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You searched for +publisher:"Purdue University" +contributor:("Pedro P. Irazoqui"). Showing records 1 – 3 of 3 total matches.

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Purdue University

1. Bercich, Rebecca A. Improving the mechanistic study of neuromuscular diseases through the development of a fully wireless and implantable recording device.

Degree: PhD, Biomedical Engineering, 2016, Purdue University

Neuromuscular diseases manifest by a handful of known phenotypes affecting the peripheral nerves, skeletal muscle fibers, and neuromuscular junction. Common signs of these diseases include demyelination, myasthenia, atrophy, and aberrant muscle activity—all of which may be tracked over time using one or more electrophysiological markers. Mice, which are the predominant mammalian model for most human diseases, have been used to study congenital neuromuscular diseases for decades. However, our understanding of the mechanisms underlying these pathologies is still incomplete. This is in part due to the lack of instrumentation available to easily collect longitudinal, in vivo electrophysiological activity from mice. There remains a need for a fully wireless, batteryless, and implantable recording system that can be adapted for a variety of electrophysiological measurements and also enable long-term, continuous data collection in very small animals. To meet this need a miniature, chronically implantable device has been developed that is capable of wirelessly coupling energy from electromagnetic fields while implanted within a body. This device can both record and trigger bioelectric events and may be chronically implanted in rodents as small as mice. This grants investigators the ability to continuously observe electrophysiological changes corresponding to disease progression in a single, freely behaving, untethered animal. The fully wireless closed-loop system is an adaptable solution for a range of long-term mechanistic and diagnostic studies in rodent disease models. Its high level of functionality, adjustable parameters, accessible building blocks, reprogrammable firmware, and modular electrode interface offer flexibility that is distinctive among fully implantable recording or stimulating devices. The key significance of this work is that it has generated novel instrumentation in the form of a fully implantable bioelectric recording device having a much higher level of functionality than any other fully wireless system available for mouse work. This has incidentally led to contributions in the areas of wireless power transfer and neural interfaces for upper-limb prosthesis control. Herein the solution space for wireless power transfer is examined including a close inspection of far-field power transfer to implanted bioelectric sensors. Methods of design and characterization for the iterative development of the device are detailed. Furthermore, its performance and utility in remote bioelectric sensing applications is demonstrated with humans, rats, healthy mice, and mouse models for degenerative neuromuscular and motoneuron diseases. Advisors/Committee Members: Pedro P. Irazoqui, Pedro P. Irazoqui, Eugenio Culurciello, Bradley S. Duerstock, Kevin L. Seburn.

Subjects/Keywords: Applied sciences; Bioelectric; Neuromuscular diseases; Recording device; Stimulation; Wireless recording device; Biomedical Engineering and Bioengineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Bercich, R. A. (2016). Improving the mechanistic study of neuromuscular diseases through the development of a fully wireless and implantable recording device. (Doctoral Dissertation). Purdue University. Retrieved from https://docs.lib.purdue.edu/open_access_dissertations/621

Chicago Manual of Style (16th Edition):

Bercich, Rebecca A. “Improving the mechanistic study of neuromuscular diseases through the development of a fully wireless and implantable recording device.” 2016. Doctoral Dissertation, Purdue University. Accessed January 19, 2020. https://docs.lib.purdue.edu/open_access_dissertations/621.

MLA Handbook (7th Edition):

Bercich, Rebecca A. “Improving the mechanistic study of neuromuscular diseases through the development of a fully wireless and implantable recording device.” 2016. Web. 19 Jan 2020.

Vancouver:

Bercich RA. Improving the mechanistic study of neuromuscular diseases through the development of a fully wireless and implantable recording device. [Internet] [Doctoral dissertation]. Purdue University; 2016. [cited 2020 Jan 19]. Available from: https://docs.lib.purdue.edu/open_access_dissertations/621.

Council of Science Editors:

Bercich RA. Improving the mechanistic study of neuromuscular diseases through the development of a fully wireless and implantable recording device. [Doctoral Dissertation]. Purdue University; 2016. Available from: https://docs.lib.purdue.edu/open_access_dissertations/621


Purdue University

2. Mei, Henry. Coupled resonator based wireless power transfer for bioelectronics.

Degree: PhD, Biomedical Engineering, 2016, Purdue University

Implantable and wearable bioelectronics provide the ability to monitor and modulate physiological processes. They represent a promising set of technologies that can provide new treatment for patients or new tools for scientific discovery, such as in long-term studies involving small animals. As these technologies advance, two trends are clear, miniaturization and increased sophistication i.e. multiple channels, wireless bi-directional communication, and responsiveness (closed-loop devices). One primary challenge in realizing miniaturized and sophisticated bioelectronics is powering. Integration and development of wireless power transfer (WPT) technology, however, can overcome this challenge. In this dissertation, I propose the use of coupled resonator WPT for bioelectronics and present a new generalized analysis and optimization methodology, derived from complex microwave bandpass filter synthesis, for maximizing and controlling coupled resonator based WPT performance. This newly developed set of analysis and optimization methods enables system miniaturization while simultaneously achieving the necessary performance to safely power sophisticated bioelectronics. As an application example, a novel coil to coil based coupled resonator arrangement to wirelessly operate eight surface electromyography sensing devices wrapped circumferentially around an able-bodied arm is developed and demonstrated. In addition to standard coil to coil based systems, this dissertation also presents a new form of coupled resonator WPT system built of a large hollow metallic cavity resonator. By leveraging the analysis and optimization methods developed here, I present a new cavity resonator WPT system for long-term experiments involving small rodents for the first time. The cavity resonator based WPT arena exhibits a volume of 60.96 x 60.96 x 30.0 cm3. In comparison to prior state of the art, this cavity resonator system enables nearly continuous wireless operation of a miniature sophisticated device implanted in a freely behaving rodent within the largest space. Finally, I present preliminary work, providing the foundation for future studies, to demonstrate the feasibility of treating segments of the human body as a dielectric waveguide resonator. This creates another form of a coupled resonator system. Preliminary experiments demonstrated optimized coupled resonator wireless energy transfer into human tissue. The WPT performance achieved to an ultra-miniature sized receive coil (2 mm diameter) is presented. Indeed, optimized coupled resonator systems, broadened to include cavity resonator structures and human formed dielectric resonators, can enable the effective use of coupled resonator based WPT technology to power miniaturized and sophisticated bioelectronics. Advisors/Committee Members: Pedro P. Irazoqui, Pedro P. Irazoqui, Jennifer Bernhard, Eugenio Culurciello, Zhongming Liu.

Subjects/Keywords: Pure sciences; Applied sciences; Bandpass filter; Bioelectronics; Cavity resonator; Coupled resonator; Evanescent fields; Wireless power transfer; Biomedical Engineering and Bioengineering; Electrical and Computer Engineering; Electromagnetics and Photonics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Mei, H. (2016). Coupled resonator based wireless power transfer for bioelectronics. (Doctoral Dissertation). Purdue University. Retrieved from https://docs.lib.purdue.edu/open_access_dissertations/678

Chicago Manual of Style (16th Edition):

Mei, Henry. “Coupled resonator based wireless power transfer for bioelectronics.” 2016. Doctoral Dissertation, Purdue University. Accessed January 19, 2020. https://docs.lib.purdue.edu/open_access_dissertations/678.

MLA Handbook (7th Edition):

Mei, Henry. “Coupled resonator based wireless power transfer for bioelectronics.” 2016. Web. 19 Jan 2020.

Vancouver:

Mei H. Coupled resonator based wireless power transfer for bioelectronics. [Internet] [Doctoral dissertation]. Purdue University; 2016. [cited 2020 Jan 19]. Available from: https://docs.lib.purdue.edu/open_access_dissertations/678.

Council of Science Editors:

Mei H. Coupled resonator based wireless power transfer for bioelectronics. [Doctoral Dissertation]. Purdue University; 2016. Available from: https://docs.lib.purdue.edu/open_access_dissertations/678


Purdue University

3. Kim, Young-Joon. Low power CMOS IC, biosensor and wireless power transfer techniques for wireless sensor network application.

Degree: PhD, Electrical and Computer Engineering, 2016, Purdue University

The emerging field of wireless sensor network (WSN) is receiving great attention due to the interest in healthcare. Traditional battery-powered devices suffer from large size, weight and secondary replacement surgery after the battery life-time which is often not desired, especially for an implantable application. Thus an energy harvesting method needs to be investigated. In addition to energy harvesting, the sensor network needs to be low power to extend the wireless power transfer distance and meet the regulation on RF power exposed to human tissue (specific absorption ratio). Also, miniature sensor integration is another challenge since most of the commercial sensors have rigid form or have a bulky size. The objective of this thesis is to provide solutions to the aforementioned challenges. Advisors/Committee Members: Pedro P Irazoqui, Vijay Raghunathan, Byunghoo Jung, Kaushik Roy, Timothy S Fisher.

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Kim, Y. (2016). Low power CMOS IC, biosensor and wireless power transfer techniques for wireless sensor network application. (Doctoral Dissertation). Purdue University. Retrieved from https://docs.lib.purdue.edu/open_access_dissertations/1389

Chicago Manual of Style (16th Edition):

Kim, Young-Joon. “Low power CMOS IC, biosensor and wireless power transfer techniques for wireless sensor network application.” 2016. Doctoral Dissertation, Purdue University. Accessed January 19, 2020. https://docs.lib.purdue.edu/open_access_dissertations/1389.

MLA Handbook (7th Edition):

Kim, Young-Joon. “Low power CMOS IC, biosensor and wireless power transfer techniques for wireless sensor network application.” 2016. Web. 19 Jan 2020.

Vancouver:

Kim Y. Low power CMOS IC, biosensor and wireless power transfer techniques for wireless sensor network application. [Internet] [Doctoral dissertation]. Purdue University; 2016. [cited 2020 Jan 19]. Available from: https://docs.lib.purdue.edu/open_access_dissertations/1389.

Council of Science Editors:

Kim Y. Low power CMOS IC, biosensor and wireless power transfer techniques for wireless sensor network application. [Doctoral Dissertation]. Purdue University; 2016. Available from: https://docs.lib.purdue.edu/open_access_dissertations/1389

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