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Princeton University
1.
Nguyen, Thanh D.
Biointerfaced Nanopiezoelectrics
.
Degree: PhD, 2013, Princeton University
URL: http://arks.princeton.edu/ark:/88435/dsp018k71nh220 
► Biointerfaced nanopiezoelectrics refers to the generation, fundamental study, and device applications of piezoelectric nanomaterials and their interfaces with cells and tissues. This field has the…
(more)
▼ Biointerfaced nanopiezoelectrics refers to the generation, fundamental study, and device applications of piezoelectric nanomaterials and their interfaces with cells and tissues. This field has the potential to impact areas ranging from new nanomaterial properties, to better understanding of electromechanical effects in biological systems, and finally to applications in bio-mechanoelectric sensing, energy harvesting and regeneration. Piezoelectric materials are smart materials which can convert between mechanical and electrical energy. Lead Zirconate Titanate (PZT) is among the most efficient piezoelectrics for this transduction, with a piezoelectric charge coefficient of ~ 250 pC/N in bulk. Accordingly, PZT nanomaterials could represent promising platforms for applications at small scales such as nanogenerators, nanosensors and nanoactuators. However, PZT nanomaterials are challenging to synthesize due to the stringent material stoichiometry for maximal conversion efficiency. Here, we show that high performance PZT nanomaterials can be fabricated over large areas, and exhibit large piezoelectric coefficients. We can transfer these nanopiezoelectrics onto flexible, stretchable, and biocompatible elastomeric substrates while retaining their performance. Most significantly, we show that the PZT nanomaterials can be used to interface with cells and tissues for applications in sensing mechanical signals that are inherent to cellular physiology. PZT nanomaterials enable size-commensurate interfaces with tiny cellular structures which are able to detect minute mechanical effects in cells. Finally, we show that the scalability of the PZT nanoribbons enables the creation of arrays which can be biointerfaced with lung tissue to measure deformations in a mimicked respiratory process. For future directions, PZT nanomaterials could function as actuators to mechanically stimulate and engineer nerve regeneration. As application first step, we demonstrate the capability of mechanical forces to induce rapid growth of neurites in a microfluidic device. Thus, research on the field of biointerfaced nanopiezoelectrics could have a substantial impact on many areas, ranging from the fundamental study of new nanomaterial properties and mechanical effects in cells to various applications such as electromechanical prosthetics, human-machine interfaces, and regenerative biomedicine.
Advisors/Committee Members: McAlpine, Michael C (advisor).
Subjects/Keywords: biomechanical engineering;
biomechanical sensing;
biomechanics;
nanopiezoelectrics
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APA (6th Edition):
Nguyen, T. D. (2013). Biointerfaced Nanopiezoelectrics
. (Doctoral Dissertation). Princeton University. Retrieved from http://arks.princeton.edu/ark:/88435/dsp018k71nh220
Chicago Manual of Style (16th Edition):
Nguyen, Thanh D. “Biointerfaced Nanopiezoelectrics
.” 2013. Doctoral Dissertation, Princeton University. Accessed February 15, 2019.
http://arks.princeton.edu/ark:/88435/dsp018k71nh220.
MLA Handbook (7th Edition):
Nguyen, Thanh D. “Biointerfaced Nanopiezoelectrics
.” 2013. Web. 15 Feb 2019.
Vancouver:
Nguyen TD. Biointerfaced Nanopiezoelectrics
. [Internet] [Doctoral dissertation]. Princeton University; 2013. [cited 2019 Feb 15].
Available from: http://arks.princeton.edu/ark:/88435/dsp018k71nh220.
Council of Science Editors:
Nguyen TD. Biointerfaced Nanopiezoelectrics
. [Doctoral Dissertation]. Princeton University; 2013. Available from: http://arks.princeton.edu/ark:/88435/dsp018k71nh220
2.
Kong, Yong Lin.
The Fabrication of Devices with Functional Nanomaterials
.
Degree: PhD, 2016, Princeton University
URL: http://arks.princeton.edu/ark:/88435/dsp01qz20sv90g
► Historically, the discovery of materials and the development of their processing methods have enabled the creation of better devices. Indeed, the advancement of nanoscience has…
(more)
▼ Historically, the discovery of materials and the development of their processing methods have enabled the creation of better devices. Indeed, the advancement of nanoscience has enabled the synthesis of various nanomaterials that can be tailored to serve as the functional components of a device. This dissertation explores the processing and assembling of various nanomaterials to fabricate novel devices that capture their unique properties. First, the microfabrication of biosensing arrays that could enable a rapid diagnosis of complex diseases is considered. Second, the additive manufacturing of active electronic devices with nanomaterials on and within a three dimensional construct is developed. Third, a study of the deposition of functional nanomaterials in a confined construct via convective self-assembly is proposed. Lastly, a method to characterize the drying induced stress during the deposition of colloidal nanomaterials is studied. In general, these results suggest the synergistic integration of functional nanomaterials with the understanding of complex fluids to fabricate novel devices with a diverse range of potential applications.
Advisors/Committee Members: Stone, Howard A (advisor), McAlpine, Michael C (advisor).
Subjects/Keywords: colloidal deposition;
device fabrication;
nanomaterials
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APA (6th Edition):
Kong, Y. L. (2016). The Fabrication of Devices with Functional Nanomaterials
. (Doctoral Dissertation). Princeton University. Retrieved from http://arks.princeton.edu/ark:/88435/dsp01qz20sv90g
Chicago Manual of Style (16th Edition):
Kong, Yong Lin. “The Fabrication of Devices with Functional Nanomaterials
.” 2016. Doctoral Dissertation, Princeton University. Accessed February 15, 2019.
http://arks.princeton.edu/ark:/88435/dsp01qz20sv90g.
MLA Handbook (7th Edition):
Kong, Yong Lin. “The Fabrication of Devices with Functional Nanomaterials
.” 2016. Web. 15 Feb 2019.
Vancouver:
Kong YL. The Fabrication of Devices with Functional Nanomaterials
. [Internet] [Doctoral dissertation]. Princeton University; 2016. [cited 2019 Feb 15].
Available from: http://arks.princeton.edu/ark:/88435/dsp01qz20sv90g.
Council of Science Editors:
Kong YL. The Fabrication of Devices with Functional Nanomaterials
. [Doctoral Dissertation]. Princeton University; 2016. Available from: http://arks.princeton.edu/ark:/88435/dsp01qz20sv90g
3.
Sebastian mannoor, Manu.
Bionic Nanosystems
.
Degree: PhD, 2014, Princeton University
URL: http://arks.princeton.edu/ark:/88435/dsp0102870w01m
► Direct multidimensional integration of functional electronics and mechanical elements with viable biological systems could allow for the creation of bionic systems and devices possessing unique…
(more)
▼ Direct multidimensional integration of functional electronics and mechanical elements with viable biological systems could allow for the creation of bionic systems and devices possessing unique and advanced capabilities. For example, the ability to three dimensionally integrate functional electronic and mechanical components with biological cells and tissue could enable the creation of bionic systems that can have tremendous impact in regenerative medicine, prosthetics, and human-machine interfaces. However, as a consequence of the inherent dichotomy in material properties and limitations of conventional fabrication methods, the attainment of truly seamless integration of electronic and/or mechanical components with biological systems has been challenging.
Nanomaterials engineering offers a general route for overcoming these dichotomies, primarily due to the existence of a dimensional compatibility between fundamental biological functional units and abiotic nanomaterial building blocks. One area of compelling interest for bionic systems is in the field of biomedical sensing, where the direct interfacing of nanosensors onto biological tissue or the human body could stimulate exciting opportunities such as on-body health quality monitoring and adaptive threat detection. Further, interfacing of antimicrobial peptide based bioselective probes onto the bionic nanosensors could offer abilities to detect pathogenic bacteria with bio-inspired selectivity. Most compellingly, when paired with additive manufacturing techniques such as 3D printing, these characteristics enable three dimensional integration and merging of a variety of functional materials including electronic, structural and biomaterials with viable biological cells, in the precise anatomic geometries of human organs, to form three dimensionally integrated, multi-functional bionic hybrids and cyborg devices with unique capabilities.
In this thesis, we illustrate these approaches using three representative bionic systems: 1) Bionic Nanosensors: featuring bio-integrated graphene nanosensors for ubiquitous sensing, 2) Bionic Organs: featuring 3D printed bionic ears with three dimensionally integrated electronics and 3) Bionic Leaves: describing ongoing work in the direction of the creation of a bionic leaf enabled by the integration of plant derived photosynthetic functional units with electronic materials and components into a leaf-shaped hierarchical structure for harvesting photosynthetic bioelectricity.
Advisors/Committee Members: MCALPINE, MICHAEL C (advisor).
Subjects/Keywords: biomaterials;
bionic
…Father Martin Miller, chaplains at
Princeton University for their prayers and personal guidance…
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APA (6th Edition):
Sebastian mannoor, M. (2014). Bionic Nanosystems
. (Doctoral Dissertation). Princeton University. Retrieved from http://arks.princeton.edu/ark:/88435/dsp0102870w01m
Chicago Manual of Style (16th Edition):
Sebastian mannoor, Manu. “Bionic Nanosystems
.” 2014. Doctoral Dissertation, Princeton University. Accessed February 15, 2019.
http://arks.princeton.edu/ark:/88435/dsp0102870w01m.
MLA Handbook (7th Edition):
Sebastian mannoor, Manu. “Bionic Nanosystems
.” 2014. Web. 15 Feb 2019.
Vancouver:
Sebastian mannoor M. Bionic Nanosystems
. [Internet] [Doctoral dissertation]. Princeton University; 2014. [cited 2019 Feb 15].
Available from: http://arks.princeton.edu/ark:/88435/dsp0102870w01m.
Council of Science Editors:
Sebastian mannoor M. Bionic Nanosystems
. [Doctoral Dissertation]. Princeton University; 2014. Available from: http://arks.princeton.edu/ark:/88435/dsp0102870w01m
4.
Cung, Kellye.
Microscale BioMEMS & Nanoscale Biomimesis
.
Degree: PhD, 2014, Princeton University
URL: http://arks.princeton.edu/ark:/88435/dsp01b5644r673
► The development of methods for exploiting and controlling biomolecular recognition at micro- to nanometer scales could enable new understandings of interactions of living and non-living…
(more)
▼ The development of methods for exploiting and controlling biomolecular recognition at micro- to nanometer scales could enable new understandings of interactions of living and non-living systems, and impact a diversity of fields including regenerative medicine, renewable energy, and bionic electronics. BioMEMS refers to the use of microfabrication technologies for biomedical and biological applications, and often capitalizes on microfluidics for precise manipulation and parallelization of processes. Contrarily, biomimesis refers to the exploitation of biological principles to address engineering problems. Having evolved over billions of years, natural systems may serve as rich exemplars for novel synthetic routes to new materials and material morphologies, particularly at the nanometer scale. Unifying these two concepts is their shared objective of furthering our understanding of biological and materials interfaces, and of implementing these insights in novel device concepts which both mimic or enhance biology and advance small-scale fabrication technologies.
This thesis explores new avenues in the use of bioMEMS and biomimesis from the micro- and nano-meter scales. Specifically, it examines 1) the use of bioMEMS for biocombinatorial studies of molecule complementarity, 2) the control of neurite growth using microfluidically-applied mechanical forces, and 3) the use of biomimesis for the rational synthesis of new nanoscale smart materials.
The results presented in this dissertation further our understanding of fundamental biomolecular dynamics and interactions, including the interfacial phenomena governing interplay with inorganic materials. Foreseeable applications run the gamut from diagnostics and therapeutics to next generation nano-sensors, actuators, and energy harvesters. The symbiosis of micro-and nanoscale devices and biological building blocks seems an instinctive partnership, forged by homologous dimensions and reinforced by complementary properties, and this thesis provides unique new contributions at this interface.
Advisors/Committee Members: McAlpine, Michael C (advisor).
Subjects/Keywords: biomimetic;
microfluidic;
nanotechnology;
phage display;
piezoelectric
Record Details
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Record Details
Similar Records
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Cung, K. (2014). Microscale BioMEMS & Nanoscale Biomimesis
. (Doctoral Dissertation). Princeton University. Retrieved from http://arks.princeton.edu/ark:/88435/dsp01b5644r673
Chicago Manual of Style (16th Edition):
Cung, Kellye. “Microscale BioMEMS & Nanoscale Biomimesis
.” 2014. Doctoral Dissertation, Princeton University. Accessed February 15, 2019.
http://arks.princeton.edu/ark:/88435/dsp01b5644r673.
MLA Handbook (7th Edition):
Cung, Kellye. “Microscale BioMEMS & Nanoscale Biomimesis
.” 2014. Web. 15 Feb 2019.
Vancouver:
Cung K. Microscale BioMEMS & Nanoscale Biomimesis
. [Internet] [Doctoral dissertation]. Princeton University; 2014. [cited 2019 Feb 15].
Available from: http://arks.princeton.edu/ark:/88435/dsp01b5644r673.
Council of Science Editors:
Cung K. Microscale BioMEMS & Nanoscale Biomimesis
. [Doctoral Dissertation]. Princeton University; 2014. Available from: http://arks.princeton.edu/ark:/88435/dsp01b5644r673
. 
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