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You searched for +publisher:"Temple University" +contributor:("Fong, Dunne"). Showing records 1 – 2 of 2 total matches.

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Temple University

1. Moore, Andrea Rossi. COX-2 inhibition impaired resolution of chronic inflammation in a murine model of autoimmune arthritis.

Degree: PhD, 2010, Temple University

Microbiology and Immunology

Rheumatoid arthritis (RA) is a chronic disease characterized by cycles of inflammation and resolution. Previously, it was believed that the resolution of inflammation is simply dissipation of pro-inflammatory signals, although current research indicates that resolution is an active process. Acute inflammation follows defined phases of induction, inflammation and resolution, and resolution occurs by an active process that requires COX-2 activity. This study aims to address whether this paradigm extends to a recognized model of chronic inflammation. We demonstrated in murine collageninduced arthritis that chronic inflammation follows the same sequential course. While there is the normal production of pro-inflammatory cytokines during inflammation and anti-inflammatory mediators such as 15-deoxyΔ12,14PGJ2 (15d-PGJ2) during resolution, interestingly there is sustained production of both COX-2 and the presumably proinflammatory PGE2 during both phases. Blocking COX-2 activity and therefore production of PGE2 during the resolution phase perpetuated instead of attenuated inflammation. Repletion with PGE2 analogs restored homeostasis, and this function is mediated by the pro-resolving lipoxygenase metabolite, lipoxin A4 (LXA4), which is a potent stop signal. Thus, the study provided in vivo evidence for a natural, endogenous link between the cyclooxygenase-lipoxygenase pathways and showed that PGE2 serves as a feedback inhibitor essential for limiting chronic inflammation in autoimmune arthritis. These findings may explain the enigma regarding why COX-2 inhibitors are palliative rather than curative in humans because blocking resolution may mitigate the benefit of preventing induction.

Temple University – Theses

Advisors/Committee Members: Chan, Marion M., Coico, Richard, Fong, Dunne, Monestier, Marc, Safadi, Fayez F., Dun, Nae J..

Subjects/Keywords: Health Sciences, Immunology; autoimmunity; inflammation; lipid mediators; rheumatoid arthritis; rodent

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Moore, A. R. (2010). COX-2 inhibition impaired resolution of chronic inflammation in a murine model of autoimmune arthritis. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,81890

Chicago Manual of Style (16th Edition):

Moore, Andrea Rossi. “COX-2 inhibition impaired resolution of chronic inflammation in a murine model of autoimmune arthritis.” 2010. Doctoral Dissertation, Temple University. Accessed April 02, 2020. http://digital.library.temple.edu/u?/p245801coll10,81890.

MLA Handbook (7th Edition):

Moore, Andrea Rossi. “COX-2 inhibition impaired resolution of chronic inflammation in a murine model of autoimmune arthritis.” 2010. Web. 02 Apr 2020.

Vancouver:

Moore AR. COX-2 inhibition impaired resolution of chronic inflammation in a murine model of autoimmune arthritis. [Internet] [Doctoral dissertation]. Temple University; 2010. [cited 2020 Apr 02]. Available from: http://digital.library.temple.edu/u?/p245801coll10,81890.

Council of Science Editors:

Moore AR. COX-2 inhibition impaired resolution of chronic inflammation in a murine model of autoimmune arthritis. [Doctoral Dissertation]. Temple University; 2010. Available from: http://digital.library.temple.edu/u?/p245801coll10,81890


Temple University

2. Evans, Kyle William. PPAR gamma AND eNOS CONTRIBUTE TO THE RESOLUTION OF CHRONIC INFLAMMATION.

Degree: PhD, 2011, Temple University

Microbiology and Immunology

Chronic inflammation follows defined phases of induction, inflammation, and resolution. The resolution phase requires cycloxygenase-2 (COX-2) activity. This study aims to address what other molecules are required for a functional resolution phase. We demonstrated that in murine collagen-induced arthritis the transcription factor, PPARgamma plays a role in the resolution phase. Inhibition of COX-2 activity results in fewer PPARgamma positive cells in the arthritic synovium. Treatment with a PPARgamma antagonist, SR202, alone, also disrupts the process of resolution. PPARgamma antagonist treatment results in a decrease in eNOS phosphorylation within the arthritic synovium. These observations indicate that PPARgamma may function to regulate eNOS activity. The source of pro-resolving nitric oxide is eNOS but not, iNOS. The effect of COX-2 inhibition on the resolution phase is ameliorated by injection of a PGE2 analog. Restoration of PGE2 levels results in an increase in PPARgamma positive cells in the arthritic synovium which correlates with this restoration of resolution. Thus, this study provides in vivo evidence for the pro-resolving role of PPARgamma and its relationship with PGE2 and eNOS.

Temple University – Theses

Advisors/Committee Members: Chan, Marion M., Fong, Dunne, Eisenstein, Toby K., Piggot, Patrick, Yang, Xiao-Feng, Ashby, Barrie.

Subjects/Keywords: Biology; eNOS; inflammation; PPARgamma; resolution; rheumatoid arthrits

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Evans, K. W. (2011). PPAR gamma AND eNOS CONTRIBUTE TO THE RESOLUTION OF CHRONIC INFLAMMATION. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,197871

Chicago Manual of Style (16th Edition):

Evans, Kyle William. “PPAR gamma AND eNOS CONTRIBUTE TO THE RESOLUTION OF CHRONIC INFLAMMATION.” 2011. Doctoral Dissertation, Temple University. Accessed April 02, 2020. http://digital.library.temple.edu/u?/p245801coll10,197871.

MLA Handbook (7th Edition):

Evans, Kyle William. “PPAR gamma AND eNOS CONTRIBUTE TO THE RESOLUTION OF CHRONIC INFLAMMATION.” 2011. Web. 02 Apr 2020.

Vancouver:

Evans KW. PPAR gamma AND eNOS CONTRIBUTE TO THE RESOLUTION OF CHRONIC INFLAMMATION. [Internet] [Doctoral dissertation]. Temple University; 2011. [cited 2020 Apr 02]. Available from: http://digital.library.temple.edu/u?/p245801coll10,197871.

Council of Science Editors:

Evans KW. PPAR gamma AND eNOS CONTRIBUTE TO THE RESOLUTION OF CHRONIC INFLAMMATION. [Doctoral Dissertation]. Temple University; 2011. Available from: http://digital.library.temple.edu/u?/p245801coll10,197871

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