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You searched for +publisher:"UNIVERSIDADE FEDERAL DE OURO PRETO" +contributor:("Silvane Maria Fonseca Murta"). One record found.

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UNIVERSIDADE FEDERAL DE OURO PRETO

1. LÃvia de Figueiredo Diniz. AvaliaÃÃo da atividade anti-Trypanosoma cruzi do derivado triazÃlico Ravuconazol utilizando o cÃo como modelo experimental.

Degree: 2013, UNIVERSIDADE FEDERAL DE OURO PRETO

Ravuconazole is an experimental triazole derivative with potent and broad-spectrum antifungal activity and also very potent in vitro anti-Trypanosoma cruzi activity. In this work, we investigated the in vivo activity of ravuconazole against Y and Berenice-78 T. cruzi strains using acutely infected dogs as hosts. Ravuconazole was well tolerated as no significant side effects were observed during the treatment using 6.0 mg/kg b.i.d (12mg/kg.d.) for up to 90 days. In all treated animals parasitemia was permanently suppressed by the first day of treatment, independently of the parasite strain. Blood culture performed post-treatment was negative in all animals, confirming a marked reduction of the parasite load induced by drug. Consistently, T.cruzi blood PCR tests performed one month post-treatment was negative in 3/5 and 2/5 of animals infected with Y strain and Berenice-78 strain, respectively. Treatment led to significant reduction on levels of anti-T. cruzi antibodies while the drug pressure was maintained, but after the end of this treatment antibodies levels (IgG and IgG2), though not those of the IgG1 subclass, raising slowly but without reaching the same level of untreated controls, indicating that parasite clearance was not achieved. However, despite being unable to induce parasitological cure, ravuconazole treatment led to a significant reduction of the cardiac lesions and IFN-gamma m-RNA expression in cardiac tissues in animals infected with the Y strain, while IL-10 mRNA expression increased. We conclude that ravuconazole has potent suppressive but not curative activity in canine model of acute Chagas disease, probably due to unfavorable pharmacokinetic properties (half-life 8.8 hours). In man, where the pharmacokinetic profile of the drug is more favorable (half-life 120 hours), it is to be expected that the anti-T. cruzi efficacy of ravuconazole should be higher, making it a promising candidate for specific Chagas disease chemotherapy.

O Ravuconazol à um derivado triazÃlico de quarta geraÃÃo que possui potente atividade antifÃngica e intensa atividade anti- Trypanosoma cruzi in vitro. Neste estudo foi avaliada a atividade do Ravuconazol in vivo contra as cepas Y e Berenice-78 do T. cruzi, utilizando cÃes na fase aguda da doenÃa como modelo experimental. A droga foi bem tolerada e nÃo foram observadas reaÃÃes adversas durante o tratamento utilizando 12,0 mg de Ravuconazol por quilograma de peso corporal durante 90 dias. Em todos os animais a parasitemia foi permanentemente suprimida a partir do primeiro dia de tratamento, independentemente da cepa do parasito. A hemocultura realizada trinta dias apÃs o tÃrmino do tratamento foi negativa em todos os animais, confirmando a acentuada reduÃÃo da carga parasitÃria induzida pela droga. Em acordo com esses resultados, a tÃcnica de PCR realizada um mÃs apÃs o tratamento revelou resultados negativos em 3/5 e 2/5 dos animais infectados com as cepas Y e Be-78, respectivamente. O tratamento levou à reduÃÃo significativa nos nÃveis de anticorpos anti-T.cruzi no sangue…

Advisors/Committee Members: Maria Terezinha Bahia, Evandro Marques de Menezes Machado, Paulo Marcos da Matta Guedes, Silvane Maria Fonseca Murta.

Subjects/Keywords: Trypanossoma cruzi; Chagas, DoenÃa de; Quimioterapia; Resposta imune; Trypanossoma cruzi; Chagas, DoenÃa de; Quimioterapia; Resposta imune; PARASITOLOGIA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Diniz, L. d. F. (2013). AvaliaÃÃo da atividade anti-Trypanosoma cruzi do derivado triazÃlico Ravuconazol utilizando o cÃo como modelo experimental. (Thesis). UNIVERSIDADE FEDERAL DE OURO PRETO. Retrieved from http://www.tede.ufop.br/tde_busca/arquivo.php?codArquivo=1149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Diniz, LÃvia de Figueiredo. “AvaliaÃÃo da atividade anti-Trypanosoma cruzi do derivado triazÃlico Ravuconazol utilizando o cÃo como modelo experimental.” 2013. Thesis, UNIVERSIDADE FEDERAL DE OURO PRETO. Accessed May 08, 2021. http://www.tede.ufop.br/tde_busca/arquivo.php?codArquivo=1149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Diniz, LÃvia de Figueiredo. “AvaliaÃÃo da atividade anti-Trypanosoma cruzi do derivado triazÃlico Ravuconazol utilizando o cÃo como modelo experimental.” 2013. Web. 08 May 2021.

Vancouver:

Diniz LdF. AvaliaÃÃo da atividade anti-Trypanosoma cruzi do derivado triazÃlico Ravuconazol utilizando o cÃo como modelo experimental. [Internet] [Thesis]. UNIVERSIDADE FEDERAL DE OURO PRETO; 2013. [cited 2021 May 08]. Available from: http://www.tede.ufop.br/tde_busca/arquivo.php?codArquivo=1149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Diniz LdF. AvaliaÃÃo da atividade anti-Trypanosoma cruzi do derivado triazÃlico Ravuconazol utilizando o cÃo como modelo experimental. [Thesis]. UNIVERSIDADE FEDERAL DE OURO PRETO; 2013. Available from: http://www.tede.ufop.br/tde_busca/arquivo.php?codArquivo=1149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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