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You searched for +publisher:"Texas A&M University" +contributor:("Payne, Susan L."). Showing records 1 – 2 of 2 total matches.

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Texas A&M University

1. Allen, Charlotte Annette. Cytokine detection in eiav-infected equine monocyte-derived macrophages using quantitative real-time polymerase chain reaction.

Degree: 2009, Texas A&M University

The replication of equine infectious anemia virus (EIAV) in macrophages not only leads to cell death, but also to the induction of a variety of cytokines that may affect immune function. Cytokine production may be responsible for the fever, anorexia, hemorrhages, lethargy or thrombocytopenia seen in the acute and chronic phases of equine infectious anemia (EIA). The study of the equine immune system and inflammatory responses, by measuring cytokine expression, can provide important insight into disease pathogenesis in the horse. We have extended studies of virulent and avirulent EIAV clones by examining the effects of Env proteins on cytokine expression in equine monocyte-derived macrophages (EMDM) using EIAV17, EIAV19, EIAV17SU, and EIAV17TM viruses. In the current studies a set of quantitative real-time polymerase chain reaction (QPCR) assays for the equine cytokines IL-1?, IL-1?, IL-6, IL-8 and TNF-? were validated using QPCR primers and probes which were generated for the aforementioned equine genes. Advisors/Committee Members: Russell, Karen E. (advisor), Cohen, Noah D. (committee member), Payne, Susan L. (committee member).

Subjects/Keywords: Cytokines; Macrophages; Horse; QPCR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Allen, C. A. (2009). Cytokine detection in eiav-infected equine monocyte-derived macrophages using quantitative real-time polymerase chain reaction. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2124

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Allen, Charlotte Annette. “Cytokine detection in eiav-infected equine monocyte-derived macrophages using quantitative real-time polymerase chain reaction.” 2009. Thesis, Texas A&M University. Accessed March 28, 2020. http://hdl.handle.net/1969.1/ETD-TAMU-2124.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Allen, Charlotte Annette. “Cytokine detection in eiav-infected equine monocyte-derived macrophages using quantitative real-time polymerase chain reaction.” 2009. Web. 28 Mar 2020.

Vancouver:

Allen CA. Cytokine detection in eiav-infected equine monocyte-derived macrophages using quantitative real-time polymerase chain reaction. [Internet] [Thesis]. Texas A&M University; 2009. [cited 2020 Mar 28]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2124.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Allen CA. Cytokine detection in eiav-infected equine monocyte-derived macrophages using quantitative real-time polymerase chain reaction. [Thesis]. Texas A&M University; 2009. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2124

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Texas A&M University

2. Yakshe, Krystle Ann. Functional Analysis of Interactions of Rotavirus NSP4 with Caveolin-1, Cyclophilin A, Cyclophilin 40, Heat Shock Protein 56, and Cholesterol.

Degree: 2015, Texas A&M University

The rotavirus enterotoxin, NSP4, is responsible for early secretory diarrhea associated with rotavirus infection and is critical for RV replication and morphogenesis. NSP4 interacts directly with caveolin-1 and cholesterol and traffics from the endoplasmic reticulum to the plasma membrane via an unconventional transport pathway for release prior to virus-induced lysis. In this study we demonstrate that NSP4 interacts with the immunophilins, cyclophilin A, cyclophilin 40, and HSP56 using co-immunoprecipitation and FRET analysis. We examined the roles of caveolin-1 and the immunophilins in NSP4 transport to the plasma membrane using silencing RNA, immunofluorescence analysis, and surface biotinylation. Cholesterol reduction was accomplished by statin inhibition of cholesterol synthesis. We found that knockdown of these cellular proteins altered the intracellular distribution of NSP4, but did not prevent NSP4 from trafficking to the PM. Cholesterol inhibition decreased the amount of NSP4 that reached the PM, indicating a role of cholesterol in NSP4 transport. Advisors/Committee Members: Ball, Judith M (advisor), Payne, Susan L (committee member), Leibowitz, Julian (committee member), Schroeder, Friedhelm (committee member).

Subjects/Keywords: Rotavirus NSP4; Cyclophilin A; Cyclophilin 40; Heat Shock Protein 56; Caveolin-1; Cholesterol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Yakshe, K. A. (2015). Functional Analysis of Interactions of Rotavirus NSP4 with Caveolin-1, Cyclophilin A, Cyclophilin 40, Heat Shock Protein 56, and Cholesterol. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/156449

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Yakshe, Krystle Ann. “Functional Analysis of Interactions of Rotavirus NSP4 with Caveolin-1, Cyclophilin A, Cyclophilin 40, Heat Shock Protein 56, and Cholesterol.” 2015. Thesis, Texas A&M University. Accessed March 28, 2020. http://hdl.handle.net/1969.1/156449.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Yakshe, Krystle Ann. “Functional Analysis of Interactions of Rotavirus NSP4 with Caveolin-1, Cyclophilin A, Cyclophilin 40, Heat Shock Protein 56, and Cholesterol.” 2015. Web. 28 Mar 2020.

Vancouver:

Yakshe KA. Functional Analysis of Interactions of Rotavirus NSP4 with Caveolin-1, Cyclophilin A, Cyclophilin 40, Heat Shock Protein 56, and Cholesterol. [Internet] [Thesis]. Texas A&M University; 2015. [cited 2020 Mar 28]. Available from: http://hdl.handle.net/1969.1/156449.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yakshe KA. Functional Analysis of Interactions of Rotavirus NSP4 with Caveolin-1, Cyclophilin A, Cyclophilin 40, Heat Shock Protein 56, and Cholesterol. [Thesis]. Texas A&M University; 2015. Available from: http://hdl.handle.net/1969.1/156449

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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