Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

You searched for +publisher:"Rutgers University" +contributor:("Baliga, Sunanda S., 1982"). One record found.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


Rutgers University

1. Baliga, Sunanda S., 1982. Acetaminophen confers neuroprotection during early cerebral ischemia-reperfusion.

Degree: PhD, Physiology and Integrative Biology, 2009, Rutgers University

Stroke is the leading cause of disability in the United States. It usually occurs from a clot blocking a cerebral artery, resulting in cerebral ischemia and infarction. Few stroke therapeutics are available that definitively improve patient outcome. Acetaminophen is a readily available, inexpensive drug with a good safety profile - properties desirable of a neuroprotectant. We have previously shown acetaminophen to be effective following myocardial infarction. Since similar cell-destructive events occur during cerebral ischemia as in myocardial infarction, we sought to determine whether acetaminophen would protect neuronal cells in a similar fashion. Biochemical and molecular assays were employed to assess cell death and mitochondrial function. Acetaminophen significantly reduced cerebral infarct size, mitochondrial swelling and rupture as well as apoptosis. Acetaminophen also preserved mitochondrial membrane potential. Furthermore, acetaminophen prevented cerebral edema, as seen histopathologically. Taken together, these data suggest that acetaminophen is effective in preventing neuronal stroke damage.

Advisors/Committee Members: Baliga, Sunanda S., 1982 (author), Weiss, Harvey (chair), Firestein, Bonnie (internal member), Merrill, Gary (internal member), Ma, Jianjie (internal member), Denhardt, David (outside member).

Subjects/Keywords: Cerebral ischemia – Treatment; Cerebrovascular disease – Treatment; Acetaminophen

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Baliga, Sunanda S., 1. (2009). Acetaminophen confers neuroprotection during early cerebral ischemia-reperfusion. (Doctoral Dissertation). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051174

Chicago Manual of Style (16th Edition):

Baliga, Sunanda S., 1982. “Acetaminophen confers neuroprotection during early cerebral ischemia-reperfusion.” 2009. Doctoral Dissertation, Rutgers University. Accessed June 25, 2019. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051174.

MLA Handbook (7th Edition):

Baliga, Sunanda S., 1982. “Acetaminophen confers neuroprotection during early cerebral ischemia-reperfusion.” 2009. Web. 25 Jun 2019.

Vancouver:

Baliga, Sunanda S. 1. Acetaminophen confers neuroprotection during early cerebral ischemia-reperfusion. [Internet] [Doctoral dissertation]. Rutgers University; 2009. [cited 2019 Jun 25]. Available from: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051174.

Council of Science Editors:

Baliga, Sunanda S. 1. Acetaminophen confers neuroprotection during early cerebral ischemia-reperfusion. [Doctoral Dissertation]. Rutgers University; 2009. Available from: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051174

.