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You searched for +publisher:"Rutgers University" +contributor:("Badmaev, Vladimir"). Showing records 1 – 2 of 2 total matches.

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Rutgers University

1. Turovskiy, Yevgeniy, 1977-. The potential of a probiotic-derived antimicrobial peptide for the control of vaginal pathogens.

Degree: PhD, Food Science, 2011, Rutgers University

Bacterial vaginosis (BV) is characterized by replacement of vaginal probiotics with several anaerobic pathogens. This condition can lead to numerous complications during pregnancy and labor. It is also a risk factor for HIV acquisition. Currently-available antibiotic treatments for BV are notorious for having a high (30-40%) rate of reoccurrence; therefore alternative treatments are critically desired. A multiple-hurdle approach involving bacteriocins may provide such an alternative. Previous studies indicate that lactocin 160, a bacteriocin produced by Lactobacillus rhamnosus, a vaginal probiotic, is active against BV - associated Gardnerella vaginalis and Prevotella bivia. The objective of the current study is to understand the mode of action of lactocin 160 against G. vaginalis and to seek out other natural antimicrobials exhibiting synergistic activity with this bacteriocin. Our results demonstrate that lactocin 160 targets the cytoplasmic membrane of G. vaginalis, causing the efflux of ATP molecules and dissipation of both, ΔΨ and ΔpH components of proton motive force. Based on these results, we presume that like many other known bacteriocin-like substances, lactocin 160 triggers formation of transient pores in the cytoplasmic membranes of its target cells. The interactions between lactocin 160 and four other natural antimicrobials in the ability to inhibit G. vaginalis were evaluated using the checkerboard assay. Our results indicate that zinc lactate and soapnut extract act synergistically with lactocin 160 against this pathogen and therefore have a potential to be successfully used as the components of the multiple-hurdle antimicrobial formulation for the treatment of BV.

Advisors/Committee Members: Turovskiy, Yevgeniy, 1977- (author), Chikindas, Michael (chair), Takhistov, Paul (internal member), Lee, Tung-Ching (internal member), Badmaev, Vladimir (outside member).

Subjects/Keywords: Vagina – Diseases; Probiotics; Bacteriocins; Bacterial vaginitis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Turovskiy, Yevgeniy, 1. (2011). The potential of a probiotic-derived antimicrobial peptide for the control of vaginal pathogens. (Doctoral Dissertation). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000057702

Chicago Manual of Style (16th Edition):

Turovskiy, Yevgeniy, 1977-. “The potential of a probiotic-derived antimicrobial peptide for the control of vaginal pathogens.” 2011. Doctoral Dissertation, Rutgers University. Accessed March 25, 2019. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000057702.

MLA Handbook (7th Edition):

Turovskiy, Yevgeniy, 1977-. “The potential of a probiotic-derived antimicrobial peptide for the control of vaginal pathogens.” 2011. Web. 25 Mar 2019.

Vancouver:

Turovskiy, Yevgeniy 1. The potential of a probiotic-derived antimicrobial peptide for the control of vaginal pathogens. [Internet] [Doctoral dissertation]. Rutgers University; 2011. [cited 2019 Mar 25]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000057702.

Council of Science Editors:

Turovskiy, Yevgeniy 1. The potential of a probiotic-derived antimicrobial peptide for the control of vaginal pathogens. [Doctoral Dissertation]. Rutgers University; 2011. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000057702

2. Riazi, Shadi, 1979-. Lactosporin, a natural antimicrobial protein for control of bacterial vaginosis.

Degree: Food Science, 2012, Rutgers University

Subjects/Keywords: Anti-infective agents; Vagina – Diseases – Treatment; Bacterial diseases – Treatment

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Riazi, Shadi, 1. (2012). Lactosporin, a natural antimicrobial protein for control of bacterial vaginosis. (Thesis). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065256

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Riazi, Shadi, 1979-. “Lactosporin, a natural antimicrobial protein for control of bacterial vaginosis.” 2012. Thesis, Rutgers University. Accessed March 25, 2019. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065256.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Riazi, Shadi, 1979-. “Lactosporin, a natural antimicrobial protein for control of bacterial vaginosis.” 2012. Web. 25 Mar 2019.

Vancouver:

Riazi, Shadi 1. Lactosporin, a natural antimicrobial protein for control of bacterial vaginosis. [Internet] [Thesis]. Rutgers University; 2012. [cited 2019 Mar 25]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065256.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Riazi, Shadi 1. Lactosporin, a natural antimicrobial protein for control of bacterial vaginosis. [Thesis]. Rutgers University; 2012. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065256

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.