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You searched for +publisher:"Texas A&M University" +contributor:("Fajt, Virginia"). Showing records 1 – 2 of 2 total matches.

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Texas A&M University

1. Nunez, Chase Michael. The Use of Drugs in Captive White-Tailed Deer (Odocoileus virginianus): An Evaluation of Two Common Extra-Label Drug Uses in the Deer Breeding Industry.

Degree: MS, Biomedical Sciences, 2019, Texas A&M University

The white-tailed deer (WTD) breeding and hunting industry is a large and growing industry with an economic impact of over a billion dollars in Texas alone. The increasing number of deer in captive breeding facilities results in increased veterinary drug use on deer. However, drugs can act differently even among similar species so further information on drug use in deer would help managers and veterinarians make more sound decisions when using drugs in deer. Two examples of novel extra-label drug use in WTD are studied, evaluated, and explained. Tulathromycin is a macrolide antibiotic used commonly to treat livestock, including deer, with bacterial respiratory infections, often delivered subcutaneous (SQ) or intramuscular (IM). Since it is logistically difficult to put hands on a WTD, even in most captive breeding situations, a study was conducted to evaluated tulathromycin as a candidate for remote-delivery dart (RDD) in WTD. Twelve WTD were darted with CO2 powered RDD projectors to administer 2.5 mg/kg of tulathromycin IM. Blood was then collected nine times over 30 days and the serum concentration for each sample was quantified in order to determine the pharmacokinetics of tulathromycin in each deer. Overall tulathromycin was poorly absorbed, reached low mean peak concentrations, had a high bioavailability, and an extremely long elimination half-life. The results indicated that darting with tulathromycin is an unpredictable means of administration and may not reach therapeutic concentrations. Flunixin meglumine (FM), a non-steroidal anti-inflammatory drug (NSAID), was also evaluated for extra-label use in WTD in a case study with 72 WTD in South Texas. Texas Parks and Wildlife has seen anecdotal evidence of FM effectively reducing the body temperature of hyperthermic animals during game captures. Three of the deer in the case study became severely hyperthermic and the FM was tested in conjunction with cold water enemas. With over half of the 72 deer being hyperthermic, and three severely hyperthermic, a 100% post 30-day survival is strong evidence of the effect of FM. Advisors/Committee Members: Cook, Walter E (advisor), Fajt, Virginia (committee member), Blue-McLendon, Alice (committee member).

Subjects/Keywords: White-tailed deer; Odocoileus virginianus; captive deer breeding; tulathromycin; Draxxin; flunixin meglumine; Banamine; darting

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Nunez, C. M. (2019). The Use of Drugs in Captive White-Tailed Deer (Odocoileus virginianus): An Evaluation of Two Common Extra-Label Drug Uses in the Deer Breeding Industry. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/188786

Chicago Manual of Style (16th Edition):

Nunez, Chase Michael. “The Use of Drugs in Captive White-Tailed Deer (Odocoileus virginianus): An Evaluation of Two Common Extra-Label Drug Uses in the Deer Breeding Industry.” 2019. Masters Thesis, Texas A&M University. Accessed November 30, 2020. http://hdl.handle.net/1969.1/188786.

MLA Handbook (7th Edition):

Nunez, Chase Michael. “The Use of Drugs in Captive White-Tailed Deer (Odocoileus virginianus): An Evaluation of Two Common Extra-Label Drug Uses in the Deer Breeding Industry.” 2019. Web. 30 Nov 2020.

Vancouver:

Nunez CM. The Use of Drugs in Captive White-Tailed Deer (Odocoileus virginianus): An Evaluation of Two Common Extra-Label Drug Uses in the Deer Breeding Industry. [Internet] [Masters thesis]. Texas A&M University; 2019. [cited 2020 Nov 30]. Available from: http://hdl.handle.net/1969.1/188786.

Council of Science Editors:

Nunez CM. The Use of Drugs in Captive White-Tailed Deer (Odocoileus virginianus): An Evaluation of Two Common Extra-Label Drug Uses in the Deer Breeding Industry. [Masters Thesis]. Texas A&M University; 2019. Available from: http://hdl.handle.net/1969.1/188786

2. Mays, Travis Parker. Establishing Decision Limits for Therapeutic Drugs Detected in Animals Exhibited at Livestock Shows.

Degree: PhD, Biomedical Sciences, 2019, Texas A&M University

Food animal species, such as cattle, sheep, goats, and pigs, are widely exhibited at stock shows and fairs across the United States. Animals are judged on phenotypical traits such as muscling, structural correctness, and frame-size. The level of competition is high, increasing the potential for illegal or unethical acts to gain a competitive advantage, such as doping. Antidoping regulation in the livestock show industry often involves drug testing. Detection of therapeutic drugs at very low concentrations in approved animal species raises questions about current anti-doping regulations in exhibition animals. Therefore, the purpose of this research was to identify and address data gaps in the current understanding of drug testing and drug disposition, and to integrate those data with published data to propose an approach to standardizing anti-doping policies, particularly those related to therapeutic drug use. To determine which drugs are most commonly identified in drug testing at livestock shows, a review of historical drug test results from a laboratory in Texas from 1999 to 2017 was performed. A total of 32,027 samples were tested during this period, of which 1,674 (5.2%) tested positive. Positive samples included a total of 42 different drugs and metabolites. Flunixin was the second most commonly identified drug. Currently no nonsteroidal anti-inflammatory drugs (NSAIDs) are approved by the Food and Drug Administration (FDA) for small ruminants, but drugs such as flunixin and meloxicam are used in small ruminants. Additionally, urine is the sample of choice when drug testing exhibition animals but there is a gap in the scientific literature describing drug concentrations in urine of small ruminants. Therefore, pharmacokinetic studies were performed describing plasma and urine concentrations of flunixin meglumine and meloxicam in goats. Drug levels in urine reached peak concentrations between 8 and 12 hours after dosing for both drugs. Urine concentrations for both flunixin and meloxicam fell below the limit of detection (LOD) of 0.5 ng/mL and 1 ng/mL, respectively, by 240 hours. Last, observed and published data, PK/PD modeling results, and measurement uncertainty were integrated to propose a method for establishing decision limits for therapeutic drugs detected in urine from animals exhibited at livestock shows. Advisors/Committee Members: Fajt, Virginia (advisor), Cohen, Noah (committee member), Stewart, Randolph (committee member), Jones, Meredyth (committee member).

Subjects/Keywords: Drug; Pharmacology; Analytical Chemistry; Doping; Livestock; Exhibition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Mays, T. P. (2019). Establishing Decision Limits for Therapeutic Drugs Detected in Animals Exhibited at Livestock Shows. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/186156

Chicago Manual of Style (16th Edition):

Mays, Travis Parker. “Establishing Decision Limits for Therapeutic Drugs Detected in Animals Exhibited at Livestock Shows.” 2019. Doctoral Dissertation, Texas A&M University. Accessed November 30, 2020. http://hdl.handle.net/1969.1/186156.

MLA Handbook (7th Edition):

Mays, Travis Parker. “Establishing Decision Limits for Therapeutic Drugs Detected in Animals Exhibited at Livestock Shows.” 2019. Web. 30 Nov 2020.

Vancouver:

Mays TP. Establishing Decision Limits for Therapeutic Drugs Detected in Animals Exhibited at Livestock Shows. [Internet] [Doctoral dissertation]. Texas A&M University; 2019. [cited 2020 Nov 30]. Available from: http://hdl.handle.net/1969.1/186156.

Council of Science Editors:

Mays TP. Establishing Decision Limits for Therapeutic Drugs Detected in Animals Exhibited at Livestock Shows. [Doctoral Dissertation]. Texas A&M University; 2019. Available from: http://hdl.handle.net/1969.1/186156

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