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You searched for +publisher:"Pontifical Catholic University of Rio Grande do Sul" +contributor:("Mendon?a, Jos? Alexandre"). Showing records 1 – 2 of 2 total matches.

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1. Bisi, Melissa Cl?udia. Correla??o do doppler espectral articular com atividade inflamat?ria na artrite reumat?ide.

Degree: 2016, Pontifical Catholic University of Rio Grande do Sul

Submitted by Caroline Xavier ([email protected]) on 2017-05-19T17:37:33Z No. of bitstreams: 1 TES_MELISSA_CLAUDIA_BISI_PARCIAL.pdf: 474029 bytes, checksum: cd9002527f3261fb305955c53e4f5cc3 (MD5)

Made available in DSpace on 2017-05-19T17:37:33Z (GMT). No. of bitstreams: 1 TES_MELISSA_CLAUDIA_BISI_PARCIAL.pdf: 474029 bytes, checksum: cd9002527f3261fb305955c53e4f5cc3 (MD5) Previous issue date: 2016-12-09

Introduction: Ultrasonography (US) is an useful tool for evaluation of synovial vascularization and proliferation in rheumatoid arthritis (RA). Differently from US power Doppler (PD), the resistive index (RI) of spectral Doppler (SD) provides a quantitative analysis of vascular inflammation, but its utility in the ultrasonographic evaluation of RA activity has not been established. Objetives: To associate the RI with US parameters of synovitis and disease activity in patients with established RA. Methods: Consecutive pD-positive RA patients were included in a prospective cross-sectional study. Disease activity and disability were evaluated using the Disease Activity Score in 28-joints (DAS28) and Health Assessment Questionnaire (HAQ), respectively. Gray scale (GS) synovitis, PD and SD analysis were performed by one of two examiners in wrists, second and third metacarpophalangeal, and proximal interphalangeal joints. The 10 joint-GS and -PD scores and the mean RI were then calculated. Weighted kappa values were employed to assess interobserver reliability. Results: out of 112 patients scanned initially, 95 patients with PD signal were included (median duration of disease, 7 years and mean DAS28, 4.32 ? 1.66). Weighted kappa values in real-time US were 0.77 for synovitis, 0.87 for PD and 0.68 for RI. There was a significant association of 10 joint-GS and -PD with swollen joints count (rs = 0.54, p <0.001 and rs = 0.39, P <0.001, respectively). There were no significant correlations of the RI with 10-joint- GS, 10-joint-PD, DAS28, joint counts or HAQ (P>0.10 for all tests). Conclusion: Spectral Doppler RI did not correlate to any US or clinical parameters of disease activity in our sample of established RA patients. The addition of the RI score does not seem to improve US performance in this scenario.

Introdu??o: A ultrassonografia (US) ? uma ferramenta ?til para a avalia??o da vasculariza??o sinovial e prolifera??o na artrite reumatoide (AR). Diferentemente do sinal de power Doppler (PD), o ?ndice de resist?ncia (RI) do Doppler espectral(SD) fornece uma an?lise quantitativa de inflama??o vascular, mas a sua utilidade na avalia??o ultrassonogr?fica da atividade reumatoide n?o foi estabelecida. Objetivos: Associar o RI com par?metros ultrassonogr?ficos e ?ndices de atividade da doen?a em pacientes com AR estabelecida. M?todos: pacientes com AR PDpositivos, consecutivos, foram inclu?dos neste estudo transversal. A atividade da doen?a e a capacidade funcional foram avaliados usando o Disease Activity Score em 28 articula??es (DAS28) e Health Assessment Questionnaire (HAQ), respectivamente. Sinovite em escala…

Advisors/Committee Members: Staub, Henrique Luiz, Mendon?a, Jos? Alexandre.

Subjects/Keywords: Artrite Reumatoide; Ultrassonografia Musculoesquel?tica; Power Doppler; Doppler Espectral; ?ndice de Resist?ncia; CIENCIAS DA SAUDE::MEDICINA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Bisi, M. C. (2016). Correla??o do doppler espectral articular com atividade inflamat?ria na artrite reumat?ide. (Doctoral Dissertation). Pontifical Catholic University of Rio Grande do Sul. Retrieved from http://tede2.pucrs.br/tede2/handle/tede/7289

Chicago Manual of Style (16th Edition):

Bisi, Melissa Cl?udia. “Correla??o do doppler espectral articular com atividade inflamat?ria na artrite reumat?ide.” 2016. Doctoral Dissertation, Pontifical Catholic University of Rio Grande do Sul. Accessed May 07, 2021. http://tede2.pucrs.br/tede2/handle/tede/7289.

MLA Handbook (7th Edition):

Bisi, Melissa Cl?udia. “Correla??o do doppler espectral articular com atividade inflamat?ria na artrite reumat?ide.” 2016. Web. 07 May 2021.

Vancouver:

Bisi MC. Correla??o do doppler espectral articular com atividade inflamat?ria na artrite reumat?ide. [Internet] [Doctoral dissertation]. Pontifical Catholic University of Rio Grande do Sul; 2016. [cited 2021 May 07]. Available from: http://tede2.pucrs.br/tede2/handle/tede/7289.

Council of Science Editors:

Bisi MC. Correla??o do doppler espectral articular com atividade inflamat?ria na artrite reumat?ide. [Doctoral Dissertation]. Pontifical Catholic University of Rio Grande do Sul; 2016. Available from: http://tede2.pucrs.br/tede2/handle/tede/7289

2. Prado, Aline Defaveri do. Achados inflamat?rios e dano estrutural vistos por ultrassonografia em pacientes com artrite reumatoide : correla??o com dados cl?nicos, linf?citos T regulat?rios e TH-17 e citocinas inflamat?rias no sangue perif?rico.

Degree: 2016, Pontifical Catholic University of Rio Grande do Sul

Submitted by Setor de Tratamento da Informa??o - BC/PUCRS ([email protected]) on 2016-06-17T19:39:46Z No. of bitstreams: 1 TES_ALINE_DEFAVERI_DO_PRADO_COMPLETO.pdf: 1737423 bytes, checksum: 77ee581083f58c46dd10a545b62097a5 (MD5)

Made available in DSpace on 2016-06-17T19:39:46Z (GMT). No. of bitstreams: 1 TES_ALINE_DEFAVERI_DO_PRADO_COMPLETO.pdf: 1737423 bytes, checksum: 77ee581083f58c46dd10a545b62097a5 (MD5) Previous issue date: 2016-03-28

Introduction: Rheumatoid Arthritis (RA) is an autoimmune, inflammatory and chronic disease. Muskuloskeletal ultrasound (MSUS) has been increasingly used for diagnostic evaluation and monitoring of patients. Regulatory T cells (Tregs) and lymphocytes producers of IL 17 (Th17) imbalance and disfuntion, as well as pro inflammatory cytokines, have been implicated in the pathogenesis of RA. There are few studies on the association of circulating lymphocites subtypes and cytokines with MSUS findings in RA. Methods: One hundred and one RA patients (1987 American College of Rheumatology criteria) treated with disease-modifying antirheumatic drugs (DMARDs) were included in this cross sectional study. A blood sample was taken just before clinical and ultrasonographic evaluation, which were all performed on the same day, consecutively and in a blinded fashion. Lymphocytes were isolated and immunophenotyped by flow cytometry to investigate regulatory FoxP3+ T cells and IL-17+ cells. Plasma Th1-Th2-Th17 cytokines (IL-2, IL-4, IL-6, IL-10, IL-17, TNF e IFN-?) and VEGF were searched using a Cytometric Bead Array (CBA; BD biosciences) kit by flow cytometry. Disease acitivity and disability were measured using Disease Activity Score in 28 joints (DAS28) and Health Assessment Questionnaire (HAQ). MSUS (MyLab 60, Esaote, Genova, Italy, 18 MHz linear probe) was performed consecutively by two ultrassound-trained rheumatologists on the wrists, 2th and 3th metacarpophalangeal and 2th and 3th proximal interphalangeal joints of both hands. Gray-scale synovial hypertrophy (PS) and power Doppler signal (pD) were searched using a semi-quantitative scale (0-3). Erosions were classified as present or absent. The sum of the individual joint scores for PS and pD (10-joint PS and pD scores) was calculated and used to correlate with clinical and laboratory data. Mann-Whitney test, Kruskal-Wallis test and Spearman correlation coefficient (rS) were used for statistical analysis, as well as liner multivariate regression. Interater agreement was tested using kappa statistics and intraclass correlation. Results: Among 101 patients, we were able to measure Treg/Th-17 in 90 individuals. Plasma cytokines were searched in 64 patients. Clinical and demographic features were: mean age, 55.8 ? 11 years; female gender, 80%; Caucasians, 85%; median (interquartile range) disease duration 6 (2-13) years; mean ? SD DAS28, 4.28 ? 1.64; mean ? SD HAQ score, 1.11 ? 0.85. Interobserver agreement (kappa) for US features varied from 0.53 to 1.0. Intraclass correlation for 10-joint PS score was 0.964 (95% CI 0.899-0.986, P <0.000)…

Advisors/Committee Members: Staub, Henrique Luiz, Mendon?a, Jos? Alexandre.

Subjects/Keywords: ARTRITE REUMATOIDE; LINF?CITOS T; INFLAMA??O; CITOCINAS; ULTRASSONOGRAFIA; MEDICINA; CIENCIAS DA SAUDE::MEDICINA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Prado, A. D. d. (2016). Achados inflamat?rios e dano estrutural vistos por ultrassonografia em pacientes com artrite reumatoide : correla??o com dados cl?nicos, linf?citos T regulat?rios e TH-17 e citocinas inflamat?rias no sangue perif?rico. (Doctoral Dissertation). Pontifical Catholic University of Rio Grande do Sul. Retrieved from http://tede2.pucrs.br/tede2/handle/tede/6773

Chicago Manual of Style (16th Edition):

Prado, Aline Defaveri do. “Achados inflamat?rios e dano estrutural vistos por ultrassonografia em pacientes com artrite reumatoide : correla??o com dados cl?nicos, linf?citos T regulat?rios e TH-17 e citocinas inflamat?rias no sangue perif?rico.” 2016. Doctoral Dissertation, Pontifical Catholic University of Rio Grande do Sul. Accessed May 07, 2021. http://tede2.pucrs.br/tede2/handle/tede/6773.

MLA Handbook (7th Edition):

Prado, Aline Defaveri do. “Achados inflamat?rios e dano estrutural vistos por ultrassonografia em pacientes com artrite reumatoide : correla??o com dados cl?nicos, linf?citos T regulat?rios e TH-17 e citocinas inflamat?rias no sangue perif?rico.” 2016. Web. 07 May 2021.

Vancouver:

Prado ADd. Achados inflamat?rios e dano estrutural vistos por ultrassonografia em pacientes com artrite reumatoide : correla??o com dados cl?nicos, linf?citos T regulat?rios e TH-17 e citocinas inflamat?rias no sangue perif?rico. [Internet] [Doctoral dissertation]. Pontifical Catholic University of Rio Grande do Sul; 2016. [cited 2021 May 07]. Available from: http://tede2.pucrs.br/tede2/handle/tede/6773.

Council of Science Editors:

Prado ADd. Achados inflamat?rios e dano estrutural vistos por ultrassonografia em pacientes com artrite reumatoide : correla??o com dados cl?nicos, linf?citos T regulat?rios e TH-17 e citocinas inflamat?rias no sangue perif?rico. [Doctoral Dissertation]. Pontifical Catholic University of Rio Grande do Sul; 2016. Available from: http://tede2.pucrs.br/tede2/handle/tede/6773

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