+publisher:"Rutgers University" +contributor:("Hu, Longqin")

Rutgers University

1. Liu, Shaodong, 1990-. Design and synthesis of chiral ligands and their application in transition metal-catalyzed asymmetric hydrogenations.

Degree: PhD, Chemistry and Chemical Biology, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/51357/

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Transition metal catalyzed hydrogenations are among the most powerful and direct approaches for the synthesis of organic molecules. During the past half century, chiral ligands… (more)

Subjects/Keywords: Hydrogenation

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APA (6^th Edition):

Liu, Shaodong, 1. (2016). Design and synthesis of chiral ligands and their application in transition metal-catalyzed asymmetric hydrogenations. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/51357/

Chicago Manual of Style (16^th Edition):

Liu, Shaodong, 1990-. “Design and synthesis of chiral ligands and their application in transition metal-catalyzed asymmetric hydrogenations.” 2016. Doctoral Dissertation, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/51357/.

MLA Handbook (7^th Edition):

Liu, Shaodong, 1990-. “Design and synthesis of chiral ligands and their application in transition metal-catalyzed asymmetric hydrogenations.” 2016. Web. 16 Apr 2021.

Vancouver:

Liu, Shaodong 1. Design and synthesis of chiral ligands and their application in transition metal-catalyzed asymmetric hydrogenations. [Internet] [Doctoral dissertation]. Rutgers University; 2016. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51357/.

Council of Science Editors:

Liu, Shaodong 1. Design and synthesis of chiral ligands and their application in transition metal-catalyzed asymmetric hydrogenations. [Doctoral Dissertation]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51357/

Rutgers University

2. Wen, Jialin, 1987-. Application of hydrogen bonding in asymmetric hydrogenation.

Degree: PhD, Chemistry and Chemical Biology, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/51496/

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Hydrogen bonding has been widely observed in biosynthesis and enzyme catalysis. It plays an important role in such fields as molecular recognition, supramolecular chemistry and… (more)

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Hydrogen bonding has been widely observed in biosynthesis and enzyme catalysis. It plays an important role in such fields as molecular recognition, supramolecular chemistry and small molecule catalysis. A new concept of organocatalysis emerged in recent two decades. Hydrogen bonding is the keystone for thiourea catalysis or phosphoric acid catalysis. With high turnover numbers and excellent enantioselectivity, transition metal catalysis not only is the arts in academia, but also find its merit in industrial application. Homogeneous hydrogenation, among many successful transition metal catalyzed reactions, has been serving the synthetic communities for many years, both in academia or in industry. The success of secondary interaction and hydrogen bonding offer us an alternative: the combination of hydrogen bonding and steric hindrance help to create a chiral environment in which substrates could be reduced efficiently. Guided by this rationale, a ferrocene-based bisphosphine/thiourea ligand, ZhaoPhos was synthesized in our group. It was applied in the asymmetric hydrogenation of nitroolefins with hydrogen bonding between the ligand and substrates. Thiourea-carbonyl hydrogen bonding is another model of non-covalent interaction. Therefore, the asymmetric hydrogenation of unsaturated carbonyl compounds is also practical. Besides neutral compounds, ionic unsaturated substrates could form non-covalent interactions with thiourea through anion binding as well. It makes the asymmetric reduction of iminium ions and N-heteroaromatics (quinolines, isoquinolines and indoles) possible. These type of unsaturated compounds were challenging for traditional transition metal catalyzed hydrogenation. They could now be achieved with high enantioselectivity with a rhodium/ZhaoPhos complex. An outer-sphere mechanism involving hydride transfer was proposed since these substrates were thought to lack of coordinating ability to the metal center. As a traditional catalytic system, rhodium/bisphosphine complexes have been applied to catalyze hydrogenation of C=C bonds in a long time. The application in hydrogenation of non- or weak coordinating unsaturated compounds changed our view towards of this class of complexes. In the meanwhile, the role of hydrogen bonding is still a mechanistically unexplored area: what is the geometry of the ligand-substrate complex? How does the hydrogen bonding influence the activation energy in the transition state? Many in-depth studies are needed in the future.

Advisors/Committee Members: Zhang, Xumu (chair), Goldman, Alan (internal member), Warmuth, Ralf (internal member), Hu, Longqin (outside member).

Subjects/Keywords: Hydrogen bonding; Hydrogenation

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APA (6^th Edition):

Wen, Jialin, 1. (2016). Application of hydrogen bonding in asymmetric hydrogenation. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/51496/

Chicago Manual of Style (16^th Edition):

Wen, Jialin, 1987-. “Application of hydrogen bonding in asymmetric hydrogenation.” 2016. Doctoral Dissertation, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/51496/.

MLA Handbook (7^th Edition):

Wen, Jialin, 1987-. “Application of hydrogen bonding in asymmetric hydrogenation.” 2016. Web. 16 Apr 2021.

Vancouver:

Wen, Jialin 1. Application of hydrogen bonding in asymmetric hydrogenation. [Internet] [Doctoral dissertation]. Rutgers University; 2016. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51496/.

Council of Science Editors:

Wen, Jialin 1. Application of hydrogen bonding in asymmetric hydrogenation. [Doctoral Dissertation]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51496/

Rutgers University

3. Ranade, Ashwini, 1993-. Design, synthesis and evaluation of potential MTA prodrugs for the treatment of MTAP-deficient tumors in combination with 5-FU/6-TG/antifolates.

Degree: MS, Medicinal Chemistry, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/59146/

► Many solid tumors and hematologic malignancies are characterized by a deficiency of the enzyme methylthioadenosine phosphorylase (MTAP). MTAP cleaves its natural substrate MTA which is… (more)

▼ Many solid tumors and hematologic malignancies are characterized by a deficiency of the enzyme methylthioadenosine phosphorylase (MTAP). MTAP cleaves its natural substrate MTA which is generated during polyamine biosynthesis to adenine via a salvage pathway for AMP production. MTAP deficient cells are unable to salvage adenine from MTA. The difference in the lack of expression of MTAP in tumor cells compared to normal healthy cells has been explored in a therapeutic strategy for selectively killing tumor cells. Antimetabolites such as 5-FU, 6-TG or antifolates disrupt DNA replication and inhibit de-novo purine synthesis through the release of cytotoxic nucleotides generated via phosphorylation using phosphoribosyl-1-pyrophosphate (PRPP). Unfortunately, one major drawback of these cytotoxic nucleotides is that they produce harmful effects on the growth and proliferation of normal cells. To eliminate or reduce the cytotoxicity of these chemotherapeutic drugs and thus increase their therapeutic index, administration of MTA or MTA analogs in conjugation with antimetabolites could prevent damage to healthy MTAP competent cells. This is because adenine generated in this process by MTAP in healthy cells will block the conversion of 5-FU/6-TG to their cytotoxic nucleotides by competing for the rate-limiting pools of PRPP. Since no adenine is produced in tumor cells due to lack of MTAP, PRPP is present in sufficient levels and the co-administered drug can be readily converted to its toxic metabolite. Thus, a high degree of selectivity can be achieved. There are several MTA prodrugs discussed in the literature for delivering MTA to protect MTAP competent cells and proof of concept exists through in vitro studies emphasizing the protective effects of MTA in the presence of antimetabolites. However, there is still no successful clinical trial reported to have co-administered MTA or its analog with an antimetabolite. Also, the optimum dose of MTA that can rescue normal MTAP competent cells without compromising the ability of antimetabolites to selectively kill MTAP deficient tumor cells remains to be identified. In this thesis work, prodrugs of MTA were designed to be activated by the carboxylesterases to release MTA. We explored two types of prodrugs, namely the N-(alkyloxy)carbonyl-MTA derivatives and N-[(acyloxy)alkyloxy]carbonyl-MTA derivatives. The N-(alkyloxy)carbonyl-MTA prodrugs were stable at physiological pH and showed longer activation half-lives when tested in mouse liver microsomes but failed to be activated in human liver microsomes. Conversely, the N-[(acyloxy)alkyloxy]carbonyl-MTA prodrugs showed shorter half-lives ranging from a few minutes to a few hours in the presence of mouse and human liver microsomes but suffered from an inherent instability at physiological pH. As expected, the hydrolytic susceptibility of the ester group in N-[(acyloxy)alkyloxy]carbonyl-MTA prodrugs decreased with increasing steric hindrance around the ester bond by replacement with bulkier alkyl groups. Therefore, the… Advisors/Committee Members: Hu, Longqin (chair), Lavoie, Edmond (internal member), Augeri, David (internal member), School of Graduate Studies.

Subjects/Keywords: Tumors; Prodrugs

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APA (6^th Edition):

Ranade, Ashwini, 1. (2018). Design, synthesis and evaluation of potential MTA prodrugs for the treatment of MTAP-deficient tumors in combination with 5-FU/6-TG/antifolates. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/59146/

Chicago Manual of Style (16^th Edition):

Ranade, Ashwini, 1993-. “Design, synthesis and evaluation of potential MTA prodrugs for the treatment of MTAP-deficient tumors in combination with 5-FU/6-TG/antifolates.” 2018. Masters Thesis, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/59146/.

MLA Handbook (7^th Edition):

Ranade, Ashwini, 1993-. “Design, synthesis and evaluation of potential MTA prodrugs for the treatment of MTAP-deficient tumors in combination with 5-FU/6-TG/antifolates.” 2018. Web. 16 Apr 2021.

Vancouver:

Ranade, Ashwini 1. Design, synthesis and evaluation of potential MTA prodrugs for the treatment of MTAP-deficient tumors in combination with 5-FU/6-TG/antifolates. [Internet] [Masters thesis]. Rutgers University; 2018. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59146/.

Council of Science Editors:

Ranade, Ashwini 1. Design, synthesis and evaluation of potential MTA prodrugs for the treatment of MTAP-deficient tumors in combination with 5-FU/6-TG/antifolates. [Masters Thesis]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59146/

Rutgers University

4. Sagong, Hye Yeon, 1988-. Design and synthesis of novel pan-targeting anti-influenza agents.

Degree: PhD, Medicinal Chemistry, 2017, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/52265/

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Pandemics and seasonal epidemics of influenza pose a major health concern worldwide. The limitation of vaccination and the emergence of influenza virus strains that are… (more)

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Pandemics and seasonal epidemics of influenza pose a major health concern worldwide. The limitation of vaccination and the emergence of influenza virus strains that are resistant to the current antivirals, have emphasized the search for a new antiviral with novel mechanisms of action. The endonuclease activity of polymerase acidic protein (PA) has been identified as an attractive target. PAN endonuclease is a highly conserved and essential viral transcription protein, which cleaves host pre-mRNA during the cap-snatching process. The cap-snatching mechanism is a unique process of the viral transcription. There are many known PAN endonuclease inhibitors, and few of them inhibited viral reproduction in the cell. iii Our research efforts began with conducting a fragment screening campaign using 2009 pandemic H1N1 PAN. The compound 5-chloro-3-hydroxypyridin-2(1H)-one was identified as a bimetal chelating ligand at the active site of the enzyme. Several scaffolds were proposed from the hit compound including 3-hydroxypyridin-2(1H)-ones, 3-hydroxyquinolin-2(1H)-ones and aza analogous of 3-hydroxypyridin-2(1H)-ones. Although initial SAR studies on 3-hydroxypyridin-2(1H)-ones led to compound 13 with a modest antiviral activity in the cellular assay (EC50 = 11 μM), neither 3-hydroxyquinolin-2(1H)-ones nor aza analogous of 3-hydroxypyridin-2(1H)-ones displayed any ex-vivo activity. Our research again focused on the initial scaffold, 3-hydroxypyridin-2(1H)-ones. Optimization of binding interaction at the 5- and 6-positions of the pyridinone ring provided compounds having inhibitory activity that is comparative compound 13 in the enzymatic assay. Unfortunately, these compounds were not active in the cellular assay. Our research then turned to preparing noncompetitive inhibitors to validate whether irreversible or a more sustained modification of PAN could result in ex-vivo activity. In the meantime, 3-hydroxypyridin-2(1H)-one derivatives with an additional chelating moiety, which could have enhanced binding interactions with PAN, were prepared. This concept, however, turned out to be unsuccessful as we could not see any ex-vivo activity with these compounds as well. Although our various attempts at designing PAN endonuclease inhibitor with a great ex-vivo activity were unsuccessful, continued efforts are being made to find a PAN endonuclease inhibitor, which could be developed into the clinic.

Advisors/Committee Members: LaVoie, Edmond J. (chair), Rice, Joseph E. (internal member), Hu, Longqin (internal member), Arnold, Edward (internal member), Pilch, Daniel S. (outside member).

Subjects/Keywords: Endonucleases; Influenza – Treatment

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sagong, Hye Yeon, 1. (2017). Design and synthesis of novel pan-targeting anti-influenza agents. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/52265/

Chicago Manual of Style (16^th Edition):

Sagong, Hye Yeon, 1988-. “Design and synthesis of novel pan-targeting anti-influenza agents.” 2017. Doctoral Dissertation, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/52265/.

MLA Handbook (7^th Edition):

Sagong, Hye Yeon, 1988-. “Design and synthesis of novel pan-targeting anti-influenza agents.” 2017. Web. 16 Apr 2021.

Vancouver:

Sagong, Hye Yeon 1. Design and synthesis of novel pan-targeting anti-influenza agents. [Internet] [Doctoral dissertation]. Rutgers University; 2017. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/52265/.

Council of Science Editors:

Sagong, Hye Yeon 1. Design and synthesis of novel pan-targeting anti-influenza agents. [Doctoral Dissertation]. Rutgers University; 2017. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/52265/

Rutgers University

5. Aloysius, Herve, 1973-. Design and synthesis of prostate specific antigen-activated prodrugs.

Degree: PhD, Medicinal Chemistry, 2014, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/45177/

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The feasibility of targeted delivery of cytotoxic agents to prostate cancer cells via selective activation of peptide-linked prodrugs by prostate-specific antigen (PSA) has been previously… (more)

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The feasibility of targeted delivery of cytotoxic agents to prostate cancer cells via selective activation of peptide-linked prodrugs by prostate-specific antigen (PSA) has been previously demonstrated. PSA is a chymotryspin-like serine protease that uniquely cleaves after Gln. Using cleavage maps for its natural substrates, semenogelins I and II, the highly specific PSA substrate glutaryl-Hyp-Ala-Ser-Chg-Gln was discovered, and subsequently coupled to various cytotoxic agents as a promoiety to synthesize prodrugs with enhanced selectivity for prostate cancer cells. In order to obtain PSA peptide substrates with improved specificity and plasma stability from the known substrate sequence glutaryl-Hyp-Ala-Ser-Chg-Gln, we systematically replaced the N-terminal segment with D-retro-inverso-peptides and incorporated 7-amino-4-methylcoumarin (7-AMC) after Gln for convenient fluorometric determination and ranking of the PSA substrate activity. Based on PSA cleavage rate and resistance to hydrolysis in plasma, GABA←mGly-Ala-Ser-Chg-Gln and glutaryl-Ser-Ala-Ser-Chg-Gln were identified as optimal promoieties and coupled to doxorubicin or phosphoramide mustard as PSA-cleavable prodrugs, using various linkers. The doxorubicin conjugates demonstrated comparable PSA cleavage rates, equal or improved cytotoxic profiles in PSA-producing tumor cells compared to the prodrug L-377,202 (glutaryl-Ser-Ala-Ser-Chg-Gln-Ser-Leu-Dox). We found that human neprilysin rapidly cleaved L-377,202 through its Ser-Leu linker and may be responsible for prodrug instability in blood and normal tissues. Thus, in addition to enhancing prodrug selectivity against non-PSA-secreting prostate cancer cell lines, stability in normal tissues was improved. Our results indicated that enhanced tumor specificity of peptide prodrugs targeted for activation by PSA in prostate cancer tumors was achievable with peptide sequence and linker modifications.

Advisors/Committee Members: Aloysius, Herve, 1973- (author), Hu, Longqin (chair), Lavoie, Edmond (internal member), Rice, Joseph (internal member), Mitra, Kaushik (outside member).

Subjects/Keywords: Antibody-directed enzyme prodrug therapy; Prostate – Cancer – Treatment

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APA (6^th Edition):

Aloysius, Herve, 1. (2014). Design and synthesis of prostate specific antigen-activated prodrugs. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/45177/

Chicago Manual of Style (16^th Edition):

Aloysius, Herve, 1973-. “Design and synthesis of prostate specific antigen-activated prodrugs.” 2014. Doctoral Dissertation, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/45177/.

MLA Handbook (7^th Edition):

Aloysius, Herve, 1973-. “Design and synthesis of prostate specific antigen-activated prodrugs.” 2014. Web. 16 Apr 2021.

Vancouver:

Aloysius, Herve 1. Design and synthesis of prostate specific antigen-activated prodrugs. [Internet] [Doctoral dissertation]. Rutgers University; 2014. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/45177/.

Council of Science Editors:

Aloysius, Herve 1. Design and synthesis of prostate specific antigen-activated prodrugs. [Doctoral Dissertation]. Rutgers University; 2014. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/45177/

Rutgers University

6. Inoyama, Daigo, 1981-. The discovery of small-molecule inhibitors of keap1-nrf2 interaction with homogeneous fluorescence-based high throughput screening assays.

Degree: PhD, Medicinal Chemistry, 2014, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/45302/

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Keap1-Nrf2 interaction is a key protein-protein interaction involved in the activation of antioxidant response element which regulates the expression of cytoprotective enzymes in response to… (more)

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Keap1-Nrf2 interaction is a key protein-protein interaction involved in the activation of antioxidant response element which regulates the expression of cytoprotective enzymes in response to oxidative stress conditions. To identify direct inhibitors of Keap1-Nrf2 interaction, a series of fluorescently-labeled Nrf2 peptides were synthesized and evaluated as tracers in the development of a fluorescence polarization (FP) assay. The optimized tracer, FITC-9mer Nrf2 amide, was determined to have the highest binding affinity and dynamic range of all tracers evaluated. The FP assay has considerable tolerance towards DMSO and was capable of distinguishing the inhibitory Nrf2 peptides with a Z'-factor of 0.70 as determined under the FP assay conditions. Taken together, these results demonstrate that the FP assay is suitable for application in high-throughput screening (HTS). In addition, a series of novel lanthanide chelates were designed, synthesized, and evaluated for the development of a time-resolved fluorescence resonance energy transfer (TR-FRET) assay using an in situ labeling approach. The cyclam and EDTA-based tris-NTA were found to have the strongest affinity to the His6-tag of Keap1 Kelch domain with a Kd of 1.6 nM and 2.2 nM, respectively. Among the tris-NTA conjugates evaluated as donors of TR-FRET, the EDTA-tris-NTA Acp6-linker conjugate was found to have the highest TR-FRET signal. The in situ labeling technique was also evaluated for Eu(III) chelate and through biotin-streptavidin interaction, increasing the choice of fluorophores and extending the application of the assay to biotinylated biomolecules. Thus, the novel labeling reagent provides an excellent solution for facile development of TR-FRET assays in drug discovery. The FP assay was adapted for HTS of the NIH MLPCN library. Eight confirmed hits were obtained and one of the promising hits (LH602) was targeted for preliminary structure-activity relationship (SAR) studies. Among the synthesized compounds, 2,4,6-trimethylbenzenesulfonamide substituted analog 81 showed the highest affinity to Keap1 Kelch domain. However, LH602 was found to be unstable due to its naphthoquinone structure with a half-life of 6 hours in the assay buffer. Further SAR studies are needed to improve the binding affinity as well as stability of the compound in our effort to identify potent inhibitors of Keap1-Nrf2 interaction.

Advisors/Committee Members: Hu, Longqin (chair), LaVoie, Edmond J. (internal member), Rice, Joseph E. (internal member), Freundlich, Joel S. (outside member).

Subjects/Keywords: Protein-protein interactions; High throughput screening (Drug development)

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APA (6^th Edition):

Inoyama, Daigo, 1. (2014). The discovery of small-molecule inhibitors of keap1-nrf2 interaction with homogeneous fluorescence-based high throughput screening assays. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/45302/

Chicago Manual of Style (16^th Edition):

Inoyama, Daigo, 1981-. “The discovery of small-molecule inhibitors of keap1-nrf2 interaction with homogeneous fluorescence-based high throughput screening assays.” 2014. Doctoral Dissertation, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/45302/.

MLA Handbook (7^th Edition):

Inoyama, Daigo, 1981-. “The discovery of small-molecule inhibitors of keap1-nrf2 interaction with homogeneous fluorescence-based high throughput screening assays.” 2014. Web. 16 Apr 2021.

Vancouver:

Inoyama, Daigo 1. The discovery of small-molecule inhibitors of keap1-nrf2 interaction with homogeneous fluorescence-based high throughput screening assays. [Internet] [Doctoral dissertation]. Rutgers University; 2014. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/45302/.

Council of Science Editors:

Inoyama, Daigo 1. The discovery of small-molecule inhibitors of keap1-nrf2 interaction with homogeneous fluorescence-based high throughput screening assays. [Doctoral Dissertation]. Rutgers University; 2014. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/45302/

Rutgers University

7. Sawant, Rajlakshmi, 1992-. Synthesis and development of small molecule inhibitors targeting viral PAn endonuclease and bacterial MreB.

Degree: MS, Medicinal Chemistry, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/57690/

► Imminent threat of pandemics of influenza, along with increasing resistance of the virus to existing anti-viral drugs has posed a need for development of an… (more)

▼ Imminent threat of pandemics of influenza, along with increasing resistance of the virus to existing anti-viral drugs has posed a need for development of an anti-viral that possesses a novel mechanism of action. PAN Endonuclease enzyme protein plays an important role in influenza A viral transcription with the cap-snatching process being highly conserved in the virus. This makes PAN an attractive target for drug development. Our efforts began with fragment screening to identify an effective pharmacophore. 5-chloro-3-hydroxypyridin-2(1H)-one was identified as a highly active chelating ligand at the endonuclease site containing metal ions. After extensive research, 3-hydroxypyridin-2(1H)-ones, 3-hydroxyquinolin-2(1H)-ones and aza analogs of 3-hydroxypyridin-2(1H)-ones were prepared which displayed modest enzymatic inhibitory activity. This activity didn’t translate in the cellular assay. Hence, we synthesized a known endonuclease inhibitor (Shionogi Co.) to check whether the established structure activity relationships were “false-positive” data. We also experimented with the development of isatin derivatives to continue the search for a lead compound. The most promising compound, 6-Bromo-1-hydroxyindoline-2,3-dione showed 45% inhibition at 200 μM concentration. This molecule was optimized to give 6-(4-fluorophenyl)-1,3-dihydroxy-3-methylindolin-2-one which showed no inhibitory activity in the enzyme assay. Despite of unsuccessful attempts, continued efforts are being made to explore PAN as a potential target for antiviral therapy. Our research efforts were then directed towards tackling another emerging global health crisis, the antibiotic resistance crisis. With increasing bacterial strains developing resistance towards currently available antibiotics, there is a need to target a novel mechanism of action in bacteria. MreB, a highly conserved actin homologue in bacteria is important in cell wall synthesis and determining the cell shape in bacteria. The significance of MreB in bacterial cell growth makes it a lucrative target for design of antibiotics. A22 was identified as an MreB inhibitor with modest inhibitory activity. Our efforts were focused on studying the structure activity relationships by modifying the aromatic core of A22. A series of benzothiophene, benzofuran and indole based isothioureas was synthesized. Deductions made from SAR studies are currently being used to develop an optimized lead that can show substantial MreB inhibitory activity and can further be developed into clinic. Advisors/Committee Members: LaVoie, Edmond J (chair), Hu, Longqin (internal member), Rice, Joseph E (internal member), School of Graduate Studies.

Subjects/Keywords: Influenza A virus; Antiviral agents

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APA (6^th Edition):

Sawant, Rajlakshmi, 1. (2018). Synthesis and development of small molecule inhibitors targeting viral PAn endonuclease and bacterial MreB. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/57690/

Chicago Manual of Style (16^th Edition):

Sawant, Rajlakshmi, 1992-. “Synthesis and development of small molecule inhibitors targeting viral PAn endonuclease and bacterial MreB.” 2018. Masters Thesis, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/57690/.

MLA Handbook (7^th Edition):

Sawant, Rajlakshmi, 1992-. “Synthesis and development of small molecule inhibitors targeting viral PAn endonuclease and bacterial MreB.” 2018. Web. 16 Apr 2021.

Vancouver:

Sawant, Rajlakshmi 1. Synthesis and development of small molecule inhibitors targeting viral PAn endonuclease and bacterial MreB. [Internet] [Masters thesis]. Rutgers University; 2018. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57690/.

Council of Science Editors:

Sawant, Rajlakshmi 1. Synthesis and development of small molecule inhibitors targeting viral PAn endonuclease and bacterial MreB. [Masters Thesis]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57690/

Rutgers University

8. Albanyan, Haifa. Synthesis and evaluation of l-cystine crystallization inhibitors and prodrugs for cystinuria.

Degree: PhD, Medicinal Chemistry, 2019, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/59930/

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Cystinuria is a lifelong and recurrent stone disease characterized by renal L-cystine calculi due to defective renal and intestinal reabsorption of L-cystine and dibasic amino… (more)

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Cystinuria is a lifelong and recurrent stone disease characterized by renal L-cystine calculi due to defective renal and intestinal reabsorption of L-cystine and dibasic amino acids. Cystinuria is caused by defects in one or both SLC3A1 and SLC7A9 genes located on chromosomes 2p and 19q, respectively. L-Cystine crystallizes in a zwitterionic form with stable crystals and low solubility due to the hydrogen-bond networks within the solid. The presence of four terminal groups, two amino and two carboxylic groups, with the ability to form hydrogen-bond networks makes L-cystine more unique than other amino acids or standard dipeptides. The medical management of the disease focuses mainly on lowering the concentration of L-cystine in urine or increasing L-cystine solubility in urine. Hyperdiuresis to decrease the concentration of L-cystine in urine and alkalinization are used to improve L-cystine solubility and if these techniques fail the next step in the treatment algorithm is introduction of thiol drugs. Drugs like D-penicillamine and tiopronin react with L-cystine to form more soluble mixed disulfides, but they are poorly tolerated due to their numerous adverse side effects. A new alternative approach to the prevention of L-cystine kidney stones through molecular mimicry was suggested recently by Ward and colleagues. L-CDME was able to reduce the mass yield of crystallization and maintain a metastable supersaturated L-cystine concentration which is sufficient for preventing stone formation. However, the in vivo stability of L-CDME is a real concern for it to be used as a therapeutic since esters are liable to esterase enzyme cleavage and its metabolite is L-cystine which would worsen the disease. Our group converted the ester to the amide which is more stable in vivo that lead to better inhibition with enhanced stability profile. The diamide analogues were more active and more stable according to our crystallization inhibition assay, real-time in situ atomic force microscopy (AFM) and in vitro chemical stability study. Research in this dissertation focused on the structure-activity relationship (SAR) of the most active analogues. Our results showed the importance of keeping the core structure of L-cystine intact in order to maintain the strong binding affinity to the L-cystine crystal and inhibit the crystallization of L-cystine. Our research led to compound 8-L-cystinyl bis(1,8-diazaspiro[4.5]decane) (56) with an EC50 of 25.1 nM which is 1.7 fold more potent than LH708 (9), L-cystine bis(N′-methylpiperazide), in our crystallization inhibition assay. The bioavailability of LH708 (9) in SLC3A1 knockout mice was found to be 18%. To improve the oral bioavailability of LH708, several prodrugs with better lipophilicity were designed, synthesized, and evaluated for their stability and activation.

Advisors/Committee Members: Hu, Longqin (chair), Lavoie, Edmond (internal member), Kholodovych, Vlad (internal member), Chackalamannil, Samuel (outside member), School of Graduate Studies.

Subjects/Keywords: Cystinuria; Cysteine – Inhibitors

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APA (6^th Edition):

Albanyan, H. (2019). Synthesis and evaluation of l-cystine crystallization inhibitors and prodrugs for cystinuria. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/59930/

Chicago Manual of Style (16^th Edition):

Albanyan, Haifa. “Synthesis and evaluation of l-cystine crystallization inhibitors and prodrugs for cystinuria.” 2019. Doctoral Dissertation, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/59930/.

MLA Handbook (7^th Edition):

Albanyan, Haifa. “Synthesis and evaluation of l-cystine crystallization inhibitors and prodrugs for cystinuria.” 2019. Web. 16 Apr 2021.

Vancouver:

Albanyan H. Synthesis and evaluation of l-cystine crystallization inhibitors and prodrugs for cystinuria. [Internet] [Doctoral dissertation]. Rutgers University; 2019. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59930/.

Council of Science Editors:

Albanyan H. Synthesis and evaluation of l-cystine crystallization inhibitors and prodrugs for cystinuria. [Doctoral Dissertation]. Rutgers University; 2019. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59930/

Rutgers University

9. Harrison, Jerry Joe Ebow Kingsley, 1981-. Structural and biophysical characterization of retroviral polyproteins: insights from prototype foamy virus (PFV) and human immunodeficiency virus type 1 (HIV-1).

Degree: PhD, Medicinal Chemistry, 2019, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/61759/

► Retroviruses continue to attract public health attention due to the increasing disease burden these viruses continue to have in animals. An estimated 38 million people… (more)

▼ Retroviruses continue to attract public health attention due to the increasing disease burden these viruses continue to have in animals. An estimated 38 million people worldwide are infected with HIV which underscores the importance of these viruses to humans. In the absence of a cure or vaccine for HIV, therapeutic interventions that have culminated in the taming of the disease, which used to be a death sentence before the discovery of these drugs, has relied on detailed understanding of key processes which underline the replication of the virus in its hosts. It is not surprising that the great majority of the currently approved drugs for treating HIV infections target the various enzymatic proteins which carry out chemical reactions that enable the virus to infect new cells. Increasing resistance to these drugs, and problems of compliance and toxicity, have necessitated the need to search for more potent and less toxic drugs to manage the disease. It is in this regard that understanding the structural and mechanistic details of polyprotein processing is important. Synthesis of polyprotein precursors which are subsequently processed into mature enzymes is unique to pathogenic viruses such as retroviruses and RNA viruses. Developing drugs selective to these polyproteins would reduce the potential for cross-reactivity with host proteins. The crystal structure of the PFV protease-reverse transcriptase (PR-RT), solved to 2.9 Å resolution, has revealed a monomeric protein containing individually folded subdomains. In PFV, PR-RT is the mature entity following the proteolytic release of IN from the C-terminus of the PFV Pol polyprotein. The structure of the PR resembles a monomer of the homodimeric HIV-1 PR even though the N-terminal and C-terminal residues involved in the formation of anti-parallel β-sheets which mediate the dimer interface, remain unstructured. The RT also contains the canonical subdomains: fingers, palm, thumb and connection, as well as the RNase H domain, which characterize retroviral RTs. The relative orientations of these subdomains are however different, resembling more the compact p51 subunit of HIV RT. This is an inactive RT conformation since the nucleic acid binding cleft is occluded. It however offers insights into the possible subdomain arrangements of the monomeric precursor polyproteins. In this work also, the Pol polyproteins from the prototype foamy virus (PFV), as well as Pol and Gag-Pol polyproteins from HIV-1 have been characterized using a combination of enzymatic assays and other biophysical methods including: gel filtration, dynamic light scattering (DLS), small angle X-ray scattering (SAXS), and single particle cryo-EM. The production of these proteins, which were isolated in yields and purity suitable for biophysical studies from bacteria for the first time, relied on a new media formulation for E. coli growth. Fundamentally, it was discovered that at non-physiologic Mg2+ concentration (~50 mM) or low pH (≤ 6.0), the proteolytic degradation of these polyproteins and by extension,… Advisors/Committee Members: Arnold, Eddy (chair), Hu, Longqin (internal member), Lavoie, Edmond (internal member), Olson, Wilma (outside member), School of Graduate Studies.

Subjects/Keywords: HIV (Viruses); Foamy viruses; Retroviruses

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Harrison, Jerry Joe Ebow Kingsley, 1. (2019). Structural and biophysical characterization of retroviral polyproteins: insights from prototype foamy virus (PFV) and human immunodeficiency virus type 1 (HIV-1). (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/61759/

Chicago Manual of Style (16^th Edition):

Harrison, Jerry Joe Ebow Kingsley, 1981-. “Structural and biophysical characterization of retroviral polyproteins: insights from prototype foamy virus (PFV) and human immunodeficiency virus type 1 (HIV-1).” 2019. Doctoral Dissertation, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/61759/.

MLA Handbook (7^th Edition):

Harrison, Jerry Joe Ebow Kingsley, 1981-. “Structural and biophysical characterization of retroviral polyproteins: insights from prototype foamy virus (PFV) and human immunodeficiency virus type 1 (HIV-1).” 2019. Web. 16 Apr 2021.

Vancouver:

Harrison, Jerry Joe Ebow Kingsley 1. Structural and biophysical characterization of retroviral polyproteins: insights from prototype foamy virus (PFV) and human immunodeficiency virus type 1 (HIV-1). [Internet] [Doctoral dissertation]. Rutgers University; 2019. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/61759/.

Council of Science Editors:

Harrison, Jerry Joe Ebow Kingsley 1. Structural and biophysical characterization of retroviral polyproteins: insights from prototype foamy virus (PFV) and human immunodeficiency virus type 1 (HIV-1). [Doctoral Dissertation]. Rutgers University; 2019. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/61759/

Rutgers University

10. Blankson, Gifty Ayensu, 1986-. Structure-activity studies on bacterial efflux inhibitors.

Degree: PhD, Medicinal Chemistry, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/49914/

►

Antibiotic resistance poses a significant challenge in anti-infective therapy. There are several mechanisms involved in antibiotic resistance with efflux being a major determinant. Overcoming efflux… (more)

▼

Antibiotic resistance poses a significant challenge in anti-infective therapy. There are several mechanisms involved in antibiotic resistance with efflux being a major determinant. Overcoming efflux will allow for the reintroduction of old antibiotics and prevent the development of resistance to new antibiotics. Several bacterial efflux pump inhibitors (EPIs) have been discovered, but none of these compounds have been FDA-approved for use in humans. There is a need for a systematic study of some of these inhibitors to gain a better understanding of their structure activity relationship (SAR). This work focuses on the SAR studies conducted on two classes of known EPI inhibitors. Analogues of aryl piperazines (biphenyl piperazines and naphthalene amines) were synthesized and tested for their EPI activity. None of the compounds in this series exhibited EPI activity and thus no further exploration was done on their SAR. Structurally simpler analogues of phenylalanine-arginine β-naphthylamide (PAβN) were also designed and an SAR study conducted on the three different scaffolds proposed. The three scaffolds include the “normal” amides, the “reverse” amides and the secondary amine series. Although these scaffolds exhibited some similarities in their SAR, there were some differences. In all cases, the 1,5-diphenylpentane core was the preferred substituent on the right hand side of the molecules. For the left hand side, diaminopentane was the preferred substituent. Further studies revealed that N5 substitution was detrimental to EPI activity. The “reverse” amides had better activity when compared against their analogous “normal” amides. The data indicated that a bis-alkylaryl was necessary for activity and that there was preference for the aryl to be hydrophobic. A methylene insertion in the reverse amides series gave a compound that caused 512-fold reduction in the minimum inhibitory concentration (MIC) of clarithromycin (PAβN, the historical EPI standard offered a 4-fold reduction in MIC). The amine analogues also offered some active compounds with one of these compounds causing a 128-fold reduction in the MIC of clarithromycin. (These tests were done in E. coli). Some success was achieved in P. aeruginosa; two compounds when independently co-administered with levofloxacin resulted in a 32-fold decrease in the MIC of levofloxacin.

Advisors/Committee Members: LaVoie, Edmond J (chair), Rice, Joseph E (internal member), Hu, Longqin (internal member), Pilch, Daniel S (outside member).

Subjects/Keywords: Drug resistance in microorganisms; Antibiotics

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APA (6^th Edition):

Blankson, Gifty Ayensu, 1. (2016). Structure-activity studies on bacterial efflux inhibitors. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/49914/

Chicago Manual of Style (16^th Edition):

Blankson, Gifty Ayensu, 1986-. “Structure-activity studies on bacterial efflux inhibitors.” 2016. Doctoral Dissertation, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/49914/.

MLA Handbook (7^th Edition):

Blankson, Gifty Ayensu, 1986-. “Structure-activity studies on bacterial efflux inhibitors.” 2016. Web. 16 Apr 2021.

Vancouver:

Blankson, Gifty Ayensu 1. Structure-activity studies on bacterial efflux inhibitors. [Internet] [Doctoral dissertation]. Rutgers University; 2016. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49914/.

Council of Science Editors:

Blankson, Gifty Ayensu 1. Structure-activity studies on bacterial efflux inhibitors. [Doctoral Dissertation]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49914/

Rutgers University

11. Abed, Dhulfiqar Ali, 1982-. Structure-activity relationships of small molecule direct inhibitors of Keap1-Nrf2 interaction.

Degree: PhD, Medicinal Chemistry, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/57461/

►

The Keap1–Nrf2–ARE system represents a crucial antioxidant defense mechanism that protects cells against oxidative stress-related diseases and inflammation. Activation of this system leads to elevated… (more)

▼

The Keap1–Nrf2–ARE system represents a crucial antioxidant defense mechanism that protects cells against oxidative stress-related diseases and inflammation. Activation of this system leads to elevated expression of a variety of antioxidant defense proteins and enzymes important for protection against oxidative damage, inflammation and tumorigenesis. Targeting Keap1–Nrf2 protein–protein interaction (PPI) has become a promising therapeutic strategy for several oxidative stress conditions and inflammatory diseases including chronic kidney disease, pulmonary fibrosis, chronic obstructive pulmonary disorder (COPD), and cancer chemoprevention. Several PPI inhibitors of Keap1–Nrf2 system have been reported; Tecfidera® is one of these inhibitors that is FDA approved for treatment of patients with relapsing multiple sclerosis. Inhibitors of Keap1–Nrf2 PPI are generally classified into direct and indirect inhibitors. Indirect inhibitors of Keap1–Nrf2 PPI are electrophilic species and can cause off-target side effects. Presently, scientists have been focusing on direct inhibitors of Keap1–Nrf2 PPI. In this work, we are focusing on the discovery of potent direct inhibitors of Keap1−Nrf2 PPI by performing a comprehensive structure-activity relationship (SAR) study in currently available scaffolds, or by designing new scaffolds. A fluorescence polarization (FP) assay has been used to evaluate the potency of synthesized compounds in vitro and cell-based assays have been used to test the most active compounds, resulting in the discovery of highly potent non-electrophilic Nrf2 activators. One of the best compounds discovered, 65v (LH835), has an IC50 of 144 ± 5 nM in the fluorescence polarization assay, and 1.7 ± 0.24 nM in a TR-FRET assay. Furthermore, we have demonstrated that the 65v (LH835) is an efficacious inducer of Nrf2 targeted genes in HepG2 C8 cells, exhibiting activity better than the well-known electrophilic activator, sulforaphane. Our direct inhibitors of Keap1–Nrf2 PPI could potentially be developed into drugs for the treatment of a number of oxidative stress-related diseases and conditions.

Advisors/Committee Members: Abed, Dhulfiqar Ali, 1982- (author), Hu, Longqin (chair), LaVoie, Edmond J. (internal member), Rice, Joseph E. (internal member), Chackalamannil, Samuel (outside member), School of Graduate Studies.

Subjects/Keywords: Molecular biology; Oxidative stress

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APA (6^th Edition):

Abed, Dhulfiqar Ali, 1. (2018). Structure-activity relationships of small molecule direct inhibitors of Keap1-Nrf2 interaction. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/57461/

Chicago Manual of Style (16^th Edition):

Abed, Dhulfiqar Ali, 1982-. “Structure-activity relationships of small molecule direct inhibitors of Keap1-Nrf2 interaction.” 2018. Doctoral Dissertation, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/57461/.

MLA Handbook (7^th Edition):

Abed, Dhulfiqar Ali, 1982-. “Structure-activity relationships of small molecule direct inhibitors of Keap1-Nrf2 interaction.” 2018. Web. 16 Apr 2021.

Vancouver:

Abed, Dhulfiqar Ali 1. Structure-activity relationships of small molecule direct inhibitors of Keap1-Nrf2 interaction. [Internet] [Doctoral dissertation]. Rutgers University; 2018. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57461/.

Council of Science Editors:

Abed, Dhulfiqar Ali 1. Structure-activity relationships of small molecule direct inhibitors of Keap1-Nrf2 interaction. [Doctoral Dissertation]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57461/

12. Tan, Renchang, 1988-. Application of phosphorus ligands in rhodium-catalyzed asymmetric hydroformylation and hydrogenation.

Degree: PhD, Chemistry and Chemical Biology, 2017, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/53998/

►

Asymmetric catalysis has been playing an important role in modern synthetic chemistry. In the past decades, chiral ligands especially phosphorus chiral ligands, have demonstrated their… (more)

Subjects/Keywords: Hydroformylation

10 more images…

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APA (6^th Edition):

Tan, Renchang, 1. (2017). Application of phosphorus ligands in rhodium-catalyzed asymmetric hydroformylation and hydrogenation. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/53998/

Chicago Manual of Style (16^th Edition):

Tan, Renchang, 1988-. “Application of phosphorus ligands in rhodium-catalyzed asymmetric hydroformylation and hydrogenation.” 2017. Doctoral Dissertation, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/53998/.

MLA Handbook (7^th Edition):

Tan, Renchang, 1988-. “Application of phosphorus ligands in rhodium-catalyzed asymmetric hydroformylation and hydrogenation.” 2017. Web. 16 Apr 2021.

Vancouver:

Tan, Renchang 1. Application of phosphorus ligands in rhodium-catalyzed asymmetric hydroformylation and hydrogenation. [Internet] [Doctoral dissertation]. Rutgers University; 2017. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/53998/.

Council of Science Editors:

Tan, Renchang 1. Application of phosphorus ligands in rhodium-catalyzed asymmetric hydroformylation and hydrogenation. [Doctoral Dissertation]. Rutgers University; 2017. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/53998/

13. Kim, Hiyun. Allene-based approach to the synthesis of De Novo erythromycinoids.

Degree: Chemistry and Chemical Biology, 2012, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000064137

Subjects/Keywords: Allene – Research

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kim, H. (2012). Allene-based approach to the synthesis of De Novo erythromycinoids. (Thesis). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000064137

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kim, Hiyun. “Allene-based approach to the synthesis of De Novo erythromycinoids.” 2012. Thesis, Rutgers University. Accessed April 16, 2021. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000064137.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kim, Hiyun. “Allene-based approach to the synthesis of De Novo erythromycinoids.” 2012. Web. 16 Apr 2021.

Vancouver:

Kim H. Allene-based approach to the synthesis of De Novo erythromycinoids. [Internet] [Thesis]. Rutgers University; 2012. [cited 2021 Apr 16]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000064137.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kim H. Allene-based approach to the synthesis of De Novo erythromycinoids. [Thesis]. Rutgers University; 2012. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000064137

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Liu, Kai, 1985-. Accessing erythronolide structure space: new reactions and applications.

Degree: Chemistry and Chemical Biology, 2012, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066895

Subjects/Keywords: Organic compounds – Synthesis

10 more images…

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APA (6^th Edition):

Liu, Kai, 1. (2012). Accessing erythronolide structure space: new reactions and applications. (Thesis). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066895

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liu, Kai, 1985-. “Accessing erythronolide structure space: new reactions and applications.” 2012. Thesis, Rutgers University. Accessed April 16, 2021. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066895.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liu, Kai, 1985-. “Accessing erythronolide structure space: new reactions and applications.” 2012. Web. 16 Apr 2021.

Vancouver:

Liu, Kai 1. Accessing erythronolide structure space: new reactions and applications. [Internet] [Thesis]. Rutgers University; 2012. [cited 2021 Apr 16]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066895.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liu, Kai 1. Accessing erythronolide structure space: new reactions and applications. [Thesis]. Rutgers University; 2012. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066895

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

15. Surabhi, Prathima. Synthesis and evaluation of phosphoramide mustard prodrugs for site-specific activation.

Degree: MS, Medicinal Chemistry, 2007, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000054801

► Advanced cancers after metastasis need to be treated systemically using chemotherapy or radiation, which are often associated with debilitating side effects. To improve the selectivity… (more)

▼ Advanced cancers after metastasis need to be treated systemically using chemotherapy or radiation, which are often associated with debilitating side effects. To improve the selectivity of the chemotherapeutic agents and reduce systemic toxicity, prodrugs with tumor targeted activation mechanisms are being developed. Efforts in this project were focused on designing phosphoramide mustard analogues incorporating two types of tumor-specific activation mechanisms: one by the reductive activation mechanism by Escherichia coli nitroreductase and the other by the proteolytic activation mechanism by prostate-specific antigen (PSA) in prostate cancer cells. 5-Nitropyridyl-2-methyl phosphoramide mustard was designed and synthesized to be a substrate of E. coli nitroreductase. In cell culture assays it showed an IC50 value of 9 nM in Chinese hamster V79 cells transfected to express E. coli nitroreductase as compared to 75 ;M in the control V79 cells that do not express E. coli nitroreductase. These results suggest that 5-nitropyridyl-2-methyl phosphoramide mustard is a good candidate for use in combination with nitroreductase for enzyme prodrug therapy. For proteolytic activation by (PSA) in prostate cancer cells, we designed a peptide conjugate by linking a substrate peptide sequence to phosphoramide mustard through a flexible linker that can be modified to better accommodate the unique structural requirements for binding to and catalysis by the target enzyme and thus improve the tumor selectivity of phosphoramide mustard. Pyridine was introduced to modulate the electron-density, to optimize the stability and rate of 1,6-elimination upon proteolytic cleavage. A new set of conditions were developed for selenocarboxylate/azide amidation reaction in order to avoid the use of unstable basic nuclephilic amine intermediates during the synthesis of the peptide conjugated analogue. Under the new amidation conditions, the half-life of the selenocarboxylate was increased by 27-fold at room temperature as compared to the previous amidation method using DMSO as a co-solvent. Excellent yields were obtained with electron-deficient azides and much improved yields were obtained with electron-rich azides upon mild heating. The peptide conjugate, glutaryl-Hyp-Ala-Ser-Chg-Gln-NH-pyridyl-2-methyl phosphoramide mustard, was successfully synthesized using our new amidation strategy and was found to be stable with a half-life >5 days at pH 7.4 and 8.0. It was shown to be a good substrate for PSA with a half-life of 46.8 min at an enzyme/substrate molar ratio of 1/100. However, the peptide conjugate did not show any selective toxicity towards PSA-expressing LNCaP cells with IC50 values of 209 ;M and 204 ;M against PSA-expressing LNCaP and non-PSA-expressing DU 145 cell lines, respectively. The low cytotoxicity against LNCaP cells may be due to the inability of the released species to penetrate the tumor membranes. Further studies are underway to identify the activated species released and to design approaches to improve its membrane permeability. Advisors/Committee Members: Surabhi, Prathima (author), Hu, Longqin (chair), Rice, Joseph E (internal member), LaVoie, Edmond J (internal member).

Subjects/Keywords: Prodrugs; Cancer – Chemotherapy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Surabhi, P. (2007). Synthesis and evaluation of phosphoramide mustard prodrugs for site-specific activation. (Masters Thesis). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000054801

Chicago Manual of Style (16^th Edition):

Surabhi, Prathima. “Synthesis and evaluation of phosphoramide mustard prodrugs for site-specific activation.” 2007. Masters Thesis, Rutgers University. Accessed April 16, 2021. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000054801.

MLA Handbook (7^th Edition):

Surabhi, Prathima. “Synthesis and evaluation of phosphoramide mustard prodrugs for site-specific activation.” 2007. Web. 16 Apr 2021.

Vancouver:

Surabhi P. Synthesis and evaluation of phosphoramide mustard prodrugs for site-specific activation. [Internet] [Masters thesis]. Rutgers University; 2007. [cited 2021 Apr 16]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000054801.

Council of Science Editors:

Surabhi P. Synthesis and evaluation of phosphoramide mustard prodrugs for site-specific activation. [Masters Thesis]. Rutgers University; 2007. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000054801

Rutgers University

16. Patel, Disha, 1985-. Application of fragment screening by X-ray crystallography for the identification of novel chemical scaffolds targeting viral proteins of HIV and influenza.

Degree: Medicinal Chemistry, 2013, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/41890/

Subjects/Keywords: X-ray crystallography; HIV (Viruses); Proteins – Affinity labeling; Viral proteins; Influenza – Research

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APA (6^th Edition):

Patel, Disha, 1. (2013). Application of fragment screening by X-ray crystallography for the identification of novel chemical scaffolds targeting viral proteins of HIV and influenza. (Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/41890/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Patel, Disha, 1985-. “Application of fragment screening by X-ray crystallography for the identification of novel chemical scaffolds targeting viral proteins of HIV and influenza.” 2013. Thesis, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/41890/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Patel, Disha, 1985-. “Application of fragment screening by X-ray crystallography for the identification of novel chemical scaffolds targeting viral proteins of HIV and influenza.” 2013. Web. 16 Apr 2021.

Vancouver:

Patel, Disha 1. Application of fragment screening by X-ray crystallography for the identification of novel chemical scaffolds targeting viral proteins of HIV and influenza. [Internet] [Thesis]. Rutgers University; 2013. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/41890/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Patel, Disha 1. Application of fragment screening by X-ray crystallography for the identification of novel chemical scaffolds targeting viral proteins of HIV and influenza. [Thesis]. Rutgers University; 2013. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/41890/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

17. Chang, Mingxin, 1979-. Transition metal-catalyzed asymmetric hydrogenation for synthesis of chiral amines.

Degree: Chemistry and Chemical Biology, 2013, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/41740/

Subjects/Keywords: Chirality; Amines – Synthesis; Amines industry

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APA (6^th Edition):

Chang, Mingxin, 1. (2013). Transition metal-catalyzed asymmetric hydrogenation for synthesis of chiral amines. (Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/41740/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chang, Mingxin, 1979-. “Transition metal-catalyzed asymmetric hydrogenation for synthesis of chiral amines.” 2013. Thesis, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/41740/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chang, Mingxin, 1979-. “Transition metal-catalyzed asymmetric hydrogenation for synthesis of chiral amines.” 2013. Web. 16 Apr 2021.

Vancouver:

Chang, Mingxin 1. Transition metal-catalyzed asymmetric hydrogenation for synthesis of chiral amines. [Internet] [Thesis]. Rutgers University; 2013. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/41740/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chang, Mingxin 1. Transition metal-catalyzed asymmetric hydrogenation for synthesis of chiral amines. [Thesis]. Rutgers University; 2013. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/41740/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

18. Zhang, Yue, 1976-. Formation and reactivity of allenes and spirodiepoxides.

Degree: PhD, Chemistry and Chemical Biology, 2010, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000056874

►

Disclosed are the studies on allene and functionalized medium sized ring synthesis as well as applications of spirodiepoxide based methods. A new method of making… (more)

Subjects/Keywords: Allene – Oxidation; Allene – Reactivity

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APA (6^th Edition):

Zhang, Yue, 1. (2010). Formation and reactivity of allenes and spirodiepoxides. (Doctoral Dissertation). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000056874

Chicago Manual of Style (16^th Edition):

Zhang, Yue, 1976-. “Formation and reactivity of allenes and spirodiepoxides.” 2010. Doctoral Dissertation, Rutgers University. Accessed April 16, 2021. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000056874.

MLA Handbook (7^th Edition):

Zhang, Yue, 1976-. “Formation and reactivity of allenes and spirodiepoxides.” 2010. Web. 16 Apr 2021.

Vancouver:

Zhang, Yue 1. Formation and reactivity of allenes and spirodiepoxides. [Internet] [Doctoral dissertation]. Rutgers University; 2010. [cited 2021 Apr 16]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000056874.

Council of Science Editors:

Zhang, Yue 1. Formation and reactivity of allenes and spirodiepoxides. [Doctoral Dissertation]. Rutgers University; 2010. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000056874

Rutgers University

19. Hu, Gaojie, 1985-. Allene synthesis, oxidation and complex molecule synthesis.

Degree: Chemistry and Chemical Biology, 2013, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/41792/

Subjects/Keywords: Allene – Synthesis; Allene – Oxidation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hu, Gaojie, 1. (2013). Allene synthesis, oxidation and complex molecule synthesis. (Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/41792/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hu, Gaojie, 1985-. “Allene synthesis, oxidation and complex molecule synthesis.” 2013. Thesis, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/41792/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hu, Gaojie, 1985-. “Allene synthesis, oxidation and complex molecule synthesis.” 2013. Web. 16 Apr 2021.

Vancouver:

Hu, Gaojie 1. Allene synthesis, oxidation and complex molecule synthesis. [Internet] [Thesis]. Rutgers University; 2013. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/41792/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hu, Gaojie 1. Allene synthesis, oxidation and complex molecule synthesis. [Thesis]. Rutgers University; 2013. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/41792/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

20. Huang, Kexuan, 1982-. Phosphorus ligand development for transition metal catalyzed reactions.

Degree: Chemistry and Chemical Biology, 2014, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/42396/

Subjects/Keywords: Ligands; Phosphorus compounds

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Huang, Kexuan, 1. (2014). Phosphorus ligand development for transition metal catalyzed reactions. (Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/42396/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Huang, Kexuan, 1982-. “Phosphorus ligand development for transition metal catalyzed reactions.” 2014. Thesis, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/42396/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Huang, Kexuan, 1982-. “Phosphorus ligand development for transition metal catalyzed reactions.” 2014. Web. 16 Apr 2021.

Vancouver:

Huang, Kexuan 1. Phosphorus ligand development for transition metal catalyzed reactions. [Internet] [Thesis]. Rutgers University; 2014. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/42396/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Huang, Kexuan 1. Phosphorus ligand development for transition metal catalyzed reactions. [Thesis]. Rutgers University; 2014. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/42396/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

21. Wu, Xinghua. Novel peptidylaminoarylmethyl phosphoramide mustards for activation by prostate-specific antigen.

Degree: PhD, Medicinal Chemistry, 2008, Rutgers University

URL: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17057

►

A series of nitroarylmethyl phosphoramide mustards was designed, synthesized and evaluated as nitroreductase-targeted prodrugs in gene-directed enzyme-prodrug therapy. Among them, fluorinated prodrugs showed improved bystander… (more)

Subjects/Keywords: Prostate – Cancer; Prostate-specific antigen

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wu, X. (2008). Novel peptidylaminoarylmethyl phosphoramide mustards for activation by prostate-specific antigen. (Doctoral Dissertation). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17057

Chicago Manual of Style (16^th Edition):

Wu, Xinghua. “Novel peptidylaminoarylmethyl phosphoramide mustards for activation by prostate-specific antigen.” 2008. Doctoral Dissertation, Rutgers University. Accessed April 16, 2021. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17057.

MLA Handbook (7^th Edition):

Wu, Xinghua. “Novel peptidylaminoarylmethyl phosphoramide mustards for activation by prostate-specific antigen.” 2008. Web. 16 Apr 2021.

Vancouver:

Wu X. Novel peptidylaminoarylmethyl phosphoramide mustards for activation by prostate-specific antigen. [Internet] [Doctoral dissertation]. Rutgers University; 2008. [cited 2021 Apr 16]. Available from: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17057.

Council of Science Editors:

Wu X. Novel peptidylaminoarylmethyl phosphoramide mustards for activation by prostate-specific antigen. [Doctoral Dissertation]. Rutgers University; 2008. Available from: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17057

Rutgers University

22. Cai, Chaoxian, 1968-. Development of tetraphosphorus ligands and their applications in olefin hydroformylation.

Degree: Medicinal Chemistry, 2012, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065089

Subjects/Keywords: Hydroformylation; Alkenes; Ligands (Biochemistry)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cai, Chaoxian, 1. (2012). Development of tetraphosphorus ligands and their applications in olefin hydroformylation. (Thesis). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065089

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cai, Chaoxian, 1968-. “Development of tetraphosphorus ligands and their applications in olefin hydroformylation.” 2012. Thesis, Rutgers University. Accessed April 16, 2021. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065089.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cai, Chaoxian, 1968-. “Development of tetraphosphorus ligands and their applications in olefin hydroformylation.” 2012. Web. 16 Apr 2021.

Vancouver:

Cai, Chaoxian 1. Development of tetraphosphorus ligands and their applications in olefin hydroformylation. [Internet] [Thesis]. Rutgers University; 2012. [cited 2021 Apr 16]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065089.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cai, Chaoxian 1. Development of tetraphosphorus ligands and their applications in olefin hydroformylation. [Thesis]. Rutgers University; 2012. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065089

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Sun, Tian, 1983-. The design of new substrates and ligands for rhodium catalyzed asymmetric hydrogenation.

Degree: Chemistry and Chemical Biology, 2013, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000068978

Subjects/Keywords: Hydrogenation; Asymmetric synthesis

3 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sun, Tian, 1. (2013). The design of new substrates and ligands for rhodium catalyzed asymmetric hydrogenation. (Thesis). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000068978

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sun, Tian, 1983-. “The design of new substrates and ligands for rhodium catalyzed asymmetric hydrogenation.” 2013. Thesis, Rutgers University. Accessed April 16, 2021. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000068978.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sun, Tian, 1983-. “The design of new substrates and ligands for rhodium catalyzed asymmetric hydrogenation.” 2013. Web. 16 Apr 2021.

Vancouver:

Sun, Tian 1. The design of new substrates and ligands for rhodium catalyzed asymmetric hydrogenation. [Internet] [Thesis]. Rutgers University; 2013. [cited 2021 Apr 16]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000068978.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sun, Tian 1. The design of new substrates and ligands for rhodium catalyzed asymmetric hydrogenation. [Thesis]. Rutgers University; 2013. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000068978

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

24. Chen, Lin, 1981-. Design and synthesis of novel small molecule modulators of KEAP1-NRF2-ARE pathway.

Degree: Medicinal Chemistry, 2014, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/42373/

Subjects/Keywords: Cytology – Research; Cells – Preservation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, Lin, 1. (2014). Design and synthesis of novel small molecule modulators of KEAP1-NRF2-ARE pathway. (Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/42373/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Lin, 1981-. “Design and synthesis of novel small molecule modulators of KEAP1-NRF2-ARE pathway.” 2014. Thesis, Rutgers University. Accessed April 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/42373/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Lin, 1981-. “Design and synthesis of novel small molecule modulators of KEAP1-NRF2-ARE pathway.” 2014. Web. 16 Apr 2021.

Vancouver:

Chen, Lin 1. Design and synthesis of novel small molecule modulators of KEAP1-NRF2-ARE pathway. [Internet] [Thesis]. Rutgers University; 2014. [cited 2021 Apr 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/42373/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen, Lin 1. Design and synthesis of novel small molecule modulators of KEAP1-NRF2-ARE pathway. [Thesis]. Rutgers University; 2014. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/42373/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations