência no Brasil: Correlation between clinical, molecular and physiological aspects of adult patients with diagnostic hypothesis of cystic fibrosis in a Brazilian reference Center. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/308606

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Bonadia, Luciana Cardoso, 1977-. “Correlação entre aspectos clínicos, moleculares e fisiológicos de pacientes adultos com hipótese diagnóstica de fibrose cística de um centro de referência no Brasil: Correlation between clinical, molecular and physiological aspects of adult patients with diagnostic hypothesis of cystic fibrosis in a Brazilian reference Center.” 2011. Thesis, Universidade Estadual de Campinas. Accessed December 03, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308606.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Bonadia, Luciana Cardoso, 1977-. “Correlação entre aspectos clínicos, moleculares e fisiológicos de pacientes adultos com hipótese diagnóstica de fibrose cística de um centro de referência no Brasil: Correlation between clinical, molecular and physiological aspects of adult patients with diagnostic hypothesis of cystic fibrosis in a Brazilian reference Center.” 2011. Web. 03 Dec 2020.

Vancouver:

Bonadia, Luciana Cardoso 1. Correlação entre aspectos clínicos, moleculares e fisiológicos de pacientes adultos com hipótese diagnóstica de fibrose cística de um centro de referência no Brasil: Correlation between clinical, molecular and physiological aspects of adult patients with diagnostic hypothesis of cystic fibrosis in a Brazilian reference Center. [Internet] [Thesis]. Universidade Estadual de Campinas; 2011. [cited 2020 Dec 03]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/308606.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bonadia, Luciana Cardoso 1. Correlação entre aspectos clínicos, moleculares e fisiológicos de pacientes adultos com hipótese diagnóstica de fibrose cística de um centro de referência no Brasil: Correlation between clinical, molecular and physiological aspects of adult patients with diagnostic hypothesis of cystic fibrosis in a Brazilian reference Center. [Thesis]. Universidade Estadual de Campinas; 2011. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/308606

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Universidade Estadual de Campinas

2. Ribeiro, Maria Angela Gonçalves de Oliveira. Uso da capnografia volumetrica associada a espirometria na identificação da disfunção pulmonar na fibrose cistica: Use of volumetric capnography associated with spirometry for the identification of pulmonary dysfunction in cystic fibrosis.

Degree: 2010, Universidade Estadual de Campinas

Abstract: Objective: To evaluate spirometry and capnography parameters on identification of respiratory pattern and homogeneity of ventilation in patients with CF and to compare them to healthy subjects. Method: 64 patients diagnosed with cystic fibrosis based on the finding of at least two abnormal sweat chloride concentrations determined by the quantitative pilocarpine iontophoresis sweat test performed capnography and spirometry in the morning return to the medical staff. Patients were divided into two groups according to age: Group I (42 patients aged 6 to 12 years) and Group II (22 patients between 13 to 20 years) and their controls were 20 and 74 patients respectively. Spirometrics parameters studied were Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV1) and FEV1/FVC index. Capnography parameters studies were, oxygen saturation (SpO2), respiratory rate (RR), inpiratory time (IT) expiratory time (ET) and phase 3slope normalized by tidal volume (slope 3/EV). Results: compared to controls, patients in Group I had presented lower SpO2 (p< 0,001), lower Ti (p = 0.047), and higher values of slope3/Ve (p <0.001). Twentyfour patients in Group I had normal spirometry and had higher values slope3/Ve when compared to the control group (p = 0.036). Patients in Group II had significantly lower SpO2 (p< 0,001), lower IT (p< 0,001), lower ET (p< 0,001), and higher values of FR (p< 0,001) and slope3/Ve (p< 0,001), and worst values of FVC, FEV1 and FEV1/FVC (p <0.05) compared to Group I. Conclusion: Compared to controls, patients with CF showed an increased slope 3. These results indicate dysfunction of the peripheral airways in all CF patients groups. Volumetric capnography identified the heterogeneity of the ventilation distribution in the peripheral airways of patients with normal spirometry. Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Paschoal, Ilma Aparecida, 1956- (advisor), Silva, Marcos Tadeu Nolasco da, 1960- (coadvisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Saúde da Criança e do Adolescente (nameofprogram), Rozov, Tatiana (committee member), Adde, Fabiola Villac (committee member), Toro, Adyléia Aparecida Dalbo Contrera (committee member), Toro, Ivan Felizardo Contrera (committee member).

Subjects/Keywords: Fibrose cística; Fisiologia pulmonar; Dióxido de carbono; Espirometria; Pediatria; Cystic fibrosis; Pulmonary physiology; Carbon dioxide; Spirometry; Pediatrics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Ribeiro, M. A. G. d. O. (2010). Uso da capnografia volumetrica associada a espirometria na identificação da disfunção pulmonar na fibrose cistica: Use of volumetric capnography associated with spirometry for the identification of pulmonary dysfunction in cystic fibrosis. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/309673

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Ribeiro, Maria Angela Gonçalves de Oliveira. “Uso da capnografia volumetrica associada a espirometria na identificação da disfunção pulmonar na fibrose cistica: Use of volumetric capnography associated with spirometry for the identification of pulmonary dysfunction in cystic fibrosis.” 2010. Thesis, Universidade Estadual de Campinas. Accessed December 03, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309673.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Ribeiro, Maria Angela Gonçalves de Oliveira. “Uso da capnografia volumetrica associada a espirometria na identificação da disfunção pulmonar na fibrose cistica: Use of volumetric capnography associated with spirometry for the identification of pulmonary dysfunction in cystic fibrosis.” 2010. Web. 03 Dec 2020.

Vancouver:

Ribeiro MAGdO. Uso da capnografia volumetrica associada a espirometria na identificação da disfunção pulmonar na fibrose cistica: Use of volumetric capnography associated with spirometry for the identification of pulmonary dysfunction in cystic fibrosis. [Internet] [Thesis]. Universidade Estadual de Campinas; 2010. [cited 2020 Dec 03]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/309673.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ribeiro MAGdO. Uso da capnografia volumetrica associada a espirometria na identificação da disfunção pulmonar na fibrose cistica: Use of volumetric capnography associated with spirometry for the identification of pulmonary dysfunction in cystic fibrosis. [Thesis]. Universidade Estadual de Campinas; 2010. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/309673

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.