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You searched for +publisher:"Technical University of Lisbon" +contributor:("Niza, Maria Manuela Rodeia Espada"). Showing records 1 – 2 of 2 total matches.

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Technical University of Lisbon

1. Félix, Nuno Manuel Mira Flor Santos. Insuficiência adrenal relativa em choque hemorrágico : estudo experimental acerca dos seus mecanismos fisiopatológicos em rato (Rattus norvegicus).

Degree: 2017, Technical University of Lisbon

Tese de Doutoramento em Ciências Veterinárias na Especialidade de Clínica

O Choque Hemorrágico (CH) pode complicar-se por “insuficiência adrenal relativa” (IAR). Neste estudo avaliou-se a contribuição do etomidato e apoptose da adrenal na IAR pós-CH. Ratos machos Wistar foram divididos em 4 grupos: G0 (anestesia geral com isoflurano e ventilação mecânica, 16 ratos), G1 (como G0 mas com buprenorfina, 16 ratos), G2 (como G1 mas com CH, 16 ratos) e G3 (como G2 mas com etomidato antes do CH, 16 ratos). CH induzido por recolha de sangue (30% volume sanguíneo). Resuscitação aos 90 minutos pós-CH, consistindo no sangue recolhido associado a soro fisiológico. Aos 0, 90, 150 and 240 minutos após início do CH, mediram-se gasimetria e níveis plasmáticos de hormona adrenocorticotrópica, corticosterona, TNF-α, IL6, IL10 e por RT-PCR, TNF-α, IL6 e IL10. Apoptose avaliada por TUNEL e caspase-3 (immunofluorescência); necrose por escala específica. G1 apresentou taxa de apoptose mais elevada que G0. G2 e G3 tiveram níveis mais elevados de apoptose e necrose que outros grupos. Comparado com G2, G3 apresentou níveis de corticosterona compativeis com IAR e níveis mais baixos de PO2, PO2/FiO2, BE, bicarbonato, apoptose e necrose, e mais altos das citoquinas e TNF- α.IAR foi associada a etomidato mas não a apoptose neste modelo.

ABSTRACT - Critical Illness-Related Corticosteroid Insufficiency in Hemorrhagic Shock- an experimental study about its pathophysiologic mechanisms in a rat model (Rattus norvegicus) - Hemorrhagic Shock (HS) can be complicated by critical illness-related corticosteroid insufficiency (CIRCI). This study evaluated if etomidate and adrenal gland apoptosis contributed to HS-associated CIRCI. Male Wistar rats were divided in 4 groups: G0 (general anesthesia with isoflurane and mechanical ventilation, 16 rats), G1 (similar to G0, but with buprenorphine, 16 rats), G2 (similar to G1 but with HS, 16 rats) and G3 (similar to G2 but with etomidate before HS, 16 rats). HS was induced by collecting 30% of the blood volume and resuscitation (90 minutes later) consisted in the collected blood and normal saline. Blood gas analysis, adrenocorticotropic hormone, corticosterone, TNF-α, IL6, IL10 and TNF-α, IL6 and IL10 mRNA quantified by RT-PCR were determined at 0, 90, 150 and 240 minutes post-HS induction. Apoptosis and necrosis were determined by TUNEL and active caspase-3 immunofluorescence and a standardized necrosis score, respectively. G1 had higher adrenal apoptosis than G0. G2 and G3 had significantly higher levels of apoptosis and necrosis. G3 had significantly lower levels of corticosterone (compatible with CIRCI), PO2, PO2/FiO2, BE, bicarbonate, apoptosis and necrosis score and higher levels of cytokines and TNF-α than G2. Etomidate but not apoptosis was associated to CIRCI in this HS model.

N/A

Advisors/Committee Members: Niza, Maria Manuela Rodeia Espada.

Subjects/Keywords: Choque; Rato; Adrenal; Insuficiência; Etomidato; Apoptose; Citoquina; Buprenorfina; Hemorrhagic; shock; rat; adrenal; insufficiency; etomidate; apoptosis; mRNA; cytokine; buprenoprhine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Félix, N. M. M. F. S. (2017). Insuficiência adrenal relativa em choque hemorrágico : estudo experimental acerca dos seus mecanismos fisiopatológicos em rato (Rattus norvegicus). (Thesis). Technical University of Lisbon. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13691

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Félix, Nuno Manuel Mira Flor Santos. “Insuficiência adrenal relativa em choque hemorrágico : estudo experimental acerca dos seus mecanismos fisiopatológicos em rato (Rattus norvegicus).” 2017. Thesis, Technical University of Lisbon. Accessed March 06, 2021. https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13691.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Félix, Nuno Manuel Mira Flor Santos. “Insuficiência adrenal relativa em choque hemorrágico : estudo experimental acerca dos seus mecanismos fisiopatológicos em rato (Rattus norvegicus).” 2017. Web. 06 Mar 2021.

Vancouver:

Félix NMMFS. Insuficiência adrenal relativa em choque hemorrágico : estudo experimental acerca dos seus mecanismos fisiopatológicos em rato (Rattus norvegicus). [Internet] [Thesis]. Technical University of Lisbon; 2017. [cited 2021 Mar 06]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13691.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Félix NMMFS. Insuficiência adrenal relativa em choque hemorrágico : estudo experimental acerca dos seus mecanismos fisiopatológicos em rato (Rattus norvegicus). [Thesis]. Technical University of Lisbon; 2017. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13691

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Technical University of Lisbon

2. Arcanjo, Ana Sofia Serrano. Prospective study of the utility of IRIS AKI grading system in detection renal injury in patients presented with probable nephrotoxin exposure at a 1st opinion veterinary hospital.

Degree: 2018, Technical University of Lisbon

Dissertação de Mestrado Integrado em Medicina Veterinária

Kidney diseases are common in dogs and cats and slight changes in kidney function do not result in organ failure but have an important role on the impact of the condition. Acute kidney injury (AKI) has been associated with high mortality and morbidity rates, and the early recognition of the disease has become necessary, to be able to use more effective therapeutic interventions, to recognise developing injury earlier and have more positive outcomes. In 2013, the International Renal Interest Society (IRIS) adopted a grading system to categorize the severity of AKI, but this criteria has not yet been validated for use in general practice population. This study aimed to relate the detection of AKI using the IRIS criteria in small animals exposed to a nephrotoxin compared with the detection of AKI using the creatinine reference range alone. The study population were client-owned dogs and cats presented at Village Vet Hampstead, a 1st opinion hospital practice (RCVS recognised), with history of exposure to a nephrotoxin. This included 11 feline patients (n=11) exposed to Lilium spp. and 7 canine patients (n=7) exposed to Vitis spp., which were later divided into two subgroups, depending on the development of AKI. In the feline sample, results demonstrated that both creatinine reference range and IRIS criteria identified AKI in the same feline patients (n=2), and when both methods were compared regarding sensitivity a p value of 1, showed no significantly difference between them regarding to sensitivity. In canine sample results showed that none of the dogs developed AKI. This was already expected since all patients were managed with fluids and monitoring, and incidence of AKI with treatment is only 8.5%. Therefore, less than 1 patient in every 10 are expected to have AKI, which corresponded to what was observed. The study was underpowered, with a power calculation of 16%, which did not allow any statistically significant results. To improve the power calculation of this study, larger samples would be required. This was a pilot stud and additional studies involving a larger sample size and funding are required to evaluate the sensitivity of IRIS AKI grading criteria when compared to the creatinine reference range alone.

RESUMO - ESTUDO PROSPETIVO DA UTILIDADE DO SISTEMA DE CLASSIFICAÇÃO DA IRIS NA DETEÇÃO DE LESÃO RENAL AGUDA EM PACIENTES QUE SE APRESENTAM COM PROVÁVEL EXPOSIÇÃO A UMA NEFROTOXINA NUM HOSPITAL VETERINÁRIO DE 1ª OPINIÃO - As doenças renais são comuns em cães e gatos, e mesmo pequenas alterações na função renal têm um papel importante no impacto da doença. A Insuficiência Renal Aguda (IRA) está associada a taxas de mortalidade e morbilidade elevadas, tornando-se necessário reconhecer precocemente a doença, para que possam ser realizadas terapêuticas eficazes, para que se reconheça o desenvolvimento de lesão mais cedo e para que os prognósticos sejam melhores. Em 2013, a International Renal Interest Society (IRIS) adotou um sistema de…

Advisors/Committee Members: Mugford, Adam, Niza, Maria Manuela Rodeia Espada.

Subjects/Keywords: Acute Kidney Injury; Nephrotoxin; Lilies; Grapes; Insuficiência Renal Aguda; Nefrotoxina; Lírios; Uvas

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Arcanjo, A. S. S. (2018). Prospective study of the utility of IRIS AKI grading system in detection renal injury in patients presented with probable nephrotoxin exposure at a 1st opinion veterinary hospital. (Thesis). Technical University of Lisbon. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/14732

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Arcanjo, Ana Sofia Serrano. “Prospective study of the utility of IRIS AKI grading system in detection renal injury in patients presented with probable nephrotoxin exposure at a 1st opinion veterinary hospital.” 2018. Thesis, Technical University of Lisbon. Accessed March 06, 2021. https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/14732.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Arcanjo, Ana Sofia Serrano. “Prospective study of the utility of IRIS AKI grading system in detection renal injury in patients presented with probable nephrotoxin exposure at a 1st opinion veterinary hospital.” 2018. Web. 06 Mar 2021.

Vancouver:

Arcanjo ASS. Prospective study of the utility of IRIS AKI grading system in detection renal injury in patients presented with probable nephrotoxin exposure at a 1st opinion veterinary hospital. [Internet] [Thesis]. Technical University of Lisbon; 2018. [cited 2021 Mar 06]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/14732.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arcanjo ASS. Prospective study of the utility of IRIS AKI grading system in detection renal injury in patients presented with probable nephrotoxin exposure at a 1st opinion veterinary hospital. [Thesis]. Technical University of Lisbon; 2018. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/14732

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.