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Purdue University

1. Bercich, Rebecca A. Improving the mechanistic study of neuromuscular diseases through the development of a fully wireless and implantable recording device.

Degree: PhD, Biomedical Engineering, 2016, Purdue University

Neuromuscular diseases manifest by a handful of known phenotypes affecting the peripheral nerves, skeletal muscle fibers, and neuromuscular junction. Common signs of these diseases include demyelination, myasthenia, atrophy, and aberrant muscle activity—all of which may be tracked over time using one or more electrophysiological markers. Mice, which are the predominant mammalian model for most human diseases, have been used to study congenital neuromuscular diseases for decades. However, our understanding of the mechanisms underlying these pathologies is still incomplete. This is in part due to the lack of instrumentation available to easily collect longitudinal, in vivo electrophysiological activity from mice. There remains a need for a fully wireless, batteryless, and implantable recording system that can be adapted for a variety of electrophysiological measurements and also enable long-term, continuous data collection in very small animals. To meet this need a miniature, chronically implantable device has been developed that is capable of wirelessly coupling energy from electromagnetic fields while implanted within a body. This device can both record and trigger bioelectric events and may be chronically implanted in rodents as small as mice. This grants investigators the ability to continuously observe electrophysiological changes corresponding to disease progression in a single, freely behaving, untethered animal. The fully wireless closed-loop system is an adaptable solution for a range of long-term mechanistic and diagnostic studies in rodent disease models. Its high level of functionality, adjustable parameters, accessible building blocks, reprogrammable firmware, and modular electrode interface offer flexibility that is distinctive among fully implantable recording or stimulating devices. The key significance of this work is that it has generated novel instrumentation in the form of a fully implantable bioelectric recording device having a much higher level of functionality than any other fully wireless system available for mouse work. This has incidentally led to contributions in the areas of wireless power transfer and neural interfaces for upper-limb prosthesis control. Herein the solution space for wireless power transfer is examined including a close inspection of far-field power transfer to implanted bioelectric sensors. Methods of design and characterization for the iterative development of the device are detailed. Furthermore, its performance and utility in remote bioelectric sensing applications is demonstrated with humans, rats, healthy mice, and mouse models for degenerative neuromuscular and motoneuron diseases. Advisors/Committee Members: Pedro P. Irazoqui, Pedro P. Irazoqui, Eugenio Culurciello, Bradley S. Duerstock, Kevin L. Seburn.

Subjects/Keywords: Applied sciences; Bioelectric; Neuromuscular diseases; Recording device; Stimulation; Wireless recording device; Biomedical Engineering and Bioengineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Bercich, R. A. (2016). Improving the mechanistic study of neuromuscular diseases through the development of a fully wireless and implantable recording device. (Doctoral Dissertation). Purdue University. Retrieved from https://docs.lib.purdue.edu/open_access_dissertations/621

Chicago Manual of Style (16th Edition):

Bercich, Rebecca A. “Improving the mechanistic study of neuromuscular diseases through the development of a fully wireless and implantable recording device.” 2016. Doctoral Dissertation, Purdue University. Accessed January 19, 2020. https://docs.lib.purdue.edu/open_access_dissertations/621.

MLA Handbook (7th Edition):

Bercich, Rebecca A. “Improving the mechanistic study of neuromuscular diseases through the development of a fully wireless and implantable recording device.” 2016. Web. 19 Jan 2020.

Vancouver:

Bercich RA. Improving the mechanistic study of neuromuscular diseases through the development of a fully wireless and implantable recording device. [Internet] [Doctoral dissertation]. Purdue University; 2016. [cited 2020 Jan 19]. Available from: https://docs.lib.purdue.edu/open_access_dissertations/621.

Council of Science Editors:

Bercich RA. Improving the mechanistic study of neuromuscular diseases through the development of a fully wireless and implantable recording device. [Doctoral Dissertation]. Purdue University; 2016. Available from: https://docs.lib.purdue.edu/open_access_dissertations/621

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