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1. Alali, Walid Qasim. Longitudinal study of antimicrobial resistance among Escherichia coli isolated from integrated multi-site cohorts of humans and swine.

Degree: PhD, Biomedical Sciences, 2009, Texas A&M University

Many studies have attempted to link antimicrobial use in food animal agriculture with an increased risk of antimicrobial-resistant (AR) bacterial levels in humans. Our data arise from longitudinal aggregated fecal samples in a 3-year cohort study of vertically integrated populations of human workers and consumers, and swine. Human and swine E. coli isolates (N = 2130 and 3485, respectively) were tested for antimicrobial susceptibility using the SensititreTM broth microdilution system. The associations between AR prevalence for each antimicrobial agent, multi-drug resistant E. coli, or multivariate AR E. coli, and the risk factors (host species, production type (swine), vocation (human swine worker versus non-worker), and season) in the study were assessed using generalized estimating equations (GEE), GLM with multinomial distribution, or GEE in a multivariate model using a SASĀ® macro to adjust for the correlated AR phenotypes. There were significant (p < 0.05) differences in AR isolates: 1) between host-species with swine at higher risk for ceftiofur, chloramphenicol, gentamicin, kanamycin, streptomycin, sulfisoxazole, and tetracycline. The prevalence of ciprofloxacin, nalidixic acid, and trimethoprim/sulfamethoxazole resistance were higher among human isolates, 2) swine production group was significantly associated with AR with purchased boars, nursery piglets, and breeding boars at a higher risk of resistance to streptomycin and tetracycline, and 3) human swine worker cohorts exhibited an elevated tetracycline prevalence, but lowered sulfisoxazole prevalence when compared to nonworkers. High variability among seasonal samples over the 3-year period was observed. There were significant differences in multiple resistance isolates between host species, with swine at higher risk than humans of carrying multi-resistant strains; however, no significant differences in multiple resistance isolates within humans by vocation or within swine by production group. The odds-ratios, adjusted for multivariate dependence of individual AR phenotypes, were increased relative to unadjusted oddsratios among 1) swine as compared to human for tetracycline (OR = 21.8 vs. 19.6), and 2) increased significantly among swine-workers as compared to non-workers only for tetracycline (OR = 1.4 vs. 1.3). Occupational exposure to swine-rearing facilities appears to be associated with an increased relative odds for the prevalence of tetracycline resistance compared to non-workers. Advisors/Committee Members: Scott, H. Morgan (advisor), Harvey, Roger (committee member), Lawhorn, D. Bruce (committee member), Norby, Bo (committee member), Pillai, Suresh (committee member).

Subjects/Keywords: ANTIMICROBIAL RESISTANCE; ESCHERICHIA COLI; LONGITUDINAL

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Alali, W. Q. (2009). Longitudinal study of antimicrobial resistance among Escherichia coli isolated from integrated multi-site cohorts of humans and swine. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2434

Chicago Manual of Style (16th Edition):

Alali, Walid Qasim. “Longitudinal study of antimicrobial resistance among Escherichia coli isolated from integrated multi-site cohorts of humans and swine.” 2009. Doctoral Dissertation, Texas A&M University. Accessed January 20, 2021. http://hdl.handle.net/1969.1/ETD-TAMU-2434.

MLA Handbook (7th Edition):

Alali, Walid Qasim. “Longitudinal study of antimicrobial resistance among Escherichia coli isolated from integrated multi-site cohorts of humans and swine.” 2009. Web. 20 Jan 2021.

Vancouver:

Alali WQ. Longitudinal study of antimicrobial resistance among Escherichia coli isolated from integrated multi-site cohorts of humans and swine. [Internet] [Doctoral dissertation]. Texas A&M University; 2009. [cited 2021 Jan 20]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2434.

Council of Science Editors:

Alali WQ. Longitudinal study of antimicrobial resistance among Escherichia coli isolated from integrated multi-site cohorts of humans and swine. [Doctoral Dissertation]. Texas A&M University; 2009. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2434

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