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Rutgers University

1. Steege, Karen Elizabeth. Fluorescence probing of complex solvent environments: polymeric nanocarrier aggregates and rilpivirine.

Degree: PhD, Chemistry and Chemical Biology, 2008, Rutgers University

The local environment of a drug molecule in polymeric drug nanocarrier solutions impacts the bioavailability of the drug and its ability to reach its target in the biological system. The local environment and aggregation properties of small, hydrophobic molecules in aqueous polymeric micelles and nanocarrier aggregates are explored using fluorescence spectroscopy for the purpose of characterizing drug delivery formulations on molecular length scales. The fluorescence properties of seven coumarin dyes in A-B-A triblock copolymer unimer, micelle, and gel solutions respond to changes in local solvent environment. The A-B-A copolymer is used as a model for the encapsulation properties of three novel amphiphilic polymers designed for hydrophobic drug delivery. Rilpivirine, a novel HIV inhibitor shows solvatochromic fluorescence spectral response due to a large charge transfer between the ground and electronic excited states. The fluorescence of rilpivirine in A-B-A triblock copolymer is investigated as a method to differentiate between the aggregated and unimer forms of the solubilized drug.

Advisors/Committee Members: Steege, Karen Elizabeth (author), Castner, Edward (chair), Uhrich, Kathryn (internal member), Arnold, Edward (internal member), Piotrowiak, Piotr (outside member).

Subjects/Keywords: Drug delivery systems

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Steege, K. E. (2008). Fluorescence probing of complex solvent environments: polymeric nanocarrier aggregates and rilpivirine. (Doctoral Dissertation). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17396

Chicago Manual of Style (16th Edition):

Steege, Karen Elizabeth. “Fluorescence probing of complex solvent environments: polymeric nanocarrier aggregates and rilpivirine.” 2008. Doctoral Dissertation, Rutgers University. Accessed June 17, 2019. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17396.

MLA Handbook (7th Edition):

Steege, Karen Elizabeth. “Fluorescence probing of complex solvent environments: polymeric nanocarrier aggregates and rilpivirine.” 2008. Web. 17 Jun 2019.

Vancouver:

Steege KE. Fluorescence probing of complex solvent environments: polymeric nanocarrier aggregates and rilpivirine. [Internet] [Doctoral dissertation]. Rutgers University; 2008. [cited 2019 Jun 17]. Available from: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17396.

Council of Science Editors:

Steege KE. Fluorescence probing of complex solvent environments: polymeric nanocarrier aggregates and rilpivirine. [Doctoral Dissertation]. Rutgers University; 2008. Available from: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17396

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