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You searched for +publisher:"Texas A&M University" +contributor:("Garcia, L. Rene"). Showing records 1 – 2 of 2 total matches.

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Texas A&M University

1. Herlihy, Sarah E. Linking Two Seemingly Unrelated Diseases, Cancer and Acute Respiratory Distress Syndrome, Through a Dictyostelium Secreted Protein.

Degree: 2014, Texas A&M University

The work in this dissertation links two diseases through a protein secreted by Dictyostelium discoideum cells. The protein, AprA, inhibits cell proliferation and induces chemorepulsion (movement away) of Dictyostelium cells. This has implications in both cancer research and the study of Acute Respiratory Distress Syndrome. Cancer is a misregulation of cellular proliferation. Often the removal of a primary tumor results in rapid metastatic cell proliferation. The rapid proliferation of metastatic cells indicates the presence of a factor, called a chalone, secreted by the primary tumor cells, that inhibits metastatic cell proliferation. The ability of AprA to inhibit proliferation of the cells that secretes it classifies it as a chalone. Using the model organism Dictyostelium and the protein AprA allows us to study chalone signaling mechanisms. Acute Respiratory Distress Syndrome (ARDS) is characterized by an excess influx of neutrophils into the lungs. Neutrophils damage the lung tissue and ultimately recruit more neutrophils that repeat the process. A need exists to remove these cells and allow resolution to occur. One way to accomplish this is through chemorepulsion, the directional movement of cells away from an external cue. We can use AprA to study the mechanisms of chemorepulsion. In this dissertation, I have found that the PTEN-like protein CnrN, which is an inhibitor of proliferation and chemotaxis, is involved in both AprA proliferation inhibition and chemorepulsion of Dictyostelium cells. I have shown that the human protein DPPIV, which is structurally similar to AprA, causes chemorepulsion of human neutrophils. Additionally, aspirated DPPIV reduces the accumulation of neutrophils in the lungs of a mouse model of ARDS. Work shown in the appendices suggests that AprA signals through specific G protein-coupled receptors. The work in this dissertation studies the role of chalones and chemorepellents. It allows the unique opportunity to study chemorepulsion in both Dictyostelium and human cells. The hope and goal is that the work in this dissertation could lead to novel therapies for diseases such as cancer and ARDS. Advisors/Committee Members: Gomer, Richard H (advisor), Polymenis, Michael (committee member), Garcia, L Rene (committee member), Ryan, Kathryn (committee member), Criscitiello, Michael (committee member).

Subjects/Keywords: chemorepulsion; AprA; Dictyostelium; DPPIV; chalone

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Herlihy, S. E. (2014). Linking Two Seemingly Unrelated Diseases, Cancer and Acute Respiratory Distress Syndrome, Through a Dictyostelium Secreted Protein. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/153282

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Herlihy, Sarah E. “Linking Two Seemingly Unrelated Diseases, Cancer and Acute Respiratory Distress Syndrome, Through a Dictyostelium Secreted Protein.” 2014. Thesis, Texas A&M University. Accessed November 13, 2019. http://hdl.handle.net/1969.1/153282.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Herlihy, Sarah E. “Linking Two Seemingly Unrelated Diseases, Cancer and Acute Respiratory Distress Syndrome, Through a Dictyostelium Secreted Protein.” 2014. Web. 13 Nov 2019.

Vancouver:

Herlihy SE. Linking Two Seemingly Unrelated Diseases, Cancer and Acute Respiratory Distress Syndrome, Through a Dictyostelium Secreted Protein. [Internet] [Thesis]. Texas A&M University; 2014. [cited 2019 Nov 13]. Available from: http://hdl.handle.net/1969.1/153282.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Herlihy SE. Linking Two Seemingly Unrelated Diseases, Cancer and Acute Respiratory Distress Syndrome, Through a Dictyostelium Secreted Protein. [Thesis]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/153282

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Texas A&M University

2. Zhai, Bing. Analysis of the Fungal Virulence of Cryptococcus and Exploration of Novel Antifungals Against Cryptococcosis.

Degree: 2014, Texas A&M University

Cryptococcosis is one of the leading causes of the deaths among AIDS patients. The high mortality rates of cryptococcosis are mainly due to inadequate information of its major causative agent Cryptococcus neoformans and the limitations of current therapies. Cryptococcus neoformans is an unconventional dimorphic fungus that can grow either as a yeast or in a filamentous form. To study this dimorphism that is critical to the pathogenicity of many fungi, we constructed the congenic a and ? strains for XL280(?), a strain with robust ability to undergo the yeast-hyphal transition. We compared the congenic strains in different in vivo models and found they are equivalent in virulence. Furthermore, deletion or overexpression of a known transcription factor Znf2 in XL280 abolished or enhanced filamentation and biofilm formation, consistent with its established role. Therefore, the congenic strains provide a new resource for the study of morphogenesis and the related virulence of Cryptococcus. Meanwhile, we searched for novel antifungals by screening of a clinical compound library. Two hits from the screen, the antibiotic polymyxin B and the antidepressant sertraline are all potently fungicidal against Cryptococcus. Polymyxin B works synergistically with the azoles both in vitro and in vivo, thus it may serve as an adjunctive therapy with fluconazole in clinic. Our investigation on sertraline has implicated its unique advantage in treating cryptococcal infections since it is able to traverse the blood brain barrier and reduce the fungal burden in brains. We further examined the fungal target of sertraline and found that this compound inhibits the fungal protein synthesis. Taken together, the studies in this thesis facilitate further research on the pathogenesis of Cryptococcus and provide new antifungal drug candidates with clinical value. Advisors/Committee Members: Lin, Xiaorong (advisor), Sachs, Matthew S. (committee member), Garcia, L. Rene (committee member), Cirillo, Jeffrey D. (committee member).

Subjects/Keywords: Cryptococcus; Cryptococcosis; antifungal; morphorgenesis; pathogenesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Zhai, B. (2014). Analysis of the Fungal Virulence of Cryptococcus and Exploration of Novel Antifungals Against Cryptococcosis. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/153414

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Zhai, Bing. “Analysis of the Fungal Virulence of Cryptococcus and Exploration of Novel Antifungals Against Cryptococcosis.” 2014. Thesis, Texas A&M University. Accessed November 13, 2019. http://hdl.handle.net/1969.1/153414.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Zhai, Bing. “Analysis of the Fungal Virulence of Cryptococcus and Exploration of Novel Antifungals Against Cryptococcosis.” 2014. Web. 13 Nov 2019.

Vancouver:

Zhai B. Analysis of the Fungal Virulence of Cryptococcus and Exploration of Novel Antifungals Against Cryptococcosis. [Internet] [Thesis]. Texas A&M University; 2014. [cited 2019 Nov 13]. Available from: http://hdl.handle.net/1969.1/153414.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhai B. Analysis of the Fungal Virulence of Cryptococcus and Exploration of Novel Antifungals Against Cryptococcosis. [Thesis]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/153414

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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