+publisher:"Texas A&M University" +contributor:("Kerwin, Sharon")

1. Starr, Alison Nicole. Genomic analyses of induced hypercholesterolemia and atherosclerosis in a mixed breed colony of dogs and developmental abnormalities in the Havanese.

Degree: PhD, Genetics, 2009, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2516

► The domestic dog, Canis lupus familiaris, is a unique model system for the dissection of hereditary diseases. Selective breeding practices have created more than 300… (more)

▼ The domestic dog, Canis lupus familiaris, is a unique model system for the dissection of hereditary diseases. Selective breeding practices have created more than 300 distinct breeds of dogs, born from a desire to create specific physical and behavioral characteristics. Breeds represent closed breeding populations and the extensive records maintained for members of each breed (e.g., multi-generational pedigrees, veterinary medical records) present an incredible tool for genetic research. Two closed populations were used in the work presented here: a colony of mixed-breed dogs segregating resistance and sensitivity to cholesterol feeding, and a purebred pet population of Havanese experiencing a high frequency of developmental abnormalities. Estimates of heritability were calculated for each disease to evaluate the degree of phenotypic variation attributable to genetics among dogs in the populations used. A heritability of 0.55 (± 0.16) was identified for cholesterol resistance and sensitivity in the mixed-breed colony. The small sample size prevented the use of complex segregation analyses to examine mode of transmission. A heritability of 0.36 (± 0.26) was calculated for the composite phenotype in the Havanese, encompassing the spectrum of abnormalities in the breed. Polygenic inheritance was identified for the composite phenotype, but the action of a major gene was identified by complex segregation analyses in the Havanese. Complex diseases preclude the use of a candidate gene approach, owing to the multitude of genes involved in the disease process. Whole genome screens provide a practical approach to the identification of chromosomal region(s) associated with a disease phenotype by narrowing the search for candidate gene(s). The Minimal Screening Set – 2 (MSS-2) was used in the present studies to evaluate the segregation of microsatellite markers in pedigrees for both the mixed-breed colony and the Havanese. No significant LOD scores were identified, though suggestive LOD scores were obtained in both analyses. A canine-specific oligonucleotide microarray was used to create gene expression profiles for developmental abnormalities in the Havanese and for cholesterol sensitivity in the mixed-breed colony dogs. Distinct expression profiles were generated for each group, and several genes of interest were identified as being both differentially expressed (>±2-fold change) and statistically significant (p-value<0.05). Advisors/Committee Members: Murphy, Keith E. (advisor), Kerwin, Sharon C. (committee member), Kier, Ann B. (committee member), Long, Charles R. (committee member).

Subjects/Keywords: canine; genetics; microsatellite; microarray; Rasch measurement

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APA (6^th Edition):

Starr, A. N. (2009). Genomic analyses of induced hypercholesterolemia and atherosclerosis in a mixed breed colony of dogs and developmental abnormalities in the Havanese. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2516

Chicago Manual of Style (16^th Edition):

Starr, Alison Nicole. “Genomic analyses of induced hypercholesterolemia and atherosclerosis in a mixed breed colony of dogs and developmental abnormalities in the Havanese.” 2009. Doctoral Dissertation, Texas A&M University. Accessed January 24, 2021. http://hdl.handle.net/1969.1/ETD-TAMU-2516.

MLA Handbook (7^th Edition):

Starr, Alison Nicole. “Genomic analyses of induced hypercholesterolemia and atherosclerosis in a mixed breed colony of dogs and developmental abnormalities in the Havanese.” 2009. Web. 24 Jan 2021.

Vancouver:

Starr AN. Genomic analyses of induced hypercholesterolemia and atherosclerosis in a mixed breed colony of dogs and developmental abnormalities in the Havanese. [Internet] [Doctoral dissertation]. Texas A&M University; 2009. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2516.

Council of Science Editors:

Starr AN. Genomic analyses of induced hypercholesterolemia and atherosclerosis in a mixed breed colony of dogs and developmental abnormalities in the Havanese. [Doctoral Dissertation]. Texas A&M University; 2009. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2516

Texas A&M University

2. Hudson, Jonathan Thomas. Assessing the repeatability and validity of a questionnaire on pain and lameness in the canine.

Degree: MS, Epidemiology, 2004, Texas A&M University

URL: http://hdl.handle.net/1969.1/28

► The measurement of pain has had a growing importance in animals for both privately owned animals and those animals involved in clinical research. Lameness is… (more)

▼ The measurement of pain has had a growing importance in animals for both privately owned animals and those animals involved in clinical research. Lameness is considered to be 1 aspect of the pain experience. The ability of a veterinarian to assess lameness during a routine orthopedic examination can be difficult given the short amount of time in which the clinician can observe the animal, and the fact that the animal is in a stressful environment. Thus, the input of the owner concerning the animal's well-being over an extended time period may be extremely useful to the clinician in assessing the degree of lameness of the animal. It was the purpose of this study to establish an instrument that was both repeatable and valid in assessing the degree of lameness. The instrument used was a questionnaire containing 39 questions in a visual analog scale format. A force platform was used as the gold-standard for detecting mechanical lameness. Peak vertical, cranial-caudal, and their associated impulses were forces used to determine lameness, along with maximum slope in some cases. A test-retest measure of repeatability was conducted on a subset of 19 dogs that were confirmed to have less than a 10% change in vertical peak force. Nineteen of the 39 questions were found to be repeatable based on a Spearman rank correlation. These 19 questions were then used as predictor variables in several multiple regression models which predicted force plate measurements. The result was 3 different models each containing 7 independent variables that were thought to be valid representations of the forces measured (vertical peak, vertical impulse, and propulsion peak forces). Each reduced model was found to fit the data as well as the full model containing all 19 of the repeatable questions. The composite of 11 questions from the 3 different models was used to calculate a total score. This total score was found to be significantly correlated with force plate measurements. These 11 questions should be useful to a clinician in detecting the degree of lameness in the dog. Advisors/Committee Members: Slater, Margaret (advisor), Scott, H. Morgan (committee member), Kerwin, Sharon (committee member), Taylor, Lathrop (committee member).

Subjects/Keywords: repeatability; validity; lameness; questionnaire; canine

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APA (6^th Edition):

Hudson, J. T. (2004). Assessing the repeatability and validity of a questionnaire on pain and lameness in the canine. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/28

Chicago Manual of Style (16^th Edition):

Hudson, Jonathan Thomas. “Assessing the repeatability and validity of a questionnaire on pain and lameness in the canine.” 2004. Masters Thesis, Texas A&M University. Accessed January 24, 2021. http://hdl.handle.net/1969.1/28.

MLA Handbook (7^th Edition):

Hudson, Jonathan Thomas. “Assessing the repeatability and validity of a questionnaire on pain and lameness in the canine.” 2004. Web. 24 Jan 2021.

Vancouver:

Hudson JT. Assessing the repeatability and validity of a questionnaire on pain and lameness in the canine. [Internet] [Masters thesis]. Texas A&M University; 2004. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1969.1/28.

Council of Science Editors:

Hudson JT. Assessing the repeatability and validity of a questionnaire on pain and lameness in the canine. [Masters Thesis]. Texas A&M University; 2004. Available from: http://hdl.handle.net/1969.1/28

Texas A&M University

3. Tsai, Kate Leanne. Genetic analysis of canine hip dysplasia.

Degree: PhD, Veterinary Microbiology, 2007, Texas A&M University

URL: http://hdl.handle.net/1969.1/4878

► The morphologic variability seen in the domestic dog, Canis lupus familiaris, is unique among mammals. Selective pressures imposed by humans have divided dogs into almost… (more)

▼ The morphologic variability seen in the domestic dog, Canis lupus familiaris, is unique among mammals. Selective pressures imposed by humans have divided dogs into almost 400 separate breeds. Selection has also led to the development of approximately 450 hereditary diseases, many of which are limited to specific breeds. Over half of these diseases present with similar clinical characteristics to those of many human hereditary diseases, making the dog an ideal model for study of the genetic bases of such diseases. Many diseases do not have candidate genes or have too many candidates to characterize. This is exacerbated in complex diseases that are caused by several genes. Whole-genome scans can provide insight into diseases by identifying marker(s) that co-segregate with a disease phenotype. The Minimal Screening Set - 2 (MSS-2) is the most recent set of microsatellites suitable for whole-genome screens. The first objective of this work was to streamline genomic screens in order to efficiently analyze large numbers of animals. To this end, chromosome-specific microsatellite panels were developed for the MSS-2. Canine hip dysplasia (CHD) is the most common orthopedic disease of the dog. CHD primarily affects medium and large breed dogs, but is found in almost every breed. The major objective of this work was to use linkage analysis to identify chromosomal regions that contain genes that are involved in CHD. Two populations were screened using the MSS-2. The first was a small family of Boykin Spaniels, though no markers were statistically significant in a whole-genome screen. An outcrossed pedigree of Greyhound/Labrador Retrievers was created for quantitative trait loci (QTL) mapping of CHD. The informativeness of markers in the F2 and backcrossed generations were calculated to show the utility of using such a population. Other factors that affect the power of this pedigree to identify QTL were also highlighted. Chromosomes that were identified in a previous screen as harboring putative QTLs were examined using the chromosome-specific panels to further define and confirm the regions of interest. Although no markers reached statistical significance, several areas of interest were identified. Advisors/Committee Members: Murphy, Keith E. (advisor), Credille, Kelly M. (committee member), Kerwin, Sharon C. (committee member), Womack, James E. (committee member).

Subjects/Keywords: canine; genetics; hip dysplasia; microsatellite

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tsai, K. L. (2007). Genetic analysis of canine hip dysplasia. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/4878

Chicago Manual of Style (16^th Edition):

Tsai, Kate Leanne. “Genetic analysis of canine hip dysplasia.” 2007. Doctoral Dissertation, Texas A&M University. Accessed January 24, 2021. http://hdl.handle.net/1969.1/4878.

MLA Handbook (7^th Edition):

Tsai, Kate Leanne. “Genetic analysis of canine hip dysplasia.” 2007. Web. 24 Jan 2021.

Vancouver:

Tsai KL. Genetic analysis of canine hip dysplasia. [Internet] [Doctoral dissertation]. Texas A&M University; 2007. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1969.1/4878.

Council of Science Editors:

Tsai KL. Genetic analysis of canine hip dysplasia. [Doctoral Dissertation]. Texas A&M University; 2007. Available from: http://hdl.handle.net/1969.1/4878

Texas A&M University

4. Rodriguez, Douglas E. Investigation of a HA/PDLGA/Carbon Foam Material System for Orthopedic Fixation Plates Based on Time-Dependent Properties.

Degree: PhD, Mechanical Engineering, 2010, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-7198

► While there is continuing interest in bioresorbable materials for orthopedic fixation devices, the major challenge in utilizing these materials in load-bearing applications is creating materials… (more)

Subjects/Keywords: bioresorbable polymers; orthopedic fixation plates; degradation; computational modeling

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rodriguez, D. E. (2010). Investigation of a HA/PDLGA/Carbon Foam Material System for Orthopedic Fixation Plates Based on Time-Dependent Properties. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-7198

Chicago Manual of Style (16^th Edition):

Rodriguez, Douglas E. “Investigation of a HA/PDLGA/Carbon Foam Material System for Orthopedic Fixation Plates Based on Time-Dependent Properties.” 2010. Doctoral Dissertation, Texas A&M University. Accessed January 24, 2021. http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-7198.

MLA Handbook (7^th Edition):

Rodriguez, Douglas E. “Investigation of a HA/PDLGA/Carbon Foam Material System for Orthopedic Fixation Plates Based on Time-Dependent Properties.” 2010. Web. 24 Jan 2021.

Vancouver:

Rodriguez DE. Investigation of a HA/PDLGA/Carbon Foam Material System for Orthopedic Fixation Plates Based on Time-Dependent Properties. [Internet] [Doctoral dissertation]. Texas A&M University; 2010. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-7198.

Council of Science Editors:

Rodriguez DE. Investigation of a HA/PDLGA/Carbon Foam Material System for Orthopedic Fixation Plates Based on Time-Dependent Properties. [Doctoral Dissertation]. Texas A&M University; 2010. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-7198

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