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You searched for +publisher:"Texas A&M University" +contributor:("Gomes, Carmen L."). Showing records 1 – 2 of 2 total matches.

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Texas A&M University

1. Alkahtani, Masfer Hassan A. Engineering Fluorescent Nanodiamonds and Upconversion Nanoparticles for Bioimaging and Optical Temperature Sensing.

Degree: PhD, Physics, 2018, Texas A&M University

An ideal fluorescent marker for high contrast imaging and optical temperature sensing in biological applications should be biocompatible, ultrasmall, photostable, and can be excited and detected within the biological transparency window (650-1350nm). To meet these criteria, fluorescent nanodiamonds (FNDs) and upconversion nanoparticles (UCNPs) doped with lanthanide ions Ln+³ (Ln=Er,Tm,Ho,etc.) are of interest. First, multi-color fluorescent nanodiamonds (FNDs) containing variety of color centers are promising fluorescent markers for most of biomedical applications. Compared to colloidal quantum dots and organic dyes, FNDs have the advantage of lower toxicity and better photostability. FNDs can be as small as fluorescent proteins, for example, green fluorescent protein (GFP) with a few nanometers (nm) in size and have exceptional chemical stability. They can be surface functionalized by techniques similar to those used for other nanoparticles. They exhibit a variety of emission wavelengths from visible to near infrared, with narrow or broad bandwidths depending on their color centers. In addition, some color centers can detect changes in magnetic fields, electric fields, and temperature. In this dissertation, I will discuss a new technique of grown small and stable fluorescent nanodiamonds. I will also discuss some applications of FNDs in bioimaging and biosensing. Second, Upconversion nanoparticles (UCNPs) are of interest because they allow suppression of tissue autofluorescence and are therefore visible deep inside biological tissue. Compared to upconversion dyes, UCNPs have a lower pump intensity threshold, better photostability, and less toxicity. Recently, Y V O₄ : Er+³, Yb+³ nanoparticles were shown to exhibit strong up-conversion luminescence (UCL) with a relatively low 10 kW.cm⁻² excitation intensity even in water, which makes them excellent bio-imaging and biosensors candidates. In this dissertation, I will discuss the UCNPs in terms of synthesis, applications in bioimaging and biosensing. Advisors/Committee Members: Hemmer, Philip (advisor), Zubairy, M.Suhail (advisor), Zheltikov, Alexey (committee member), Gomes, Carmen L. (committee member).

Subjects/Keywords: Fluorescent nanodiamonds; upconversion nanoparticles; seeded growth; and high pressure and high temperature nanodiamonds growth

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Alkahtani, M. H. A. (2018). Engineering Fluorescent Nanodiamonds and Upconversion Nanoparticles for Bioimaging and Optical Temperature Sensing. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/173401

Chicago Manual of Style (16th Edition):

Alkahtani, Masfer Hassan A. “Engineering Fluorescent Nanodiamonds and Upconversion Nanoparticles for Bioimaging and Optical Temperature Sensing.” 2018. Doctoral Dissertation, Texas A&M University. Accessed February 26, 2021. http://hdl.handle.net/1969.1/173401.

MLA Handbook (7th Edition):

Alkahtani, Masfer Hassan A. “Engineering Fluorescent Nanodiamonds and Upconversion Nanoparticles for Bioimaging and Optical Temperature Sensing.” 2018. Web. 26 Feb 2021.

Vancouver:

Alkahtani MHA. Engineering Fluorescent Nanodiamonds and Upconversion Nanoparticles for Bioimaging and Optical Temperature Sensing. [Internet] [Doctoral dissertation]. Texas A&M University; 2018. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1969.1/173401.

Council of Science Editors:

Alkahtani MHA. Engineering Fluorescent Nanodiamonds and Upconversion Nanoparticles for Bioimaging and Optical Temperature Sensing. [Doctoral Dissertation]. Texas A&M University; 2018. Available from: http://hdl.handle.net/1969.1/173401

2. Aquino, Mayra. Regulation of Zinc Transport in the Choroid Plexus.

Degree: MS, Food Science and Technology, 2014, Texas A&M University

The choroid plexus epithelium forms the blood-cerebrospinal fluid barrier, but also accumulates and transports nutritive minerals, such as zinc, into and out of the cerebrospinal fluid. The goal of this thesis was to analyze interdependent regulation of zinc transporters with metallothionein as the choroid plexus epithelium adapts to increases or decreases in extracellular zinc. My first objective was to characterize time-dependent changes in zinc transporter and MT-1 expression as extracellular zinc was pharmacologically depleted or supplemented. My second objective was to characterize changes in zinc transporter and MT-1 expression in response to exposure to prolactin. My experimental approach was to analyze gene expression of ZnT1, Zip1, Zip6, MT-1 and carbonic anhydrase (CA-2) in primary cell cultures of neonatal rat choroid plexus and isolated tissues in which extracellular zinc was depleted with 10 μM diethylene triamine pentaacetic acid or supplemented with 25 μM ZnCl_(2) for 48 h. Gene expression was analyzed by fluorescence quantitative real-time polymerase chain reaction. Zinc accumulation studies indicate choroid plexus cells maintain capacity to accumulate zinc, even when zinc is chelated. In cells, zinc depletion decreased expression of MT-1 and ZnT1 at 3 h and increased Zip1 expression; Zip6 expression fluctuated. In isolated tissues, zinc depletion down-regulated MT-1 and ZnT1 expression, while up-regulating Zip1 and Zip6 expression. In cells, zinc supplementation induced MT-1, ZnT1 and Zip6 expression at 3 h. Zip1 expression decreased at 3 h. In isolated tissues zinc supplementation up-regulated MT-1 and ZnT1 expression, but did not alter Zip1 and Zip6 expression. These data indicate there is coordinated regulation of MT-1 and zinc transporters as extracellular zinc altered. Prolactin up-regulated gene expression of CA-2, MT-1, ZnT-1 and Zip6 in choroid plexus cells. The JAK/STAT inhibitor AG-490 increased CA-2 and MT-1 expression, but decreased ZnT1 and Zip6 expression. AG-490 further increased expression of CA-2 and MT-1 in prolactin treated cells. This suggests the JAK/STAT signaling pathway might tonically suppress basal expression of MT-1 and CA-2. AG-490 partially reversed up-regulation of ZnT-1 and Zip6 expression by prolactin. These data indicate there is a coordinated regulation of MT-1 and zinc transporters during extracellular zinc depletion or supplementation. Advisors/Committee Members: Harris, Kerri B. (advisor), Villalobos, Alice R.A. (advisor), Gomes, Carmen L. (committee member).

Subjects/Keywords: Zinc; Choroid Plexus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Aquino, M. (2014). Regulation of Zinc Transport in the Choroid Plexus. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/153201

Chicago Manual of Style (16th Edition):

Aquino, Mayra. “Regulation of Zinc Transport in the Choroid Plexus.” 2014. Masters Thesis, Texas A&M University. Accessed February 26, 2021. http://hdl.handle.net/1969.1/153201.

MLA Handbook (7th Edition):

Aquino, Mayra. “Regulation of Zinc Transport in the Choroid Plexus.” 2014. Web. 26 Feb 2021.

Vancouver:

Aquino M. Regulation of Zinc Transport in the Choroid Plexus. [Internet] [Masters thesis]. Texas A&M University; 2014. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1969.1/153201.

Council of Science Editors:

Aquino M. Regulation of Zinc Transport in the Choroid Plexus. [Masters Thesis]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/153201

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