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You searched for +publisher:"Texas A&M University" +contributor:("Satterfield, Carey"). Showing records 1 – 2 of 2 total matches.

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Texas A&M University

1. Gilbreath, Kyler Richard. Arginine Supplementation For Improved Reproductive Performance in Beef Cattle.

Degree: MS, Animal Science, 2018, Texas A&M University

The reproductive efficiency of beef cows has long been a major determinant of success for cattle producers nationwide, and any method of improvement to this efficiency will aid the industry in being more profitable. Arginine has been proven as an effective nutrient for enhancing embryonic survival in non-ruminant species. Arginine improves the intrauterine environment by increasing levels of nitric oxide (NO) and polyamines, which promote angiogenesis, increase the amounts of nutrients for the fetus, and enhance placental and fetal development. Therefore, its use in ruminant species should provide an effective means of improving pregnancy rates among cow-calf producers. This study also establishes for the first time that two extracellular amino acids (AAs), glutamate and citrulline, may be able to bypass the rumen and its microbes without undergoing significant degradation. This was substantiated in two in-vivo studies with multiple ruminant species and in one in-vitro study. The experimental results go against the long-held notion that all AAs undergo extensive degradation when exposed to the rumen’s microbial population. The fact that no degradation of extracellular citrulline occurs in the rumen allows for the provision of this AA to ruminants as an economically viable and easily implemented means for cow-calf producers to increase arginine concentrations in cows. Collectively, the results of this thesis research indicate that dietary supplementation with citrulline is a useful, cost-effective method for improving reproductive efficiency across the beef cattle industry. Advisors/Committee Members: Wu, Guoyao (advisor), Satterfield, Carey (committee member), Bazer, Fuller (committee member).

Subjects/Keywords: Amino Acid; Arginine; Citrulline; Glutamine; Glutamate

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Gilbreath, K. R. (2018). Arginine Supplementation For Improved Reproductive Performance in Beef Cattle. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/188938

Chicago Manual of Style (16th Edition):

Gilbreath, Kyler Richard. “Arginine Supplementation For Improved Reproductive Performance in Beef Cattle.” 2018. Masters Thesis, Texas A&M University. Accessed January 16, 2021. http://hdl.handle.net/1969.1/188938.

MLA Handbook (7th Edition):

Gilbreath, Kyler Richard. “Arginine Supplementation For Improved Reproductive Performance in Beef Cattle.” 2018. Web. 16 Jan 2021.

Vancouver:

Gilbreath KR. Arginine Supplementation For Improved Reproductive Performance in Beef Cattle. [Internet] [Masters thesis]. Texas A&M University; 2018. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1969.1/188938.

Council of Science Editors:

Gilbreath KR. Arginine Supplementation For Improved Reproductive Performance in Beef Cattle. [Masters Thesis]. Texas A&M University; 2018. Available from: http://hdl.handle.net/1969.1/188938

2. Snyder, Matthew D. Analysis of the Histone Methyltransferase ASH2L via RNA Interference and CRISPR-Cas9 during Bovine Early Embryonic Development.

Degree: MS, Biomedical Sciences, 2016, Texas A&M University

Epigenetic patterns established during early bovine embryogenesis via DNA methylation and histone modification patterns are essential for proper gene expression and embryonic development. Epigenome patterns established during this period, if improperly maintained, can lead to developmental anomalies and may partially explain the lower pregnancy rates of in vitro-produced embryos. We hypothesized that the histone methyltransferase of ASH2L would alter preimplantation development, epigenetic reprogramming, and gene expression profiles in the early bovine embryo. We observed that the depleted and deleted ASH2L embryos developed to the blastocyst stage with suppressed ASH2L having comparable development rates with its respective control (31.3 ± 2.0%, n = 466 v. 34.8 ± 1.9%, n = 418). To see if errors were in the chromatin structure at the blastocyst stage, DNA methylation and histone modifications were examined to further explain the role of ASH2L during embryonic development. Blastocysts from each treatment (N = 601) were fixed and prepared for immunocytochemistry following standard laboratory protocol. Our findings show ASH2L may play a role in DNA methylation by decreasing 5mc and 5hmc conversion, which is a key event during early embryonic development. Suppression of ASH2L also alters global levels of H3H4me3 and H3K27me3 (p<0.001), which may lead to transcription aberrations. RNA-seq showed altered gene expression profiles in 407 genes in the morphologically comparable Day 17 conceptus (p<0.05). Closer examination showed that there is altered mesenchymal stem cell differentiation present in the Day 17 conceptuses. Analysis of ASH2L shows to not have a detrimental effect during preimplantation development but altered chromatin status and gene expression profiles suggest that ASH2L could play a vital role later in development. Advisors/Committee Members: Long, Charles R (advisor), Westhusin, Mark E (committee member), Golding, Michael C (committee member), Satterfield, Carey (committee member).

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Snyder, M. D. (2016). Analysis of the Histone Methyltransferase ASH2L via RNA Interference and CRISPR-Cas9 during Bovine Early Embryonic Development. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/157784

Chicago Manual of Style (16th Edition):

Snyder, Matthew D. “Analysis of the Histone Methyltransferase ASH2L via RNA Interference and CRISPR-Cas9 during Bovine Early Embryonic Development.” 2016. Masters Thesis, Texas A&M University. Accessed January 16, 2021. http://hdl.handle.net/1969.1/157784.

MLA Handbook (7th Edition):

Snyder, Matthew D. “Analysis of the Histone Methyltransferase ASH2L via RNA Interference and CRISPR-Cas9 during Bovine Early Embryonic Development.” 2016. Web. 16 Jan 2021.

Vancouver:

Snyder MD. Analysis of the Histone Methyltransferase ASH2L via RNA Interference and CRISPR-Cas9 during Bovine Early Embryonic Development. [Internet] [Masters thesis]. Texas A&M University; 2016. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/1969.1/157784.

Council of Science Editors:

Snyder MD. Analysis of the Histone Methyltransferase ASH2L via RNA Interference and CRISPR-Cas9 during Bovine Early Embryonic Development. [Masters Thesis]. Texas A&M University; 2016. Available from: http://hdl.handle.net/1969.1/157784

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