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1. Yousefi Gharebaghi, Farzad. Near Infrared (NIR) Spectroscopic Assessment of Engineered Cartilage.
Degree: PhD, 2017, Temple University
Articular cartilage has limited intrinsic healing capacity due to its dense and avascular structure. Clinical approaches have been developed to address the limitations associated with the poor ability of articular cartilage to regenerate. Current clinically approved techniques, however, can result in repair tissue that lacks appropriate hyaline cartilage biochemical and biomechanical properties, which lead to uncertain long-term clinical outcomes. Using tissue engineering strategies and a range of scaffolding materials, cell types, growth factors, culture conditions, and culture times, engineered tissues have been produced with compositional and biomechanical properties that approximate that of native tissue. In these studies, a considerable number of samples are typically sacrificed to evaluate compositional and mechanical properties, such as the amount of deposited collagen and sulfated glycosaminoglycan (sGAG) in the constructs. The number of sacrificed samples, as well as the amount of time and resources spent to evaluate the sacrificed samples using current gold standards, motivates an alternative method for evaluation of compositional properties. Vibrational spectroscopy, including infrared, has been considered as an alternative technique for assessment of tissues over the last 15-20 years. Infrared spectroscopy is based on absorbance of infrared light by tissue functional groups at specific vibrational frequencies, and thus, no external contrast is required. Vibrational spectroscopy is typically performed in two frequency regions, the mid infrared region (750-4000 cm-1), where penetration depth is limited to approximately 10 microns, and the near infrared (NIR) region (4000-12000 cm-1). In the NIR region, penetration of light is on the order of millimeters or centimeters, which makes it ideal for obtaining data through the full depth of engineered constructs. Here we employ NIR spectroscopy to nondestructively monitor the development of tissue-engineered constructs over culture period.
Temple University – ThesesAdvisors/Committee Members: Pleshko, Nancy;, Patil, Chetan A., Bellas, Evangelia, Burdick, Jason A.;.
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APA (6th Edition):
Yousefi Gharebaghi, F. (2017). Near Infrared (NIR) Spectroscopic Assessment of Engineered Cartilage. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,477078
Chicago Manual of Style (16th Edition):
Yousefi Gharebaghi, Farzad. “Near Infrared (NIR) Spectroscopic Assessment of Engineered Cartilage.” 2017. Doctoral Dissertation, Temple University. Accessed September 28, 2020. http://digital.library.temple.edu/u?/p245801coll10,477078.
MLA Handbook (7th Edition):
Yousefi Gharebaghi, Farzad. “Near Infrared (NIR) Spectroscopic Assessment of Engineered Cartilage.” 2017. Web. 28 Sep 2020.
Yousefi Gharebaghi F. Near Infrared (NIR) Spectroscopic Assessment of Engineered Cartilage. [Internet] [Doctoral dissertation]. Temple University; 2017. [cited 2020 Sep 28]. Available from: http://digital.library.temple.edu/u?/p245801coll10,477078.
Council of Science Editors:
Yousefi Gharebaghi F. Near Infrared (NIR) Spectroscopic Assessment of Engineered Cartilage. [Doctoral Dissertation]. Temple University; 2017. Available from: http://digital.library.temple.edu/u?/p245801coll10,477078