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You searched for +publisher:"The Catholic University of America" +contributor:("Wieczorek, Lindsay"). One record found.

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1. Barrows, Brittani. Evaluation of the Protective Role of ADCC Mediating Antibodies in Mother-To-Child Transmission of HIV-1.

Degree: 2020, The Catholic University of America

During pregnancy, the fetus acquires maternal antibodies by Fc receptor transfer across the placenta. Many of these Fc receptors are also expressed on immune cells and are responsible for recognition, activation and killing of HIV-1 infected cells as demonstrated in antibody dependent cellular cytotoxicity (ADCC). This study evaluated HIV+ maternal and respective HIV+ or HIV- infant plasma antibodies to understand potential factors that contribute to protection from HIV vertical transmission. Plasma antibodies were assessed for the functional capacity of mediating ADCC against heterologous and autologous HIV-1 infected target cells. While no differences in ADCC mediation were found between transmitting and nontransmitting mothers, HIV- infants had antibodies with greater ADCC potency and breadth. Both HIV+ and HIV- infants had natural killer cells with cytotoxic maturation markers, indicating necessary cellular maturity to implement ADCC. However, no differences were found in cytotoxic frequency. Maternal and infant antibody binding features were distinct in maternal transmission and infant infection status. Nontransmitting mothers and their HIV- infants had greater HIV-1 antigen-specific antibodies that engaged common placental transport and immune cell activation receptors. Nontransmitting mothers transferred higher HIV-specific antibodies that engaged the neonatal transport receptor (FcRn). HIV-1 recognizing antibodies that engage placental FcRn were found to be the greatest predictive feature of reduced MTCT. This study supports that HIV- infants acquire antibodies with greater recognition of HIV-1 antigen and mediation of ADCC.

Immunology

Virology

ADCC, HIV-1, MTCT, Placental Transport

Biology

Degree Awarded: Ph.D. Biology. The Catholic University of America

Advisors/Committee Members: The Catholic University of America (Degree granting institution), Rao, Venigalla (Thesis advisor), Wieczorek, Lindsay (Committee member), Tovanabutra, Sodsai (Committee member), Chung, Byung Min (Committee member), Choy, John (Committee member).

Subjects/Keywords: ADCC; HIV-1; MTCT; Placental Transport

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Barrows, B. (2020). Evaluation of the Protective Role of ADCC Mediating Antibodies in Mother-To-Child Transmission of HIV-1. (Thesis). The Catholic University of America. Retrieved from http://hdl.handle.net/1961/cuislandora:213975

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Barrows, Brittani. “Evaluation of the Protective Role of ADCC Mediating Antibodies in Mother-To-Child Transmission of HIV-1.” 2020. Thesis, The Catholic University of America. Accessed April 10, 2021. http://hdl.handle.net/1961/cuislandora:213975.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Barrows, Brittani. “Evaluation of the Protective Role of ADCC Mediating Antibodies in Mother-To-Child Transmission of HIV-1.” 2020. Web. 10 Apr 2021.

Vancouver:

Barrows B. Evaluation of the Protective Role of ADCC Mediating Antibodies in Mother-To-Child Transmission of HIV-1. [Internet] [Thesis]. The Catholic University of America; 2020. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1961/cuislandora:213975.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Barrows B. Evaluation of the Protective Role of ADCC Mediating Antibodies in Mother-To-Child Transmission of HIV-1. [Thesis]. The Catholic University of America; 2020. Available from: http://hdl.handle.net/1961/cuislandora:213975

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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