Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

You searched for +publisher:"Texas Woman\'s University" +contributor:("Harris, Diane"). One record found.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters

1. Hussein, Deema. d-δ-tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic tumor cells.

Degree: PhD, Nutrition, 2008, Texas Woman's University

The rate-limiting enzyme of the mevalonate pathway, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, provides essential intermediates for the prenylation or dolichylation of numerous growth-related proteins including nuclear lamins Ras and growth factor receptors. Competitive inhibitors of HMG CoA reductase, the statins, and down-regulators of HMG CoA reductase, the monoterpene geraniol and the sesquitepene farnesol, have been shown to suppress pancreatic tumor growth both in vitro and in vivo by inducing cell cycle arrest and initiating apoptosis. d-δ-Tocotrienol, a vitamin E isomer with a farnesol moiety, has been shown to be growth-suppressive in a number of in vitro and in vivo tumor models. These considerations led to an in vitro evaluation of the tumor-suppressive impact of d-δ-tocotrienol in human MIA PaCa-2 and PANC-1 pancreas carcinoma cells and BxPC-3 pancreas ductal adenocarcinoma cells. d-δ-Tocotrienol induced concentration-dependent suppression of the proliferation of all three cell lines with 50% inhibitory concentrations of 28 ± 6, 35 ± 8, and 35 ± 7 µmol/L for MIA PaCa-2, PANC-1, and BxPC-3, respectively. Cell cycle analyses revealed d-δ-tocotrienol induced Gl arrest in MIA PaCa-2, PANC-1 and BxPC-3 cells. d-δ-Tocotrienol-mediated morphological changes resemble those occurring in apoptotic cells. d-δ-Tocotrienol also induced apoptosis in all three types of pancreatic tumor cells by flow cytometric analysis and fluorescence microscopy. A blend of lovastatin (2 µmol/L) and d-δ-tocotrienol (5 and 10 µmol/L) synergistically suppressed the proliferation of MIA PaCa-2 cells. Supplemental mevalonate attenuated the growth inhibition induced by d-δ-tocotrienol in all three types of pancreatic tumor cells tested. The results of these studies suggested that d-δ-tocotrienol as a down-regulator of the mevalonate pathway may have potential as an adjuvant therapy in pancreatic cancer. Advisors/Committee Members: Mo, Huanbiao (Committee Chair), Grossie, Bruce (committee member), Imrhan, Victorine (committee member), Hsueh, Andie (committee member), Harris, Diane (committee member).

Subjects/Keywords: Health and environmental sciences; Biological sciences; BxPC-3; K-Ras; MIA PaCa-2; PANC-1; Pancreatic cancer; d-delta-tocotrienol

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hussein, D. (2008). d-δ-tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic tumor cells. (Doctoral Dissertation). Texas Woman's University. Retrieved from http://hdl.handle.net/11274/10845

Chicago Manual of Style (16th Edition):

Hussein, Deema. “d-δ-tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic tumor cells.” 2008. Doctoral Dissertation, Texas Woman's University. Accessed October 27, 2020. http://hdl.handle.net/11274/10845.

MLA Handbook (7th Edition):

Hussein, Deema. “d-δ-tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic tumor cells.” 2008. Web. 27 Oct 2020.

Vancouver:

Hussein D. d-δ-tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic tumor cells. [Internet] [Doctoral dissertation]. Texas Woman's University; 2008. [cited 2020 Oct 27]. Available from: http://hdl.handle.net/11274/10845.

Council of Science Editors:

Hussein D. d-δ-tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic tumor cells. [Doctoral Dissertation]. Texas Woman's University; 2008. Available from: http://hdl.handle.net/11274/10845

.